Allele Dmel\wb⁰⁹⁴³⁷

General Information
Symbol	Dmel\wb⁰⁹⁴³⁷	Species	D. melanogaster
Name		FlyBase ID	FBal0018476
Feature type	allele	Associated gene	Dmel\wb

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:14,288,960..14,319,552 2L:14,300,958..14,300,958 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Martin et al., 1999, Brown and Freeman, 2003, Ashburner et al., 1999, Han et al., 2012)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{PZ} insertion at position 15219 of DS03792. (Ashburner et al., 1999.10.12) P{PZ} insertion within an intron. (Ashburner et al., 1999) P{PZ} insertion in the fourth intron. (Martin et al., 1999)
Caused by insertion	P{PZ}wb⁰⁹⁴³⁷ (BDGP Project Members, 1994-1999, Spradling et al., 1999, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Martin et al., 1999, Brown and Freeman, 2003, Ashburner et al., 1999, Han et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Ashburner et al., 1999) lethal \| embryonic stage \| recessive (Martin et al., 1999) lethal \| recessive (Spradling et al., 1999, Ashburner et al., 1999, Roote, 1995.5.15)
Phenotype Manifest In
	wing (Martin et al., 1999)
Detailed Description
	Statement Reference wb¹/wb⁰⁹⁴³⁷ flies show blistering of the wing. (Martin et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference wb⁰⁹⁴³⁷ is a non-enhancer of cell polarity defective phenotype of S⁰⁵⁶⁷¹ (Brown and Freeman, 2003)
NOT Suppressor of
Statement Reference wb⁰⁹⁴³⁷ is a non-suppressor of cell polarity defective phenotype of S⁰⁵⁶⁷¹ (Brown and Freeman, 2003)
Other
Statement Reference mew[+]/mew^M6, wb⁰⁹⁴³⁷ has neuroanatomy defective \| third instar larval stage phenotype (Han et al., 2012) mys¹/mys[+], wb⁰⁹⁴³⁷ has neuroanatomy defective \| third instar larval stage phenotype (Han et al., 2012)
Phenotype Manifest In
NOT Enhancer of
Statement Reference wb⁰⁹⁴³⁷ is a non-enhancer of ommatidium phenotype of S⁰⁵⁶⁷¹ (Brown and Freeman, 2003)
NOT Suppressor of
Statement Reference wb⁰⁹⁴³⁷ is a non-suppressor of ommatidium phenotype of S⁰⁵⁶⁷¹ (Brown and Freeman, 2003)
Other
Statement Reference mew[+]/mew^M6, wb⁰⁹⁴³⁷ has dorsal multidendritic neuron ddaC \| third instar larval stage phenotype (Han et al., 2012) mys¹/mys[+], wb⁰⁹⁴³⁷ has dorsal multidendritic neuron ddaC \| third instar larval stage phenotype (Han et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference mys[1]/wb[09437] mutant third instar larvae show a mild but statistically significant increase in the proportion of dorsal midline ddaC dendritic length that is enclosed within the epidermis rather than attached to the ECM. The amount of enclosed dendrite seen in each heterozygote is similar to wild type. mew[M6]/wb[09437] mutant third instar larvae show a mild but statistically significant increase in the proportion of dorsal midline ddaC dendritic length that is enclosed within the epidermis rather than attached to the ECM. The amount of enclosed dendrite seen in each heterozygote is similar to wild type. (Han et al., 2012) wb⁰⁹⁴³⁷ has no effect on the S⁰⁵⁶⁷¹/+ ommatidial polarity phenotype. (Brown and Freeman, 2003) S^48-5/wb⁴⁴¹⁸ mutants show 7.17%+-0.60 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. (Gaengel and Mlodzik, 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	wb¹⁰⁰⁰² (BDGP Project Members, 1994-1999) wb^unspecified (Martin et al., 1999)
Comments
Stocks ( 1 )
Bloomington	12362 cn¹ P{PZ}wb⁰⁹⁴³⁷/CyO; ry⁵⁰⁶
Notes on Origin
Discoverer	A. Spradling.

Comments
	Complements: cenG1A⁰⁶⁶⁴⁶. Complements: l(2)35Bd¹⁰⁴⁰⁸. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	l(2)09437 (Spradling et al., 1999, ) PZ09437 (Ashburner et al., 1999) wb-09437 (Gaengel and Mlodzik, 2003) wb⁰⁹⁴³⁷ (Vanderploeg et al., 2012, Han et al., 2012) wb^PZ12 (Roote, 1995.5.15) wb^PZ09437 (Martin et al., 1999)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Han et al., 2012, Neuron 73(1): 64--78 Integrins Regulate Repulsion-Mediated Dendritic Patterning of Drosophila Sensory Neurons by Restricting Dendrites in a 2D Space. [FBrf0217239] Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8 Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831] Brown and Freeman, 2003, Development 130(22): 5401--5412 Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. [FBrf0167498] Gaengel and Mlodzik, 2003, Development 130(22): 5413--5423 Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. [FBrf0167499] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Martin et al., 1999, J. Cell Biol. 145(1): 191--201 wing blister, a new Drosophila laminin alpha chain required for cell adhesion and migration during embryonic and imaginal development. [FBrf0108234] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Supplementary material	Ashburner et al., 1999, Genetics 153(1): Table S1. P-element insertions in the Adh region. [FBrf0112150]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] Roote, 1995.5.15, PZ alleles. PZ alleles. [FBrf0080527] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\wb09437

Allele Dmel\wb⁰⁹⁴³⁷