Allele Dmel\y^2S

General Information
Symbol	Dmel\y^2S	Species	D. melanogaster
Name	2 from Swedish	FlyBase ID	FBal0018615
Feature type	allele	Associated gene	Dmel\y
Also Known As	y^2s

Allele class	hypomorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Drapeau et al., 2006)
Mutagen	spontaneous (Chia et al., 1986, Morris et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name S57430

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Structural alteration in the promoter. (Morris et al., 1999) Insertion of DNA into the regulatory region of y. (Georgiev and Gerasimova, 1989) 4.5kb insertion 5' to the start of transcription, within the 489bp HindIII/BalI fragment. (Chia et al., 1986)
Caused by insertion	?{}y^2S (Chia et al., 1986, Georgiev and Gerasimova, 1989)
Cytology
Phenotypic Data
Phenotypic Class
	body color defective (Drapeau et al., 2006, Chia et al., 1986, ) mating defective \| male (Drapeau et al., 2006)
Phenotype Manifest In
	adult (Drapeau et al., 2006) adult cuticle (Chia et al., 1986) chaeta (Drapeau et al., 2006) embryonic/larval mouth (Drapeau et al., 2006) sex comb (Drapeau et al., 2006) wing (Drapeau et al., 2006)
Detailed Description
	Statement Reference y^2S males have significantly reduced mating success compared to control males. The Dp(1;f)1187 minichromosome rescues the mating success of these mutants. y^2S adults show a reduction in pigmentation in the wing and a partial reduction in the body, bristles and sex combs. Larval mouth pigmentation is also reduced. (Drapeau et al., 2006) Similar to y²⁵. (Morris et al., 1999) Body colour: type 2 allele - some areas of cuticle are wild type, others have mutant pigmentation. (Chia et al., 1986) Body colour: body yellow, but darker than that of y²; bristles lighter. Larval mouth part colour: golden-brown; mouth-hooks light.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement Reference y^2S has phenotype, non-enhanceable by mod(mdg4)^ul (Georgiev and Gerasimova, 1989)
Suppressed by
Statement Reference y^2S has phenotype, suppressible \| partially by su(Hw)² (Lindsley and Grell, 1968)
NOT suppressed by
Statement Reference y^2S has phenotype, non-suppressible by mod(mdg4)^ul (Georgiev and Gerasimova, 1989)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	y² (Morris et al., 1999) y^62a (Morris et al., 1999) y^82f29 (Morris et al., 1999) y²³⁷⁴ (Morris et al., 1999)
Fails to complement	y^59b (Morris et al., 1999)
Comments
Stocks ( 2 )
Bloomington	194 y^2S fw^34e
Kyoto	105781 y^2S fw^34e
Notes on Origin
Discoverer	Bridges.

Comments
	Allelic series of reduced male mating success phenotype: y^59b = y^D91 >= y^3d > y^a77 >= y^2S. (Drapeau et al., 2006)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	y^2s (Krachinska et al., 1992, Chia et al., 1986, Alexandrov et al., 1985) y^2S
Name Synonym	2 from Swedish
Secondary FlyBase IDs

References ( 14 )
Research paper	Drapeau et al., 2006, Genetics 172(2): 1009--1030 A cis-regulatory sequence within the yellow locus of Drosophila melanogaster required for normal male mating success. [FBrf0190716] Morris et al., 1999, Genetics 151(2): 633--651 An analysis of transvection at the yellow locus of Drosophila melanogaster. [FBrf0106981] Kroczynska et al., 1993, Molec. Biol. Rep. 17(2): 115--121 P-element-flanked inserts at the yellow locus of Drosophila melanogaster strains. [FBrf0059028] Krachinska et al., 1992, Genetika, Moscow 28(3): 13--23 [Analysis of super-unstable mutations in the yellow locus of Drosophila melanogaster.] [FBrf0056274] Georgiev and Gerasimova, 1989, Mol. Gen. Genet. 220: 121--126 Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster. [FBrf0050555] Chia et al., 1986, EMBO J. 5: 3597--3605 Molecular analysis of the yellow locus of Drosophila. [FBrf0044248] Parkhurst and Corces, 1986, Mol. Cell. Biol. 6: 47--53 Interactions among the gypsy transposable element and the yellow and the Suppressor of Hairy-wing loci in Drosophila melanogaster. [FBrf0045039] Alexandrov et al., 1985, D. I. S. 61: 212--213 Report of new mutants. [FBrf0042282] Biessmann, 1985, Proc. Natl. Acad. Sci. U.S.A. 82: 7369--7373 Molecular analysis of the yellow gene (y) region of Drosophila melanogaster. [FBrf0043479] Nash, 1976, Dev. Biol. 48: 336--343 Patterns of pigmentation color states regulated by the y locus in Drosophila melanogaster. [FBrf0028555] Nash and Yarkin, 1974, Genet. Res. (Camb.) 24: 19--26 Genetic regulation and pattern formation: A study of the yellow locus in Drosophila melanogaster. [FBrf0026311] Sanger, 1969, D. I. S. 44: 45 [New mutants report.] [FBrf0063847] Brehme, 1941, Proc. Natl. Acad. Sci. U.S.A. 27: 254--261 The effect of adult body color mutations upon the larva of Drosophila melanogaster. [FBrf0005535]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\y2S

Allele Dmel\y^2S