A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\y1

General Information
SymbolDmel\y1SpeciesD. melanogaster
NameFlyBase IDFBal0018607
Feature typealleleAssociated geneDmel\y
Allele classloss of function allele, amorphic allele - genetic evidence
Mutagenspontaneous
hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Deletion of the y promoter, not enhancer.
A to C tranversion in the ATG translation initiation codon.
Carried on aberration
 
 
 
Cytology
Polytene chromosomes normal.
hide Phenotypic Data
hide Phenotypic Class
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
y[1]/y[1#8] females have a completely null y[-] pigmentation phenotype in the wings and in the body. The presence of Dp(1;2)y[2]A increases pigmentation in both the body and wing cuticle in y[1]/y[1#8] females.
y1 males have significantly reduced mating success compared to control males. The Dp(1;f)1187 minichromosome rescues the mating success of these mutants. y1 adults lack pigmentation throughout the body, the wings, bristles, aristae and tarsal claws. The sex combs of y1 males have a lighter colour than wild type.
Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): homozygote: 1 (wing), 1 (body), hemizygote: 1 (wing), 1 (body), y1/yeve-tata: 2 (wing), 2-3 (body), y1/yhsp70-tata: 4-5 (wing), 4+-5 (body), y1/yw-DPE26: 4 (wing), 4 (body), y1/yw-DPE29: 2 (wing), 1+-2 (body), y1/yeve-tata-1: 1 (wing), 1 (body), y1/yhsp70-tata-1: 1 (wing), 1 (body), y1/yw-DPE26-1: 1 (wing), 1 (body), y1/yw-DPE29-1: 1 (wing), 1 (body), y1/yP1\loxP.eve-700gin: 2+-3 (wing), 2+ (body), y1/yP1\loxP.hsp70-700gin: 5 (wing), 4+-5 (body), y1/yP1\loxP.w-700gin: 2+-3 (wing), 2+ (body).
Males have a reduced wing extension index (the percentage of each courtship ritual during which a male's wing is extended and vibrating) compared to wild type.
A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. I y1 mutants the black melanin is lost from the stripes leaving a brown pigment. The cuticle anterior to the stripe has a tan appearance relative to wild-type. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan.
Homozygous y+s7 or y2s14 females have a stronger mutant phenotype than y+s7/y1 or y2s14/y1 females in the presence of ph-pP1.
The pigmentation induced in unpigmented y1 pharate adult tissue by incubation with dopamine in vitro closely resembles the y1 phenotype, producing brown pigmentation in all cuticle structures.
Body colour: no pigmentation.
Body colour: yellow; hairs & bristles brown with yellow tips; wing veins, wing hairs, yellow. Larval mouth part colour: yellow-brown. Larval denticle belt colour: yellow-brown.
 
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideEnhanced by
Statement
Reference
hideNOT Enhanced by
Statement
Reference
hideSuppressed by
Statement
Reference
hideNOT suppressed by
Statement
Reference
hideEnhancer of
Statement
Reference
hideSuppressor of
Statement
Reference
hideOther
Statement
Reference
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
y1, yEn.GλSλG has cuticle phenotype, enhanceable by su(Hw)unspecified
y1, yEn.GλSλG has wing phenotype, enhanceable by su(Hw)unspecified
hideNOT Enhanced by
Statement
Reference
y1, y2En.2G has cuticle phenotype, non-enhanceable by su(Hw)unspecified
y1, y2En.2G has wing phenotype, non-enhanceable by su(Hw)unspecified
y1, y2En.3G has cuticle phenotype, non-enhanceable by su(Hw)unspecified
y1, y2En.3G has wing phenotype, non-enhanceable by su(Hw)unspecified
y1, yEn.GλGλS has cuticle phenotype, non-enhanceable by su(Hw)unspecified
y1, yEn.GλGλS has wing phenotype, non-enhanceable by su(Hw)unspecified
y1, yEn.SλGλG has cuticle phenotype, non-enhanceable by su(Hw)unspecified
y1, yEn.SλGλG has wing phenotype, non-enhanceable by su(Hw)unspecified
hideSuppressed by
Statement
Reference
y1, y2En.G has cuticle phenotype, suppressible by su(Hw)unspecified
hideNOT suppressed by
Statement
Reference
y1, y2En.2G has cuticle phenotype, non-suppressible by su(Hw)unspecified
y1, y2En.2G has wing phenotype, non-suppressible by su(Hw)unspecified
y1, y2En.3G has cuticle phenotype, non-suppressible by su(Hw)unspecified
y1, y2En.3G has wing phenotype, non-suppressible by su(Hw)unspecified
y1, yEn.GλGλS has cuticle phenotype, non-suppressible by su(Hw)unspecified
y1, yEn.GλGλS has wing phenotype, non-suppressible by su(Hw)unspecified
y1, yEn.SλGλG has cuticle phenotype, non-suppressible by su(Hw)unspecified
y1, yEn.SλGλG has wing phenotype, non-suppressible by su(Hw)unspecified
y1 has phenotype, non-suppressible by su(Hw)2
hideSuppressor of
Statement
Reference
y1 is a suppressor of phenotype of svrpoi-Ca
 
hideOther
Statement
Reference
hide Additional Comments
hide Genetic Interactions
Statement
Reference
The glycerol hypersensitivity of flies expressing Gyk[dsRNA.Scer\UAS] under the control of Scer\GAL4[c564] (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for y[1].
In a y[1] hemizygous background, pigmentation in the thorax of Pk92B[ΔN.Scer\UAS.T:Zzzz\FLAG], Scer\GAL4[pnr-MD237] flies is brown rather than black, particularly in the scutellum.
A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. y1, e1 double mutants have brown pigment throughout the abdomen and the stripe is no longer distinct. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan. In e1 mutants the thorax and wings become more darkly pigmented, and new pigmentation patterns are seen. y1, e1 double mutants also show these patterns, but the black pigment is absent, and they consist of two shades of brown pigment.
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Fails to complement
Rescued by
Partially rescued by
Comments
Flies carrying y[Δ1A-2.w-hs.Scer\SceI.RS] or y[Δ1A-2.Δ1A-2'.w-hs.Scer\SceI.RS] in a y[1] background have dark pigmentation of all cuticle structures except the wing.
hide Stocks ( 29351 )
Bloomington
169
1495
1496
1509
Kyoto
105766
101249
101254
101257
106349
106355
hide Notes on Origin
Discoverer
E.M. Wallace, Jan. 1911.
hide Comments
Marker mutation present in the strain used in the genome sequencing project.
y2 promoter causes trans-activation of enhancer.
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym
Name Synonym
Secondary FlyBase IDs
hide References ( 60 )
Generate a list of
List References by type
hide Recent research papers ( 3 )
Wightman et al., 2012, PLoS ONE 7(3): e31779
Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes. [FBrf0217823]
Riedel et al., 2011, Development 138(1): 149--158
Megalin-dependent Yellow endocytosis restricts melanization in the Drosophila cuticle. [FBrf0212536]
Sekine et al., 2011, J. Cell Sci. 124(17): 3006--3016
p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. [FBrf0215011]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2011