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General Information
Symbol
Dmel\z1
Species
D. melanogaster
Name
FlyBase ID
FBal0018822
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
A2449753T
Amino acid change:
K425M | z-PA; K425M | z-PB; K425M | z-PC
Reported amino acid change:
K425M
Comment:
z1 carries several polymorphisms in addition to the K425M substitution.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Polytene chromosomes normal.
Nature of the lesion
Statement
Reference
Single base change that causes the replacement of Lys with Met.
Point mutation.
Amino acid replacement: K425M. Amino acid replacement: S496A. S496A is also found in wild type flies.
Comparison between the sequences of z+ and za shows many polymorphisms concentrated in the middle, repetitive part of the gene (Pirrotta, Manet, Hardon, Bickel and Benson, 1987). There are no changes in the 5' flanking region or in the untranslated leader. Most of the changes do not affect the predicted amino acid sequence since they are in the introns or in the third position of the codons; the change from A to T (Lys to Met in the middle repetitive part of the protein) is believed to have an important effect on the properties of the mutant product (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes.
Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-51. Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-204. Eye colour: zeste with white sectors with w11E4; In(2L)TE35B-63. Eye colour: zeste with white sectors with w11E4; In(2LR)TE35B-50. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-202. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-GV209. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-221. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-229. Eye colour: zeste with white sectors with w11E4; Tp(2;3)TE35B-203. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17. Eye colour: red with w11E4; Tp(1;2)TE35B-GR20. Eye colour: red with w11E4; Tp(1;2)TE35B-GR2. Eye colour: red with w11E4; Tp(1;2)TE35B-GR5. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9. Eye colour: red with w11E4; Tp(1;2)TE35B-GR19. Eye colour: red with w11E4; Tp(1;2)TE35B-GR57. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR12. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR21. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR23. Eye colour: zeste with red crescent with w11E4; T(1;2)TE35B-217. Eye colour: zeste with w11E4; In(2LR)TE35B-4. Eye colour: dark-zeste with w11E4; Tp(1;2)TE35B-GR20/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35BC. Eye colour: zeste with w11E4; Tp(1;2)TE35B-SR22/Tp(1;2)TE35B. Eye colour: zeste with w11E4; In(2LR)TE35B-4/Tp(1;2)TE35B-SR22. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17/Tp(1;2)TE35B. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-SZ1/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR2/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR12/Tp(1;2)TE35B
Eye colour: yellow, in w+/w+ female; wild-type in w+ male. Eye colour: dark red/brown mottled as z+ In(1)wm4 at 25oC.
Eye colour: yellow, in w+/w+ female; wild-type in w+ male.
Eye colour: white in z1 wzl; In(3)Msu1/In(3)Msu2. In(3)Msu1 and In(3)Msu2 have no effect on z1, wzm.
Eye colour: yellow, in w+/w+ female; wild-type in male.
Eye colour: yellow as homozygote.
Eye colour: white in homozygous z1 we59 female. Eye colour: yellow in z1/z1 we59/+ female. Eye colour: ligher than we59 in z1 we59 male.
Eye colour: yellow, in w+/w+ female. Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type.
Eye colour: yellow, in w+/w+ female.
Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type. Eye colour: yellow, in w+/w+ female at 25oC, mottled yellow and brownish red at 19oC; wild-type in w+/Y male.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
g53d/g[+], z1 has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)1
g53d, z[+]/z1 has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)1
g53d, z1 has eye color defective | male phenotype, enhanceable by E(z)1
wsp2, z1 has eye color defective phenotype, enhanceable by e(y)11
wsp2, z1 has eye color defective phenotype, enhanceable by e(y)34
wsp4, z1 has eye color defective phenotype, enhanceable by e(y)11
wsp4, z1 has eye color defective phenotype, enhanceable by e(y)34
wsp1, z1 has eye color defective phenotype, enhanceable by e(y)11
wsp1, z1 has eye color defective phenotype, enhanceable by e(y)34
wzm, z1 has eye color defective phenotype, enhanceable by mw1
NOT Enhanced by
Statement
Reference
wsp2, z1 has eye color defective phenotype, non-enhanceable by e(y)21
wsp4, z1 has eye color defective phenotype, non-enhanceable by e(y)21
wsp1, z1 has eye color defective phenotype, non-enhanceable by e(y)21
Suppressed by
Statement
Reference
z1 has eye color defective phenotype, suppressible by Su(z)24-31
z1 has eye color defective phenotype, suppressible by Su(z)24-34
z1 has eye color defective | recessive phenotype, suppressible by Dvir\z+tCa
z1 has eye color defective phenotype, suppressible by Su(z)24
z1 has eye color defective phenotype, suppressible by Su(z)25
z1 has eye color defective phenotype, suppressible by E(z)60
z1 has eye color defective phenotype, suppressible by E(z)60/E(z)61
z1 has eye color defective phenotype, suppressible by Su(z)21
z1 has eye color defective phenotype, suppressible by E(z)61
Enhancer of
Statement
Reference
z1 is an enhancer of eye color defective phenotype of g53d
z1 is an enhancer of eye color defective phenotype of g2
z1 is an enhancer of eye color defective phenotype of g50e
z1 is an enhancer of visible | dominant phenotype of snaSco/snaSco
z1 is an enhancer of eye color defective phenotype of wsp2
z1 is an enhancer of eye color defective phenotype of wsp4
z1 is an enhancer of eye color defective phenotype of wsp1
Suppressor of
Statement
Reference
z1 is a suppressor | partially of visible phenotype of ap56f/Df(2R)DG
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
g53d, z1 has pigment cell | male phenotype, enhanceable by E(z)1
g53d, z1 has pigment cell phenotype, enhanceable | male by E(z)1
g53d/g[+], z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1
g53d, z[+]/z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1
z1 has phenotype, enhanceable by e(y)34
wsp2, z1 has pigment cell phenotype, enhanceable by e(y)11
wsp2, z1 has pigment cell phenotype, enhanceable by e(y)34
wsp4, z1 has pigment cell phenotype, enhanceable by e(y)11
wsp4, z1 has pigment cell phenotype, enhanceable by e(y)34
wsp1, z1 has pigment cell phenotype, enhanceable by e(y)11
wsp1, z1 has pigment cell phenotype, enhanceable by e(y)34
z1 has phenotype, enhanceable by Df(YL)G22
z1 has phenotype, enhanceable by Df(YL)S10
z1 has phenotype, enhanceable by Df(2R)M41A4
z1 has phenotype, enhanceable by Df(2R)M41A1
z1 has phenotype, enhanceable by Df(2R)M41A8
wzm, z1 has pigment cell phenotype, enhanceable by mw1
z1 has phenotype, enhanceable by E(z)2
z1 has phenotype, enhanceable by E(z)3
z1 has phenotype, enhanceable by E(z)4
NOT Enhanced by
Statement
Reference
z1 has phenotype, non-enhanceable by Alhunspecified
z1 has phenotype, non-enhanceable by Low1
z1 has phenotype, non-enhanceable by Pcf11EMS2
z1 has phenotype, non-enhanceable by MowEMS
z1 has phenotype, non-enhanceable by Ufo1
z1 has phenotype, non-enhanceable by Wowunspecified
wsp2, z1 has pigment cell phenotype, non-enhanceable by e(y)21
wsp4, z1 has pigment cell phenotype, non-enhanceable by e(y)21
wsp1, z1 has pigment cell phenotype, non-enhanceable by e(y)21
Suppressed by
Statement
Reference
z1 has phenotype, suppressible by Scm4
z1 has phenotype, suppressible by Scm5
z1 has phenotype, suppressible by ScmD1
z1 has phenotype, suppressible by ScmD2
z1 has phenotype, suppressible by ScmET50
z1 has phenotype, suppressible by ScmH1
z1 has phenotype, suppressible by ScmK2
z1 has phenotype, suppressible by ScmM36
z1 has phenotype, suppressible by ScmM56
z1 has phenotype, suppressible by ScmR5-13
z1 has phenotype, suppressible by ScmSuz302
z1 has phenotype, suppressible by wa/Low1
z1 has phenotype, suppressible by ScmP11
z1 has phenotype, suppressible by ScmP12
z1 has phenotype, suppressible by ScmP22
z1 has phenotype, suppressible by w1
z1 has phenotype, suppressible by Sam-S1
z1 has phenotype, suppressible by mxcG43
z1 has phenotype, suppressible by mxcG46
z1 has phenotype, suppressible by mxcG48
z1 has phenotype, suppressible by Su(z)24
z1 has phenotype, suppressible by Su(z)25
z1 has phenotype, suppressible by Su(z)2eos
z1 has phenotype, suppressible by Df(YS)B4
z1 has phenotype, suppressible by Df(YL)S6
z1 has phenotype, suppressible by Df(YS)S12
z1 has pigment cell phenotype, suppressible by Dvir\z+tCa
z1 has phenotype, suppressible by Su(z)21
z1 has phenotype, suppressible by Psc[+]/Psc1
z1 has phenotype, suppressible by Su(z)21/Su(z)2[+]
z1 has phenotype, suppressible by E(z)61
z1 has phenotype, suppressible by E(z)66
z1 has phenotype, suppressible by wsp81d
z1 has phenotype, suppressible by Su(z)41
z1 has phenotype, suppressible by Su(z)61
z1 has phenotype, suppressible by Su(z)71
z1 has phenotype, suppressible by E(z)37
z1 has phenotype, suppressible by E(z)38
z1 has phenotype, suppressible by E(z)39
z1 has phenotype, suppressible by E(z)40
z1 has phenotype, suppressible by E(z)41
z1 has phenotype, suppressible by E(z)42
z1 has phenotype, suppressible by E(z)43
z1 has phenotype, suppressible by E(z)44
z1 has phenotype, suppressible by E(z)45
z1 has phenotype, suppressible by E(z)46
z1 has phenotype, suppressible by E(z)47
z1 has phenotype, suppressible by E(z)48
z1 has phenotype, suppressible by E(z)49
z1 has phenotype, suppressible by E(z)50
z1 has phenotype, suppressible by E(z)51
z1 has phenotype, suppressible by E(z)52
z1 has phenotype, suppressible by E(z)53
z1 has phenotype, suppressible by E(z)54
z1 has phenotype, suppressible by E(z)55
z1 has phenotype, suppressible by E(z)56
z1 has phenotype, suppressible by E(z)57
z1 has phenotype, suppressible by E(z)58
z1 has phenotype, suppressible by E(z)59
z1 has phenotype, suppressible by E(z)5
z1 has phenotype, suppressible by E(z)62
z1 has phenotype, suppressible by E(z)63
z1 has phenotype, suppressible by E(z)64
z1 has phenotype, suppressible by E(z)65
z1 has phenotype, suppressible by E(z)67
z1 has phenotype, suppressible by E(z)68
z1 has phenotype, suppressible by E(z)69
z1 has phenotype, suppressible by E(z)6
z1 has phenotype, suppressible by E(z)70
z1 has phenotype, suppressible by E(z)71
z1 has phenotype, suppressible by E(z)72
z1 has phenotype, suppressible by E(z)73
z1 has phenotype, suppressible by E(z)74
z1 has phenotype, suppressible by E(z)75
z1 has phenotype, suppressible by E(z)8
z1 has phenotype, suppressible by E(z)9
z1 has phenotype, suppressible by E(z)10
z1 has phenotype, suppressible by E(z)11
z1 has phenotype, suppressible by E(z)12
z1 has phenotype, suppressible by E(z)13
z1 has phenotype, suppressible by E(z)14
z1 has phenotype, suppressible by E(z)15
z1 has phenotype, suppressible by E(z)16
z1 has phenotype, suppressible by E(z)17
z1 has phenotype, suppressible by E(z)18
z1 has phenotype, suppressible by E(z)19
z1 has phenotype, suppressible by E(z)20
z1 has phenotype, suppressible by E(z)21
z1 has phenotype, suppressible by E(z)22
z1 has phenotype, suppressible by E(z)23
z1 has phenotype, suppressible by E(z)24
z1 has phenotype, suppressible by E(z)25
z1 has phenotype, suppressible by E(z)26
z1 has phenotype, suppressible by E(z)27
z1 has phenotype, suppressible by E(z)28
z1 has phenotype, suppressible by E(z)29
z1 has phenotype, suppressible by E(z)30
z1 has phenotype, suppressible by E(z)31
z1 has phenotype, suppressible by E(z)32
z1 has phenotype, suppressible by E(z)33
z1 has phenotype, suppressible by E(z)34
z1 has phenotype, suppressible by E(z)35
z1 has phenotype, suppressible by E(z)36
NOT suppressed by
Statement
Reference
z1 has phenotype, non-suppressible by Alhunspecified
z1 has phenotype, non-suppressible by Low1
z1 has phenotype, non-suppressible by Pcf11EMS2
z1 has phenotype, non-suppressible by MowEMS
z1 has phenotype, non-suppressible by Ufo1
z1 has phenotype, non-suppressible by Wowunspecified
z1 has phenotype, non-suppressible by wis/Low1
z1 has phenotype, non-suppressible by Su(z)2unspecified
Enhancer of
Statement
Reference
z1 is an enhancer of pigment cell phenotype of g53d
z1 is an enhancer of pigment cell phenotype of g50e
z1 is an enhancer of macrochaeta phenotype of snaSco/snaSco
z1 is an enhancer of phenotype of ctpN1
z1 is an enhancer of phenotype of ctpN30
z1 is an enhancer of pigment cell phenotype of wsp2
z1 is an enhancer of pigment cell phenotype of wsp4
z1 is an enhancer of pigment cell phenotype of wsp1
z1 is an enhancer of phenotype of wAR4-24
NOT Enhancer of
Statement
Reference
z1 is a non-enhancer of sex comb phenotype of ScrWrv4/ScrTpl9
z1 is a non-enhancer of mesothoracic leg & sex comb | ectopic phenotype of ScrMsc
z1 is a non-enhancer of metathoracic leg & sex comb | ectopic phenotype of ScrMsc
z1 is a non-enhancer of sex comb phenotype of ScrAntp-A41/ScrTpl9
z1 is a non-enhancer of sex comb phenotype of ScrTpl9
z1/Low1 is a non-enhancer of phenotype of wis
Suppressor of
Statement
Reference
z1 is a suppressor | partially of wing phenotype of ap56f/Df(2R)DG
Mowgamma/z1 is a suppressor of phenotype of wis
z1 is a suppressor of phenotype of wzvl
NOT Suppressor of
Statement
Reference
z1 is a non-suppressor of sex comb phenotype of ScrWrv4/ScrTpl9
z1 is a non-suppressor of metathoracic leg & sex comb | ectopic phenotype of ScrMsc
z1 is a non-suppressor of mesothoracic leg & sex comb | ectopic phenotype of ScrMsc
z1 is a non-suppressor of sex comb phenotype of ScrAntp-A41/ScrTpl9
z1 is a non-suppressor of sex comb phenotype of ScrTpl9
z1/Low1 is a non-suppressor of phenotype of wis
Other
Additional Comments
Genetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of z1.
Su(z)24-31 suppresses the eye colour phenotype of z1, and Su(z)24-34 is a weak suppressor of the eye colour phenotype of z1.
z1 partially suppresses the wing phenotypes seen in ap56f/Df(2R)DG mutant flies. z1 does not enhance the mild wing phenotypes seen in apUGO35/Df(2R)DG mutant flies.
g53d, za double mutants have a reduced amount of red pigment in the eye compared to g53d single mutants in both male and female flies. The same is true for g50e and g2 alleles. Male E(z)1/+, g53d, z1 triple mutants have less red pigment in the eye than g53d, z1 double mutants. Likewise, female E(z)1/+, g53d/+, z1/+ triple mutants have a reduction in red eye pigment compared to g53d/+, z1/+ double mutants.
The average number of sex comb teeth per first leg in ScrTpl9 heterozygous males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of sex comb teeth per first leg in ScrTpl9/ScrAntp-A41 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The viability and average number of sex comb teeth per first leg in ScrTpl9/ScrWrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of ectopic sex comb teeth on the second and third legs in ScrMsc heterozygous males is not affected if they are also carrying z1.
Eye colour: small brown spots on an otherwise wild-type background in z1/Y; E(z)Trm/+ males or z1/+; E(z)Trm/+ females. Eye colour: orange-brown in z1/Y; E(z)Trm/In(3L)Ez2 males or z1/+; E(z)Trm/In(3L)Ez2 females (rescued by dissecting out of the pupal case).
Enhances the bristle loss phenotype of Tp(2;2)Sco/+ flies.
Enhances the eye colour phenotype by suppressing the transactivation of the mini-w gene seen when wMcp.y.scs'.1 and ywe.Mcp.2 are combined and when wMcp.scs'.21 and ywe.Mcp.1 are combined leading to lighter eyes.
Dominantly represses w when one of the w genes contains a tandem duplication of the regulatory region, such as Dp(1;1)wrdp+. z1 Dp(1;1)wrdp+/+ females exhibit a red-orange eye colour between that of wild type and the yellow of hemizygous z1 Dp(1;1)wrdp+ males. Supports transvection at Ubx.
Eye colour: yellow in Dp(1;1)w+61e19 male.
z1 has no effect on the mod(mdg4)ul effect on ct6.
Eye colour: fewer red/brown patches on lighter background than with z+ as z1 In(1)wm4 males and females. Eye colour: as z1 in z1 In(1)rst3 female.
Eye colour: brownish, with e(y)11 or e(y)34 in male. Eye colour: like z1, with e(y)12.
Eye colour: orange, as wis z1 males. Eye colour: orange, as wis z1/z+ females. Eye colour: yellow-white variegated as In(1)wis z1 males. Eye colour: red-orange or orange-yellow variegated as z1 In(1)wis/z1 w+ females. The phenotypic interactions with Df(YS)B4, Df(YL)S6, Df(YS)S12, Df(YL)G22, Df(YL)S10, Df(2R)M41A4, Df(2R)M41A1, Df(2R)M41A8 are seen in z1 In(1)wis; z1 In(1)wis; Su(z)2unspecified have an unaltered background level of pigmentation (white) but the yellow flecks in the eye are darkened to orange or red.
Xenogenetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of z1.
Eye colour phenotype is rescued by Dvir\z+tCa.
Complementation and Rescue Data
Complements
Rescued by
Comments
Rescue is dosage-dependent.
Images (0)
Mutant
Wild-type
Stocks (75)
Notes on Origin
Discoverer
Gans, Feb. 1946.
Comments
Comments
Supports transvection at Ubx but not at dpp.
Allelic series: zop6 > zop11 > zRN4 > z1 > zRN1 > wild type.
This allele behaves as an antagonist of normal z function.
z1 product subliminally inhibits the complementation of dpphr4 and dppd-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis.
Unpaired w+ alleles suppress z1 eye colour.
Causes a specific underexpression of w in the eye when two copies of the w gene are physically apposed by chromosome pairing or by tandem duplication. Expression of w in other tissues is not affected. Behaves like z+ in promoting transvection effects at Ubx but fails to permit transvection at the dpp locus.
The z1 mutation causes a new hydrophobic nucleus in the region of the protein preceding the C-terminal domain, resulting in a further stage of multimerization.
z1 gene product in combination with structural changes imposed by transposons and intercalary heterochromatin, modifies the determination and stability of w expression.
The phenotype of Abd-Biab7-MX2/Abd-Biab8-D14 is unaffected by alleles of z.
Does not alter the effect of mod(mdg4)ul on y2/y+.
Every w+ gene must be near another w+ gene in order for the z1 phenotype to be realized.
Does not effect the level of w expression in ph-plac+3 flies.
Expression of the mutant lemon yellow eye colour requires two proximate or paired copies of w+ Paired copies of In(1)wm4 are not repressed by z1. Repression of In(1)wm4 by z1 cannot be restored by Su(var)205. z1 In(1)rst3 combination exhibits more extreme variegation for rst than seen in z+ In(1)rst3 combination. Recessive enhancer of PEV in a fashion clearly distinguishable from standard transvection effects.
Does not suppress transvection of UbxCbx-1/+.
Two synapsed copies of w+ are required for expression of zeste eye color.
z1 mediated repression of flies carrying two to five ectopic w genes (produced using Tp(1;2)TE35B derivatives) is insensitive to copy number and does not distinguish between w genes that are in cis or in trans. Suppression does not require the juxtaposition of even numbers of w genes, but is extremely sensitive to chromosomal topology.
All iab-7 PRE pairing-sensitive lines show strong interactions with z1 when the transgene insert is heterozygous: dominant enhancement of iab-7 PRE repression.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0062327
References (106)