Allele Dmel\w^sp4

General Information
Symbol	Dmel\w^sp4	Species	D. melanogaster
Name	spotted 4	FlyBase ID	FBal0018305
Feature type	allele	Associated gene	Dmel\w

Map ( GBrowse )
Allele class
Mutagen	spontaneous, X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	spontaneous X ray (Zachar and Bingham, 1982, Davison et al., 1985)
Mutations Mapped to the Genome

Type Location Additional Notes References deletion X:2,691,604..2,692,404 comment=Deletion endpoints from FBrf0041384 and GB:X02974. evidence=experimental (O'Hare et al., 1984)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deletion of sequences in the 5' regulatory region. (Bhadra et al., 1997) Deficiency in 5' regulatory region. (Csink et al., 1994, Bhadra and Birchler, 1996) Deficiency in 5' cis regulatory region. (Rabinow and Birchler, 1989) Deficiency in 5' cis-regulatory region. (Chapman and Bingham, 1985, Birchler and Hiebert, 1989, Rabinow et al., 1991) Deletion of 1kb between nucleotide positions -2200 and -1029. (Davison et al., 1985) Deletion of 1.1kb from map position +4.9 to +6.0 relative to the transcription start site of w. (Collins et al., 1983) Deletion of 1.2kb between coordinates +5 and +6.4, using coordinate system of FBrf0038648 where coordinate 0 is the copia insert of w^a. (Zachar and Bingham, 1982) deletion in regulatory region map site (kb): +4.78 to +5.85; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective (Bhadra et al., 1997) visible \| recessive
Phenotype Manifest In
	pigment cell (Bhadra et al., 1997)
Detailed Description
	Statement Reference Fails to respond to E(w^a). (Birchler and Hiebert, 1989) Phenotype is not affected by Doa mutations. (Rabinow and Birchler, 1989) Eye colour: yellowish to brown; fine-grained mottling; male darker than female.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference w^sp4, z¹ has eye color defective phenotype, enhanceable by e(y)1¹ (Georgiev, 1994) w^sp4, z¹ has eye color defective phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4, z^op6 has eye color defective phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4, z^op6R1 has eye color defective phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4, z^v77h has eye color defective phenotype, enhanceable by e(y)1¹ (Georgiev, 1994) w^sp4, z^v77h has eye color defective phenotype, enhanceable by e(y)2¹ (Georgiev, 1994) w^sp4, z^v77h has eye color defective phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4 has eye color defective phenotype, enhanceable by z¹ (Georgiev, 1994) w^sp4 has eye color defective phenotype, enhanceable by z^v77h (Georgiev, 1994)
NOT Enhanced by
Statement Reference w^sp4, z¹ has eye color defective phenotype, non-enhanceable by e(y)2¹ (Georgiev, 1994)
Phenotype Manifest In
Enhanced by
Statement Reference w^sp4, z¹ has pigment cell phenotype, enhanceable by e(y)1¹ (Georgiev, 1994) w^sp4, z¹ has pigment cell phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4, z^op6 has pigment cell phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4, z^op6R1 has pigment cell phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4, z^v77h has pigment cell phenotype, enhanceable by e(y)1¹ (Georgiev, 1994) w^sp4, z^v77h has pigment cell phenotype, enhanceable by e(y)2¹ (Georgiev, 1994) w^sp4, z^v77h has pigment cell phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4 has phenotype, enhanceable by e(y)1¹ (Georgiev, 1994) w^sp4 has phenotype, enhanceable by e(y)3⁴ (Georgiev, 1994) w^sp4 has phenotype, enhanceable by Wow^ems1 (Birchler et al., 1994) w^sp4 has phenotype, enhanceable by Wow^hd1 (Birchler et al., 1994) w^sp4 has phenotype, enhanceable by Wow^γb (Birchler et al., 1994) w^sp4 has phenotype, enhanceable by Wow^γe (Birchler et al., 1994) w^sp4 has pigment cell phenotype, enhanceable by z¹ (Georgiev, 1994) w^sp4 has pigment cell phenotype, enhanceable by z^v77h (Georgiev, 1994)
NOT Enhanced by
Statement Reference w^sp4, z¹ has pigment cell phenotype, non-enhanceable by e(y)2¹ (Georgiev, 1994) w^sp4 has phenotype, non-enhanceable by In(3)Msu¹ (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by In(3)Msu² (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by Low¹ (Bhadra et al., 1997) w^sp4 has phenotype, non-enhanceable by Rm62^D (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by Rm62^Dem (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by Rm62^E (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by Rm62^F (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by Rm62^H (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by Rm62^K (Csink et al., 1994) w^sp4 has phenotype, non-enhanceable by Ufo¹ (Bhadra et al., 1997)
Suppressed by
Statement Reference w^sp4 has phenotype, suppressible by east¹ (Chapman and Bingham, 1985) w^sp4 has phenotype, suppressible by Mow^gamma (Bhadra and Birchler, 1996)
NOT suppressed by
Statement Reference w^sp4 has phenotype, non-suppressible by In(3)Msu¹ (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by In(3)Msu² (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by Inr-a^EMS3 (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Inr-a^EMS4 (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Inr-a^EMS5 (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Inr-a^hd1 (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Inr-a^γb (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Inr-a^γc (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Inr-a^γd (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Inr-a^γsc (Rabinow et al., 1991) w^sp4 has phenotype, non-suppressible by Low¹ (Bhadra et al., 1997) w^sp4 has phenotype, non-suppressible by Rm62^D (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by Rm62^Dem (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by Rm62^E (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by Rm62^F (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by Rm62^H (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by Rm62^K (Csink et al., 1994) w^sp4 has phenotype, non-suppressible by Ufo¹ (Bhadra et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	LeFever.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	sp-w⁴ w^sp4
Name Synonym	spotted-4 (Rabinow and Birchler, 1989) spotted 4
Secondary FlyBase IDs

References ( 17 )
Research paper	Bhadra et al., 1997, Genetics 146(3): 903--917 A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. [FBrf0094158] Bhadra et al., 1997, Mol. Gen. Genet. 254(6): 621--634 A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster. [FBrf0094159] Bhadra and Birchler, 1996, Mol. Gen. Genet. 250(5): 601--613 Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation in Drosophila. [FBrf0086910] Birchler et al., 1994, Genetics 137(4): 1057--1070 Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. [FBrf0074960] Csink et al., 1994, Genetics 138(1): 153--163 The Lighten up (Lip) gene of Drosophila melanogaster, a modifier of retroelement expression, position effect variegation and white locus insertion alleles. [FBrf0076540] Csink et al., 1994, Genetics 136(2): 573--583 Mosaic suppressor, a gene in Drosophila that modifies retrotransposon expression and interacts with zeste. [FBrf0068460] Georgiev, 1994, Genetics 138(3): 733--739 Identification of mutations in three genes that interact with zeste in the control of white gene expression in Drosophila melanogaster. [FBrf0080045] Rabinow et al., 1991, Genetics 129: 463--480 A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. [FBrf0054158] Birchler and Hiebert, 1989, Genetics 122: 129--138 Interaction of the Enhancer of white-apricot with transposable element alleles at the white locus in Drosophila melanogaster. [FBrf0049880] Rabinow and Birchler, 1989, EMBO J. 8: 879--889 A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus. [FBrf0049635] Davis et al., 1987, Proc. Natl. Acad. Sci. U.S.A. 84: 174--178 Asymmetrical pairings of transposons in and proximal to the white locus of Drosophila account for four classes of regularly occurring exchange products. [FBrf0047211] Chapman and Bingham, 1985, D. I. S. 61: 48--50 Evidence that the locus of a novel type of suppressor mutation regulates transcription of the white locus. [FBrf0042308] Davison et al., 1985, Genetics 110: 479--494 Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and in synapsis-dependent interactions in Drosophila adult tissues. [FBrf0042644] O'Hare et al., 1984, J. Mol. Biol. 180: 437--455 DNA sequence of the white locus of Drosophila melanogaster. [FBrf0041384] Collins et al., 1983, Yb. Carnegie Instn, Wash. 82: 180--182 Transposable genetic elements and the white locus of Drosophila. [FBrf0063381] Zachar and Bingham, 1982, Cell 30: 529--541 Regulation of white locus expression: The structure of mutant alleles at the white locus of Drosophila melanogaster. [FBrf0037612] LeFever, 1973, D. I. S. 50: 109--110 Analysis of three white mutants resulting in two new recombination sites at the white locus in Drosophila melanogaster. [FBrf0024727]

Allele Dmel\wsp4

Allele Dmel\w^sp4