A2449753T
K425M | z-PA; K425M | z-PB; K425M | z-PC
K425M
z1 carries several polymorphisms in addition to the K425M substitution.
Polytene chromosomes normal.
Amino acid replacement: K425M.
Single base change that causes the replacement of Lys with Met.
Point mutation.
Amino acid replacement: K425M. Amino acid replacement: S496A. S496A is also found in wild type flies.
Comparison between the sequences of z+ and za shows many polymorphisms concentrated in the middle, repetitive part of the gene (Pirrotta, Manet, Hardon, Bickel and Benson, 1987). There are no changes in the 5' flanking region or in the untranslated leader. Most of the changes do not affect the predicted amino acid sequence since they are in the introns or in the third position of the codons; the change from A to T (Lys to Met in the middle repetitive part of the protein) is believed to have an important effect on the properties of the mutant product (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).
Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes.
Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-51. Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-204. Eye colour: zeste with white sectors with w11E4; In(2L)TE35B-63. Eye colour: zeste with white sectors with w11E4; In(2LR)TE35B-50. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-202. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-GV209. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-221. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-229. Eye colour: zeste with white sectors with w11E4; Tp(2;3)TE35B-203. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17. Eye colour: red with w11E4; Tp(1;2)TE35B-GR20. Eye colour: red with w11E4; Tp(1;2)TE35B-GR2. Eye colour: red with w11E4; Tp(1;2)TE35B-GR5. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9. Eye colour: red with w11E4; Tp(1;2)TE35B-GR19. Eye colour: red with w11E4; Tp(1;2)TE35B-GR57. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR12. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR21. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR23. Eye colour: zeste with red crescent with w11E4; T(1;2)TE35B-217. Eye colour: zeste with w11E4; In(2LR)TE35B-4. Eye colour: dark-zeste with w11E4; Tp(1;2)TE35B-GR20/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35BC. Eye colour: zeste with w11E4; Tp(1;2)TE35B-SR22/Tp(1;2)TE35B. Eye colour: zeste with w11E4; In(2LR)TE35B-4/Tp(1;2)TE35B-SR22. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17/Tp(1;2)TE35B. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-SZ1/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR2/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR12/Tp(1;2)TE35B
Eye colour: yellow as homozygote.
g53d/g[+], z1 has abnormal eye color | female phenotype, enhanceable by E(z)[+]/E(z)1
g53d, z[+]/z1 has abnormal eye color | female phenotype, enhanceable by E(z)[+]/E(z)1
g53d, z1 has abnormal eye color | male phenotype, enhanceable by E(z)1
wsp2, z1 has abnormal eye color phenotype, enhanceable by Taf91
wsp2, z1 has abnormal eye color phenotype, enhanceable by e(y)34
wsp4, z1 has abnormal eye color phenotype, enhanceable by Taf91
wsp4, z1 has abnormal eye color phenotype, enhanceable by e(y)34
wsp1, z1 has abnormal eye color phenotype, enhanceable by Taf91
wsp1, z1 has abnormal eye color phenotype, enhanceable by e(y)34
wzm, z1 has abnormal eye color phenotype, enhanceable by mw1
wsp2, z1 has abnormal eye color phenotype, non-enhanceable by e(y)21
wsp4, z1 has abnormal eye color phenotype, non-enhanceable by e(y)21
wsp1, z1 has abnormal eye color phenotype, non-enhanceable by e(y)21
z1 has abnormal eye color phenotype, suppressible by Su(z)24-31
z1 has abnormal eye color phenotype, suppressible by Su(z)24-34
z1 has abnormal eye color | recessive phenotype, suppressible by Dvir\z+tCa
z1 has abnormal eye color phenotype, suppressible by Su(z)24
z1 has abnormal eye color phenotype, suppressible by Su(z)25
z1 has abnormal eye color phenotype, suppressible by E(z)60
z1 has abnormal eye color phenotype, suppressible by E(z)60/E(z)61
z1 has abnormal eye color phenotype, suppressible by Su(z)21
z1 has abnormal eye color phenotype, suppressible by E(z)61
z1 is an enhancer of abnormal eye color phenotype of g53d
z1 is an enhancer of abnormal eye color phenotype of g2
z1 is an enhancer of abnormal eye color phenotype of g50e
z1 is an enhancer of abnormal eye color phenotype of wsp2
z1 is an enhancer of abnormal eye color phenotype of wsp4
z1 is an enhancer of abnormal eye color phenotype of wsp1
z[+]/z1 is a suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
z[+]/z1 is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
E(z)Trm, z1 has abnormal eye color phenotype
E(z)Trm/In(3L)Ez2, z1 has abnormal eye color phenotype
E(z)[+]/E(z)Trm, z1 has abnormal eye color phenotype
Dp(1;1)wrdp+, z1 has abnormal eye color phenotype
Dp(1;1)w+61e19, z1 has abnormal eye color phenotype
Low1, wa, z1 has abnormal eye color phenotype
wzm, z1 has abnormal eye color phenotype
g53d, z1 has pigment cell | male phenotype, enhanceable by E(z)1
g53d, z1 has pigment cell phenotype, enhanceable | male by E(z)1
g53d/g[+], z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1
g53d, z[+]/z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1
wsp2, z1 has pigment cell phenotype, enhanceable by Taf91
wsp2, z1 has pigment cell phenotype, enhanceable by e(y)34
wsp4, z1 has pigment cell phenotype, enhanceable by Taf91
wsp4, z1 has pigment cell phenotype, enhanceable by e(y)34
wsp1, z1 has pigment cell phenotype, enhanceable by Taf91
wsp1, z1 has pigment cell phenotype, enhanceable by e(y)34
z1 has phenotype, enhanceable by Df(2R)M41A4
z1 has phenotype, enhanceable by Df(2R)M41A1
z1 has phenotype, enhanceable by Df(2R)M41A8
wzm, z1 has pigment cell phenotype, enhanceable by mw1
z1 has phenotype, non-enhanceable by Alhunspecified
z1 has phenotype, non-enhanceable by Wowunspecified
wsp2, z1 has pigment cell phenotype, non-enhanceable by e(y)21
wsp4, z1 has pigment cell phenotype, non-enhanceable by e(y)21
wsp1, z1 has pigment cell phenotype, non-enhanceable by e(y)21
z1 has phenotype, non-suppressible by Alhunspecified
z1 has phenotype, non-suppressible by Wowunspecified
z1 has phenotype, non-suppressible by Su(z)2unspecified
z1 is an enhancer of pigment cell phenotype of g53d
z1 is an enhancer of pigment cell phenotype of g50e
z1 is an enhancer of macrochaeta phenotype of snaSco/snaSco
z1 is an enhancer of pigment cell phenotype of wsp2
z1 is an enhancer of pigment cell phenotype of wsp4
z1 is an enhancer of pigment cell phenotype of wsp1
z[+]/z1 is a suppressor of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
z[+]/z1 is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
E(z)Trm, z1 has pigment cell phenotype
E(z)Trm/In(3L)Ez2, z1 has pigment cell phenotype
E(z)[+]/E(z)Trm, z1 has pigment cell phenotype
Dp(1;1)wrdp+, z1 has pigment cell phenotype
Low1, wa, z1 has pigment cell phenotype
Dp(1;1)w+61e19, z1 has eye phenotype
Dp(1;1)w+61e19, z1 has pigment cell phenotype
wd1, z1 has pigment cell phenotype
wzm, z1 has pigment cell phenotype
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of z1.
Su(z)24-31 suppresses the eye colour phenotype of z1, and Su(z)24-34 is a weak suppressor of the eye colour phenotype of z1.
g53d, za double mutants have a reduced amount of red pigment in the eye compared to g53d single mutants in both male and female flies. The same is true for g50e and g2 alleles. Male E(z)1/+, g53d, z1 triple mutants have less red pigment in the eye than g53d, z1 double mutants. Likewise, female E(z)1/+, g53d/+, z1/+ triple mutants have a reduction in red eye pigment compared to g53d/+, z1/+ double mutants.
The average number of sex comb teeth per first leg in ScrTpl9 heterozygous males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of sex comb teeth per first leg in ScrTpl9/ScrAntp-A41 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The viability and average number of sex comb teeth per first leg in ScrTpl9/ScrWrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of ectopic sex comb teeth on the second and third legs in ScrMsc heterozygous males is not affected if they are also carrying z1.
Enhances the bristle loss phenotype of Tp(2;2)Sco/+ flies.
Enhances the eye colour phenotype by suppressing the transactivation of the mini-w gene seen when wMcp.y.scs'.1 and ywe.Mcp.2 are combined and when wMcp.scs'.21 and ywe.Mcp.1 are combined leading to lighter eyes.
Dominantly represses w when one of the w genes contains a tandem duplication of the regulatory region, such as Dp(1;1)wrdp+. z1 Dp(1;1)wrdp+/+ females exhibit a red-orange eye colour between that of wild type and the yellow of hemizygous z1 Dp(1;1)wrdp+ males. Supports transvection at Ubx.
Eye colour: yellow in Dp(1;1)w+61e19 male.
z1 has no effect on the mod(mdg4)ul effect on ct6.
Eye colour: orange, as wis z1 males. Eye colour: orange, as wis z1/z+ females. Eye colour: yellow-white variegated as In(1)wis z1 males. Eye colour: red-orange or orange-yellow variegated as z1 In(1)wis/z1 w+ females. The phenotypic interactions with Df(YS)B4, Df(YL)S6, Df(YS)S12, Df(YL)G22, Df(YL)S10, Df(2R)M41A4, Df(2R)M41A1, Df(2R)M41A8 are seen in z1 In(1)wis; z1 In(1)wis; Su(z)2unspecified have an unaltered background level of pigmentation (white) but the yellow flecks in the eye are darkened to orange or red.
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of z1.
Eye colour phenotype is rescued by Dvir\z+tCa.
Rescue is dosage-dependent.
Gans, Feb. 1946.
Supports transvection at Ubx but not at dpp.
Allelic series: zop6 > zop11 > zRN4 > z1 > zRN1 > wild type.
This allele behaves as an antagonist of normal z function.
z1 product subliminally inhibits the complementation of dpphr4 and dppd-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis.
Unpaired w+ alleles suppress z1 eye colour.
Causes a specific underexpression of w in the eye when two copies of the w gene are physically apposed by chromosome pairing or by tandem duplication. Expression of w in other tissues is not affected. Behaves like z+ in promoting transvection effects at Ubx but fails to permit transvection at the dpp locus.
The z1 mutation causes a new hydrophobic nucleus in the region of the protein preceding the C-terminal domain, resulting in a further stage of multimerization.
z1 gene product in combination with structural changes imposed by transposons and intercalary heterochromatin, modifies the determination and stability of w expression.
The phenotype of Abd-Biab7-MX2/Abd-Biab8-D14 is unaffected by alleles of z.
Does not alter the effect of mod(mdg4)ul on y2/y+.
Every w+ gene must be near another w+ gene in order for the z1 phenotype to be realized.
Does not effect the level of w expression in ph-plac+3 flies.
Expression of the mutant lemon yellow eye colour requires two proximate or paired copies of w+ Paired copies of In(1)wm4 are not repressed by z1. Repression of In(1)wm4 by z1 cannot be restored by Su(var)205. z1 In(1)rst3 combination exhibits more extreme variegation for rst than seen in z+ In(1)rst3 combination. Recessive enhancer of PEV in a fashion clearly distinguishable from standard transvection effects.
Does not suppress transvection of UbxCbx-1/+.
Two synapsed copies of w+ are required for expression of zeste eye color.
z1 mediated repression of flies carrying two to five ectopic w genes (produced using Tp(1;2)TE35B derivatives) is insensitive to copy number and does not distinguish between w genes that are in cis or in trans. Suppression does not require the juxtaposition of even numbers of w genes, but is extremely sensitive to chromosomal topology.
All iab-7 PRE pairing-sensitive lines show strong interactions with z1 when the transgene insert is heterozygous: dominant enhancement of iab-7 PRE repression.