FlyBase Allele Report: Dmel\wg[l-17]

General Information

Symbol

Dmel\wg^l-17

Species

D. melanogaster

Name

FlyBase ID

FBal0018509

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

Also Known As

wg^CX4, wg^1-17, wgCX4, wg^I-17

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Mutagen

X ray

(Baker, 1987)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Baker, 1987)

Description

Point mutation caused by a small deletion removing the wg promoter.

(Neumann and Cohen, 1996)

Small deletion at the 5' end of the wg locus.

(Neumann and Cohen, 1996)

Deletion of 2.7kb removing the first exon.

(van den Heuvel et al., 1993)

Deletion in the 5' region of the wg gene.

(Gonzalez et al., 1991)

2kb deletion around position 0 on the wg map.

(Baker, 1987)

deletion of 2 kb at 5' end of gene

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis type 2

modeled by Als2^Δ1

(Kim et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | pupal stage | somatic clone

(Cordero and Cagan, 2010)

abnormal neuroanatomy (with wg^l-12)

(Karim and Moore, 2011)

abnormal neuroanatomy | embryonic stage

(Gaziova and Bhat, 2009)

abnormal size

(Kaphingst and Kunes, 1994)

abnormal size | embryonic stage

(Wan et al., 2000)

abnormal size | recessive | somatic clone

(Baena-Lopez et al., 2009)

decreased cell death | heat sensitive (with wg^l-12)

(Cordero et al., 2004)

decreased cell death | pupal stage | heat sensitive (with wg^l-12)

(Cordero and Cagan, 2010)

decreased cell death | pupal stage | somatic clone

(Cordero and Cagan, 2010)

decreased cell death | somatic clone

(Cordero et al., 2004)

decreased cell number | embryonic stage

(Wan et al., 2000)

decreased cell number | pupal stage | somatic clone

(Cordero and Cagan, 2010)

decreased cell number | somatic clone | third instar larval stage

(Cordero and Cagan, 2010)

decreased occurrence of cell division | embryonic stage

(Deb et al., 2008, Wan et al., 2000)

decreased occurrence of cell division | third instar larval stage

(Kaphingst and Kunes, 1994)

increased cell death | embryonic stage

(Bossing and Brand, 2006)

increased cell number | pupal stage | heat sensitive (with wg^l-12)

(Cordero and Cagan, 2010)

lethal | recessive

(Emerald and Roy, 1997, Morcillo et al., 1996, Heemskerk and DiNardo, 1994)

lethal - all die before end of larval stage (with wg^GBM)

(Huang et al., 2018)

lethal - all die during embryonic stage

(Cavallo et al., 1998)

lethal - all die during embryonic stage (with wg^Gal4)

(Won et al., 2019)

lethal - all die during embryonic stage | germline clone

(Schweizer et al., 2003)

lethal - all die during embryonic stage | recessive

(Buratovich et al., 1997, Neumann and Cohen, 1996, Baylies et al., 1995, Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993, Phillips and Whittle, 1993, van den Heuvel et al., 1993)

partially lethal - majority live (with wg^Gal4), with Scer\GAL4^wg-Gal4, wg^UAS.GFP

(Won et al., 2019)

segment polarity phenotype

(Desbordes and Sanson, 2003)

segment polarity phenotype | embryonic stage

(Cavallo et al., 1998)

segment polarity phenotype | embryonic stage | germline clone

(Schweizer et al., 2003)

some die during embryonic stage

(Cavallo et al., 1998)

some die during embryonic stage | germline clone

(Schweizer et al., 2003)

some die during embryonic stage | recessive

visible (with wg¹)

(Lee et al., 2009)

visible (with wg^l-12)

(Buratovich and Wilder, 2001)

visible (with wg^l-16)

(Gieseler et al., 2001)

visible (with wg^Sp-1)

(Yang et al., 2012)

visible (with wg^spd-fg:Sp-1)

(Bourouis, 2002)

visible | dominant

(Buratovich et al., 1997)

visible | embryonic stage

(Ripp et al., 2018)

visible | recessive

(Sato et al., 1999)

visible | somatic clone

(Held and Heup, 1996)

Phenotype Manifest In

3rd axillary sclerite (with wg^l-12)

(Buratovich and Wilder, 2001)

abdominal 1 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal 2 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal 3 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal 4 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal 5 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal 6 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal 7 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal 8 ventral denticle belt

(Klingensmith et al., 1994, Bejsovec and Wieschaus, 1993)

abdominal lateral oblique muscle 1 founder cell

(Cox and Baylies, 2005, Cox et al., 2005)

abdominal ventral acute muscle 1 founder cell

(Cox and Baylies, 2005, Cox et al., 2005)

abdominal ventral acute muscle 2 founder cell

(Cox and Baylies, 2005, Cox et al., 2005)

abdominal ventral acute muscle 3 founder cell

(Cox and Baylies, 2005, Cox et al., 2005)

abdominal ventral bipolar dendrite neuron vbd (with wg^l-12)

(Karim and Moore, 2011)

abdominal ventral transverse muscle 1 founder cell

(Cox and Baylies, 2005)

adult prothoracic segment

(Emerald and Roy, 1997)

aedeagus

(Chen and Baker, 1997)

alar lobe (with wg^spd-fg:Sp-1)

(Bourouis, 2002)

antenna (with wg^l-16)

(Gieseler et al., 2001)

antennal sense organ

(Gallitano-Mendel and Finkelstein, 1998)

anterior dorsocentral bristle

(Phillips and Whittle, 1993)

anterior dorsocentral bristle (with wg^Sp-1)

(Yang et al., 2012)

anterior scutellar bristle

(Phillips and Whittle, 1993)

cardiogenic mesoderm

(Grigorian et al., 2011, Mandal et al., 2004)

cone cell | pupal stage | somatic clone

(Cordero and Cagan, 2010)

corpus cardiacum primordium

(De Velasco et al., 2004)

denticle

(Bejsovec and Chao, 2012, Alexandre et al., 1999, McCartney et al., 1999, Willert et al., 1999, Szuts et al., 1997)

denticle | ectopic

(Overton et al., 2007, Morel and Arias, 2004, Desbordes and Sanson, 2003, Angelats et al., 2002, Dubois et al., 2001)

denticle field

(Cox et al., 2005)

denticle row 2 | ectopic

(Angelats et al., 2002)

denticle row 3 | ectopic

(Angelats et al., 2002)

denticle row 4 | ectopic

(Angelats et al., 2002)

dorsal denticle

(Buratovich et al., 2000)

dorsal vessel wall cell

(Mandal et al., 2004)

embryonic/first instar larval cuticle

(Bejsovec and Chao, 2012, Chao et al., 2007, Overton et al., 2007, Bullock et al., 2004, Morel and Arias, 2004, Desbordes and Sanson, 2003, Schweizer et al., 2003, Tolwinski et al., 2003, Angelats et al., 2002, Simmonds et al., 2001, McCartney et al., 1999, Gallet et al., 1998, Hays et al., 1997, Buttgereit, 1996, van den Heuvel and Ingham, 1996)

embryonic/first instar larval cuticle | dorsal

(Dierick and Bejsovec, 1998, Heemskerk and DiNardo, 1994)

embryonic/first instar larval cuticle | ventral

(Dierick and Bejsovec, 1998)

embryonic/larval cuticle

(Cox et al., 2005, Szuts et al., 1997)

embryonic/larval dorsal tracheal branch

(Llimargas, 2000)

embryonic/larval dorsal vessel

(Baylies et al., 1995)

embryonic/larval dorsal vessel & embryonic myoblast

(Lee and Frasch, 2000)

embryonic/larval lymph gland

(Mandal et al., 2004)

embryonic/larval midgut | embryonic stage

(Baylies et al., 1995)

embryonic/larval posterior spiracle

(Merabet et al., 2005)

embryonic/larval somatic muscle & embryonic myoblast | dorsal

(Lee and Frasch, 2000)

embryonic/larval tracheal lateral trunk

(Llimargas, 2000)

embryonic epidermis

(Angelats et al., 2002, Payre et al., 1999, Willert et al., 1999, Cavallo et al., 1998, Ouellette et al., 1992)

embryonic epidermis | dorsal

(Buratovich et al., 2000)

embryonic gnathal segment

(Rusch and Kaufman, 2000)

embryonic head

(Klingensmith et al., 1994)

embryonic leading edge cell

(Kaltschmidt et al., 2002)

embryonic leading edge cell & actin filament

(Kaltschmidt et al., 2002)

embryonic leading edge cell & filopodium

(Kaltschmidt et al., 2002)

embryonic leading edge cell & microtubule

(Kaltschmidt et al., 2002)

embryonic leading edge cell primordium

(Morel and Arias, 2004)

embryonic leading edge cell primordium & microtubule

(Morel and Arias, 2004)

embryonic maxillary segment (with wg^l-12)

(Hueber et al., 2007)

embryonic midgut constriction 2

(Yu et al., 1996, Immergluck et al., 1990)

embryonic midgut constriction 2 | embryonic stage

(Klingensmith et al., 1994)

embryonic myoblast

(Buttgereit, 1996)

embryonic pericardial cell

(Mandal et al., 2004)

epandrial ventral lobe

(Chen and Baker, 1997)

eye disc | heat sensitive (with wg^l-12)

(Cordero et al., 2004)

eye disc | somatic clone

(Cordero et al., 2004)

female reproductive system

(Chen and Baker, 1997)

filzkorper

(Klingensmith et al., 1994)

filzkorper | embryonic stage

(Buttgereit, 1996)

genital disc (with wg^l-16)

(Keisman and Baker, 2001)

genital disc primordium

(Chen et al., 2005)

haltere

(Emerald and Roy, 1997)

haltere (with wg^l-16)

(Gieseler et al., 2001)

head

(Buttgereit, 1996)

hindgut visceral muscle primordium

(San Martin and Bate, 2001)

interommatidial cell | pupal stage | heat sensitive (with wg^l-12)

(Cordero and Cagan, 2010)

Keilin organ

(Simcox et al., 1989)

larval hindgut & ectoderm

(San Martin and Bate, 2001)

larval RP2 motor neuron

(Gaziova and Bhat, 2009, Cox et al., 2005, Bhat et al., 2000, Duman-Scheel et al., 1997)

larval somatic muscle cell

(Buttgereit, 1996)

larval tracheal system

(Llimargas, 2000, Lin et al., 1999)

leg (with wg^l-16)

(Gieseler et al., 2001)

leg | somatic clone | ventral

(Held and Heup, 1996)

male reproductive system

(Chen and Baker, 1997)

Malpighian tubule

(Wan et al., 2000)

Malpighian tubule primordium

(Wan et al., 2000)

Malpighian tubule tip cell

(Wan et al., 2000)

medulla anlage

(Kaphingst and Kunes, 1994)

mesonotum | ectopic (with wg¹)

(Lee et al., 2009, Wang et al., 2000)

mesonotum | ectopic (with wg^l-16)

(Gieseler et al., 2001)

mesothoracic ventral denticle belt

(Klingensmith et al., 1994)

metathoracic ventral denticle belt

(Klingensmith et al., 1994)

multidendritic neuron (with wg^l-12)

(Karim and Moore, 2011)

neuroblast NB4-2

(Bhat et al., 2000, Duman-Scheel et al., 1997)

neuroblast NB5-2

(Gaziova and Bhat, 2009, Hartenstein et al., 1994)

neuroblast NB5-4

(Gaziova and Bhat, 2009)

neuroblast NB5-5

(Gaziova and Bhat, 2009)

neuroblast NB7-3

(Deshpande et al., 2001)

ommatidium

(Kaphingst and Kunes, 1994)

posterior dorsocentral bristle

(Phillips and Whittle, 1993)

posterior postalar bristle

(Phillips and Whittle, 1993)

posterior scutellar bristle

(Phillips and Whittle, 1993)

presumptive embryonic/larval peripheral nervous system

(Deb et al., 2008)

prothoracic ventral denticle belt

(Klingensmith et al., 1994)

retina | pupal stage | heat sensitive (with wg^l-12)

(Cordero and Cagan, 2010)

RP2sib neuron

(Bhat et al., 2000)

sensory mother cell

(Phillips and Whittle, 1993)

sensory organ cell (with wg^l-12)

(Karim and Moore, 2011)

somatic muscle cell

(Baylies et al., 1995)

surstylus

(Chen and Baker, 1997)

tracheal dorsal trunk primordium

(Llimargas and Lawrence, 2001)

ventral denticle belt

(Chao et al., 2007, Angelats et al., 2002, Payre et al., 1999, Sanson et al., 1999, Cavallo et al., 1998, Dierick and Bejsovec, 1998, Hays et al., 1997, Szuts et al., 1997, Zecca et al., 1996)

ventral denticle belt | ectopic

(Tolwinski et al., 2003)

ventral epidermis primordium

(Franch-Marro et al., 2006)

ventral midline of embryo

(Bossing and Brand, 2006)

visceral trunk mesoderm

(Hosono et al., 2003, Duan et al., 2001)

wing

(Baena-Lopez et al., 2009, Sato et al., 1999, Klein and Martinez Arias, 1998, Buratovich et al., 1997, Emerald and Roy, 1997, Neumann and Cohen, 1997, Diaz-Benjumea and Cohen, 1995)

wing (with wg¹)

(Lee et al., 2009, Wang et al., 2000)

wing (with wg^l-16)

(Gieseler et al., 2001, Klein and Martinez Arias, 1998)

wing (with wg^spd-fg:Sp-1)

(Bourouis, 2002)

wing disc

(Baena-Lopez et al., 2009)

wing disc (with wg^l-16)

(Cavodeassi et al., 2002, Gieseler et al., 2001)

wing disc | heat sensitive (with wg^l-12)

(Gieseler et al., 2001)

wing margin (with wg^spd-fg:Sp-1)

(Bourouis, 2002)

Detailed Description

Statement

Reference

wg¹/wg^l-17 larvae have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls.

(Huang et al., 2018)

wg^l-17 homozygous embryos have severe morphological defects.

(Ripp et al., 2018)

On average, wg^l-17 clones induced in the wing disc in a wg^KO;NRT-wg homozygous background are smaller than wg^l-17 clones induced in the wing disc in a wild-type background.

(Alexandre et al., 2014)

Mutant embryos have a "lawn of denticles" phenotype, lacking the naked cuticle that normally separates the eight abdominal segments. The denticles are large and strongly hooked, with the direction of the hook alternating between anterior and posterior in a segmentally repeating pattern.

(Bejsovec and Chao, 2012)

The anterior dorsocentral bristle is missing in 61% of wg^Sp-1/wg^l-17 flies. When present, it is 14% shorter than normal.

(Yang et al., 2012)

The cardiogenic mesoderm is absent in stage 12 mutant embryos.

(Grigorian et al., 2011)

wg^l-17/wg^l-12 embryos show a loss of neurons derived from SOPs in the posterior of the parasegment: the vbd neuron is lost in 100%, the class III lost in 85% and class II neurons in 73% of parasegments. Both class IV neurons, vdaB and v'ada, always form. Multidendritic neuron loss in wg^l-17/wg^l-12 mutants is always preceded by the loss of posterior SOPs: all four SOPs are lost in 45%, three are lost in 35%, and two lost in 20% of parasegments.

(Karim and Moore, 2011)

wg^l-12/wg^l-17 mid-pupal stage flies switched to the non-permissive temperature exhibit less cell death and a higher interommatidial precursor cell (IPC) number per hexagon than flies maintained at the permissive temperature.

wg^l-17 retinal clones 28 hours after puparium formation display reduced cell death compared to controls.

There are abnormalities in the shape, organisation and number of cone cells in wg^l-17 retinal clones 42 hours after pupal formation. This phenotype is seen throughout the eye epithelium.

wg^l-17 clones in the eye discs of third instar larvae have fewer cone cells than controls.

wg^l-17 clones in photoreceptors are sufficient to cause defects in cone cell specification at both the third instar larval and pupal stages. No cone cell defects are seen when clones are induced only in the cone cells or the interommatidial cells.

(Cordero and Cagan, 2010)

wg^l-17 mutants exhibit defects in para-segmental boundary interfaces.

(Monier et al., 2010)

The posterior compartment of wings composed of mainly homozygous wg^l-17 mutant cells (in a "Minute" background) are reduced in size compared with control wild-type posterior compartments. This correlates with with the loss of a substantial portion of the posterior tissue in imaginal wing discs.

(Baena-Lopez et al., 2009)

Mutants lack the eve-positive RP2 lineage.

~70% of hemisegments in mutant embryos are missing one or more row 5 neuroblasts (NBs), such as NB5-4 (which is affected the most), NB5-5 and NB5-2.

(Gaziova and Bhat, 2009)

wg¹/wg^l-17 mutants display a wing-to-notum transformation.

(Lee et al., 2009)

Cell proliferation (assayed through BrdU incorporation) is not observed in the PNS region of wg^l-17 homozygous embryos. Proliferation can be seen in wg^l-17 heterozygotes. Proliferation is also observed in the head and ventral CNS.

(Deb et al., 2008)

The RNA-null wg^l-17 mutant produces a 'lawn of denticles' phenotype.

(Chao et al., 2007)

The maxillary segments of wg^l-12/wg^l-17 mutant embryos are smaller than those of wild-type embryos.

(Hueber et al., 2007)

Mutant embryos show a "lawn of denticles" cuticle phenotype.

(Overton et al., 2007)

In wg^l-17 mutants, midline cells do not differentiate and instead die during late embryogenesis.

(Bossing and Brand, 2006)

Cells within the leg primordia of wg^l-17 mutant embryos begin a process of invagination that is characteristic of tracheal cells.

(Franch-Marro et al., 2006)

Stage 15 wg^l-17 embryos have only 14 genital disc precursor cells, instead of the wild-type number of 15.

(Chen et al., 2005)

Mutant embryos exhibit a complete loss of cI and cII cluster of slou expressing muscle founder cells.

(Cox and Baylies, 2005)

wg^l-17 embryos lack the slou-expressing cluster I and II founder cells and have no RP2 neurons. wg^l-17 larvae lack naked cuticle and proper denticle diversity.

(Cox et al., 2005)

No posterior spiracles are present in wg^l-17 larvae.

(Merabet et al., 2005)

Around 30% of wg^l-17/+ first instar larvae have cuticular segmentation defects.

(Bullock et al., 2004)

wg^l-12/wg^l-17 animals raised at 18^oC until 28 hours after puparium formation (developmentally equivalent to approximately 17 hours APF at 25^oC) and then shifted to 25^oC for 7 hours show a small but significant decrease in cell death in the pupal retina. Homozygous clones in the eye disc result in a decrease in the amount of cell death in eye discs assayed at 20 hours after puparium formation.

(Cordero et al., 2004)

The corpus cardiacum is normal in size in mutant embryos, but shows defects in migration.

(De Velasco et al., 2004)

In stage-15 wg^l-17 mutant embryos, the lymph gland, cardioblasts and pericardial nephrocytes fails to develop from the cardiogenic mesoderm.

(Mandal et al., 2004)

Instead of being elongated in a dorsal-ventral direction, embryonic leading edge cells in stage 13 wg^l-17 homozygous embryos are stretched in an anterior-posterior direction. Only the posterior dorsal closure zipper is initiated in these embryos.

(Morel and Arias, 2004)

The areas of naked cuticle are replaced by denticles in the mutant embryos, resulting in a "lawn of denticles" without clear polarity.

(Desbordes and Sanson, 2003)

Mutant embryos have a reduced number of visceral mesoderm parasegmental cells.

(Hosono et al., 2003)

Mutant animals exhibit separated nerve roots and dendritic fields in the embryonic motor system, as in wild type.

(Landgraf et al., 2003)

In homozygous mutant germ-line clones, The alternation of naked cuticle and denticle belts seen in wild-type is replaced by a continuous lawn of denticles.

(Schweizer et al., 2003)

The cuticles of wg^l-17/wg^l-17 mutant embryos lack of smooth cuticle.

(Tolwinski et al., 2003)

The cuticles of mutant embryos have reduced bands of naked cells, though they are not totally lost and the number of denticles is increased. This is due to an increase in numbers of denticle types 2,3 and 4.

(Angelats et al., 2002)

wg^spd-fg:Sp-1/wg^l-17 animals have a severely atrophied wing with no margin. The alula of the proximal wing is missing.

(Bourouis, 2002)

wg^l-17 clones at the edge of the eye are identical to wild type.

(Cadigan et al., 2002)

wg^l-16/wg^l-17 wing discs raised at 18^oC show a double notum phenotype.

(Cavodeassi et al., 2002)

Dorsal closure is much slower and more disorganized in wg^l-17 mutant embryos than in wild-type. The leading edge cells lack filopodial activity, and have only a thin cable of actin, lacking distinguishable actin nucleation centers. This cable does not look contractile in time-lapse movies. In these mutants, the leading edge cells do not undergo D-V elongation or D-V polarization. One manifestation of this is that the microtubule bundles that form in these cells do not align perpendicular to the leading edge.

(Kaltschmidt et al., 2002)

wg^l-12/wg^l-17 animals upshifted to the restrictive temperature during the late second or early third instar develop into pharate adults with hinge defects that consistently show reductions of axillary sclerite 3. Homozygous clones do not cause wing hinge phenotypes.

(Buratovich and Wilder, 2001)

Neuroblast NB 7-3 is missing in 75% of mutant hemisegments.

(Deshpande et al., 2001)

Visceral mesoderm is expanded in mutant embryos.

(Duan et al., 2001)

The wg^l-16/wg^l-17 combination results in pharate adults with wing to notum transformations and loss of halteres. Loss of antennae and dorsalisation of leg structures is also seen. Wing discs show replacement of the wing blade by a mirror duplication of the notum in these animals. wg^l-12/wg^l-17 wing discs shifted to the restrictive temperature for 24 hours at the beginning of the second larval instar show a profound wing to notum transformation.

(Gieseler et al., 2001)

wg^l-16/wg^l-17 genital discs are smaller than wild type.

(Keisman and Baker, 2001)

In wg^l-17 mutants some dorsal trunk is still formed.

(Llimargas and Lawrence, 2001)

Hindgut visceral mesoderm does not differentiate. Hindgut ectoderm is small, due to failure of division of proctodeal cells after gastrulation.

(San Martin and Bate, 2001)

The naked regions between denticle belts are deleted and the length of the cuticle is greatly reduced in mutant embryos.

(Simmonds et al., 2001)

wg^l-12/wg^l-17 embryos raised at the restrictive temperature from 8 hours of development show a reduction in the number of 4^o denticle rows from 8-9 to 4-5 in the dorsal epidermis of the embryo. The anterior half of the parasegment is unaffected (an expansion of 3^o denticles is never seen).

(Buratovich et al., 2000)

The mesodermal P2 progenitor is missing in mutant embryos.

(Halfon et al., 2000)

Heart and dorsal muscle progenitors do not form.

(Lee and Frasch, 2000)

No lateral trunk fusion is seen in the tracheal system in mutant embryos, but some fragments of dorsal trunk are formed and often fuse, even though the embryo and the tracheae are generally malformed. Defects in tracheal invagination, branch fusion and loss of dorsal branches are seen.

(Llimargas, 2000)

The gnathal lobes are reduced in mutant embryos.

(Rusch and Kaufman, 2000)

Cell division fails in the Malpighian tubule primordia of mutant embryos, producing tubules of very reduced size. In these tiny tubules no tip cells develop.

(Wan et al., 2000)

wg¹/wg^l-17 flies exhibit ectopic notum and have no wings.

(Wang et al., 2000)

Different types of ordered denticle types, particularly types 4 and 5 can be seen in mutant embryos.

(Alexandre et al., 1999)

Mesoderm migration is normal in mutant embryos. Embryos develop an extensive tracheal network which has an abnormal pattern due to the associated segmentation defect. Expression of bnl^Scer\UAS.cSa under the control of Scer\GAL4^69B in these embryos leads to an overproduction of fine tracheal branches, much as occurs when bnl^Scer\UAS.cSa is ectopically expressed in a wild-type background.

(Lin et al., 1999)

Mutant embryos show a lawn of uniform denticles.

(McCartney et al., 1999)

Homozygous clones in the wing disc have no effect on the shape of the dorsal/ventral boundary.

(Micchelli and Blair, 1999)

wg^l-17 transforms the whole ventral epidermis towards the denticle fate.

(Payre et al., 1999)

Embryonic cuticle is covered with denticles and lacks intervening naked cuticle.

(Willert et al., 1999)

The eve-positive GMC-1 -> RP2/sib lineage is missing in wg^l-17 embryos.

(Bhat, 1998)

Formation of the visceral mesoderm is normal in homozygous embryos, and the visceral mesoderm migrates to cover the gut and form midgut constrictions.

(Bilder and Scott, 1998)

Homozygous embryos secrete no ventral naked cuticle and instead produce denticles consisting primarily of a single morphology which resembles the large denticles found in the fifth row of the wild-type denticle belt. Segmental pattern in the dorsal cuticle is abolished and the dorsal expanse is greatly reduced. wg^DE/wg^l-17 embryos show all 6 denticle types, separated by small expanses of naked cuticle. These embryos show segmentally repeating dorsal cuticle structures, with a slightly abnormal arrangement.

(Dierick and Bejsovec, 1998)

The lawn of denticles phenotype of wg^l-17 embryos is replaced by naked cuticle if the embryos are also expressing tsh^Scer\UAS.cGa under the control of Scer\GAL4^69B.

(Gallet et al., 1998)

Homozygous embryos show severe disruptions in head formation. The antennal sense organ is frequently duplicated.

(Gallitano-Mendel and Finkelstein, 1998)

wg^l-16/wg^l-17 is a strong hypomorphic combination that causes a wing to notum transformation in 92% of flies.

(Klein and Martinez Arias, 1998)

Does not affect the polarity reversal phenotype produced by sgg^M11 clones in the eye.

(Wehrli and Tomlinson, 1998)

Double mutant phenotype with CrebA mutants is additive.

(Andrew et al., 1997)

Transheterozygotes with wg^Sp-1 exhibit occasional etching of the wing margin and hold their wings in an abnormal out-stretched position.

(Buratovich et al., 1997)

wg^l-16/wg^l-17 mutant clones cause a phenotype in the external male genitalia; a reduction in number of clasper teeth, two lateral plates are fused to one with reduced number of bristles and there is rudimentary penis apparatus. Internal male and female genitalia are completely deleted. External female genitalia is generally normal.

(Chen and Baker, 1997)

Homozygous mutants lack RP2 and RP2 sibling neurons. Double mutants with gsb⁵²⁵ exhibit duplicated RP2 and RP2 sibling neurons.

(Duman-Scheel et al., 1997)

25% of wg^l-17/wg^P flies have wings on the prothoracic segment, and the mesothoracic wings and metathoracic halteres are always absent.

(Emerald and Roy, 1997)

Embryos show little denticle diversity and secrete no naked cuticle. Expression of wg^{PE2.hs.T:Ivir\HA1} or wg^PE2.hs by three consecutive heat shocks in wg^l-17 embryos restores denticle diversity, but there is no secretion of naked cuticle. Expression of wg^{PE2.hs.T:Ivir\HA1} or wg^PE2.hs using a single heat shock at 6 hours of development in wg^l-17 embryos produces reorientation of the denticles toward the ventral midline, but no specification of naked cuticle. Expression of wg^{PE2.Scer\UAS.T:Ivir\HA1} or wg^PE2.Scer\UAS using Scer\GAL4^e22c in wg^l-17 embryos restores denticle diversity, but there is no specification of naked cuticle along the ventral midline. Expression of wg^{PE4.hs.T:Ivir\HA1}, wg^PE4.hs, wg^{hs.T:Ivir\HA1} or wg^hs.PH by three consecutive heat shocks in wg^l-17 embryos restores denticle diversity and naked cuticle. Expression of wg^{hs.T:Ivir\HA1} or wg^hs.PH using a single heat shock at 6 hours of development in wg^l-17 embryos produces specification of naked cuticle along the ventral midline, but little denticle diversity. The denticles are reoriented toward the ventral midline. Expression of wg^Scer\UAS.cHa, wg^{Scer\UAS.cHa.T:Ivir\HA1}, wg^{PE4.Scer\UAS.T:Ivir\HA1} or wg^PE4.Scer\UAS using Scer\GAL4^e22c in wg^l-17 embryos causes all ventral epidermal cells to secrete naked cuticle.

(Hays et al., 1997)

wg^spd-fg:Sp-1/wg^l-17 flies have a substantial loss of wing tissue, and structures distal to the posterior cross vein are missing.

(Neumann and Cohen, 1997)

Clones in the adult abdomen that are doubly mutant for Pka-C1^E95 and wg^l-17, or triply mutant for Pka-C1^E95, wg^l-17 and dpp^unspecified have the same phenotype as single mutant Pka-C1^E95 clones.

(Struhl et al., 1997)

Homozygous larvae have a lawn of denticles, almost exclusively of the row 5 type, with no interspersed naked cuticle.

(Szuts et al., 1997)

Stage 11 embryos exhibit normal segmental organisation of the dorsal median cells.

(Zhou et al., 1997)

Segments shows a mirror image duplication of the denticle belts at the expense of naked cuticle so that a continuous sheet of denticle is produced. Embryos lack head structures and filzkorper. Dorsally many myoblasts remain unfused and no segment identities can be assigned. Ventrally the structure and appearance of attachments seems quite normal though the number of apodemes is reduced roughly to half. Structure of myotubes is severely disturbed.

(Buttgereit, 1996)

Clones in the eye lack interommatidial bristles.

(Cadigan and Nusse, 1996)

Homozygous clones induced in first instar larvae produce abnormalities in the ventral side of the leg. Pattern elements from the ventral side are missing, and may or may not be replaced with a duplicate version of the remaining dorsal part of the leg. Duplications are arranged as mirror images. Leg truncations are also seen. Homozygous clones doubly mutant for dpp^d12 and wg^l-17 show defects in both the ventral and dorsal sides of the leg. The frequency of duplications is reduced compared to the single mutant homozygous dpp^d12 or wg^l-17 clones.

(Held and Heup, 1996)

ct^L32; su(Hw)^e2 flies heterozygous for wg^l-17 display a weak ct wing phenotype.

(Morcillo et al., 1996)

wg^l-17/wg^spd-fg flies show a milder version of the hinge phenotype seen in wg^spd-fg homozygotes. Milder phenotype is thought to be due to transvection. Heterozygotes with wg^spd-fg are embryonic lethal.

(Neumann and Cohen, 1996)

wg^l-17/wg^Sp-1 flies are viable and exhibit loss of anterior dorsocentrals and loss of microbristles located in the wg-expression domain of the notum. Individuals in combination with wg^P and wg^l-16 are pupal lethal, and in combination with wg^spd-j2 are embryonic lethal. Individuals are adult viable and exhibit the wing phenotype when in combination with wg¹. When in combination with wg^Sp-revP individuals are pupal lethal, pharate escapers lack antennae, legs and anterior dorsocentrals.

(Neumann and Cohen, 1996)

Dorsolateral ectoderm of the embryo shows a transformation towards tracheal cells but most of them do not invaginate. Some dorsal trunk forms.

(Uemura et al., 1996)

In homozygous embryos the second constriction is missing.

(Yu et al., 1996)

Embryos give rise to abnormally short larvae which form a lawn of ventral denticles.

(Zecca et al., 1996)

Complete loss of naked cuticle but vestiges of polarity remain visible.

(van den Heuvel and Ingham, 1996)

Abnormally patterned muscle fibres form dorsally and ventrally, but laterally only myosin expressing cells are detected. Heart is absent and the gut has grossly abnormal morphology. Loss of slou expression normally seen in wg^l-17 mutants is rescued by Scer\GAL4 line 69B acting on P{UAS(-FRT)wg.ts}, slou-expressing cells are in the appropriately positioned clusters and the epidermis phenotype is substantially rescued. wg expression in the mesoderm, driven by P{GAL4-twi.B} expression, is capable of restoring some ectodermal en expression as well as partially rescuing the cuticle mutant phenotype.

(Baylies et al., 1995)

Clones that cross the wing dorsal/ventral boundary can cause extensive non-autonomous loss of wing tissue. Clones restricted to one side do not cause nicking of the wing.

(Diaz-Benjumea and Cohen, 1995)

Coordinate mutant.

(Sturtevant and Bier, 1995)

Embryos exhibit variability in the pattern of NB 5-2.

(Hartenstein et al., 1994)

Surviving cells of the embryonic dorsal cuticle form a lawn of fine hairs of the 4^o cell type. When en is restored in dorsal patches using en^hs.P, all cells show altered identities even though en is only expressed in a subset. 1^o, 2^o and 3^o cell types are all restored.

(Heemskerk and DiNardo, 1994)

When newly hatched wg^l-12/wg^l-17 larvae are shifted to a non-permissive temperature the normal crescent-shaped neuropil of the medulla, the target for retinal axons R7 and R8, collapsed into a small circular remnant. The number of developing ommatidia is reduced. Later inactivations of wg produce less severe reductions in the number of developing ommatidia, the size of the lamina and the size of the medulla neuropil. In all cases the reduction of the structures is from their dorsal and ventral extents. The number of outer proliferative center cells incorporating BrdU is markedly decreased in the Fas2 expressing domain of wg and dpp early third instar brains.

(Kaphingst and Kunes, 1994)

When both maternal and zygotic components of dsh are lacking, dsh embryos display patterning defects identical to those for wg null mutants such as wg^l-17 : no segment borders form to define segments, the usual naked regions of cuticle are not seen and filzkorper and head structures are missing. The second midgut constriction fails to form.

(Klingensmith et al., 1994)

The cuticle of double mutant wg^hs.PN, wg^l-17 embryos shows an embryo of almost wild type size with partially restored head and tail structures (filzkorper) and a segmental denticle pattern.

(Noordermeer et al., 1994)

Similar mutant leg phenotypes, e.g. duplications and bifurcations, are produced by dsh clones, dsh, wg double heterozygotes and wg mutants. There is allele specificity in these interactions. A small fraction of wg^P/wg^l-17 pharate adults have misoriented bristles on the notum, head and abdomen.

(Theisen et al., 1994)

Mutant embryos have a lawn of row-5-type ventral denticles, with segmental polarity reversals.

(Bejsovec and Wieschaus, 1993)

The sensory mother cells of the posterior postalar, and the anterior and posterior dorsocentral and scutellar sense organs are absent from wg^l-12/wg^l-17 discs.

(Phillips and Whittle, 1993)

Segmental boundaries normally found in the embryonic epidermis are absent in homozygotes.

(Ouellette et al., 1992)

Instead of usual four, only get two Malpighian tubule primordia in the embryo. These eventually elongate to produce two rudimentary tubules, that go on to produce uric acid. BrdU labelling indicates that the cells in the primordia are not replicating their DNA. Expression of stg in proctodeum is absent.

(Skaer and Martinez Arias, 1992)

lab expression in midgut (as indicated by lab-lacZ fusion genes) reduced but extended posteriorly as far as the third midgut constriction, though effects likely to be indirect.

(Tremml and Bienz, 1992)

Cuticle ventral pattern resembles that of wg individuals: abdominal segments are covered in denticles.

(Hidalgo, 1991)

Does not interact with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

After stage 11 most ptc transcripts begin to disappear and by the end of germ band retraction ptc is absent from most of the cells.

(Hidalgo and Ingham, 1990)

lab and abd-A expression is not altered in wg^l-17 mutant embryos. wg^l-17 homozygotes lack the second midgut constriction.

(Immergluck et al., 1990)

wg^l-8 and wg^l-17 embryos show no localized increases of arm protein in the epidermis at the time the stripes would be apparent in wild type embryos, but increases were seen in domains that do not express wg.

(Riggleman et al., 1990)

wg mutant embryos lack all Keilin's organs. wg^L4/wg^l-17 embryos grew in in vivo culture, but produced rather small implants containing larval gut, salivary gland, fat body and occasionally Malpighian tubules, but lacked imaginal disc material. Metamorphosed implants were necrotic and none had recognisable adult cuticular structures.

(Simcox et al., 1989)

embryonic lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

wg^l-17 has decreased cell number | embryonic stage phenotype, non-enhanceable by ptc⁹

(Chen et al., 2005)

Suppressed by

Statement

Reference

wg^Sp-1/wg^l-17 has visible phenotype, suppressible by pnr^SA.UAS.β/Scer\GAL4^pnr-MD237

(Yang et al., 2012)

wg^Sp-1/wg^l-17 has visible phenotype, suppressible by Scer\GAL4^pnr-MD237/sc^SA.UAS

(Yang et al., 2012)

wg¹/wg^l-17 has visible phenotype, suppressible by Hipk^UAS.Tag:HA/Scer\GAL4^69B

(Lee et al., 2009)

wg^l-16/wg^l-17 has visible phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

wg¹/wg^l-17 has visible phenotype, suppressible by fz3^G10

(Sato et al., 1999)

Enhancer of

Statement

Reference

wg[+]/wg^l-17 is an enhancer of visible | adult stage phenotype of Scer\GAL4^sd.PU, dome^KK104700

(Recasens-Alvarez et al., 2017)

wg^l-17 is an enhancer of visible phenotype of Nsf2^EQ.UAS, Scer\GAL4^bbg-C96

(Stewart et al., 2001)

wg^l-17 is an enhancer of visible phenotype of Scer\GAL4^unspecified, nkd^UAS.cZa

(Zeng et al., 2000)

wg[+]/wg^l-17 is an enhancer of visible phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

wg^l-17 is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

wg^l-17 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

wg^l-17 is an enhancer of visible phenotype of Scer\GAL4^69B, fz2^UAS.N

(Zhang and Carthew, 1998)

Suppressor of

Statement

Reference

wg[+]/wg^l-17 is a suppressor of abnormal size phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

wg[+]/wg^l-17 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

wg[+]/wg^l-17 is a suppressor of increased cell number | female | adult stage | heat sensitive phenotype of Df(2R)BSC132/Mmp2^Y53N

(Wang and Page-McCaw, 2014)

wg[+]/wg^l-17 is a suppressor | partially of visible phenotype of N^GD144, Scer\GAL4^sev.PU

(Cordero and Cagan, 2010)

wg[+]/wg^l-17 is a suppressor | partially of decreased cell number | third instar larval stage phenotype of N^GD144, Scer\GAL4^sev.PU

(Cordero and Cagan, 2010)

wg[+]/wg^l-17 is a suppressor of abnormal size | adult stage phenotype of N^spl-1

(Cordero and Cagan, 2010)

wg[+]/wg^l-17 is a suppressor of decreased cell number | third instar larval stage phenotype of N^spl-1

(Cordero and Cagan, 2010)

wg^l-17 is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of mid^los1

(Gaziova and Bhat, 2009)

wg^l-17 is a suppressor of decreased cell number | embryonic stage phenotype of ptc⁹

(Chen et al., 2005)

wg[+]/wg^l-17 is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

wg^l-17 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

wg[+]/wg^l-17 is a suppressor of visible phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

wg^l-17 is a suppressor of visible phenotype of Scer\GAL4^69B, fz^UAS.N

(Zhang and Carthew, 1998)

NOT Suppressor of

Statement

Reference

wg^l-17 is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^69B, fz^UAS.cZa

(Zhang and Carthew, 1998)

wg^l-17 is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

Other

Statement

Reference

Phenotype Manifest In

Enhanced by

Statement

Reference

wg^l-17 has embryonic/first instar larval cuticle phenotype, enhanceable by dsh^ΔDIX.UAS/Scer\GAL4^da.G32

(Morel and Arias, 2004)

NOT Enhanced by

Statement

Reference

wg^l-17 has wing phenotype, non-enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

wg^l-17 has phenotype, non-enhanceable by fz2^UAS.cZa/Scer\GAL4^e22c

(Moline et al., 2000)

wg^l-17 has phenotype, non-enhanceable by Nipped-A³²³

(Rollins et al., 1999)

wg^l-17 has phenotype, non-enhanceable by Nipped-B^292.1

(Rollins et al., 1999)

wg^l-17 has phenotype, non-enhanceable by Nipped-B⁴⁰⁷

(Rollins et al., 1999)

wg^l-17 has phenotype, non-enhanceable by RpL38^45-72

(Rollins et al., 1999)

wg^l-17 has phenotype, non-enhanceable by Nipped-A^222.3

(Rollins et al., 1999)

wg^l-17 has phenotype, non-enhanceable by Nipped-A²

(Rollins et al., 1999)

Suppressed by

Statement

Reference

wg^l-17 has embryonic/first instar larval cuticle phenotype, suppressible by pan²

(Bejsovec and Chao, 2012)

wg^l-17 has denticle phenotype, suppressible by pan²

(Bejsovec and Chao, 2012)

wg^l-17 has denticle phenotype, suppressible by SoxN^NC14

(Bejsovec and Chao, 2012)

wg^Sp-1/wg^l-17 has dorsocentral bristle phenotype, suppressible by pnr^SA.UAS.β/Scer\GAL4^pnr-MD237

(Yang et al., 2012)

wg^Sp-1/wg^l-17 has dorsocentral bristle phenotype, suppressible by Scer\GAL4^pnr-MD237/sc^SA.UAS

(Yang et al., 2012)

wg¹/wg^l-17 has wing phenotype, suppressible by Hipk^UAS.Tag:HA/Scer\GAL4^69B

(Lee et al., 2009)

wg¹/wg^l-17 has mesonotum | ectopic phenotype, suppressible by Hipk^UAS.Tag:HA/Scer\GAL4^69B

(Lee et al., 2009)

wg^l-17 has embryonic/first instar larval cuticle phenotype, suppressible by SoxN^NC14

(Chao et al., 2007)

wg^l-17 has ventral denticle belt phenotype, suppressible by SoxN^NC14

(Chao et al., 2007)

wg^l-17 has denticle | ectopic phenotype, suppressible by SoxN^U6-35

(Overton et al., 2007)

wg^l-17 has abdominal lateral oblique muscle 1 founder cell phenotype, suppressible by Scer\GAL4^twi.PB/twi^UAS.cBa

(Cox and Baylies, 2005)

wg^l-17 has abdominal ventral transverse muscle 1 founder cell phenotype, suppressible by Scer\GAL4^twi.PB/twi^UAS.cBa

(Cox and Baylies, 2005)

wg^l-17 has abdominal ventral acute muscle 1 founder cell phenotype, suppressible by Nrt::wg^{Scer\FRT-.UAS.Tag:HA}/Scer\GAL4^wg.PM

(Cox et al., 2005)

wg^l-17 has abdominal ventral acute muscle 2 founder cell phenotype, suppressible by Nrt::wg^{Scer\FRT-.UAS.Tag:HA}/Scer\GAL4^wg.PM

(Cox et al., 2005)

wg^l-17 has abdominal ventral acute muscle 3 founder cell phenotype, suppressible by Nrt::wg^{Scer\FRT-.UAS.Tag:HA}/Scer\GAL4^wg.PM

(Cox et al., 2005)

wg^l-17 has abdominal lateral oblique muscle 1 founder cell phenotype, suppressible by Nrt::wg^{Scer\FRT-.UAS.Tag:HA}/Scer\GAL4^wg.PM

(Cox et al., 2005)

wg^l-17 has denticle | ectopic phenotype, suppressible by Scer\GAL4^da.G32/dsh^ΔDEP+.UAS

(Morel and Arias, 2004)

wg^l-17 has denticle | ectopic phenotype, suppressible by dsh^UAS.cAa/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 has embryonic leading edge cell primordium & microtubule phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 has embryonic leading edge cell primordium phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 has embryonic leading edge cell primordium phenotype, suppressible by Scer\GAL4^da.G32/dsh^ΔDEP+.UAS

(Morel and Arias, 2004)

wg^l-17 has embryonic leading edge cell primordium phenotype, suppressible by dsh^UAS.cAa/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 has embryonic/first instar larval cuticle phenotype, suppressible by Scer\GAL4^da.G32/dsh^ΔDEP+.UAS

(Morel and Arias, 2004)

wg^l-17 has embryonic/first instar larval cuticle phenotype, suppressible by dsh^UAS.cAa/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 has denticle | ectopic phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 has ventral denticle belt | ectopic phenotype, suppressible by Scer\GAL4^prd.RG1/arr::fz2^{arr.intra.UAS.Tag:MYC}

(Tolwinski et al., 2003)

wg^l-17 has embryonic/first instar larval cuticle phenotype, suppressible by Scer\GAL4^prd.RG1/arr::fz2^{arr.intra.UAS.Tag:MYC}

(Tolwinski et al., 2003)

wg^l-17 has embryonic/first instar larval cuticle phenotype, suppressible by Axn^S044230

(Tolwinski et al., 2003)

wg^l-17 has ventral denticle belt | ectopic phenotype, suppressible by Axn^S044230

(Tolwinski et al., 2003)

wg^l-16/wg^l-17 has antenna phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

wg^l-16/wg^l-17 has wing disc phenotype, suppressible by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

wg^l-16/wg^l-17 has haltere phenotype, suppressible by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

wg^l-16/wg^l-17 has leg phenotype, suppressible by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

wg^l-16/wg^l-17 has mesonotum | ectopic phenotype, suppressible by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

wg^l-16/wg^l-17 has wing phenotype, suppressible by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

wg^l-12/wg^l-17 has wing disc phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/Wnt4^UAS.cGa

(Gieseler et al., 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by Wnt6^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by Wnt6^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by wntD^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by wntD^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

wg^l-17 has hindgut visceral muscle primordium phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^455.2

(San Martin and Bate, 2001)

wg^l-17 has hindgut visceral muscle primordium phenotype, suppressible by Scer\GAL4^twi.PB/arm^{S10.UAS.Tag:MYC}

(San Martin and Bate, 2001)

wg^l-17 has RP2sib neuron phenotype, suppressible by slp1^hs.PC

(Bhat et al., 2000)

wg^l-17 has neuroblast NB4-2 phenotype, suppressible by slp1^hs.PC

(Bhat et al., 2000)

wg^l-17 has larval RP2 motor neuron phenotype, suppressible by slp1^hs.PC

(Bhat et al., 2000)

wg^l-17 has larval RP2 motor neuron phenotype, suppressible by slp2^hs.PC

(Bhat et al., 2000)

wg^l-17/Df(2L)DE has phenotype, suppressible | partially by dally^hs.PJ

(Moline et al., 2000)

wg^l-17 has phenotype, suppressible by Nrt::wg^UAS.Tag:HA/Scer\GAL4^wg.PM

(Pfeiffer et al., 2000)

wg^l-17 has denticle phenotype, suppressible by Apc2^ΔS

(McCartney et al., 1999)

wg^l-17 has embryonic/first instar larval cuticle phenotype, suppressible by Apc2^ΔS

(McCartney et al., 1999)

wg^l-17 has embryonic epidermis phenotype, suppressible by ovo^svb-2

(Payre et al., 1999)

wg^l-17 has ventral denticle belt phenotype, suppressible by ovo^svb-2

(Payre et al., 1999)

wg¹/wg^l-17 has wing phenotype, suppressible by fz3^G10

(Sato et al., 1999)

wg^l-17 has embryonic epidermis phenotype, suppressible by Df(3R)Espl22

(Cavallo et al., 1998)

wg^l-17 has ventral denticle belt phenotype, suppressible by Df(3R)Espl22

(Cavallo et al., 1998)

wg^l-17 has embryonic epidermis phenotype, suppressible by pan³

(Cavallo et al., 1998)

wg^l-17 has ventral denticle belt phenotype, suppressible by pan³

(Cavallo et al., 1998)

wg^l-16/wg^l-17 has wing phenotype, suppressible by Scer\GAL4^dpp.blk1/vg^UAS.cKa

(Klein and Martinez Arias, 1998)

wg^l-17 has embryonic/larval dorsal vessel phenotype, suppressible by dsh^hs.PA

(Park et al., 1996)

NOT suppressed by

Statement

Reference

wg^l-17 has abdominal ventral acute muscle 1 founder cell phenotype, non-suppressible by Scer\GAL4^twi.PB/twi^UAS.cBa

(Cox and Baylies, 2005)

wg^l-17 has abdominal ventral acute muscle 2 founder cell phenotype, non-suppressible by Scer\GAL4^twi.PB/twi^UAS.cBa

(Cox and Baylies, 2005)

wg^l-17 has abdominal ventral acute muscle 3 founder cell phenotype, non-suppressible by Scer\GAL4^twi.PB/twi^UAS.cBa

(Cox and Baylies, 2005)

wg^l-17 has denticle | ectopic phenotype, non-suppressible by dsh^ΔDIX.UAS/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 has embryonic leading edge cell primordium & microtubule phenotype, non-suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^332.3

(Morel and Arias, 2004)

wg^l-17 has embryonic leading edge cell primordium phenotype, non-suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^332.3

(Morel and Arias, 2004)

wg^l-17 has ventral denticle belt | ectopic phenotype, non-suppressible by Scer\GAL4^prd.RG1/fz2^UAS.ECFP

(Tolwinski et al., 2003)

wg^l-17 has ventral denticle belt | ectopic phenotype, non-suppressible by Scer\GAL4^prd.RG1/fz2^{UAS.cTa.Tag:MYC}

(Tolwinski et al., 2003)

wg^l-17 has ventral denticle belt | ectopic phenotype, non-suppressible by Scer\GAL4^prd.RG1/fz2^UAS.cCa

(Tolwinski et al., 2003)

wg^l-17 has embryonic/first instar larval cuticle phenotype, non-suppressible by Scer\GAL4^prd.RG1/fz2^UAS.ECFP

(Tolwinski et al., 2003)

wg^l-17 has embryonic/first instar larval cuticle phenotype, non-suppressible by Scer\GAL4^prd.RG1/fz2^{UAS.cTa.Tag:MYC}

(Tolwinski et al., 2003)

wg^l-17 has embryonic/first instar larval cuticle phenotype, non-suppressible by Scer\GAL4^prd.RG1/fz2^UAS.cCa

(Tolwinski et al., 2003)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt10^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt10^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt4^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt4^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt5^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt5^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

wg^l-17 has hindgut visceral muscle primordium phenotype, non-suppressible by Scer\GAL4^how-24B/arm^{S10.UAS.Tag:MYC}

(San Martin and Bate, 2001)

wg^l-17 has wing phenotype, non-suppressible by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

wg^l-17 has phenotype, non-suppressible by Wnt4^UAS.cGa/Scer\GAL4^da.G32

(Buratovich et al., 2000)

wg^l-17 has embryonic/larval somatic muscle & embryonic myoblast | dorsal phenotype, non-suppressible by Scer\GAL4^twi.PG/slp1^UAS.cSa

(Lee and Frasch, 2000)

wg^l-17 has embryonic/larval dorsal vessel & embryonic myoblast phenotype, non-suppressible by Scer\GAL4^twi.PG/slp1^UAS.cSa

(Lee and Frasch, 2000)

wg^l-17 has phenotype, non-suppressible by fz2^UAS.cZa/Scer\GAL4^e22c

(Moline et al., 2000)

wg^l-17 has phenotype, non-suppressible by dally^hs.PJ

(Tsuda et al., 1999)

wg^l-17 has denticle phenotype, non-suppressible by Scer\GAL4^arm.PS/Egfr^DN.UAS

(Szuts et al., 1997)

wg^l-17 has denticle phenotype, non-suppressible by Egfr^f1

(Szuts et al., 1997)

Enhancer of

Statement

Reference

wg[+]/wg^l-17 is an enhancer of wing hair | ectopic phenotype of arm^Ndel.vg.MQ

(Marcetteau et al., 2021)

wg[+]/wg^l-17 is an enhancer of wing margin bristle | decreased number phenotype of Arf6¹

(Marcetteau et al., 2021)

wg[+]/wg^l-17 is an enhancer of wing margin bristle | decreased number phenotype of Arf6^GX16w-

(Marcetteau et al., 2021)

wg[+]/wg^l-17 is an enhancer of mesonotum | adult stage | ectopic phenotype of Scer\GAL4^sd.PU, dome^KK104700

(Recasens-Alvarez et al., 2017)

wg[+]/wg^l-17 is an enhancer of ventral denticle belt phenotype of Cow^5Δ

(Chang and Sun, 2014)

wg[+]/wg^l-17 is an enhancer of abdominal ventral denticle belt | embryonic stage phenotype of Scer\GAL4^e22c, pav^UASp.mGFP6, tum^UAS.cSa

(Jones et al., 2010)

wg^l-17 is an enhancer of denticle phenotype of Scer\GAL4^69B, ci^UAS.cAa

(Angelats et al., 2002)

wg^l-17 is an enhancer of embryonic/first instar larval cuticle phenotype of Scer\GAL4^69B, ci^UAS.cAa

(Angelats et al., 2002)

wg^l-17/Scer\GAL4^69B is an enhancer of embryonic epidermis phenotype of ci^UAS.cAa

(Angelats et al., 2002)

wg^l-17 is an enhancer of posterior supraalar bristle phenotype of dally^gem/dally⁰⁶⁴⁶⁴

(Fujise et al., 2001)

wg^l-17 is an enhancer of wing margin phenotype of Nsf2^EQ.UAS, Scer\GAL4^bbg-C96

(Stewart et al., 2001)

wg[+]/wg^l-17 is an enhancer of wing phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

wg^l-17 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

wg^l-17 is an enhancer of phenotype of ro^DOM

(Treisman et al., 1997)

wg[+]/wg^l-17 is an enhancer of wing phenotype of ct^L32, su(Hw)^e2

(Morcillo et al., 1996)

wg[+]/wg^l-17 is an enhancer of wing margin phenotype of ct^L32, su(Hw)^e2

(Morcillo et al., 1996)

NOT Enhancer of

Statement

Reference

wg^l-17 is a non-enhancer of genital disc phenotype of ix¹

(Chatterjee et al., 2015)

wg^l-17 is a non-enhancer of embryonic/first instar larval cuticle phenotype of Axn^S044230

(Tolwinski et al., 2003)

Suppressor of

Statement

Reference

wg[+]/wg^l-17 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

wg[+]/wg^l-17 is a suppressor of stalk follicle cell | increased number | heat sensitive phenotype of Df(2R)BSC132/Mmp2^Y53N

(Wang and Page-McCaw, 2014)

wg[+]/wg^l-17 is a suppressor | partially of cone cell phenotype of N^GD144, Scer\GAL4^sev.PU

(Cordero and Cagan, 2010)

wg[+]/wg^l-17 is a suppressor | partially of eye phenotype of N^GD144, Scer\GAL4^sev.PU

(Cordero and Cagan, 2010)

wg[+]/wg^l-17 is a suppressor of eye phenotype of N^spl-1

(Cordero and Cagan, 2010)

wg[+]/wg^l-17 is a suppressor of cone cell phenotype of N^spl-1

(Cordero and Cagan, 2010)

wg[+]/wg^l-17 is a suppressor of photoreceptor phenotype of N^spl-1

(Cordero and Cagan, 2010)

wg^l-17 is a suppressor of larval RP2 motor neuron | ectopic phenotype of mid^los1

(Gaziova and Bhat, 2009)

Scer\GAL4^twi.PB/wg^l-17 is a suppressor of abdominal ventral transverse muscle 1 founder cell phenotype of twi^UAS.cBa

(Cox and Baylies, 2005)

wg[+]/wg^l-17 is a suppressor of ventral denticle belt phenotype of nkd²

(Jones and Bejsovec, 2005)

wg[+]/wg^l-17 is a suppressor of embryonic/first instar larval cuticle phenotype of nkd²

(Jones and Bejsovec, 2005)

wg^l-17 is a suppressor of arista | increased number phenotype of obk¹

(Atallah et al., 2004)

wg[+]/wg^l-17 is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

wg^l-17 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

wg[+]/wg^l-17 is a suppressor of wing | posterior phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

wg[+]/wg^l-17 is a suppressor of genitalia phenotype of dally^gem/dally⁰⁶⁴⁶⁴

(Tsuda et al., 1999)

wg^l-17 is a suppressor of wing margin bristle | ectopic | somatic clone phenotype of nub¹

(Neumann and Cohen, 1998)

wg^l-17 is a suppressor of wing sensillum | ectopic phenotype of Scer\GAL4^69B, fz2^UAS.cZa

(Zhang and Carthew, 1998)

wg^l-17 is a suppressor of leg | somatic clone phenotype of Pka-C1^H2

(Li et al., 1995)

NOT Suppressor of

Statement

Reference

wg^l-17 is a non-suppressor of genital disc phenotype of ix¹

(Chatterjee et al., 2015)

wg^l-17 is a non-suppressor of ventral denticle belt phenotype of Axn^S044230

(Tolwinski et al., 2003)

wg^l-17 is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

wg^l-17 is a non-suppressor of phenotype of dsh^hs.sev.B

(Boutros et al., 1998)

wg^l-17 is a non-suppressor of wing margin bristle phenotype of Scer\GAL4^69B, fz^UAS.cZa

(Zhang and Carthew, 1998)

Other

Statement

Reference

ck^AN9, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

ck^CB16, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

ck^KT9, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

ck^PS10, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

ck^PT14, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

ck^PJ17, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

ck⁷, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

ck^KT9, pan², wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

SoxN^NC14, ck^KT9, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

lqfR⁰³⁶⁸⁵/lqfR^Δ117, wg[+]/wg^l-17 has head | P-stage phenotype

(Lee and Fischer, 2012)

lqfR⁰³⁶⁸⁵/lqfR^Δ117, wg[+]/wg^l-17 has eye | P-stage phenotype

(Lee and Fischer, 2012)

Scer\GAL4^prd.RG1, dsh^UAS.cAa, wg^l-17 has embryonic/first instar larval cuticle | maternal effect phenotype

(Metcalfe et al., 2010)

Scer\GAL4^prd.RG1, dsh^UAS.cAa, wg^l-17 has ventral denticle belt | maternal effect phenotype

(Metcalfe et al., 2010)

ptc⁹, wg^l-17 has genital disc primordium phenotype

(Chen et al., 2005)

Scer\GAL4^twi.PB, twi^UAS.cBa, wg^l-17 has abdominal lateral oblique muscle 1 founder cell phenotype

(Cox and Baylies, 2005)

Scer\GAL4^twi.PB, twi^UAS.cBa, wg^l-17 has abdominal ventral acute muscle 1 founder cell phenotype

(Cox and Baylies, 2005)

Scer\GAL4^twi.PB, twi^UAS.cBa, wg^l-17 has abdominal ventral acute muscle 2 founder cell phenotype

(Cox and Baylies, 2005)

Scer\GAL4^twi.PB, twi^UAS.cBa, wg^l-17 has abdominal ventral acute muscle 3 founder cell phenotype

(Cox and Baylies, 2005)

Scer\GAL4^e22c, nkd^UAS.cZa, wg[+]/wg^l-17 has embryonic/first instar larval cuticle phenotype

(Jones and Bejsovec, 2005)

Scer\GAL4^e22c, nkd^UAS.cZa, wg^l-17 has embryonic/first instar larval cuticle phenotype

(Jones and Bejsovec, 2005)

Scer\GAL4^αTub84B.PP, ci^UAS.cAa, wg^l-17 has embryonic/first instar larval cuticle phenotype

(Angelats et al., 2002)

Scer\GAL4^wg.PM, ci^UAS.cAa, wg^l-17 has embryonic/first instar larval cuticle phenotype

(Angelats et al., 2002)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype

(Llimargas and Lawrence, 2001)

ci⁹⁴, wg^l-17 has ventral denticle belt phenotype

(Methot and Basler, 2001)

ci⁹⁴, wg^l-17 has embryonic/first instar larval cuticle phenotype

(Methot and Basler, 2001)

en^E, wg^l-17 has denticle phenotype

(Alexandre et al., 1999)

Scer\GAL4^en-e16E, arm^UAS.cWa, wg^l-17 has wing margin bristle phenotype

(Greaves et al., 1999)

Scer\GAL4^en-e16E, arm^UAS.cWa, wg[+]/wg^l-17 has wing margin bristle phenotype

(Greaves et al., 1999)

Scer\GAL4^en-e16E, arm^{S10.UAS.Tag:MYC}, wg^l-17 has embryonic epidermis phenotype

(Gritzan et al., 1999)

Scer\GAL4^en-e16E, arm^{S10.UAS.Tag:MYC}, wg^l-17 has ventral denticle belt phenotype

(Gritzan et al., 1999)

Scer\GAL4^e22c, fz2^UAS.cCa, wg[+]/wg^l-17 has ventral denticle belt phenotype

(Moline et al., 1999)

Scer\GAL4^e22c, fz2^UAS.cCa, wg[+]/wg^l-17 has embryonic/first instar larval cuticle phenotype

(Moline et al., 1999)

Scer\GAL4^e22c, fz2^UAS.cCa, wg^l-17 has ventral denticle belt phenotype

(Moline et al., 1999)

Scer\GAL4^e22c, fz2^UAS.cCa, wg^l-17 has embryonic/first instar larval cuticle phenotype

(Moline et al., 1999)

Scer\GAL4^e22c, pan^ΔN.UAS, wg^l-17 has embryonic epidermis phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, pan^ΔN.UAS, wg^l-17 has ventral denticle belt phenotype

(Cavallo et al., 1998)

dpp^s4, wg^l-17 has embryonic midgut constriction 2 phenotype

(Aspland and White, 1997)

dpp^s4, wg^l-17 has embryonic midgut constriction 3 phenotype

(Aspland and White, 1997)

Df(2R)en^E, wg^l-17 has embryo phenotype

(Lawrence et al., 1996)

Df(2R)en^E, wg^l-17 has embryonic/first instar larval cuticle phenotype

(Lawrence et al., 1996)

Df(2R)en^E, wg^l-17 has Keilin organ phenotype

(Lawrence et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The highly prevalent duplication of mesanotum structures observed upon the expression of dome^KK104700 under the control of Scer\GAL4^sd.PU is slightly enhanced by wg^l-17 heterozygosity (and Dicer-2, for more efficient RNAi).

(Recasens-Alvarez et al., 2017)

The increase in average cell number in the stalks between egg chambers which is seen in Mmp2^Y53N/Df(2R)BSC132 and in Mmp2^Y675N/Df(2R)BSC132 females after being shifted to the restrictive temperature is dominantly suppressed if the females also carry a single copy of wg^l-17.

(Wang and Page-McCaw, 2014)

The wg^l-17 denticle phenotype is modified in combination with any of ck^AN9, ck^CB16, ck^KT9, ck^PS10, ck^PT14, ck^PJ17 or ck⁷, such that the double mutants have denticles with a rounded appearance and no distinctive hook.

pan² partially suppresses the wg^l-17 denticle phenotype: denticle diversity is restored but not naked cuticle.

In wg^l-17 ck^KT9 ; pan² triple mutants, smaller anterior denticles can have sharp points, while larger posterior denticles remain rounded and some appear fragmented.

SoxN^NC14 partially suppresses the wg^l-17 denticle phenotype: some segmentation is restored to the pattern, without increasing denticle diversity.

wg^l-17 ck^KT9 SoxN^NC14 triple mutant embryos show a dramatic reduction in denticle size and many of the denticles are fragmented into one or two short projections. Actin bundles in the epidermal cells are split into two or sometimes three separate aggregates.

(Bejsovec and Chao, 2012)

wg^l-17/+ ; lqfR⁰³⁶⁸⁵/lqfR^Δ117 adult escapers have severely defective eyes, ranging from kidney-shaped to nearly absent. They also have defects in the head cuticle.

(Lee and Fischer, 2012)

Expression of pnr^{SA.Scer\UAS.β} under the control of Scer\GAL4^pnr-MD237 results in greater rescue of the loss of dorsocentral bristles seen in wg^Sp-1/wg^l-17 flies than expression of pnr^Scer\UAS.β under the control of Scer\GAL4^pnr-MD237.

Expression of sc^SA.Scer\UAS under the control of Scer\GAL4^DC results in greater rescue of the loss of dorsocentral bristles seen in wg^Sp-1/wg^l-17 flies than expression of sc^Scer\UAS.cUa under the control of Scer\GAL4^DC.

(Yang et al., 2012)

wg^l-17/+ suppresses the necrosis seen in adult eyes when N^GD144 is driven by Scer\GAL4^sev.PU.

wg^l-17/+ suppresses the cone cell loss phenotype seen in the third instar eye discs when N^GD144 is driven by Scer\GAL4^sev.PU.

N^spl-1 with one copy of wg^l-17 suppresses the adult eye size phenotype seen in N^spl-1 mutants.

N^spl-1 with one copy of wg^l-17 suppresses the cone cell and photoreceptor loss phenotypes seen in N^spl-1 third instar larvae.

(Cordero and Cagan, 2010)

The leading edge cell in the anterior compartment just anterior to the parasegment boundary is transformed into an ectopic mixer cell in wg^l-17 embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E assayed by marker expression (in the abdominal segments of wild-type embryos at the end of dorsal closure, the "mixer cell" moves across the segment boundary from the anterior compartment to the posterior compartment, but the cell in the equivalent position relative to the parasegment boundary does not show this "mixing" behaviour).

(Gettings et al., 2010)

Scer\GAL4^prd.RG1>dsh^Scer\UAS.cAa-overexpressing embryos are readily identifiable amongst wg^l-17 homozygotes by their four wide naked zones interspersed between their denticle bands.

(Metcalfe et al., 2010)

The ectopic RP2 neuron seen in mid^los1 mutants is missing in 75-96% of the hemisegments in mid^los1, wg^l-17 double mutants.

(Gaziova and Bhat, 2009)

Expression of hipk^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^69B in a wg¹/wg^l-17 mutant background results in proper wing development and rescues the wing-to-notum transformation.

(Lee et al., 2009)

The RNA-null wg^l-17 mutant 'lawn of denticles' phenotype is partially suppressed by SoxN^NC14.

(Chao et al., 2007)

wg^l-17; SoxN^U6-35 double mutant embryos have cuticles with few or no ectopic denticles.

(Overton et al., 2007)

Stage 15 ptc⁹ wg^l-17 double mutant embryos have the same number of genital disc precursor cells as wg^l-17 single mutants. This is a reduction compared to wild type, and a huge reduction compared to ptc⁹ single mutant embryos.

(Chen et al., 2005)

Expression of Nrt::wg^{Scer\FRT-.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^wg.PM rescues the slou expressing founder cell phenotype in wg^l-17 embryos. In fact, there is an expansion of slou cluster II in 57% of hemisegments examined, indicating that the mesoderm is experiencing increased wg signalling.

(Cox et al., 2005)

The excess naked cuticle phenotype seen in nkd² embryos is partially suppressed by wg^l-17/+. The ability of wg^l-17/+ to suppress the excess naked cuticle phenotype of nkd² embryos is suppressed by RacGAP50C^AR2 or RacGAP50C^DH15; the triple mutant embryos secrete uniform cuticle with no denticle belts. Expression of nkd^Scer\UAS.cZa under the control of Scer\GAL4^e22c in a wg^l-17/+ background results in fusions between denticle belts due to loss of intervening naked cuticle. This effect is suppressed if the embryos are also heterozygous for RacGAP50C^AR2; the triple mutant embryos have a wild-type cuticle pattern.

(Jones and Bejsovec, 2005)

Wnt4^K2/wg^l-17 flies show no detectable eye defects.

(Lim et al., 2005)

The frequency of cuticular segmentation phenotypes in wg^l-17/+ first instar larvae is not significantly changed in animals with a egl^3e/egl¹ mutant mother.

(Bullock et al., 2004)

arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^da.G32 suppresses the transformation of naked ventral cuticle to denticles in wg^l-17 homozygous embryos. Many of the resulting embryos have the arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^da.G32 overexpression phenotype of a completely naked ventral cuticle. arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^da.G32 suppresses the dorsal-ventral elongation and orientation of microtubule bundles in the leading edge cells of stage 13 wg^l-17 homozygous embryos. arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^332.3 completely fails to suppress these phenotypes. dsh^Scer\UAS.cAa; Scer\GAL4^da.G32 partially suppresses he transformation of naked ventral cuticle to denticles and the shortening of the cuticle seen in wg^l-17 homozygous embryos. The dorsal side of these cuticles have some 'warts'. dsh^Scer\UAS.cAa; Scer\GAL4^da.G32 suppresses the loss of dorsal ventral polarity in the leading edge cells of stage 13 wg^l-17 homozygous embryos, but only weakly rescues elongation of these cells. dsh^{ΔDEP+.Scer\UAS}; Scer\GAL4^da.G32 partially suppresses the transformation of naked ventral cuticle into denticles and reduction in cuticle length seen in cuticles from wg^l-17 homozygous embryos, and an completely suppress the dorsal hole in these cuticles. dsh^{ΔDEP+.Scer\UAS}; Scer\GAL4^da.G32 suppresses, the loss of dorsal ventral polarity in the leading edge cells of stage 13 wg^l-17 homozygous embryos but fails to rescue elongation of these cells. However, initiation of the anterior zipper during dorsal closure is rescued. dsh^{ΔDIX.Scer\UAS}; Scer\GAL4^da.G32 does not suppress the transformation of naked ventral cuticle into denticles in cuticles from wg^l-17 homozygous embryos. The resulting cuticles are even shorter and more puckered than those from wg^l-17 homozygous embryos, have an enlarged dorsal hole.

(Morel and Arias, 2004)

hh^Scer\UAS.cIa; Scer\GAL4^prd.RG1 fails to rescue metameric furrow formation in Df(2R)en^E; wg^l-17 double homozygous embryos. en^Scer\UAS.cGa; Scer\GAL4^prd.RG1 rescues metameric furrow formation in Df(2R)en^E; wg^l-17 double homozygous embryos, but these furrows disappear prematurely (before stage 13) on the ventral side of the embryo. Failure of metameric furrow formation in arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^en-e16E embryos homozygous for hh^AC is not suppressed by wg^l-17/wg^l-17. In stage 13+ arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^en-e16E embryos homozygous for wg^l-17, the metameric furrows are duplicated - forming on both sides of the en expression stripes. In the lateral regions of these embryos, en expression is broken up into islands, each surrounded by an ectopic furrow.

(Larsen et al., 2003)

The loss of segmentation and lack of smooth cuticle due to wg^l-17/wg^l-17 is partially maternally suppressed by Axn^S044230/Axn^S044230. If these embryos are also zygotically Axn^S044230/Axn^S044230, they produce cuticles consisting entirely of smooth cuticle, just as they would if they were wild-type for wg. arr::fz2^{arr.intra.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^prd.RG1 restores smooth cuticle formation in wg^l-17/wg^l-17 embryos. No such effect is seen with fz2^Scer\UAS.cCa; Scer\GAL4^prd.RG1, fz2^{Scer\UAS.cTa.T:Hsap\MYC}; Scer\GAL4^prd.RG1 or fz2^{Scer\UAS.T:Avic\GFP-ECFP}; Scer\GAL4^prd.RG1.

(Tolwinski et al., 2003)

The dorsal hole phenotype, loss of leading edge actin cable, and loss of adhesion between the amnioserosa and dorsal epidermis of hep¹ mutant embryos are all partially suppressed by Scer\GAL4^69B with wg^Scer\UAS.cGa.

(Kaltschmidt et al., 2002)

Has no effect on the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

The addition of wg^l-17 to dally^gem/dally⁰⁶⁴⁶⁴ flies, leads to enhancement of the posterior supraalar bristle phenotype seen in dally^gem/dally⁰⁶⁴⁶⁴ flies alone: 30% of flies have the phenotype, rather than 1%.

(Fujise et al., 2001)

Many of the phenotypes caused by wg^l-16/wg^l-17 can be rescued by expression of Wnt4^Scer\UAS.cGa under the control of Scer\GAL4^ptc-559.1; wing rescue is seen at high frequency, halteres appear well developed, leg morphology is often rescued, but partial rescue of the antenna is only occasionally seen. The wing disc defect caused by shifting wg^l-12/wg^l-17 wing discs to the restrictive temperature for 24 hours at the beginning of the second larval instar can be rescued by expression of Wnt4^Scer\UAS.cGa under the control of Scer\GAL4^ptc-559.1 during the 24 hour period. When wg^l-12/wg^l-17 wing discs expressing Wnt4^Scer\UAS.cGa under the control of Scer\GAL4^ptc-559.1 are continuously maintained at the restrictive temperature from the second until the late third instar stage, the resulting discs fail to develop normally and remain very small.

(Gieseler et al., 2001)

In wg^l-17 Wnt2^unspecified double mutants in 40-45% of hemisegments, the dorsal trunk is completely missing, and in the remaining hemisegments only some reduced and thin dorsal trunk forms. Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS can substantially rescue the dorsal trunk which is missing in wg^l-17 Wnt2^unspecified double mutant embryos. Expression of Wnt2^Scer\UAS.cSa under the control of Scer\GAL4^wg.PM in a wg^l-17 Wnt2^unspecified double mutant background rescues some dorsal trunk in the trachea. However when Wnt2^Scer\UAS.cSa is expressed under the control of Scer\GAL4^btl.PS there is strong rescue, and more dorsal trunk is made. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^wg.PM in a wg^l-17 Wnt2^unspecified double mutant background rescues some dorsal trunk in the trachea. However when wg^Scer\UAS.cLa is expressed under the control of Scer\GAL4^btl.PS there is strong rescue, and more dorsal trunk is made.

(Llimargas and Lawrence, 2001)

ci⁹⁴ wg^l-17 double mutant embryos are short and show a "lawn of denticles" phenotype.

(Methot and Basler, 2001)

Expression of slp1^hs.PC in wg^l-17 embryos rescues the RP2/sib lineage in as many as 85% of hemisegments. Rescue of NB4-2 is seen in approximately 43% of hemisegments. Expression of slp2^hs.PC in wg^l-8 or wg^l-17 embryos rescues the RP2 lineage in approximately 50% of hemisegments.

(Bhat et al., 2000)

Expression of Wnt4^Scer\UAS.cGa under the control of Scer\GAL4^da.G32 does not rescue the phenotype of wg^l-17 embryos.

(Buratovich et al., 2000)

The wg^l-17 phenotype is not affected by the expression of fz2^Scer\UAS.cZa under the control of Scer\GAL4^e22c.

(Moline et al., 2000)

Expression of Nrt::wg^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^wg.PM to wg^l-17 flies rescues the phenotypes caused by wg^l-17 alone.

(Pfeiffer et al., 2000)

en^E wg^l-17 double mutant embryos have segmentally repeated denticle whorls.

(Alexandre et al., 1999)

Dominantly enhances the wing notching phenotype caused by expression of argos::shg^{i.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E. Dominantly suppresses the wing phenotype caused by expression of arm^Scer\UAS.cWa under the control of Scer\GAL4^en-e16E. Also, wing margin bristles are lost between veins 4 and 5.

(Greaves et al., 1999)

The addition of wg^l-17 also enhances the wing phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies, in a partially penetrant manner, exhibiting loss of additional wing blade material along the posterior margin and bristle loss along the anterior margin. A small percentage of more sever strap wings is also observed.

(Helms et al., 1999)

The wg^l-17 lawn of denticles phenotype is partially rescued if the embryos are also maternally and zygotically homozygous for Apc2^ΔS; the normal diversity of cuticular pattern elements and small expanses of naked cuticle are restored.

(McCartney et al., 1999)

Overexpression of fz2^Scer\UAS.cCa under the control of Scer\GAL4^e22c in a wg^l-17/+ background results in cuticle patterning defects in 60% of embryos; ectopic denticles appear in the domain of cells that normally secrete naked cuticle.

(Moline et al., 1999)

wg^l-17, ovo^svb-2 double mutant embryos produce naked cuticle, with some residual abortive denticles. This phenotype is characteristic of ovo^svb-2 embryos.

(Payre et al., 1999)

Expression of Nrt::wg^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^en-e16E in a wg^l-17 background rescues an expanse of naked cuticle only 1-2 cells wide. Cuticle posterior to row 6 that would be naked in wild type are covered in additional denticles.

(Sanson et al., 1999)

The wingless phenotype of wg¹/wg^l-17 flies is partially rescued by fz3^G10; the fraction of flies with two wings increases from 46% to 87%, while the fraction of one wing and wingless flies reduces from 44% and 10% to 13% and 0.5% respectively.

(Sato et al., 1999)

Heat shock expression of dally^hs.PJ cannot rescue wg^l-17. wg^l-17 dominantly suppresses the genitalia defects seen in about 70% of dally⁰⁶⁴⁶⁴/dally^gem flies, so that abnormalities are only seen in less than 10% of flies.

(Tsuda et al., 1999)

Reducing the dose of maternally supplied gro gene product, using Df(3R)Espl22, suppresses the wg null phenotype. Paternal contribution of Df(3R)Espl22 has no effect.

(Cavallo et al., 1998)

Scer\GAL4^dpp.blk1-mediated expression of vg^Scer\UAS.cKa restores the wing.

(Klein and Martinez Arias, 1998)

Clones of cells in the wing that are simultaneously mutant for wg^l-17 and nub¹ do not form ectopic bristle precursors.

(Neumann and Cohen, 1998)

The supernumerary wing bristle phenotypes of fz2^Scer\UAS.cZa, Scer\GAL4^69B can be dominantly suppressed by wg^l-17, though the polarity phenotype of fz^Scer\UAS.cZa, Scer\GAL4^69B cannot. The wing margin loss phenotype of fz2^Scer\UAS.N, Scer\GAL4^69B can be slightly dominantly enhanced by wg^l-17.

(Zhang and Carthew, 1998)

dpp^s4 wg^l-17 embryos lack the second and third midgut constrictions.

(Aspland and White, 1997)

Does not alter the eye tissue polarity phenotype produced by fz^Scer\UAS.cAa expressed under the control of Scer\GAL4^hs.2sev.

(Strutt et al., 1997)

The denticle phenotype of wg^l-17 homozygous larvae is not altered if the larvae are also homozygous for Egfr^f1 or are carrying Egfr^DN.Scer\UAS (expressed under the control of Scer\GAL4^arm.PS). Homozygous wg^l-17 larvae derived from embryos in which spi^s.Scer\UAS is expressed under the control of Scer\GAL4^arm.PS have lawns of denticles; these denticles are clearly smaller than those present in homozygous wg^l-17 larvae that do not carry spi^s.Scer\UAS, and probably correspond to row 1-4 denticles.

(Szuts et al., 1997)

Df(2R)en^E wg^l-17 embryos are small, spherical, carry a lawn of unpolarised denticles (A cell type denticles), have no Keilin's organs (presumably due to lack of functional parasegment boundaries) and the thoracic and abdominal identities are differentiated. Scer\GAL4^arm.PS mediated expression of wg^Scer\UAS.cLa in wg^l-17 Df(2R)en^E embryos does not rescue segmentation, the embryos lengthen only a little and no Keilin's organs form. Instead of a lawn of denticles the ventral abdomen now makes naked cuticle. The T1 becomes largely covered by fine denticles normally found in the beard, the beard is not small and localised. Scer\GAL4^arm.PS mediated expression of both wg^Scer\UAS.cLa and en^Scer\UAS.cGa in wg^l-17 Df(2R)en^E embryos causes a small beardless, near-spherical and unsegmented embryo with extruded organs (believed to be foregut and hindgut), i.e. less phenotypic rescue than for Scer\GAL4^arm.PS mediated expression of wg^Scer\UAS.cLa alone. Scer\GAL4^arm.PS mediated expression of both wg^Scer\UAS.cLa and hh^Scer\UAS.cIa in wg^l-17 Df(2R)en^E embryos causes naked cuticle to form in the place of the T1 beard. Scer\GAL4^arm.PS mediated expression of wg^{l-12.Scer\UAS} in wg^l-17 Df(2R)en^E embryos at varying temperatures can be used to study the dose response to wg for A cells. At 17.5^oC wg^{l-12.Scer\UAS} produces the same phenotype as when wild type wg (wg^Scer\UAS.cLa) is added. At 20^oC there are only a few ventral denticles and some beard in T1. At 22^oC there are two lateral stripes of ventral denticles and some beard in T1. At 23^oC the abdomen is completely covered in denticles but there is no beard in T1. At 25^oC the abdomen is completely covered in denticles, weak thoracic denticles are present, but there is no beard in T1. At 28.5^oC embryos are indistinguishable from wg^l-17 Df(2R)en^E embryo. Scer\GAL4^prd.RG1 mediated expression of wg^Scer\UAS.cLa in wg^l-17 Df(2R)en^E embryos causes a lengthening of the whole embryo and instead of a lawn of denticles alternate stripes of naked and denticulate cuticle appear. Two types of denticle form in each band, small ones on the outside and larger ones inward. Individual denticles tend to point towards the nearest naked domain.

(Lawrence et al., 1996)

Heart formation does not occur in dsh^hs.PA, wg^l-17 flies reared at 25^oC or 27^oC. Heat shock for 30 minutes between 3 and 4 hours of development rescues heart development, often flies exhibit cardiac hyperplasia.

(Park et al., 1996)

wg^l-17 Pka-C1^E95 clones cause local outgrowths of leg tissue and on rare occasions form of supernumerary legs.

(Jiang and Struhl, 1995)

Partially suppression of the defects caused by Pka-C1^H2 clones in the ventral regions of the leg, without affecting the majority of pattern defects in the wing, notum, halteres and antennae.

(Li et al., 1995)

ptc⁹, wg^l-17 double mutants have lateral whirls of denticles.

(Hidalgo, 1991)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^Scer\UAS.cHa driven by Scer\GAL4^hh-Gal4 in posterior wing compartments composed of homozygous wg^l-17 mutant cells does not substantially restore normal wing size.

(Baena-Lopez et al., 2009)

The neoplastic tumours induced by wg^l-17 mutant cells blocked for apoptosis (described in FBrf0191458) appear to be due to the loss of l(2)gl function from the mutant chromosome studied.

(Roegiers et al., 2009)

FlyBase curator comment: The neoplastic tumours induced by wg^l-17 mutant cells blocked for apoptosis (described in FBrf0191458) appear to be due to the loss of l(2)gl function from the mutant chromosome studied and not due to an affect of the wg^l-17 mutation (see FBrf0207678).

(Perez-Garijo et al., 2005)

Complementation and Rescue Data

Rescued by

wg^l-17 is rescued by wg^UAS.cGa/Scer\GAL4^da.G32

(Kaltschmidt et al., 2002)

wg^l-17 is rescued by Scer\GAL4^en-e16E/wg^UAS.GFP

(Pfeiffer et al., 2002)

wg^l-17 is rescued by wg^UAS.GFP/Scer\GAL4^wg.PM

(Pfeiffer et al., 2002)

wg^l-17 is rescued by wg^PE2.UAS/Scer\GAL4^e22c

(Moline et al., 2000)

wg^l-17 is rescued by wg^Δ85.UAS/Scer\GAL4^prd.RG1

(Hays et al., 1997)

wg^l-17 is rescued by wg^hs.PH

(Hays et al., 1997)

wg^l-17 is rescued by Scer\GAL4^prd.RG1/wg^{Δ85.UAS.Tag:HA}

(Hays et al., 1997)

wg^l-17 is rescued by wg^{UAS.cHa.Tag:HA}/Scer\GAL4^wg.PM

(Hays et al., 1997)

wg^l-17 is rescued by wg^hs.Tag:HA

(Hays et al., 1997)

wg^l-17 is rescued by wg^PE4.hs

(Hays et al., 1997)

wg^l-17 is rescued by wg^UAS.cHa/Scer\GAL4^wg.PM

(Hays et al., 1997)

wg^l-17 is rescued by wg^{PE4.hs.Tag:HA}

(Hays et al., 1997)

Partially rescued by

wg^Gal4/wg^l-17 is partially rescued by Scer\GAL4^wg-Gal4/wg^UAS.GFP

(Won et al., 2019)

wg^l-17 is partially rescued by Scer\GAL4^prd.RG1/wg^UAS.cHa

(Bejsovec and Chao, 2012)

wg^l-17 is partially rescued by Scer\GAL4^hh-Gal4/wg^{S239A.UAS.Tag:HA}

(Baena-Lopez et al., 2009)

wg^l-17 is partially rescued by Scer\GAL4^pros.PMG/wg^UAS.cGa

(Cox et al., 2005)

wg^l-17 is partially rescued by wg^UAS.cGa/Scer\GAL4^332.3

(Morel and Arias, 2004)

wg^l-17 is partially rescued by wg^UAS.cGa/Scer\GAL4^da.G32

(Morel and Arias, 2004)

wg^l-17 is partially rescued by wg^UAS.HRP/Scer\GAL4^wg.PM

(Dubois et al., 2001)

wg^l-17 is partially rescued by wg^wg.3'UTR.UAS/Scer\GAL4^wg.PM

(Simmonds et al., 2001)

wg^l-17 is partially rescued by wg^{SV40.3'UTR.UAS}/Scer\GAL4^wg.PM

(Simmonds et al., 2001)

wg^l-17 is partially rescued by Scer\GAL4^en-e16E/wg^UAS.cLa

(Sanson et al., 1999)

wg^l-17 is partially rescued by wg^PE6.UAS/Scer\GAL4^e22c

(Dierick and Bejsovec, 1998)

wg^l-17 is partially rescued by wg^{PE2.UAS.Tag:HA}/Scer\GAL4^wg.PM

(Hays et al., 1997)

wg^l-17 is partially rescued by Scer\GAL4^e22c/wg^{PE2.UAS.Tag:HA}

(Hays et al., 1997)

wg^l-17 is partially rescued by wg^PE4.UAS/Scer\GAL4^wg.PM

(Hays et al., 1997)

wg^l-17 is partially rescued by wg^PE2.hs

(Hays et al., 1997)

wg^l-17 is partially rescued by wg^{PE2.hs.Tag:HA}

(Hays et al., 1997)

wg^l-17 is partially rescued by wg^PE2.UAS/Scer\GAL4^wg.PM

(Hays et al., 1997)

wg^l-17 is partially rescued by wg^PE2.UAS/Scer\GAL4^e22c

(Hays et al., 1997)

wg^l-17 is partially rescued by wg^{PE4.UAS.Tag:HA}/Scer\GAL4^wg.PM

(Hays et al., 1997)

Not rescued by

wg^Gal4/wg^l-17 is not rescued by wg^{CTD.UAS.Tag:MYC}/Scer\GAL4^wg-Gal4

(Won et al., 2019)

wg^l-17 is not rescued by wg^{Ppa.3'UTR.UAS}/Scer\GAL4^wg.PM

(Simmonds et al., 2001)

wg^l-17 is not rescued by wg^PE6.UAS/Scer\GAL4^e22c

(Dierick and Bejsovec, 1998)

wg^l-17 is not rescued by Scer\GAL4^e22c/wg^NE1.UAS

(Dierick and Bejsovec, 1998)

Comments

Expression of wg^Scer\UAS.cHa under the control of Scer\GAL4^prd.RG1 in wg^l-17 embryos fully rescues naked cuticle in odd-numbered segments and substantially rescues denticle diversity in the epidermal cells adjacent to the Scer\GAL4^prd.RG1 expression domain.

(Bejsovec and Chao, 2012)

Expression of wg^{S239A.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^hh-Gal4 in posterior wing compartments composed of homozygous wg^l-17 mutant cells substantially restores wing size and the rate of cell proliferation. Rescued wings appear well proportioned, but they lack a proper margin in the posterior compartment.

(Baena-Lopez et al., 2009)

Expression of wg^Scer\UAS.cGa under the control of Scer\GAL4^pros.PMG partially rescues the loss of naked cuticle in wg^l-17 larvae, but reduces denticle diversity. This expression restores RP2 neurons to wg^l-17 embryos.

(Cox et al., 2005)

wg^Scer\UAS.cGa; Scer\GAL4^da.G32 rescues the loss of naked ventral cuticle in wg^l-17 homozygous embryos. About half of the resulting embryos have the wg^Scer\UAS.cGa; Scer\GAL4^da.G32 overexpression phenotype of a completely naked ventral cuticle. wg^Scer\UAS.cGa; Scer\GAL4^da.G32 rescues the dorsal-ventral elongation and orientation of microtubule bundles in the leading edge cells of stage 13 wg^l-17 homozygous embryos. wg^Scer\UAS.cGa; Scer\GAL4^332.3 rescues the dorsal-ventral polarity of leading edge cells in these embryos, including orientation of the microtubule bundles. But dorsal-ventral elongation of these cells is not rescued. tkv^{Q253D.Scer\UAS.cNb}; Scer\GAL4^da.G32 only weakly rescues polarisation of leading edge cells in stage 13 wg^l-17 homozygous embryos, and fails to rescue elongation of these cells.

(Morel and Arias, 2004)

wg^Scer\UAS.cGa; Scer\GAL4^da.G32 s the polarity and organization of leading edge cells during dorsal closure in wg^l-17 mutant embryos.

(Kaltschmidt et al., 2002)

When wg^{Scer\UAS.T:λ\cI-hinge,T:Arus\HRP} is driven by Scer\GAL4^wg.PM in wg^l-17 mutants, the phenotypes are extensively rescued, the cuticular pattern, including the polarity and shape of individual denticles is completely restored in many segments. In some segments rescue is incomplete, as some denticle belts remain fused.

(Dubois et al., 2001)

wg^PE2.Scer\UAS rescues denticle diversity in wg^l-17 larvae when driven by Scer\GAL4^e22c.

(Moline et al., 2000)

Expression of wg^Scer\UAS.cLa driven by Scer\GAL4^en-e16E in a wg^l-17 background rescues many rows of the denticle belts, except row 1.

(Sanson et al., 1999)

wg^PE6.Scer\UAS fails to rescue the dorsal cuticle pattern of wg^l-17 embryos when expressed under the control of Scer\GAL4^e22c at 25^oC. wg^PE6.Scer\UAS substantially rescues dorsal pattern elements in wg^l-17 embryos when expressed under the control of Scer\GAL4^e22c at 18^oC. wg^NE1.Scer\UAS fails to rescue the dorsal cuticle pattern of wg^l-17 embryos when expressed under the control of Scer\GAL4^e22c at 18^oC.

(Dierick and Bejsovec, 1998)

wg^l-17 embryos expressing wg^Scer\UAS.cHa or wg^{Scer\UAS.cHa.T:Ivir\HA1} under the control of Scer\GAL4^wg.PM show full rescue of the ventral cuticle pattern, although the embryos are slightly distorted as the dorsal pattern elements are not rescued. Expression of wg^PE2.Scer\UAS or wg^{PE2.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^wg.PM in wg^l-17 embryos rescues denticle diversity, but there is no specification of naked cuticle. Expression of wg^PE4.Scer\UAS or wg^{PE4.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^wg.PM in wg^l-17 embryos rescues naked cuticle, but these embryos show little denticle diversity.

(Hays et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

6908

wg^l-17 Wnt2^L/CyO

2980

wg^l-17 Adc^b-1 pr¹/CyO, P{sevRas1.V12}FK1

Kyoto

107505

wg^l-17 Adc^b-1 pr¹/CyO

Notes on Origin

Discoverer

Baker.

Comments

The expression of l(1)sc is unaltered in early homozygous mutant embryos.

(Martin-Bermudo et al., 1991)

Derepression of en in Pc group mutants is not acting through wg.

(Moazed and O'Farrell, 1992)

gsb-n protein expression has been studied in wg^l-17 embryos.

(Ouellette et al., 1992)

The wg phenotype is suppressed by mutations in nkd and enhanced by mutations in hh.

(Bejsovec and Wieschaus, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CX4

(Payre et al., 1999)

Wg^CX4

(Jafar-Nejad et al., 2006)

wg (CX4)

(Bourouis, 2002)

wg CX4

(Franch-Marro et al., 2006)

wg^1-17

(Kopke et al., 2017, Zhang et al., 2015, Karim and Moore, 2011, Lee et al., 2009, Bossing and Brand, 2006, Brumby et al., 2004)

wg^CV4

(Andrew et al., 1997)

wg^CX41

(Edgar et al., 1994)

wg^CX4

(Molina-Gil et al., 2023, Gracia-Latorre et al., 2022, Sharrock et al., 2022, Marcetteau et al., 2021, Bridi et al., 2020, Kim and Cho, 2020, Lybrand et al., 2019, Won et al., 2019, Huang et al., 2018, Ogura et al., 2018, Ripp et al., 2018, Recasens-Alvarez et al., 2017, Rizzo and Bejsovec, 2017, Yamazaki et al., 2016, Yang et al., 2016, Alexandre et al., 2014, Herrero et al., 2014, Linnemannstöns et al., 2014, Wang and Page-McCaw, 2014, Paul et al., 2013, Bejsovec and Chao, 2012, Kuroda et al., 2012, Sagner et al., 2012, Yang et al., 2012, Cordero and Cagan, 2010, Jones et al., 2010, Monier et al., 2010, Sotillos et al., 2010, Baena-Lopez et al., 2009, Chang et al., 2008, Chao et al., 2007, Tanaka et al., 2007, Zecca and Struhl, 2007, Estrada et al., 2006, Mirkovic and Mlodzik, 2006, Singh et al., 2006, Chen et al., 2005, Cox and Baylies, 2005, Cox et al., 2005, Franch-Marro et al., 2005, Jones and Bejsovec, 2005, Lim et al., 2005, Merabet et al., 2005, Perez-Garijo et al., 2005, Buescher et al., 2004, Bullock et al., 2004, Cordero et al., 2004, De Velasco et al., 2004, Mandal et al., 2004, Morel and Arias, 2004, Wang and Struhl, 2004, Alexandre and Vincent, 2003, Desbordes and Sanson, 2003, Grienenberger et al., 2003, Hosono et al., 2003, Landgraf et al., 2003, Larsen et al., 2003, Reim et al., 2003, Tolwinski et al., 2003, Angelats et al., 2002, Bauer et al., 2002, Cadigan et al., 2002, Cavodeassi et al., 2002, Glise et al., 2002, Kaltschmidt et al., 2002, Parker et al., 2002, Pfeiffer et al., 2002, Streit et al., 2002, Sudarsan et al., 2002, Tang and Sun, 2002, Buratovich and Wilder, 2001, Deshpande et al., 2001, Dubois et al., 2001, Fuss et al., 2001, Gieseler et al., 2001, Keisman and Baker, 2001, Knirr and Frasch, 2001, Llimargas and Lawrence, 2001, Marty et al., 2001, Methot and Basler, 2001, San Martin and Bate, 2001, Simmonds et al., 2001, Thumm and Kadowaki, 2001, Bhat et al., 2000, Fanto, 2000, Fanto et al., 2000, Halfon et al., 2000, Llimargas, 2000, Moline et al., 2000, Pfeiffer et al., 2000, Rusch and Kaufman, 2000, Wan et al., 2000, Wang et al., 2000, Zeng et al., 2000, Adachi-Yamada et al., 1999, Bhanot et al., 1999, Brennan et al., 1999, Chen and Struhl, 1999, de Celis et al., 1999, Gallet et al., 1999, Garcia-Garcia et al., 1999, Gieseler et al., 1999, Gorfinkiel et al., 1999, Greaves et al., 1999, Hays et al., 1999, Helms et al., 1999, Lin et al., 1999, McCartney et al., 1999, Micchelli and Blair, 1999, Moline et al., 1999, Rollins et al., 1999, Sanson et al., 1999, Sato et al., 1999, Tsuda et al., 1999, Bachmann and Knust, 1998, Bhat, 1998, Bilder and Scott, 1998, Cadigan et al., 1998, Carmena et al., 1998, Cavallo et al., 1998, Dierick and Bejsovec, 1998, Fuss and Hoch, 1998, Gajewski et al., 1998, Gallet et al., 1998, Gallitano-Mendel and Finkelstein, 1998, Klein and Martinez Arias, 1998, Martinez Arias, 1998, Nakagoshi et al., 1998, Neumann and Cohen, 1998, Richter et al., 1998, Wehrli and Tomlinson, 1998, White et al., 1998, Zhang and Carthew, 1998, Bhat and Schedl, 1997, Buratovich et al., 1997, Chen and Baker, 1997, Dominguez and Hafen, 1997, Duman-Scheel et al., 1997, Emerald and Roy, 1997, Gallitano-Mendel and Finkelstein, 1997, Hays et al., 1997, Jagla et al., 1997, McDonald and Doe, 1997, Micchelli et al., 1997, Neumann and Cohen, 1997, Shishido et al., 1997, Struhl et al., 1997, Strutt et al., 1997, Treisman et al., 1997, Zhou et al., 1997, Bhat, 1996, Buttgereit, 1996, Cadigan and Nusse, 1996, Held and Heup, 1996, Jiang and Struhl, 1996, Lawrence et al., 1996, Ma et al., 1996, Mann and Abu-Shaar, 1996, Morcillo et al., 1996, Neumann and Cohen, 1996, Neumann and Cohen, 1996, Park et al., 1996, Ranganayakulu et al., 1996, Uemura et al., 1996, van den Heuvel and Ingham, 1996, Wilk et al., 1996, Zecca et al., 1996, Baylies et al., 1995, Bejsovec and Wieschaus, 1995, Cimbora and Sakonju, 1995, Jiang and Struhl, 1995, Lawrence et al., 1995, Li et al., 1995, Pan and Rubin, 1995, Hartenstein et al., 1994, Heemskerk and DiNardo, 1994, Jackson and Hoffmann, 1994, Kaphingst and Kunes, 1994, Klingensmith et al., 1994, Lawrence et al., 1994, Noordermeer et al., 1994, Theisen et al., 1994, Vincent and Lawrence, 1994, Bejsovec and Wieschaus, 1993, Phillips and Whittle, 1993, Sampedro et al., 1993, van den Heuvel et al., 1993, van den Heuvel et al., 1993, Gonzalez-Reyes et al., 1992, Moazed and O'Farrell, 1992, Ouellette et al., 1992, Gonzalez et al., 1991, Heemskerk et al., 1991, Martin-Bermudo et al., 1991, Parkhurst and Ish-Horowicz, 1991, Kassis, 1990, Simcox et al., 1989, Tremml and Bienz, 1989, Baker, 1987)

wg^CXC4

(Macias et al., 1994)

wg^I-17

(Kim et al., 2021, Lee and Fischer, 2012)

wg^cx4

(Becker et al., 2016, Chatterjee et al., 2015, Svendsen et al., 2015, Chang and Sun, 2014, Gettings et al., 2010, Metcalfe et al., 2010, Gaziova and Bhat, 2009, Port et al., 2008, Overton et al., 2007, Tsai et al., 2007, Bartscherer et al., 2006, Yasunaga et al., 2006, Miskolczi-McCallum et al., 2005, Atallah et al., 2004, Tian et al., 2004, Giraldez and Cohen, 2003, Schweizer et al., 2003, Whitworth and Russell, 2003, Ponzielli et al., 2002, Thompson et al., 2002, Duan et al., 2001, Freeman and Bienz, 2001, Fujise et al., 2001, Hatini and DiNardo, 2001, Buratovich et al., 2000, Lee and Frasch, 2000, Rulifson et al., 2000, Alexandre et al., 1999, Gritzan et al., 1999, Oppenheimer et al., 1999, Boutros et al., 1998, Johnston and Edgar, 1998, Nguyen and Xu, 1998, Steitz et al., 1998, Yu et al., 1998, Aspland and White, 1997, Riese et al., 1997, Riese et al., 1997, Szuts et al., 1997, Azpiazu et al., 1996, D'Alessio and Frasch, 1996, Gomez-Skarmeta and Modolell, 1996, Neumann and Cohen, 1996, Rulifson et al., 1996, Yu et al., 1996, Diaz-Benjumea and Cohen, 1995, Sturtevant and Bier, 1995, Thuringer et al., 1993, Hidalgo, 1991, Hidalgo and Ingham, 1990, Immergluck et al., 1990, DiNardo et al., 1988)

wg^l-17

(Bosch et al., 2020, Bosch and Perrimon, 2019.9.30, Golovin et al., 2019, Knox et al., 2011, Deb et al., 2008, Hueber et al., 2007)

wgCX4

(Grigorian et al., 2011, Lecourtois et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (287)

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