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General Information
Symbol
Dmel\wg1
Species
D. melanogaster
Name
FlyBase ID
FBal0018482
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

A 2416 bp deletion in the 3' enhancer region of wg, starting coordinate 2L:7324252 (Release 5 coordinates). See also Fig. S1.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

A 2416 bp deletion in the 3' enhancer region of wg.

Small deletion in the 3' untranslated region (UTR).

Insertion downstream of coding region.

Approximately 2.5kb deletion at the 3' end of the wg transcript.

Small deficiency extending from the interval +16.8 to +17.1 on the wg map off to the right.

deletion from +16.8 to +17.1 kb

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

wg1/wgl-17 and wg1/wgGBM, but not wg1/+, larvae have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls.

In a significant proportion of wg1 homozygotes, adults show transformation of one or both wings into notum and third instar larvae present wing discs with presumptive wing tissue replaced by notum tissue; these adults also present decreased wing regeneration capacity, as shown by the significant decrease in the number of adults with fully regenerated wings following rpr-induced damage to the third instar wing disc pouch, as compared to wild-type controls.

A minority of wg1/+ flies have at least one wing transformed into notum.

wg1/wgl-12 flies show loss of indirect flight muscles.

wg1/wgl-17 mutants display a wing-to-notum transformation.

Homozygous wg1 larvae do not show the increase in ghost bouton formation seen in controls upon spaced 5X K[+] depolarisation.

Homozygotes show a wing to notum transformation.

wg1/wg17en40cP1 wing discs show replacement of wing by a duplication of notum structures, which is also seen in the adult flies.

wg1/wgl-17 flies exhibit ectopic notum and have no wings.

25% of wg1/wgP flies have wings on the prothoracic segment, and mesothoracic wings and metathoracic halteres develop variably.

wg wing phenotype. Individuals are adult viable and exhibit the wing phenotype when in combination with wgSp-revP, wgl-17, wgl-16 or wgP. Individuals are wild type when in combination with wgSp-1 and wgspd-j2.

Flies often lack wings and show a symmetric duplication of body wall structures.

Semiviable, deletion of the ventralmost part of the eye. Ectopic furrow movement initiates predominantly from the ventral margin.

N, wg1 and arm4 triple mutants display, with about 10-20% penetrance, a perfect duplication of the notum charcateristic of wg mutations.

Additional bristles present on the second leg.

Flies exhibit a variable loss of one or two wings.

Adult homeotic transformation of wing to notum.

Phenotype shows incomplete penetrance and expressivity; 50.8% of flies have no wings, 40.67% have one wing, and 8.47% have two wings.

The progeny of wg1 parents are composed of flies with no wings, one wing and two wings in approximately 2:2:1 ratio. wg1 flies may also have no, one, or both halteres. The two phenotypes are independent of each other as mutants can be found that have wings but no halteres, and vice versa.

viable

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

wg1 has visible | dominant | adult stage phenotype, enhanceable by p53[+]/p53-ns

wg1 has visible | dominant | adult stage phenotype, enhanceable by p53[+]/p5311-1B-1

wg1 has visible | dominant | adult stage phenotype, enhanceable by p535A-1-4/p53[+]

wg1 has visible | recessive phenotype, enhanceable by ap78j

NOT Enhanced by
Suppressed by
Statement
Reference

wg1/wgl-17 has visible phenotype, suppressible by fz3G10

NOT suppressed by
NOT Enhancer of
Statement
Reference

wg1 is a non-enhancer of visible phenotype of upd1GMR.PB

Suppressor of
Statement
Reference

wg1/fz3G10 is a suppressor of visible | dominant phenotype of ap78j

NOT Suppressor of
Statement
Reference

wg1 is a non-suppressor of visible phenotype of upd1GMR.PB

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

wg1 has wing phenotype, enhanceable by p53[+]/p53-ns

wg1 has wing phenotype, enhanceable by p53[+]/p5311-1B-1

wg1 has wing phenotype, enhanceable by p535A-1-4/p53[+]

wg1 has wing phenotype, enhanceable by ap78j

wg1 has phenotype, enhanceable by oro1

NOT Enhanced by
Suppressed by
Statement
Reference

wg1/wgl-17 has wing phenotype, suppressible by HipkUAS.Tag:HA/Scer\GAL469B

wg1/wgl-17 has wing phenotype, suppressible by fz3G10

NOT suppressed by
NOT Enhancer of
Statement
Reference

wg1 is a non-enhancer of eye phenotype of upd1GMR.PB

Suppressor of
Statement
Reference

wg1 is a suppressor | partially of eye | somatic clone phenotype of exMGH1

wg1 is a suppressor | partially of eye disc | pupal stage phenotype of exMGH1

wg1 is a suppressor of eye | ventral phenotype of L2

wg1 is a suppressor of eye disc | ventral phenotype of L2

wg1/fz3G10 is a suppressor of wing phenotype of ap78j

wg1 is a suppressor of pigment cell phenotype of sgl05007, wa

NOT Suppressor of
Statement
Reference

wg1 is a non-suppressor of eye phenotype of upd1GMR.PB

Other
Additional Comments
Genetic Interactions
Statement
Reference

wg1/+; egh62d18/+ double heterozygotes have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls, unlike either heterozygote alone.

Expression of hipkScer\UAS.T:Ivir\HA1 under the control of Scer\GAL469B in a wg1/wgl-17 mutant background results in proper wing development and rescues the wing-to-notum transformation.

The small eye phenotype of eyes composed almost entirely of exMGH1 mutant tissue is suppressed by the presence of wg1.

The irregular ommatidial patterning of exMGH1 mutant pupal eye disc tissue is suppressed by wg1. No additional supernumerary interommatidial cells are observed.

The loss-of-ventral eye phenotype of L2/+ mutants is restored in L2, wg1/+ double mutants. Ommatidia in the restored ventral section show correct ventral eye polarity.

The wingless phenotype of wg1/wgl-17 flies is partially rescued by fz3G10; the fraction of flies with two wings increases from 46% to 87%, while the fraction of one wing and wingless flies reduces from 44% and 10% to 13% and 0.5% respectively. The wingless phenotype of wg1 homozygotes is dominantly enhanced by ap78j; no wing blade is formed at approximately 90% of presumptive wing-blade-forming sites. This phenotype is partially suppressed by fz3G10.

Xenogenetic Interactions
Statement
Reference

wg1/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTTQ93.ex1p.Scer\UAS driven by Scer\GAL4elav.PU.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer

Sharma.

Comments
Comments

A genotypically wg1 mutant hemithorax is usually also phenotypically mutant in gynandromorphs; thus wg1 is disc-autonomous.

Pairwise complementation analysis of wg1, wgl-8, wgH and an allele of spd reveals a complex complementation pattern.

wg function during second larval instar affected.

FlyBase curator comment: the wg1 mutation is reported as being caused by ethyl methanesulfonate in this reference but in FBrf0096285, a reference by the same author in the same issue of D.I. S., the mutation is reported as being X-ray-induced.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (47)