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Allele Dmel\z¹

General Information
Symbol	Dmel\z1	Species	D. melanogaster
Name		FlyBase ID	FBal0018822
Feature type	allele	Associated gene	Dmel\z
Map ( GBrowse )
Allele class	neomorphic allele - genetic evidence, gain of function allele
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	gain of function allele (Lloyd et al., 2002) neomorphic allele - genetic evidence (Mariani et al., 1985, Tearle, 1991, Peterson et al., 1994, Judd, 1995, Simonelig et al., 1996, Hagstrom et al., 1997, Muller et al., 1999)
Mutagen	spontaneous (Mariani et al., 1985)
Mutations Mapped to the Genome
Type Location Additional Notes References point mutation X:2,343,786..2,343,786 evidence=experimental na_change=A2343786T pr_change=K425M|z-PA,K425M|z-PB reported_pr_change=K425M comment=z1 carries several polymorphisms in addition to the K425M substitution. (Bickel and Pirrotta, 1990, Pirrotta et al., 1987)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion	Statement Reference Single base change that causes the replacement of Lys with Met. (Judd, 1995) Point mutation. (Georgiev, 1994) Amino acid replacement: K425M. Amino acid replacement: S496A. S496A is also found in wild type flies. (Chen and Pirrotta, 1993) Amino acid replacement: K425M. (Bickel and Pirrotta, 1990, Chen et al., 1992, Rosen et al., 1998) Comparison between the sequences of z+ and za shows many polymorphisms concentrated in the middle, repetitive part of the gene (Pirrotta, Manet, Hardon, Bickel and Benson, 1987). There are no changes in the 5' flanking region or in the untranslated leader. Most of the changes do not affect the predicted amino acid sequence since they are in the introns or in the third position of the codons; the change from A to T (Lys to Met in the middle repetitive part of the protein) is believed to have an important effect on the properties of the mutant product (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).
Cytology	Polytene chromosomes normal. (Pattatucci and Kaufman, 1991)
Phenotypic Data
Phenotypic Class
	eye color defective (Wu and Howe, 1995, Rosen et al., 1998, Smolik-Utlaut and Gelbart, 1987) eye color defective | recessive (Chen et al., 1992) visible (Judd, 1995) visible | recessive
Phenotype Manifest In
	pigment cell (Chen et al., 1992, Wu and Howe, 1995, Rosen et al., 1998, Smolik-Utlaut and Gelbart, 1987)
Detailed Description
	Statement Reference Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes. (Cryderman et al., 1999) Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-51. Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-204. Eye colour: zeste with white sectors with w11E4; In(2L)TE35B-63. Eye colour: zeste with white sectors with w11E4; In(2LR)TE35B-50. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-202. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-GV209. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-221. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-229. Eye colour: zeste with white sectors with w11E4; Tp(2;3)TE35B-203. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17. Eye colour: red with w11E4; Tp(1;2)TE35B-GR20. Eye colour: red with w11E4; Tp(1;2)TE35B-GR2. Eye colour: red with w11E4; Tp(1;2)TE35B-GR5. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9. Eye colour: red with w11E4; Tp(1;2)TE35B-GR19. Eye colour: red with w11E4; Tp(1;2)TE35B-GR57. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR12. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR21. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR23. Eye colour: zeste with red crescent with w11E4; T(1;2)TE35B-217. Eye colour: zeste with w11E4; In(2LR)TE35B-4. Eye colour: dark-zeste with w11E4; Tp(1;2)TE35B-GR20/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35BC. Eye colour: zeste with w11E4; Tp(1;2)TE35B-SR22/Tp(1;2)TE35B. Eye colour: zeste with w11E4; In(2LR)TE35B-4/Tp(1;2)TE35B-SR22. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17/Tp(1;2)TE35B. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-SZ1/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR2/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR12/Tp(1;2)TE35B (Gubb et al., 1997) Eye colour: yellow, in w+/w+ female; wild-type in w+ male. Eye colour: dark red/brown mottled as z+ In(1)wm4 at 25oC. (Judd, 1995) Eye colour: yellow, in w+/w+ female; wild-type in w+ male. (Wu and Howe, 1995) Eye colour: white in z1 wzl; In(3)Msu1/In(3)Msu2. In(3)Msu1 and In(3)Msu2 have no effect on z1, wzm. (Csink et al., 1994) Eye colour: yellow, in w+/w+ female; wild-type in male. (Chen and Pirrotta, 1993) Eye colour: yellow as homozygote. (Chen et al., 1992) Eye colour: white in homozygous z1 we59 female. Eye colour: yellow in z1/z1 we59/+ female. Eye colour: ligher than we59 in z1 we59 male. (Dalby and O'Hare, 1991) Eye colour: yellow, in w+/w+ female. Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type. (Tearle, 1991) Eye colour: yellow, in w+/w+ female. (Smolik-Utlaut and Gelbart, 1987, Wu et al., 1989) Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type. Eye colour: yellow, in w+/w+ female at 25oC, mottled yellow and brownish red at 19oC; wild-type in w+/Y male.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference g53d, z[+]/z1 has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)1 (Lloyd et al., 2002) g53d, z1 has eye color defective | male phenotype, enhanceable by E(z)1 (Lloyd et al., 2002) g53d/g[+], z1 has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)1 (Lloyd et al., 2002) wsp1, z1 has eye color defective phenotype, enhanceable by e(y)11 (Georgiev, 1994) wsp1, z1 has eye color defective phenotype, enhanceable by e(y)34 (Georgiev, 1994) wsp2, z1 has eye color defective phenotype, enhanceable by e(y)11 (Georgiev, 1994) wsp2, z1 has eye color defective phenotype, enhanceable by e(y)34 (Georgiev, 1994) wsp4, z1 has eye color defective phenotype, enhanceable by e(y)11 (Georgiev, 1994) wsp4, z1 has eye color defective phenotype, enhanceable by e(y)34 (Georgiev, 1994) wzm, z1 has eye color defective phenotype, enhanceable by mw1 (Birchler et al., 1989)
NOT Enhanced by
Statement Reference wsp1, z1 has eye color defective phenotype, non-enhanceable by e(y)21 (Georgiev, 1994) wsp2, z1 has eye color defective phenotype, non-enhanceable by e(y)21 (Georgiev, 1994) wsp4, z1 has eye color defective phenotype, non-enhanceable by e(y)21 (Georgiev, 1994)
Suppressed by
Statement Reference z1 has eye color defective | recessive phenotype, suppressible by Dvir\z+tCa (Chen et al., 1992) z1 has eye color defective phenotype, suppressible by E(z)60 (Wu et al., 1989) z1 has eye color defective phenotype, suppressible by E(z)60/E(z)61 (Wu et al., 1989) z1 has eye color defective phenotype, suppressible by E(z)61   z1 has eye color defective phenotype, suppressible by Su(z)21 (Wu et al., 1989) z1 has eye color defective phenotype, suppressible by Su(z)24-31 (Emmons et al., 2009) z1 has eye color defective phenotype, suppressible by Su(z)24-34 (Emmons et al., 2009) z1 has eye color defective phenotype, suppressible by Su(z)24 (Wu et al., 1989) z1 has eye color defective phenotype, suppressible by Su(z)25 (Wu et al., 1989)
Enhancer of
Statement Reference z1 is an enhancer of eye color defective phenotype of g2 (Lloyd et al., 2002) z1 is an enhancer of eye color defective phenotype of g50e (Lloyd et al., 2002) z1 is an enhancer of eye color defective phenotype of g53d (Lloyd et al., 2002) z1 is an enhancer of eye color defective phenotype of wMcp.scs'.21, ywe.Mcp.1 (Muller et al., 1999) z1 is an enhancer of eye color defective phenotype of wMcp.y.scs'.1, ywe.Mcp.2 (Muller et al., 1999) z1 is an enhancer of eye color defective phenotype of wsp1 (Georgiev, 1994) z1 is an enhancer of eye color defective phenotype of wsp2 (Georgiev, 1994) z1 is an enhancer of eye color defective phenotype of wsp4 (Georgiev, 1994) z1 is an enhancer of visible | dominant phenotype of snaSco/snaSco (Fuse et al., 1999)
Suppressor of
Statement Reference z1 is a suppressor | partially of visible phenotype of ap56f/Df(2R)DG (Gohl et al., 2008) z1 is a suppressor of eye color defective phenotype of wMcp.scs'.21, ywe.Mcp.1 (Muller et al., 1999) z1 is a suppressor of eye color defective phenotype of wMcp.y.scs'.1, ywe.Mcp.1 (Muller et al., 1999)
Other
Statement Reference Dp(1;1)w+61e19, z1 has eye color defective phenotype (Bhadra et al., 1997) Dp(1;1)wrdp+, z1 has eye color defective phenotype (Rosen et al., 1998) E(z)[+]/E(z)Trm, z1 has eye color defective phenotype (Bajusz et al., 2001) E(z)Trm, z1 has eye color defective phenotype (Bajusz et al., 2001) E(z)Trm/In(3L)Ez2, z1 has eye color defective phenotype (Bajusz et al., 2001, Bajusz et al., 2001) Low1, wa, z1 has eye color defective phenotype (Bhadra et al., 1997) Trl13C, z1 has lethal | recessive phenotype (Laney and Biggin, 1996) wd1, z1 has visible | heat sensitive phenotype (Coen, 1990) wzm, z1 has eye color defective phenotype (Birchler et al., 1989)
Phenotype Manifest In
Enhanced by
Statement Reference g53d, z[+]/z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1 (Lloyd et al., 2002) g53d, z1 has pigment cell | male phenotype, enhanceable by E(z)1 (Lloyd et al., 2002) g53d, z1 has pigment cell phenotype, enhanceable | male by E(z)1 (Lloyd et al., 2002) g53d/g[+], z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1 (Lloyd et al., 2002) wsp1, z1 has pigment cell phenotype, enhanceable by e(y)11 (Georgiev, 1994) wsp1, z1 has pigment cell phenotype, enhanceable by e(y)34 (Georgiev, 1994) wsp2, z1 has pigment cell phenotype, enhanceable by e(y)11 (Georgiev, 1994) wsp2, z1 has pigment cell phenotype, enhanceable by e(y)34 (Georgiev, 1994) wsp4, z1 has pigment cell phenotype, enhanceable by e(y)11 (Georgiev, 1994) wsp4, z1 has pigment cell phenotype, enhanceable by e(y)34 (Georgiev, 1994) wzm, z1 has pigment cell phenotype, enhanceable by mw1 (Birchler et al., 1989) z1 has phenotype, enhanceable by Df(2R)M41A1 (Rasmuson-Lestander et al., 1993) z1 has phenotype, enhanceable by Df(2R)M41A4 (Rasmuson-Lestander et al., 1993) z1 has phenotype, enhanceable by Df(2R)M41A8 (Rasmuson-Lestander et al., 1993) z1 has phenotype, enhanceable by Df(YL)G22 (Rasmuson-Lestander et al., 1993) z1 has phenotype, enhanceable by Df(YL)S10 (Rasmuson-Lestander et al., 1993) z1 has phenotype, enhanceable by e(y)34 (Georgiev, 1994) z1 has phenotype, enhanceable by E(z)1 (Kalisch and Rasmuson, 1974, Jones and Gelbart, 1990) z1 has phenotype, enhanceable by E(z)2 (Kalisch and Rasmuson, 1974) z1 has phenotype, enhanceable by E(z)3 (Kalisch and Rasmuson, 1974) z1 has phenotype, enhanceable by E(z)4 (Kalisch and Rasmuson, 1974)
NOT Enhanced by
Statement Reference wsp1, z1 has pigment cell phenotype, non-enhanceable by e(y)21 (Georgiev, 1994) wsp2, z1 has pigment cell phenotype, non-enhanceable by e(y)21 (Georgiev, 1994) wsp4, z1 has pigment cell phenotype, non-enhanceable by e(y)21 (Georgiev, 1994) z1 has phenotype, non-enhanceable by Alhunspecified (Perrin et al., 2003) z1 has phenotype, non-enhanceable by Inr-aEMS2 (Bhadra et al., 1998) z1 has phenotype, non-enhanceable by Low1 (Bhadra et al., 1998) z1 has phenotype, non-enhanceable by MowEMS (Bhadra et al., 1998) z1 has phenotype, non-enhanceable by Ufo1 (Bhadra et al., 1998) z1 has phenotype, non-enhanceable by Wowunspecified (Bhadra et al., 1998)
Suppressed by
Statement Reference z1 has phenotype, suppressible by Df(YL)S6 (Rasmuson-Lestander et al., 1993) z1 has phenotype, suppressible by Df(YS)B4 (Rasmuson-Lestander et al., 1993) z1 has phenotype, suppressible by Df(YS)S12 (Rasmuson-Lestander et al., 1993) z1 has phenotype, suppressible by E(z)5   z1 has phenotype, suppressible by E(z)6   z1 has phenotype, suppressible by E(z)8   z1 has phenotype, suppressible by E(z)9   z1 has phenotype, suppressible by E(z)10   z1 has phenotype, suppressible by E(z)11   z1 has phenotype, suppressible by E(z)12   z1 has phenotype, suppressible by E(z)13   z1 has phenotype, suppressible by E(z)14   z1 has phenotype, suppressible by E(z)15   z1 has phenotype, suppressible by E(z)16   z1 has phenotype, suppressible by E(z)17   z1 has phenotype, suppressible by E(z)18   z1 has phenotype, suppressible by E(z)19   z1 has phenotype, suppressible by E(z)20   z1 has phenotype, suppressible by E(z)21   z1 has phenotype, suppressible by E(z)22   z1 has phenotype, suppressible by E(z)23   z1 has phenotype, suppressible by E(z)24   z1 has phenotype, suppressible by E(z)25   z1 has phenotype, suppressible by E(z)26   z1 has phenotype, suppressible by E(z)27   z1 has phenotype, suppressible by E(z)28   z1 has phenotype, suppressible by E(z)29   z1 has phenotype, suppressible by E(z)30   z1 has phenotype, suppressible by E(z)31   z1 has phenotype, suppressible by E(z)32   z1 has phenotype, suppressible by E(z)33   z1 has phenotype, suppressible by E(z)34   z1 has phenotype, suppressible by E(z)35   z1 has phenotype, suppressible by E(z)36   z1 has phenotype, suppressible by E(z)37   z1 has phenotype, suppressible by E(z)38   z1 has phenotype, suppressible by E(z)39   z1 has phenotype, suppressible by E(z)40   z1 has phenotype, suppressible by E(z)41   z1 has phenotype, suppressible by E(z)42   z1 has phenotype, suppressible by E(z)43   z1 has phenotype, suppressible by E(z)44   z1 has phenotype, suppressible by E(z)45   z1 has phenotype, suppressible by E(z)46   z1 has phenotype, suppressible by E(z)47   z1 has phenotype, suppressible by E(z)48   z1 has phenotype, suppressible by E(z)49   z1 has phenotype, suppressible by E(z)50   z1 has phenotype, suppressible by E(z)51   z1 has phenotype, suppressible by E(z)52   z1 has phenotype, suppressible by E(z)53   z1 has phenotype, suppressible by E(z)54   z1 has phenotype, suppressible by E(z)55   z1 has phenotype, suppressible by E(z)56   z1 has phenotype, suppressible by E(z)57   z1 has phenotype, suppressible by E(z)58   z1 has phenotype, suppressible by E(z)59   z1 has phenotype, suppressible by E(z)60 (Jones and Gelbart, 1990, Jones and Gelbart, 1993, Peterson et al., 1994) z1 has phenotype, suppressible by E(z)61 (Jones and Gelbart, 1990) z1 has phenotype, suppressible by E(z)62   z1 has phenotype, suppressible by E(z)63   z1 has phenotype, suppressible by E(z)64   z1 has phenotype, suppressible by E(z)65   z1 has phenotype, suppressible by E(z)66 (Jones and Gelbart, 1990, ) z1 has phenotype, suppressible by E(z)67   z1 has phenotype, suppressible by E(z)68   z1 has phenotype, suppressible by E(z)69   z1 has phenotype, suppressible by E(z)70   z1 has phenotype, suppressible by E(z)71   z1 has phenotype, suppressible by E(z)72   z1 has phenotype, suppressible by E(z)73   z1 has phenotype, suppressible by E(z)74   z1 has phenotype, suppressible by E(z)75   z1 has phenotype, suppressible by mxcG43 (Santamaria and Randsholt, 1995) z1 has phenotype, suppressible by mxcG46 (Santamaria and Randsholt, 1995) z1 has phenotype, suppressible by mxcG48 (Santamaria and Randsholt, 1995) z1 has phenotype, suppressible by Psc[+]/Psc1 (Brunk and Adler, 1990) z1 has phenotype, suppressible by Psc1 (Wu and Howe, 1995, Martin and Adler, 1993, Brunk et al., 1991) z1 has phenotype, suppressible by Sam-S1 (Kalisch and Rasmuson, 1974, Larsson et al., 1995) z1 has phenotype, suppressible by Scm4 (Bornemann et al., 1998) z1 has phenotype, suppressible by Scm5 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmD1 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmD2 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmET50 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmH1 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmK2 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmM36 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmM56 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmP11 (Bornemann et al., 1996) z1 has phenotype, suppressible by ScmP12 (Bornemann et al., 1996) z1 has phenotype, suppressible by ScmP22 (Bornemann et al., 1996) z1 has phenotype, suppressible by ScmR5-13 (Bornemann et al., 1998) z1 has phenotype, suppressible by ScmSuz302 (Bornemann et al., 1998) z1 has phenotype, suppressible by Su(z)21 (Kalisch and Rasmuson, 1974, Brunk et al., 1991) z1 has phenotype, suppressible by Su(z)21/Su(z)2[+] (Brunk and Adler, 1990) z1 has phenotype, suppressible by Su(z)23-1 (Wu and Howe, 1995, Kalisch and Rasmuson, 1974, Brunk et al., 1991) z1 has phenotype, suppressible by Su(z)24 (Wu and Howe, 1995, Brunk et al., 1991) z1 has phenotype, suppressible by Su(z)25 (Wu and Howe, 1995) z1 has phenotype, suppressible by Su(z)2eos (Wu and Howe, 1995) z1 has phenotype, suppressible by Su(z)41 (Kalisch and Rasmuson, 1974) z1 has phenotype, suppressible by Su(z)61 (Kalisch and Rasmuson, 1974) z1 has phenotype, suppressible by Su(z)71 (Kalisch and Rasmuson, 1974) z1 has phenotype, suppressible by w1 (Judd, 1995) z1 has phenotype, suppressible by wa/Low1 (Bhadra et al., 1997) z1 has phenotype, suppressible by wsp81d (Davison et al., 1985) z1 has pigment cell phenotype, suppressible by Dvir\z+tCa (Chen et al., 1992)
NOT suppressed by
Statement Reference z1 has phenotype, non-suppressible by Alhunspecified (Perrin et al., 2003) z1 has phenotype, non-suppressible by Inr-aEMS2 (Bhadra et al., 1998) z1 has phenotype, non-suppressible by Low1 (Bhadra et al., 1997, Bhadra et al., 1998) z1 has phenotype, non-suppressible by MowEMS (Bhadra et al., 1998) z1 has phenotype, non-suppressible by Su(z)2unspecified (Rasmuson-Lestander et al., 1993) z1 has phenotype, non-suppressible by Ufo1 (Bhadra et al., 1998) z1 has phenotype, non-suppressible by wis/Low1 (Bhadra et al., 1997) z1 has phenotype, non-suppressible by Wowunspecified (Bhadra et al., 1998)
Enhancer of
Statement Reference z1 is an enhancer of macrochaeta phenotype of snaSco/snaSco (Fuse et al., 1999) z1 is an enhancer of phenotype of ctpN1 (Melnikova et al., 1996) z1 is an enhancer of phenotype of ctpN30 (Melnikova et al., 1996) z1 is an enhancer of phenotype of wAR4-24 (Hazelrigg and Petersen, 1992) z1 is an enhancer of pigment cell phenotype of g50e (Lloyd et al., 2002) z1 is an enhancer of pigment cell phenotype of g53d (Lloyd et al., 2002) z1 is an enhancer of pigment cell phenotype of wMcp.scs'.21, ywe.Mcp.1 (Muller et al., 1999) z1 is an enhancer of pigment cell phenotype of wMcp.y.scs'.1, ywe.Mcp.2 (Muller et al., 1999) z1 is an enhancer of pigment cell phenotype of wsp1 (Georgiev, 1994) z1 is an enhancer of pigment cell phenotype of wsp2 (Georgiev, 1994) z1 is an enhancer of pigment cell phenotype of wsp4 (Georgiev, 1994)
NOT Enhancer of
Statement Reference z1/Low1 is a non-enhancer of phenotype of wis (Bhadra et al., 1997) z1 is a non-enhancer of mesothoracic leg & sex comb | ectopic phenotype of ScrMsc (Southworth and Kennison, 2002) z1 is a non-enhancer of metathoracic leg & sex comb | ectopic phenotype of ScrMsc (Southworth and Kennison, 2002) z1 is a non-enhancer of sex comb phenotype of ScrAntp-A41/ScrTpl9 (Southworth and Kennison, 2002) z1 is a non-enhancer of sex comb phenotype of ScrTpl9 (Southworth and Kennison, 2002) z1 is a non-enhancer of sex comb phenotype of ScrWrv4/ScrTpl9 (Southworth and Kennison, 2002)
Suppressor of
Statement Reference Mowgamma/z1 is a suppressor of phenotype of wis (Bhadra and Birchler, 1996) z1 is a suppressor | partially of wing phenotype of ap56f/Df(2R)DG (Gohl et al., 2008) z1 is a suppressor of phenotype of wzvl (Peterson et al., 1994) z1 is a suppressor of pigment cell phenotype of wMcp.scs'.21, ywe.Mcp.1 (Muller et al., 1999) z1 is a suppressor of pigment cell phenotype of wMcp.y.scs'.1, ywe.Mcp.1 (Muller et al., 1999)
NOT Suppressor of
Statement Reference z1/Low1 is a non-suppressor of phenotype of wis (Bhadra et al., 1997) z1 is a non-suppressor of mesothoracic leg & sex comb | ectopic phenotype of ScrMsc (Southworth and Kennison, 2002) z1 is a non-suppressor of metathoracic leg & sex comb | ectopic phenotype of ScrMsc (Southworth and Kennison, 2002) z1 is a non-suppressor of sex comb phenotype of ScrAntp-A41/ScrTpl9 (Southworth and Kennison, 2002) z1 is a non-suppressor of sex comb phenotype of ScrTpl9 (Southworth and Kennison, 2002) z1 is a non-suppressor of sex comb phenotype of ScrWrv4/ScrTpl9 (Southworth and Kennison, 2002)
Other
Statement Reference Dp(1;1)w+61e19, z1 has eye phenotype (Bhadra et al., 1997) Dp(1;1)w+61e19, z1 has pigment cell phenotype (Bhadra et al., 1997) Dp(1;1)wrdp+, z1 has pigment cell phenotype (Rosen et al., 1998) E(z)[+]/E(z)Trm, z1 has pigment cell phenotype (Bajusz et al., 2001) E(z)Trm, z1 has pigment cell phenotype (Bajusz et al., 2001) E(z)Trm/In(3L)Ez2, z1 has pigment cell phenotype (Bajusz et al., 2001, Bajusz et al., 2001) Low1, wa, z1 has eye phenotype (Bhadra et al., 1997) Low1, wa, z1 has pigment cell phenotype (Bhadra et al., 1997) wd1, z1 has pigment cell phenotype (Coen, 1990, Delattre et al., 1995) wzm, z1 has pigment cell phenotype (Birchler et al., 1989)
Additional Comments
Genetic Interactions
Statement Reference Su(z)2[4-31] suppresses the eye colour phenotype of z[1], and Su(z)2[4-34] is a weak suppressor of the eye colour phenotype of z[1]. (Emmons et al., 2009) z[1] partially suppresses the wing phenotypes seen in ap[56f]/Df(2R)DG mutant flies. z[1] does not enhance the mild wing phenotypes seen in ap[UGO35]/Df(2R)DG mutant flies. (Gohl et al., 2008) g53d, za double mutants have a reduced amount of red pigment in the eye compared to g53d single mutants in both male and female flies. The same is true for g50e and g2 alleles. Male E(z)1/+, g53d, z1 triple mutants have less red pigment in the eye than g53d, z1 double mutants. Likewise, female E(z)1/+, g53d/+, z1/+ triple mutants have a reduction in red eye pigment compared to g53d/+, z1/+ double mutants. (Lloyd et al., 2002) The average number of sex comb teeth per first leg in ScrTpl9 heterozygous males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of sex comb teeth per first leg in ScrTpl9/ScrAntp-A41 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The viability and average number of sex comb teeth per first leg in ScrTpl9/ScrWrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of ectopic sex comb teeth on the second and third legs in ScrMsc heterozygous males is not affected if they are also carrying z1. (Southworth and Kennison, 2002) Eye colour: small brown spots on an otherwise wild-type background in z1/Y; E(z)Trm/+ males or z1/+; E(z)Trm/+ females. Eye colour: orange-brown in z1/Y; E(z)Trm/In(3L)Ez2 males or z1/+; E(z)Trm/In(3L)Ez2 females (rescued by dissecting out of the pupal case). (Bajusz et al., 2001) Enhances the bristle loss phenotype of Tp(2;2)Sco/+ flies. (Fuse et al., 1999) Enhances the eye colour phenotype by suppressing the transactivation of the mini-w gene seen when wMcp.y.scs'.1 and ywe.Mcp.2 are combined and when wMcp.scs'.21 and ywe.Mcp.1 are combined leading to lighter eyes. (Muller et al., 1999) z1 is dominantly suppressed by ScmM56, ScmD1, ScmSuz302, ScmM36, Scm4, ScmD2, ScmH1, ScmET50, ScmR5-13, Scm5 and ScmK2. (Bornemann et al., 1998) Dominantly represses w when one of the w genes contains a tandem duplication of the regulatory region, such as Dp(1;1)wrdp+. z1 Dp(1;1)wrdp+/+ females exhibit a red-orange eye colour between that of wild type and the yellow of hemizygous z1 Dp(1;1)wrdp+ males. Supports transvection at Ubx. (Rosen et al., 1998) Eye colour: yellow in Dp(1;1)w+61e19 male. (Bhadra et al., 1997) z1 has no effect on the mod(mdg4)ul effect on ct6. (Melnikova et al., 1996) Eye colour: fewer red/brown patches on lighter background than with z+ as z1 In(1)wm4 males and females. Eye colour: as z1 in z1 In(1)rst3 female. (Judd, 1995) Eye colour: brownish, with e(y)11 or e(y)34 in male. Eye colour: like z1, with e(y)12. (Georgiev, 1994) Eye colour: orange, as wis z1 males. Eye colour: orange, as wis z1/z+ females. Eye colour: yellow-white variegated as In(1)wis z1 males. Eye colour: red-orange or orange-yellow variegated as z1 In(1)wis/z1 w+ females. The phenotypic interactions with Df(YS)B4, Df(YL)S6, Df(YS)S12, Df(YL)G22, Df(YL)S10, Df(2R)M41A4, Df(2R)M41A1, Df(2R)M41A8 are seen in z1 In(1)wis; z1 In(1)wis; Su(z)2unspecified have an unaltered background level of pigmentation (white) but the yellow flecks in the eye are darkened to orange or red. (Rasmuson-Lestander et al., 1993)
Xenogenetic Interactions
Statement Reference Eye colour phenotype is rescued by Dvir\z+tCa. (Chen et al., 1992)
Complementation & Rescue Data
Complements	z11G3 (Gans, 1953)
Rescued by	z1 is rescued by zCZ (Chen and Pirrotta, 1993)
Comments	Rescue is dosage-dependent. (Chen and Pirrotta, 1993)
Stocks ( 76 )
Bloomington	200 z1 w11E4 3604 sc1 z1 wDZL 102 sc1 z1 Nfa-g62
Kyoto	101273 z1 101167 pn1 z1 105784 z1 w11E4 101181 sc1 z1 wh 101030 sc1 z1 ec1 101168 pn1 z1 wis 101182 sc1 z1 wis 101183 sc1 z1 wzmzrb 105735 sc1 z1 Nfa-g62
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Notes on Origin
Discoverer	Gans, Feb. 1946.
Comments
	z1 mediated repression of flies carrying two to five ectopic w genes (produced using Tp(1;2)TE35B derivatives) is insensitive to copy number and does not distinguish between w genes that are in cis or in trans. Suppression does not require the juxtaposition of even numbers of w genes, but is extremely sensitive to chromosomal topology. (Gubb et al., 1997) All iab-7 PRE pairing-sensitive lines show strong interactions with z1 when the transgene insert is heterozygous: dominant enhancement of iab-7 PRE repression. (Hagstrom et al., 1997) Does not suppress transvection of UbxCbx-1/+. (Goldsborough and Kornberg, 1996) Does not effect the level of w expression in ph-plac+3 flies. (Fauvarque et al., 1995) Does not alter the effect of mod(mdg4)ul on y2/y+. (Georgiev and Corces, 1995) The phenotype of Abd-Biab7-MX2/Abd-Biab8-D14 is unaffected by alleles of z. (Hendrickson and Sakonju, 1995) Expression of the mutant lemon yellow eye colour requires two proximate or paired copies of w+ Paired copies of In(1)wm4 are not repressed by z1. Repression of In(1)wm4 by z1 cannot be restored by Su(var)205. z1 In(1)rst3 combination exhibits more extreme variegation for rst than seen in z+ In(1)rst3 combination. Recessive enhancer of PEV in a fashion clearly distinguishable from standard transvection effects. (Judd, 1995) Every w+ gene must be near another w+ gene in order for the z1 phenotype to be realized. (Wu and Howe, 1995) z1 gene product in combination with structural changes imposed by transposons and intercalary heterochromatin, modifies the determination and stability of w expression. (Peterson et al., 1994) The z1 mutation causes a new hydrophobic nucleus in the region of the protein preceding the C-terminal domain, resulting in a further stage of multimerization. (Chen and Pirrotta, 1993) Causes a specific underexpression of w in the eye when two copies of the w gene are physically apposed by chromosome pairing or by tandem duplication. Expression of w in other tissues is not affected. Behaves like z+ in promoting transvection effects at Ubx but fails to permit transvection at the dpp locus. (Bickel and Pirrotta, 1990) Unpaired w+ alleles suppress z1 eye colour. (Wu et al., 1989) z1 product subliminally inhibits the complementation of dpphr4 and dppd-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis. (Smolik-Utlaut and Gelbart, 1987) This allele behaves as an antagonist of normal z function. (Mariani et al., 1985) Allelic series: zop6 > zop11 > zRN4 > z1 > zRN1 > wild type. (Lifschytz and Green, 1984) Two synapsed copies of w+ are required for expression of zeste eye color. (Gans, 1953) Supports transvection at Ubx but not at dpp.
External Crossreferences & Linkouts
Other Crossreferences
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Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	unspecified (Bhadra et al., 1997) z1 (Sultana et al., 2011, Gohl et al., 2008, Emmons et al., 2009)
Name Synonym
Secondary FlyBase IDs
	FBal0062327
References ( 105 )
Generate a list of	All references relating to this allele ( 105 )
List References by type	Research paper  ( 89 ) Review  ( 8 ) Personal communication to FlyBase  ( 1 ) Abstract  ( 6 ) Stock list  ( 1 )
Recent research papers ( 1 )
	Sultana et al., 2011, Nucleic Acids Res. 39(9): 3543--3557 A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. [FBrf0213641] Show all research papers ...
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	All reviews listed in FlyBase were published before 2011 Show reviews ...