Allele Dmel\W¹

General Information
Symbol	Dmel\W¹	Species	D. melanogaster
Name		FlyBase ID	FBal0018404
Feature type	allele	Associated gene	Dmel\W
Also Known As	hid¹

Allele class
Mutagen	stratosphere exposure
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	stratosphere exposure (Lindsley and Zimm, 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	viable (Lindsley and Zimm, 1992)
Phenotype Manifest In
	head (Lindsley and Zimm, 1992) wing (Waddington, 1940, Lindsley and Zimm, 1992)
Detailed Description
	Statement Reference Wings remain small and unexpanded. Black spots on head beside proboscis or ocelli. Heterozygous female like homozygote but less extreme. Male much less extreme; wings often expanded but wrinkled, blistered and surface finely pebbled and grayish; no overlap with wild type. Suppressed by D¹ in male and nearly so in female. RK1 as dominant. (Lindsley and Zimm, 1992) From prepupal stage through adult, wing bases abnormally narrow, possibly preventing flow of body fluid in sufficient quantity to expand wings. (Waddington, 1940)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference W[+]/W¹ is a suppressor \| partially of visible phenotype of bft^unspecified/bft^Δ263a (Hilgers et al., 2010) W[+]/W¹ is a suppressor \| partially of visible phenotype of Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^GMR.PF, foxo^Scer\UAS.cKb (Kanao et al., 2010) W[+]/W¹ is a suppressor of neuroanatomy defective \| adult stage \| RU486 conditional phenotype of Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO}, foxo^Scer\UAS.cKb (Kanao et al., 2010)
Phenotype Manifest In
Suppressor of
Statement Reference W[+]/W¹ is a suppressor \| partially of eye phenotype of Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^GMR.PF, foxo^Scer\UAS.cKb (Kanao et al., 2010) W[+]/W¹ is a suppressor \| partially of interommatidial bristle phenotype of bft^unspecified/bft^Δ263a (Hilgers et al., 2010) W[+]/W¹ is a suppressor of dopaminergic neuron \| RU486 conditional phenotype of Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO}, foxo^Scer\UAS.cKb (Kanao et al., 2010) W[+]/W¹ is a suppressor of dopaminergic PPL1 neuron \| RU486 conditional phenotype of Lrrk^{I1915T.Scer\UAS}, Scer\GAL4^{elav.Switch.PO}, foxo^Scer\UAS.cKb (Kanao et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference W[1]/+ partially suppresses the loss of interommatidial bristles which is seen in bft[Δ263a]/bft[unspecified] flies. (Hilgers et al., 2010) The eye phenotype caused by co-expression of foxo[Scer\UAS.cKb] and Lrrk[I1915T.Scer\UAS] under the control of Scer\GAL4[GMR.PF] is significantly suppressed by W[1]/+. The degeneration of the PPM1/2 and PPL1 neurons which is seen in flies co-expressing foxo[Scer\UAS.cKb] and Lrrk[I1915T.Scer\UAS] under the control of Scer\GAL4[elav.Switch.PO] in the presence of RU486 is suppressed if they alo carry W[1]/+. (Kanao et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 9 )
Bloomington	631 W¹ 1447 ru¹ h¹ W¹ Sb^sbd-2 Tb¹
Kyoto	106018 W¹ 106019 W¹ Sb¹/In(3LR)Cx 107568 Adh^S; W¹/TM3, Sb¹ 107309 W¹ red¹ e¹/TM3, Sb¹ 107645 st¹ W¹ cu¹ ry¹ ss¹ 106317 ru¹ h¹ W¹ Sb^sbd-2 Tb¹ 106192 st¹ W¹ Crn¹ in¹ kni^ri-1/TM3, Sb¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	hid¹ (Kanao et al., 2012, Kanao et al., 2010) W¹ (Hilgers et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Kanao et al., 2012, PLoS ONE 7(2): e30958 The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila. [FBrf0217639] Hilgers et al., 2010, PLoS Biol. 8(6): e1000396 Drosophila microRNAs 263a/b Confer Robustness during Development by Protecting Nascent Sense Organs from Apoptosis. [FBrf0211074] Kanao et al., 2010, Hum. Mol. Genet. 19(19): 3747--3758 Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. [FBrf0211787] Abbott and Lengyel, 1991, Genetics 129: 783--789 Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective. [FBrf0054189] Waddington, 1940, J. Genet. 41: 75--139 The genetic control of wing development in Drosophila. [FBrf0005070]
Abstract	Sedore and Cronmiller, 2004, A. Dros. Res. Conf. 45: 616A Monoamine and hormone signaling regulate various stages of oogenesis in Drosophila. [FBrf0173797]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\W1

Allele Dmel\W¹