FlyBase Allele Report: Dmel\IP3K2[wy-74i]

General Information

Symbol

Dmel\IP3K2^wy-74i

Species

D. melanogaster

Name

FlyBase ID

FBal0018548

Feature type

allele

Associated gene

Dmel\IP3K2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Dean et al., 2015)

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992, Craymer, 1980)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Dean et al., 2015)

visible (with Df(1)Exel6245)

(Dean et al., 2015)

visible (with IP3K2^wy-1)

(Dean et al., 2015)

visible (with IP3K2^wy-2)

(Dean et al., 2015)

Phenotype Manifest In

wing

(Dean et al., 2015)

wing (with Df(1)Exel6245)

(Dean et al., 2015)

wing (with IP3K2^wy-1)

(Dean et al., 2015)

wing (with IP3K2^wy-2)

(Dean et al., 2015)

Detailed Description

Statement

Reference

Particular wing phenotypes are seen in flies (percentages rounded) of the listed genotypes, (1) being the least severe - (1) a wave-like buckle along the costal vein (distal to its intersection with the subcostal region), (2) an upturn at the most distal margin of the wing, (3) overall shriveled morphology (distinguishable from mechanical damage or failure to inflate after eclosion); overall, IP3K2^wy-74i has the most severe phenotype, followed by IP3K2^wy-2 and IP3K2^wy-1 :

(1) IP3K2^wy-74i/IP3K2^wy-74i 0%, IP3K2^wy-1/IP3K2^wy-74i 13%, IP3K2^wy-2/IP3K2^wy-74i 0%, IP3K2^wy-74i/Df(1)Exel6245 0%;

(2) IP3K2^wy-74i/IP3K2^wy-74i 38%, IP3K2^wy-1/IP3K2^wy-74i 84%, IP3K2^wy-2/IP3K2^wy-74i 36%, IP3K2^wy-74i/Df(1)Exel6245 100%;

(3) IP3K2^wy-74i/IP3K2^wy-74i 62%, IP3K2^wy-1/IP3K2^wy-74i 3%, IP3K2^wy-2/IP3K2^wy-74i 64%, IP3K2^wy-74i/Df(1)Exel6245 0%.

(Dean et al., 2015)

Extreme wy allele.

(Lindsley and Zimm, 1992)

RK1.

(Craymer, 1980)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

IP3K2^wy-74i has visible phenotype, suppressible by Itpr^ug3/Itp-r83A[+]

(Dean et al., 2015)

IP3K2^wy-74i has visible phenotype, suppressible by Itpr^90B.0/Itp-r83A[+]

(Dean et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

IP3K2^wy-74i has wing phenotype, suppressible by Itpr^ug3/Itp-r83A[+]

(Dean et al., 2015)

IP3K2^wy-74i has wing phenotype, suppressible by Itpr^90B.0/Itp-r83A[+]

(Dean et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Itp-r83A^ug3/+ or Itp-r83A^90B.0/+ partially suppresses the wing phenotypes seen in sibling IP3K2^wy-74i/IP3K2^wy-74i control flies.

(Dean et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

IP3K2^wy-74i is partially rescued by IP3K2^UAS.cDa

(Dean et al., 2015)

Comments

IP3K2^Scer\UAS.cDa (without a GAL4) partially rescues wing phenotypes in IP3K2^wy-74i/IP3K2^wy-74i flies (all flies have a wave-like buckle along the costal vein).

(Dean et al., 2015)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type