FB2025_01 , released February 20, 2025
Allele: Dmel\wap9
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General Information
Symbol
Dmel\wap9
Species
D. melanogaster
Name
FlyBase ID
FBal0018417
Feature type
allele
Associated gene
Dmel\wap
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
male recombination induced by dysgenesis
(Perrimon et al., 1989, Eeken et al., 1985)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wap2/wap9 mutant flies are characterised by three phenotypes: 1) In ~10% of adult flies there are supernumerary crossveins located between the second and third longitudinal wing veins 2) the tergal depressor of the trochanter (TDT) (a prominent tubular jump muscle in the thorax) is missing 3) mutants show semi-lethality.

      wap9 mutants initiate founder cell specification and myoblast fusion of the tergal depressor of the trochanter (TDT) jump muscle, but this is not sustained and the nascent jump muscles don't continue development.

      (Morriss et al., 2013)

      Maternal-effect.

      (Lindsley and Zimm, 1992)

      Lethality occurs during pupal or adult stages. Homozygous germline clones display maternal effect lethality. Embryos derived from heterozygous mothers exhibit no CNS or PNS defects.

      (Perrimon et al., 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      wap9 is partially rescued by wap+tMa

      (Morriss et al., 2013)
      Comments

      Expression of wap+tMa partially rescues the phenotypes seen in wap9/Y mutant flies. The pupal lethality is not rescued, but the loss of the jump muscle is completely rescued.

      (Morriss et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Induced in a chromosome carrying mei-9a and mei-41D5.

      (Eeken et al., 1985)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      D48
      (Eeken et al., 1985)
      l(1)D48
      (Lindsley and Zimm, 1992)
      wap9
      (Morriss et al., 2013)
      wapD48
      (Perrimon et al., 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)