Amino acid replacement: K425M.
Single base change that causes the replacement of Lys with Met.
Amino acid replacement: K425M. Amino acid replacement: S496A. S496A is also found in wild type flies.
Comparison between the sequences of z+
shows many polymorphisms concentrated in the middle, repetitive part of the gene (Pirrotta, Manet, Hardon, Bickel and Benson, 1987). There are no changes in the 5' flanking region or in the untranslated leader. Most of the changes do not affect the predicted amino acid sequence since they are in the introns or in the third position of the codons; the change from A to T (Lys to Met in the middle repetitive part of the protein) is believed to have an important effect on the properties of the mutant product (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).