A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\y2

General Information
SymbolDmel\y2SpeciesD. melanogaster
NameFlyBase IDFBal0018612
Feature typealleleAssociated geneDmel\y
Map ( GBrowse ) Untitled Document detailed view FBti0071916 FBti0002420 FBti0036729 FBti0055779 FBti0151835 FBti0104357 FBti0071875 FBti0132374 FBti0071615
Allele class
Mutagenspontaneous
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Insertion of gypsy -700bp from the start site.
Insertion of a gypsy element between an upstream body cuticle enhancer and a downstream bristle enhancer.
Insertion of a gypsy element at -700bp relative to the transcription start site.
gypsy insertion into the 5' region of the y gene at position -700bp from the transcription start site.
Insertion of gypsy causes inactivation of certain y enhancers.
Insertion of gypsy transposable element.
Insertion of gypsy element 700bp upstream from start of transcription.
gypsy insertion 700bp upstream from the transcription initiation site of y.
gypsy insertion.
Insertion of a gypsy element.
Insertion of gypsy element at -700bp from the transcription start site. This separates transcriptional enhancers that control y expression in the wing and body cuticle from the promoter.
Insertion of gypsy element.
Insertion of a gypsy element at -700bp.
gypsy insertion 700bp upstream of the transcriptional start site.
gypsy insertion between coordinates +72.4 and +73.7.
Caused by insertion
Carried on aberration
Cytology
hide Phenotypic Data
hide Phenotypic Class
hide Phenotype Manifest In
adult cuticle & wing
leg & macrochaeta
hide Detailed Description
Statement
Reference
Homozygous females have an almost completely null y[-] pigmentation phenotype in the wings and in the body. y[2]/y[1#8] females show nearly wild-type pigmentation levels in the wing and body. Dp(1;2)y[2]A reduces the level of complementation that is normally observed between y[1#8] and y[2] (the progenitor of Dp(1;2)y[2]A), such that the body and wing cuticle of y[1#8]/Dp(1;2)y[2]A females has a more severe pigmentation phenotype than that of y[1#8]/y[2] females. Dp(1;4)y[2]B reduces the level of complementation that is normally observed between y[1#8] and y[2] (the progenitor of Dp(1;4)y[2]B), such that the body and wing cuticle of y[1#8]/Dp(1;4)y[2]B females has a more severe pigmentation phenotype than that of y[1#8]/y[2] females. Dp(1;4)y[2]C reduces the level of complementation that is normally observed between y[1#8] and y[2] (the progenitor of Dp(1;4)y[2]C), such that the body and wing cuticle of y[1#8]/Dp(1;4)y[2]C females has a more severe pigmentation phenotype than that of y[1#8]/y[2] females.
y[2] flies have a pale abdomen with dark bristles.
y2 mutants exhibit discoloration of the cuticle, especially apparent in the abdomen.
The male mating success of y2 males is statistically equivalent to controls. y2 flies have greatly reduced pigmentation throughout their entire body and wings.
Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): homozygote: 1 (wing), 1-2 (body), hemizygote: 1 (wing), 1 (body), y2/yeve-tata: 4 (wing), 4-4+ (body), y2/yhsp70-tata: 5 (wing), 5 (body), y2/yw-DPE26: 4-5 (wing), 4+-5 (body), y2/yw-DPE29: 4 (wing), 4 (body), y2/yeve-tata-1: 4 (wing), 3+-4 (body), y2/yhsp70-tata-1: 1 (wing), 1+-2 (body), y2/yw-DPE26-1: 1 (wing), 1+-2 (body), y2/yw-DPE29-1: 3+-4 (wing), 3+-4 (body).
Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): hemizygote: 1 (wing), 1 (body), homozygote: 1 (wing), 1-2 (body), y2/ytata: 4 (wing), 3 (body), y2/yinr: 5 (wing), 5 (body), y2/ytata-inr: 4 (wing), 3-4 (body), y2/ytata-1: 3 (wing), 2-3 (body), y2/yinr-1: 3 (wing), 2-3 (body), y2/ytata-inr-1: 4 (wing), 3-4 (body), y2/ytT: 5 (wing), 5 (body), y2/yTT: 5 (wing), 5 (body), y2/ytT-1: 1 (wing), 1-2 (body), y2/yTT-1: 1 (wing), 1-2 (body), y2/yps1: 5 (wing), 5 (body), y2/yps2: 5 (wing), 5 (body), y2/yps3: 5 (wing), 5 (body), y2/yps4: 5 (wing), 5 (body), y2/yps1-1: 1 (wing), 1-2 (body), y2/yps2-1: 1 (wing), 1-2 (body), y2/yps3-1: 1 (wing), 1-2 (body), y2/yps4-1: 1 (wing), 1-2 (body), y2/yeve: 5 (wing), 5 (body), y2/yhsp70: 5 (wing), 5 (body), y2/yw: 4 (wing), 4 (body), y2/yeve-1: 1 (wing), 1-2 (body), y2/yhsp70-1: 1 (wing), 1-2 (body), y2/yw-1: 1 (wing), 1-2 (body).
Body colour: flies carrying y2 (in a y- background) have a pigmentation score of 1 (where 1 = absence of y expression and 5 = wild type) in both the body and wing. Body colour: y2/y1#8 flies have a pigmentation score of 4 in both the body and wing. Body colour: y2/y59b flies have a pigmentation score of 4 in both the body and wing. Body colour: y2 in transheterozygous combination with yTDH+165, yTDH+161, yTDH+105, yTDH+51, yTDH+48, yTDH+36, yTDH+1, yTDH-4b, yTDH-28c, yTDH-46, yTDH-55, yTDH-59 or yTDH-80 results in flies with a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: y2 in transheterozygous combination with yTDH-98, yTDH-99, yTDH-108 or yTDH-116 results in flies with a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: y2 in transheterozygous combination with yTDH-162, yTDH-163, yTDH-166, yTDH-169, yTDH-172, yTDH-231, yTDH-244b, yTDH-288, yTDH-321, yTDH-363, yTDH-370, yTDH-376, yTDH-385, yTDH-442, yTDH-470, yTDH-479b, yTDH-490, yTDH-499, yTDH-586, yTDH-743a, yTDH-743b, yTDH-743c or yTDH-743d results in flies with a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: y2 in transheterozygous combination with yTDH-158, yTDH-641 or yTDH-1039 results in flies with a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: y2 in transheterozygous combination with yTDH-178 or yTDH-786 results in flies with a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: yTDH-981/y2 flies have a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: yTDH-1061/y2 flies have a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: yTDH-1111/y2 flies have a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: yTDH-1142/y2 flies have a pigmentation score of 1 in the wing and 1-2 in the body. Body colour: yTDH-1491/y2 flies have a pigmentation score of 1 in the wing and 3 in the body. Body colour: yTDH-1583/y2 flies have a pigmentation score of 1 in the wing and 3-4 in the body. Body colour: yTDH-1683/y2 flies have a pigmentation score of 1 in the wing and 3-4 in the body. Body colour: yTDH-1872/y2 flies have a pigmentation score of 2 in the wing and 3-4 in the body. Body colour: yTDH-1924/y2 flies have a pigmentation score of 3 in the wing and 4 in the body. Body colour: yTDH-2097/y2 flies have a pigmentation score of 4 in the wing and 5 in the body. Body colour: yTDH-2491/y2 flies have a pigmentation score of 5 in the both the wing and body. Body colour: yTDH-2576/y2 flies have a pigmentation score of 5 in the both the wing and body.
Abdominal pigmentation is lost in the adult.
ytata can support transvection when placed in trans to y2; y2/ytata flies have a darker wing and body colour than flies homozygous or hemizygous for either y2 or ytata.
Body colour: mutant flies have reduced pigmentation in the body and wings, but wild-type pigmentation in the thoracic, leg and abdominal bristles.
Body colour: the abdominal pigment of y2 males is lighter than normal, but uniformly distributed in the last two abdominal segments.
Body colour: pigmentation of the body and wings is reduced, pigmentation of thoracic, leg, wing and abdominal bristles is normal.
Body color score: 1 Wing color score: 1 Thoracic bristle color score: 5 Leg bristle color score: 5 Wing bristle color score: 5 Abdomen bristle color score: 5
Body colour: fifth and sixth abdominal segments brown.
Body colour: body yellow; hairs & bristles black.
Body colour: body, wings yellow; hairs & bristles black.
The pigmentation induced in unpigmented y2 pharate adult tissue by incubation with dopamine in vitro closely resembles the y2 phenotype, producing brown pigmentation of cuticle structures, except for black melanin deposition in the bristles.
Body colour: body, wing blade yellow; bristles wild-type. The colouration of the adult cuticular structures shows a variegated pattern. The effect increases at 18oC and decrease in the presence of extra Y.
Body colour: body, wing yellow; bristles, tarsal claws, wild-type. Larval denticle belt colour: wild-type.
Body colour: body, wing blade yellow; bristles wild-type.
Body colour: body, wing blade yellow; wing veins grey; bristles & hairs wild-type.
Body colour: type 2 allele - some areas of cuticle are wild type, others have mutant pigmentation.
Body colour: body yellow; hairs & bristles black; wing veins grey. Larval mouth part colour: wild-type.
 
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hideEnhanced by
Statement
Reference
y2 has visible | dominant phenotype, enhanceable by mod(mdg4)ul
y2 has visible | recessive phenotype, enhanceable by mod(mdg4)ul
hideNOT Enhanced by
Statement
Reference
hideSuppressed by
Statement
Reference
y2 has visible | recessive phenotype, suppressible | partially by mod(mdg4)T6
y2 has visible | recessive phenotype, suppressible | partially by mod(mdg4)ul
hideNOT suppressed by
Statement
Reference
e(y)21, y2 has lethal | male | partially phenotype, non-suppressible by e(y)2bsu(Hw).PK
hideOther
Statement
Reference
dvr2, y2 has visible phenotype
 
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
y2 has adult cuticle & wing phenotype, enhanceable by mod(mdg4)ul
y2 has adult cuticle phenotype, enhanceable by mod(mdg4)ul
y2 has macrochaeta & abdomen phenotype, enhanceable by mod(mdg4)ul
y2 has macrochaeta & adult abdomen phenotype, enhanceable by mod(mdg4)ul
y2 has macrochaeta & adult thorax phenotype, enhanceable by mod(mdg4)ul
y2 has macrochaeta & leg phenotype, enhanceable by mod(mdg4)ul
y2 has macrochaeta & thorax phenotype, enhanceable by mod(mdg4)ul
y2 has macrochaeta & wing phenotype, enhanceable by mod(mdg4)ul
y2 has macrochaeta phenotype, enhanceable by mod(mdg4)ul
y2 has phenotype, enhanceable by e(y)12
y2 has phenotype, enhanceable by e(y)1P1
y2 has phenotype, enhanceable by e(y)21
y2 has phenotype, enhanceable by e(y)32
y2 has phenotype, enhanceable by e(y)33
y2 has phenotype, enhanceable by e(y)34
y2 has phenotype, enhanceable by e(y)61
y2 has phenotype, enhanceable by e(y)62
y2 has phenotype, enhanceable by e(y)63
y2 has phenotype, enhanceable by su(Hw)ΔA/mod(mdg4)ul
y2 has unguis phenotype, enhanceable by mod(mdg4)ul
y2 has wing sensillum phenotype, enhanceable by mod(mdg4)ul
hideNOT Enhanced by
Statement
Reference
y2 has phenotype, non-enhanceable by Doa6
y2 has phenotype, non-enhanceable by DoaHD
y2 has phenotype, non-enhanceable by ph-pP1
y2 has phenotype, non-enhanceable by su(Hw)ΔB/mod(mdg4)ul
y2 has phenotype, non-enhanceable by su(Hw)ΔC/mod(mdg4)ul
hideSuppressed by
Statement
Reference
mod(mdg4)ul, y2 has adult abdomen | male phenotype, suppressible by lawcp1
y2 has adult abdomen phenotype, suppressible | partially by mod(mdg4)ul
y2 has adult abdomen phenotype, suppressible by mod(mdg4)T6
y2 has adult cuticle & wing phenotype, suppressible by su(Hw)2
y2 has adult cuticle | male phenotype, suppressible by mod(mdg4)ul
y2 has adult cuticle phenotype, suppressible by Df(2R)P34/+
y2 has cuticle phenotype, suppressible by su(Hw)ΔB
y2 has cuticle phenotype, suppressible by su(Hw)ΔC
y2 has macrochaeta phenotype, suppressible by su(Hw)ΔB
y2 has macrochaeta phenotype, suppressible by su(Hw)ΔC
y2 has phenotype, suppressible | partially by su(Hw)2
y2 has phenotype, suppressible by su(Hw)7/su(Hw)V/su(Hw)Δ2-203.673-943
y2 has phenotype, suppressible by su(Hw)7/su(Hw)V/su(Hw)Δ706-736
y2 has phenotype, suppressible by su(Hw)7/su(Hw)V/su(Hw)Δ738-780
y2 has phenotype, suppressible by su(Hw)7/su(Hw)V/su(Hw)Δ782-944
y2 has phenotype, suppressible by su(Hw)7/su(Hw)V/su(Hw)Δ853-880
y2 has phenotype, suppressible by su(Hw)8
y2 has phenotype, suppressible by su(Hw)E8
y2 has phenotype, suppressible by su(Hw)J
y2 has phenotype, suppressible by su(Hw)L775K
y2 has phenotype, suppressible by su(Hw)NoAD2/mod(mdg4)ul
y2 has phenotype, suppressible by su(Hw)NoAD
y2 has phenotype, suppressible by su(Hw)u1
y2 has phenotype, suppressible by su(Hw)u2
y2 has phenotype, suppressible by su(Hw)V/su(Hw)ΔB
y2 has phenotype, suppressible by su(Hw)Δ100
y2 has phenotype, suppressible by su(Hw)Δ283
y2 has phenotype, suppressible by su(Hw)Δ673-943/su(Hw)7/su(Hw)V
y2 has phenotype, suppressible by su(Hw)ΔC/su(Hw)V
y2 has phenotype, suppressible by su(Hw)ΔCTAD/mod(mdg4)ul
y2 has unguis phenotype, suppressible by su(Hw)ΔB
y2 has unguis phenotype, suppressible by su(Hw)ΔC
hideNOT suppressed by
Statement
Reference
e(y)21, y2 has chaeta & adult thorax phenotype, non-suppressible by e(y)2bsu(Hw).PK
e(y)21, y2 has head bristle phenotype, non-suppressible by e(y)2bsu(Hw).PK
e(y)21, y2 has tergite phenotype, non-suppressible by e(y)2bsu(Hw).PK
y2 has phenotype, non-suppressible by Doa6
y2 has phenotype, non-suppressible by DoaHD
y2 has phenotype, non-suppressible by e(y)11/Su(mg)1-61-6
y2 has phenotype, non-suppressible by e(y)11/Su(mg)1-71-7
y2 has phenotype, non-suppressible by e(y)11/Su(mg)1-81-8
y2 has phenotype, non-suppressible by e(y)12/Su(mg)1-61-6
y2 has phenotype, non-suppressible by e(y)12/Su(mg)1-71-7
y2 has phenotype, non-suppressible by e(y)12/Su(mg)1-81-8
y2 has phenotype, non-suppressible by su(Hw)7/su(Hw)V/su(Hw)wt
y2 has phenotype, non-suppressible by su(Hw)7/su(Hw)V/su(Hw)Δ2-203
y2 has phenotype, non-suppressible by su(Hw)7/su(Hw)V/su(Hw)Δ881-944
y2 has phenotype, non-suppressible by su(Hw)7/su(Hw)Δ656-705/su(Hw)V
y2 has phenotype, non-suppressible by su(Hw)J
y2 has phenotype, non-suppressible by su(Hw)V/su(Hw)ΔA
hideOther
Statement
Reference
dvr2, y2 has wing phenotype
 
e(y)11, y2 has adult thorax & macrochaeta phenotype
e(y)11, y2 has leg & external sensory organ phenotype
e(y)1P1, y2 has adult thorax & chaeta phenotype
e(y)21, y2 has adult thorax & chaeta phenotype
e(y)21, y2 has chaeta & adult thorax phenotype
e(y)32, y2 has adult thorax & chaeta phenotype
e(y)33, y2 has adult thorax & chaeta phenotype
e(y)34, y2 has adult thorax & chaeta phenotype
mod(mdg4)ul, y2 has adult abdomen & macrochaeta phenotype
mod(mdg4)ul, y2 has adult thorax & macrochaeta phenotype
mod(mdg4)ul, y2 has leg & macrochaeta phenotype
mod(mdg4)ul, y2 has wing & macrochaeta phenotype
hide Additional Comments
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Statement
Reference
y[2] mod(mdg4)[ul] double mutant flies have a dappled abdomen with pale bristles. y[2] mod(mdg4)[T6] double mutant flies have a dappled abdomen with pale bristles.
Body colour: y2 ; mod(mdg4)Z3-3401/mod(mdg4)T16 and mod(mdg4)T6/mod(mdg4)T16 flies have a y- phenotype (yellow bristles, wings and bodies). Body colour: the y2 phenotype (black bristles, yellow body and wings) is not altered by mod(mdg4)Z3-5578/mod(mdg4)T16.
y2 mod(mdg4)ul double mutants exhibit a suppression of the y2 cuticle phenotype, and so exhibit a more pigmented abdomen. The transheterozygote lwr05486/smt304493 suppresses the mod(mdg4)ul suppression of the y2 cuticle phenotype, leading to a lighter coloration of the abdomen (due to a reduction in y expression).These phenotypic changes occur in approximately 30% of the mutant flies, with the remaining 70% displaying a continuum of less-pronounced effect. The phenotype is also particularly pronounced in females, although it is detectable in both sexes. The transheterozygote lwr02858/smt3k06307 suppresses the mod(mdg4)ul suppression of the y2 cuticle phenotype, leading to a lighter coloration of the abdomen (due to a reduction in y expression). These phenotypic changes occur in approximately 30% of the mutant flies, with the remaining 70% displaying a continuum of less-pronounced effect. The phenotype is also particularly pronounced in females, although it is detectable in both sexes.
Body colour: y2 ; Df(2R)P34/+ flies show increased production of black pigment in the abdomen compared to y2 flies. Body colour: y2 ; mod(mdg4)ul/+ flies show increased production of black pigment in the abdomen compared to y2 flies. Body colour: y2 flies expressing ToporsdsRNA.Scer\UAS under the control of Scer\GAL4Act show increased production of black pigment in the abdomen compared to y2 flies. Body colour: y2 ; mod(mdg4)ul flies that are also expressing ToporsScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4Act have a very low level of black pigment in the abdomen. Body colour: y2 ; Lam04643/+ ; mod(mdg4)ul flies show increased production of black pigment in the abdomen compared to y2 ; mod(mdg4)ul flies.
e(y)2[1] y[2] males show reduced viability compared to wild type. 14% of the mutant males have distorted tergites. Body colour: e(y)2[1] y[2] males have reduced pigmentation of head and thorax bristles compared to wild type. The reduced viability, reduced pigmentation of head and thorax bristles and distorted tergite phenotype that is seen in e(y)2[1] y[2] males is not rescued by e(y)2b[su(Hw).PK].
y2 ct6; Df(3R)E(mod)4-1P11/Cp190H53-2 flies, which are removed from the pupal cases very late in pupal development, display a black cuticle coloration in the abdomen, indicating complete suppression of y2. The shape and margins of the wings are normal, indicating complete suppression of ct6. The wings of y2 ct6; Cp190H4-1 male flies are rounder in shape, suggesting that ct6 is partially suppressed, whereas the bristles are yellow, indicating that the y2 phenotype is altered. The body cuticle colour is only slightly darker in the background of the Cp190H4-1 mutation.
The presence of sc[D1] in y[2] sc[D1]/y[59b] flies abolishes interallelic complementation. y[2] sc[D1]/y[59b] females show weak pigmentation of the body and wings. The presence of sc[D1] in y[2] sc[D1]/y[1#8] flies abolishes interallelic complementation. y[2] sc[D1]/y[1#8] females show weak pigmentation of the body and wings. The presence of sc[D1h33] in y[2] sc[D1h33]/y[1#8] flies abolishes interallelic complementation. y[2] sc[D1h33]/y[1#8] females show weak pigmentation of the body and wings. The presence of sc[D1h33] in y[2] sc[D1h33]/y[59b] flies abolishes interallelic complementation. y[2] sc[D1h33]/y[1#8] females show weak pigmentation of the body and wings. y[2] sc[+1MC]/y[1#8] females show the same wild-type like pigmentation phenotype as y[2]/y[1#8] heterozygotes. y[2] sc[+1MC]/y[59b] females show the same wild-type like pigmentation phenotype as y[2]/y[59b] heterozygotes. y[2] sc[+2MC]/y[1#8] females show the same wild-type like pigmentation phenotype as y[2]/y[1#8] heterozygotes. y[2] sc[+2MC]/y[59b] females show the same wild-type like pigmentation phenotype as y[2]/y[59b] heterozygotes. y[2] sc[R1]/y[1#8] females show the same wild-type like pigmentation phenotype as y[2]/y[1#8] heterozygotes. y[2] sc[R1]/y[59b] females show the same wild-type like pigmentation phenotype as y[2]/y[59b] heterozygotes. y[2] sc[R2]/y[1#8] females show the same wild-type like pigmentation phenotype as y[2]/y[1#8] heterozygotes. y[2] sc[R2]/y[59b] females show the same wild-type like pigmentation phenotype as y[2]/y[59b] heterozygotes.
Pigmentation of the thoracic and leg bristles is reduced in combination with e(y)11.
y2; mod(mdg4)ul males have variegated abdominal pigmentation with individual spots of wild-type dark pigment against a lighter pigmented background in the last two abdominal segments. This variegated phenotype is suppressed if the flies are also carrying lawcp1; the areas of lighter pigmentation increase at the expense of darkly pigmented regions so that the phenotype is closer to y2 rather than y2 ; mod(mdg4)ul flies.
The pigmentation of y2/y2s11 and y2/yds62 flies is unaffected by ph-pP1. The phenotype is unaffected by ph-pP1.
su(Hw)NoAD, su(Hw)V and su(Hw)Δ283 suppress the mutant phenotype.
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Complements
 
Partially complements
Fails to complement
Comments
y[2]/y[1#8] or y[2]/y[59b] heterozygotes show a practically wild-type body and wing pigmentation phenotype.
sc1 y2/y59b are y2-like in phenotype.
hide Stocks ( 138 )
Bloomington
184
Kyoto
101259
105780
105777
hide Notes on Origin
Discoverer
Bridges, 26th Oct. 1925.
hide Comments
y2/Y; mod(mdg4)ul/+ males derived from mod(mdg4)+ females have a similar phenotype to y2/Y males, y2/Y; mod(mdg4)ul/+ males derived from mod(mdg4)ul/mod(mdg4)ul females have a variegated pigmentation phenotype.
Promoter causes trans-activation of y1 enhancer.
The y2 phenotype can be reproduced by transforming y- flies with a construct carrying a gypsy insert into y. gypsy insertion separates the wing and body tissue-specific enhancers from the y promoter (FBrf0046293).
The ability of various null y alleles to complement the y2 phenotype has been studied. The results suggest that where the null y allele can complement the y2 phenotype, functional wing and body cuticle enhancers located in the null y allele may be acting in trans on the promoter in the y2 allele.
See Campuzano et al., Cell 40:327--338.
Mutates to y1-like alleles with X-rays or mutator gene mutations.
 
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