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General Information
Symbol
Dmel\whd1
Species
D. melanogaster
Name
FlyBase ID
FBal0018515
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

16bp deletion in exon 2 (coordinates +55 through +70), which produces a frameshift that results in a stop codon in exon 3.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

16bp deletion in exon 2 (coordinates +55 through +70), which produces a frameshift that results in a stop codon in exon 3.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

whd1 homozygotes show increased mortality when exposed to 7% ethanol during development compared to controls.

Mutant flies show significantly increased survival compared to wild-type flies after infection with E. chaffeensis. Bacterial replication is significantly reduced in the mutant flies compared to wild type.

Homozygotes are highly sensitive to both ionizing radiation and dietary paraquat compared to controls.

Homozygotes have a weak mutant wing phenotype.

Mutants show no significant difference in longevity compared to control flies.

Wings warped and waved or reduced to shrunken black pupal pads. Synthetic lethal in presence of su(r). RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

whd1 ry506 double homozygotes have a much more severe wing phenotype than either single homozygote.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Bridges, 6th Jan. 1938.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)