Allele Dmel\y^76d28

General Information
Symbol	Dmel\y^76d28	Species	D. melanogaster
Name		FlyBase ID	FBal0018651
Feature type	allele	Associated gene	Dmel\y

Allele class
Mutagen	PM hybrid dysgenesis
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	PM hybrid dysgenesis
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of 1.1kb P-element in the 5' untranslated region, in the opposite transcriptional orientation to the y gene. The P-element is the same size, and is inserted in the same position as y^1#7, but the P-element is in opposite orientation relative to the y gene in the two alleles. (Geyer et al., 1991) Insertion of a P-element into y at +76bp (in the transcribed untranslated region). The P-element is inserted in the opposite orientation to that in y^1#7. (Geyer et al., 1990) Insertion of a 1.1kb P-element integrated 76bp downstream from the mRNA cap site in the 5' transcribed, untranslated portion of the y gene, in the opposite orientation to the transcription of y. (Geyer et al., 1988)
Caused by insertion	P{}y^76d28 (Soldatov et al., 1999, Geyer et al., 1990, Geyer et al., 1991, Geyer et al., 1988)
Cytology
Phenotypic Data
Phenotypic Class
	body color defective (Geyer et al., 1990, Belenkaya et al., 1998, Geyer et al., 1988, Soldatov et al., 1999)
Phenotype Manifest In
	adult (Soldatov et al., 1999) adult abdomen & macrochaeta (Soldatov et al., 1999) adult abdominal sensillum (Belenkaya et al., 1998) adult cuticle (Belenkaya et al., 1998) adult thorax & macrochaeta (Belenkaya et al., 1998, Soldatov et al., 1999) leg & external sensory organ (Soldatov et al., 1999) mesothoracic leg sensillum (Belenkaya et al., 1998) metathoracic leg sensillum (Belenkaya et al., 1998) prothoracic leg sensillum (Belenkaya et al., 1998) wing (Belenkaya et al., 1998, Soldatov et al., 1999) wing sensillum (Belenkaya et al., 1998)
Detailed Description
	Statement Reference Body colour: mutant flies have reduced pigmentation in the body and wings and in the thoracic, leg and abdominal bristles. (Soldatov et al., 1999) Body colour: pigmentation of all adult cuticle structures is tan. (Belenkaya et al., 1998) Body colour: tan. Larval mouth part colour: reduced pigmentation. Larval denticle belt colour: reduced pigmentation. (Geyer et al., 1990) Body colour: tan. (Geyer et al., 1988)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference y^76d28 has body color defective phenotype, enhanceable by e(y)1¹ (Soldatov et al., 1999) y^76d28 has body color defective phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998)
Phenotype Manifest In
Enhanced by
Statement Reference y^76d28 has adult abdomen & macrochaeta phenotype, enhanceable by e(y)1¹ (Soldatov et al., 1999) y^76d28 has adult abdominal sensillum phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998) y^76d28 has adult cuticle phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998) y^76d28 has adult thorax & macrochaeta phenotype, enhanceable by e(y)1¹ (Soldatov et al., 1999) y^76d28 has adult thorax & macrochaeta phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998) y^76d28 has leg & external sensory organ phenotype, enhanceable by e(y)1¹ (Soldatov et al., 1999) y^76d28 has mesothoracic leg sensillum phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998) y^76d28 has metathoracic leg sensillum phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998) y^76d28 has prothoracic leg sensillum phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998) y^76d28 has wing sensillum phenotype, enhanceable by ph-p^P1 (Belenkaya et al., 1998)
Suppressed by
Statement Reference y^76d28 has phenotype, suppressible by su(s)⁹⁴ (Geyer et al., 1991) y^76d28 has phenotype, suppressible by su(s)⁹⁵ (Geyer et al., 1991)
Additional Comments
Genetic Interactions
Statement Reference Pigmentation of the thoracic, leg and abdominal bristles is further reduced in combination with e(y)1¹. (Soldatov et al., 1999) The phenotype is enhanced by ph-p^P1; pigmentation of the body, and of the thoracic, leg, wing and abdominal bristles is further reduced in y^76d28 ph-p^P1 flies. (Belenkaya et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Geyer.

Comments
	Reverts to wild-type.
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	y^76d28
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Morris et al., 1999, Genetics 151(2): 633--651 An analysis of transvection at the yellow locus of Drosophila melanogaster. [FBrf0106981] Soldatov et al., 1999, Mol. Cell. Biol. 19(5): 3769--3778 TAFII40 protein is encoded by the e(y)1 gene: biological consequences of mutations. [FBrf0108279] Belenkaya et al., 1998, Genetics 150(2): 687--697 P-Element insertion at the polyhomeotic gene leads to formation of a novel chimeric protein that negatively regulates yellow gene expression in P-element-induced alleles of Drosophila melanogaster. [FBrf0104732] Geyer et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88: 7116--7120 Mutations in the su(s) gene affect RNA processing in Drosophila melanogaster. [FBrf0055001] Geyer et al., 1990, EMBO J. 9: 2247--2256 Tissue-specific transcriptional enhancers may act in trans on the gene located in the homologous chromosome: the molecular basis of transvection in Drosophila. [FBrf0051634] Spana and Corces, 1990, Genes Dev. 4: 1505--1515 DNA bending is a determinant of binding specificity for a Drosophila zinc finger protein. [FBrf0051829] Geyer et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85: 6455--6459 Genetic instability in Drosophila melanogaster: P-element mutagenesis by gene conversion. [FBrf0048943]

Allele Dmel\y76d28

Allele Dmel\y^76d28