Allele Dmel\y1
| General Information | |||
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| Symbol | Dmel\y1 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0018607 | |
| Feature type | allele | Associated gene | Dmel\y |
| Allele class | loss of function allele, amorphic allele - genetic evidence | ||
| Mutagen | spontaneous | ||
Recent Updates
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| Description |
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| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
Nature of the Allele
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| Allele class | |||
| Mutagen | |||
| Mutations Mapped to the Genome | |||
Type Location Additional Notes References | |||
| Associated Sequence Data | |||
| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Progenitor genotype | |||
| Nature of the lesion | Statement Reference Deletion of the y promoter, not enhancer. A to C tranversion in the ATG translation initiation codon. | ||
| Carried on aberration | |||
| Cytology | Polytene chromosomes normal. | ||
Phenotypic Data
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Phenotypic Class
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body color defective (with y1#8) | |||
Phenotype Manifest In
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adult cuticle (with y1#8) adult cuticle (with yeve-tata-1) adult cuticle (with yeve-tata) adult cuticle (with yw-DPE26-1) adult cuticle (with yw-DPE26) adult cuticle (with yw-DPE29-1) adult cuticle (with yw-DPE29) wing (with yeve-tata-1) wing (with yhsp70-tata-1) wing (with yP1\loxP.eve-700gin) wing (with yP1\loxP.w-700gin) wing (with yw-DPE26-1) wing (with yw-DPE29-1) | |||
Detailed Description
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Statement Reference y1 males have significantly reduced mating success compared to control males. The Dp(1;f)1187 minichromosome rescues the mating success of these mutants. y1 adults lack pigmentation throughout the body, the wings, bristles, aristae and tarsal claws. The sex combs of y1 males have a lighter colour than wild type. Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): homozygote: 1 (wing), 1 (body), hemizygote: 1 (wing), 1 (body), y1/yeve-tata: 2 (wing), 2-3 (body), y1/yhsp70-tata: 4-5 (wing), 4+-5 (body), y1/yw-DPE26: 4 (wing), 4 (body), y1/yw-DPE29: 2 (wing), 1+-2 (body), y1/yeve-tata-1: 1 (wing), 1 (body), y1/yhsp70-tata-1: 1 (wing), 1 (body), y1/yw-DPE26-1: 1 (wing), 1 (body), y1/yw-DPE29-1: 1 (wing), 1 (body), y1/yP1\loxP.eve-700gin: 2+-3 (wing), 2+ (body), y1/yP1\loxP.hsp70-700gin: 5 (wing), 4+-5 (body), y1/yP1\loxP.w-700gin: 2+-3 (wing), 2+ (body). Males have a reduced wing extension index (the percentage of each courtship ritual during which a male's wing is extended and vibrating) compared to wild type. A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. I y1 mutants the black melanin is lost from the stripes leaving a brown pigment. The cuticle anterior to the stripe has a tan appearance relative to wild-type. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan. Body colour: no pigmentation. Body colour: yellow; hairs & bristles brown with yellow tips; wing veins, wing hairs, yellow. Larval mouth part colour: yellow-brown. Larval denticle belt colour: yellow-brown. | |||
External Data
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| Linkouts | |||
Interactions
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Phenotypic Class
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Enhanced by | |||
Statement Reference | |||
NOT Enhanced by | |||
Statement Reference y1, yP1\loxP.gyp-gyp has body color defective phenotype, non-enhanceable by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG y1, yP1\loxP.su(Hw)BR-y-AS-C.-900 has body color defective phenotype, non-enhanceable by Df(3R)su(Hw)V/su(Hw)7 yP1\loxP.gyp-gyp/y1 has body color defective phenotype, non-enhanceable by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG | |||
Suppressed by | |||
Statement Reference y1, yP1\loxP.2scs'-2scs' has body color defective phenotype, suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG y1, yP1\loxP.scs-2scs' has body color defective phenotype, suppressible | partially by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG y1/yP1\loxP.2scs'-2scs' has body color defective phenotype, suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG yP1\loxP.scs-2scs'/y1 has body color defective phenotype, suppressible | partially by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG | |||
NOT suppressed by | |||
Statement Reference y1, yP1\loxP.gyp-gyp has body color defective phenotype, non-suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG y1, yP1\loxP.su(Hw)BR-y-AS-C.-900 has body color defective phenotype, non-suppressible by Df(3R)su(Hw)V/su(Hw)7 yP1\loxP.gyp-gyp/y1 has body color defective phenotype, non-suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG | |||
Enhancer of | |||
Statement Reference | |||
Suppressor of | |||
Statement Reference y1 is a suppressor | partially of body color defective phenotype of Pk92BΔN.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4pnr-MD237 | |||
Other | |||
Statement Reference | |||
Phenotype Manifest In
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Enhanced by | |||
Statement Reference | |||
NOT Enhanced by | |||
Statement Reference y1, yP1\loxP.gyp-gyp has adult cuticle phenotype, non-enhanceable by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG yP1\loxP.gyp-gyp/y1 has adult cuticle phenotype, non-enhanceable by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG | |||
Suppressed by | |||
Statement Reference y1, yP1\loxP.2scs'-2scs' has adult cuticle phenotype, suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG y1, yP1\loxP.scs-2scs' has adult cuticle phenotype, suppressible | partially by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG y1/yP1\loxP.2scs'-2scs' has adult cuticle phenotype, suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG yP1\loxP.scs-2scs'/y1 has adult cuticle phenotype, suppressible | partially by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG | |||
NOT suppressed by | |||
Statement Reference y1, yP1\loxP.gyp-gyp has adult cuticle phenotype, non-suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG yP1\loxP.gyp-gyp/y1 has adult cuticle phenotype, non-suppressible by BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2/Scer\GAL4y.PG | |||
Suppressor of | |||
Statement Reference y1 is a suppressor | partially of adult thorax phenotype of Pk92BΔN.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4pnr-MD237 | |||
Other | |||
Statement Reference | |||
Additional Comments
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Genetic Interactions
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Statement Reference The glycerol hypersensitivity of flies expressing Gyk[dsRNA.Scer\UAS] under the control of Scer\GAL4[c564] (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for y[1]. In a y[1] hemizygous background, pigmentation in the thorax of Pk92B[ΔN.Scer\UAS.T:Zzzz\FLAG], Scer\GAL4[pnr-MD237] flies is brown rather than black, particularly in the scutellum. A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. y1, e1 double mutants have brown pigment throughout the abdomen and the stripe is no longer distinct. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan. In e1 mutants the thorax and wings become more darkly pigmented, and new pigmentation patterns are seen. y1, e1 double mutants also show these patterns, but the black pigment is absent, and they consist of two shades of brown pigment. | |||
Xenogenetic Interactions
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Statement Reference | |||
Complementation & Rescue Data
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| Fails to complement | |||
| Rescued by | |||
| Partially rescued by | y1 is partially rescued by yΔ1A-2.w-hs.Scer\SceI.RS y1 is partially rescued by yΔ1A-2.Δ1A-2'.w-hs.Scer\SceI.RS | ||
| Comments | Flies carrying y[Δ1A-2.w-hs.Scer\SceI.RS] or y[Δ1A-2.Δ1A-2'.w-hs.Scer\SceI.RS] in a y[1] background have dark pigmentation of all cuticle structures except the wing. | ||
Stocks
( 29351 ) | |||
| Bloomington | 169 1628 1495 1496 1509 | ||
| Kyoto | 105766 108948 101249 101254 101257 106349 106355 | ||
Notes on Origin
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| Discoverer | E.M. Wallace, Jan. 1911. | ||
Comments
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Marker mutation present in the strain used in the genome sequencing project. y2 promoter causes trans-activation of enhancer. | |||
External Crossreferences & Linkouts
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| Other Crossreferences | |||
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Synonyms & Secondary IDs
( 2 ) | |||
| Reported As | |||
| Symbol Synonym | y1 (Lee and Wu, 2006, Gilbert et al., 2006, Kuhn et al., 2004, Riedel et al., 2011, Konev et al., 2003, Kyrchanova and Georgiev, 2010, Wightman et al., 2012, Soshnev et al., 2008, Meyer et al., 2008, Ou et al., 2009, Song et al., 2007, Sekine et al., 2011, Takeuchi et al., 2007, Maksimenko and Georgiev, 2007) | ||
| Name Synonym | |||
| Secondary FlyBase IDs | |||
References
( 60 ) | |||
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Recent research papers ( 3 ) | |||
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Recent reviews (0)
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| All reviews listed in FlyBase were published before 2011 | |||
Recent Updates
External Crossreferences & Linkouts