Allele Dmel\w^sat

General Information
Symbol	Dmel\w^sat	Species	D. melanogaster
Name	satsuma	FlyBase ID	FBal0018300
Feature type	allele	Associated gene	Dmel\w

Allele class
Mutagen	spontaneous
Recent Updates
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FB2013_03
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Nature of the Allele
Allele class
Mutagen	spontaneous (Zachar and Bingham, 1982)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: F590G. Mutation is at the C-terminal end of putative transmembrane spanning α-helix 5. (Mackenzie et al., 1999) Point mutation in the structural portion of w. (Rabinow et al., 1991) Point mutation. (Rabinow and Birchler, 1989, Birchler and Hiebert, 1989, Bhadra and Birchler, 1996, Bhadra et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective (Bhadra et al., 1997, Lloyd et al., 2002, Mackenzie et al., 1999) visible \| recessive
Phenotype Manifest In
	pigment cell (Zachar and Bingham, 1982, Lloyd et al., 2002, Mackenzie et al., 1999)
Detailed Description
	Statement Reference Homozygotes have brown-orange eyes with only 7% red pigment (compared to 100% pigment in wild type). (Lloyd et al., 2002) Drosopterin (red pigment) levels are 4% of wild-type levels, xanthommatin levels (brown pigments) are 79% of wild-type levels. (Mackenzie et al., 1999) Eye colour: deep ruby. (Zachar and Bingham, 1982) Eye colour: deep ruby Malpighian tubule colour: nearly wild-type.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference w^sat has eye color defective \| recessive phenotype, suppressible by Low¹ (Bhadra et al., 1997)
Enhancer of
Statement Reference w^sat/w^e(g) is an enhancer of eye color defective phenotype of g² (Lloyd et al., 2002) w^sat/w^e(g) is an enhancer of eye color defective phenotype of g^53d (Lloyd et al., 2002)
NOT Enhancer of
Statement Reference w^sat/w^e(g) is a non-enhancer of eye color defective phenotype of g^50e (Lloyd et al., 2002)
Phenotype Manifest In
Enhanced by
Statement Reference w^sat has phenotype, enhanceable by Ufo¹ (Bhadra et al., 1997) w^sat has phenotype, enhanceable by Wow^ems1 (Birchler et al., 1994) w^sat has phenotype, enhanceable by Wow^hd1 (Birchler et al., 1994) w^sat has phenotype, enhanceable by Wow^γb (Birchler et al., 1994) w^sat has phenotype, enhanceable by Wow^γe (Birchler et al., 1994)
NOT Enhanced by
Statement Reference w^sat has phenotype, non-enhanceable by Doa³ (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by Doa⁴ (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by Doa⁵ (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by Doa⁶ (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by Doa⁷ (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by Doa⁸ (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by Doa⁹ (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by Doa^HD (Rabinow and Birchler, 1989) w^sat has phenotype, non-enhanceable by E(w^a)¹ (Birchler and Hiebert, 1989) w^sat has phenotype, non-enhanceable by In(3)Msu¹ (Csink et al., 1994) w^sat has phenotype, non-enhanceable by In(3)Msu² (Csink et al., 1994)
Suppressed by
Statement Reference w^sat has phenotype, suppressible by Inr-a^EMS3 (Rabinow et al., 1991) w^sat has phenotype, suppressible by Inr-a^EMS4 (Rabinow et al., 1991) w^sat has phenotype, suppressible by Inr-a^EMS5 (Rabinow et al., 1991) w^sat has phenotype, suppressible by Inr-a^hd1 (Rabinow et al., 1991) w^sat has phenotype, suppressible by Inr-a^γb (Rabinow et al., 1991) w^sat has phenotype, suppressible by Inr-a^γc (Rabinow et al., 1991) w^sat has phenotype, suppressible by Inr-a^γd (Rabinow et al., 1991) w^sat has phenotype, suppressible by Mow^gamma (Bhadra and Birchler, 1996) w^sat has pigment cell phenotype, suppressible by Low¹ (Bhadra et al., 1997)
NOT suppressed by
Statement Reference w^sat has phenotype, non-suppressible by Doa³ (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by Doa⁴ (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by Doa⁵ (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by Doa⁶ (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by Doa⁷ (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by Doa⁸ (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by Doa⁹ (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by Doa^HD (Rabinow and Birchler, 1989) w^sat has phenotype, non-suppressible by In(3)Msu¹ (Csink et al., 1994) w^sat has phenotype, non-suppressible by In(3)Msu² (Csink et al., 1994) w^sat has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Enhancer of
Statement Reference w^sat/w^e(g) is an enhancer of pigment cell phenotype of g² (Lloyd et al., 2002) w^sat/w^e(g) is an enhancer of pigment cell phenotype of g^53d (Lloyd et al., 2002)
NOT Enhancer of
Statement Reference w^sat/w^e(g) is a non-enhancer of pigment cell phenotype of g^50e (Lloyd et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Flies with a w^sat/w^e(g) mutant genotype enhance the eye colour defective phenotype of g² homozygous mutants leading to a greater reduction of red pigment in the eye. In contrast, w^sat/w^e(g), g^50e mutants have similar levels of red pigment in the eye to single g^50e mutants. (Lloyd et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	164 w^sat
Kyoto	101229 w^sat
Notes on Origin
Discoverer	Bridges, 26th Dec. 1933.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	w^33l w³³¹ w^sat
Name Synonym	satsuma
Secondary FlyBase IDs
	FBal0018099
References ( 16 )
Research paper	Lloyd et al., 2002, Genome 45(2): 296--312 Enhancer of garnet/δAP-3 is a cryptic allele of the white gene and identifies the intracellular transport system for the white protein. [FBrf0147069] Mackenzie et al., 1999, Biochim. Biophys. Acta 1419(2): 173--185 Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration. [FBrf0110254] Bhadra et al., 1997, Genetics 146(3): 903--917 A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. [FBrf0094158] Bhadra et al., 1997, Mol. Gen. Genet. 254(6): 621--634 A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster. [FBrf0094159] Bhadra and Birchler, 1996, Mol. Gen. Genet. 250(5): 601--613 Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation in Drosophila. [FBrf0086910] Birchler et al., 1994, Genetics 137(4): 1057--1070 Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. [FBrf0074960] Csink et al., 1994, Genetics 136(2): 573--583 Mosaic suppressor, a gene in Drosophila that modifies retrotransposon expression and interacts with zeste. [FBrf0068460] Rabinow et al., 1991, Genetics 129: 463--480 A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. [FBrf0054158] Birchler and Hiebert, 1989, Genetics 122: 129--138 Interaction of the Enhancer of white-apricot with transposable element alleles at the white locus in Drosophila melanogaster. [FBrf0049880] Rabinow and Birchler, 1989, EMBO J. 8: 879--889 A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus. [FBrf0049635] Zachar and Bingham, 1982, Cell 30: 529--541 Regulation of white locus expression: The structure of mutant alleles at the white locus of Drosophila melanogaster. [FBrf0037612] Green, 1959, Heredity 13: 302--315 Spatial and functional properties of pseudo-alleles at the white locus in Drosophila melanogaster. [FBrf0012683] Brehme and Demerec, 1942, Growth 6: 351--355 A survey of Malpighian tube color in the eye color mutants of Drosophila melanogaster. [FBrf0005752] Bridges, 1935, D. I. S. 3: 5--19 Drosophila melanogaster: Legend for symbols, mutants, valuations. [FBrf0063325]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]
Stock list	The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130 Stock list. [FBrf0098381]

Allele Dmel\wsat

Allele Dmel\w^sat