FlyBase Allele Report: Dmel\z[1]

(Muller et al., 1999, Hagstrom et al., 1997, Simonelig et al., 1996, Judd, 1995, Peterson et al., 1994, Tearle, 1991, Mariani et al., 1985)

Mutagen

spontaneous

(Mariani et al., 1985)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point mutation

X:2,449,753..2,449,753 [+]

Nucleotide change:

A2449753T

Amino acid change:

K425M | z-PA; K425M | z-PB; K425M | z-PC

Reported amino acid change:

K425M

Comment:

z¹ carries several polymorphisms in addition to the K425M substitution.

(Bickel and Pirrotta, 1990, Pirrotta et al., 1987)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Pattatucci and Kaufman, 1991)

Nature of the lesion

Statement

Reference

Amino acid replacement: K425M.

(Rosen et al., 1998, Chen et al., 1992, Bickel and Pirrotta, 1990)

Single base change that causes the replacement of Lys with Met.

(Judd, 1995)

Point mutation.

(Georgiev, 1994)

Amino acid replacement: K425M. Amino acid replacement: S496A. S496A is also found in wild type flies.

(Chen and Pirrotta, 1993)

Comparison between the sequences of z⁺ and z^a shows many polymorphisms concentrated in the middle, repetitive part of the gene (Pirrotta, Manet, Hardon, Bickel and Benson, 1987). There are no changes in the 5' flanking region or in the untranslated leader. Most of the changes do not affect the predicted amino acid sequence since they are in the introns or in the third position of the codons; the change from A to T (Lys to Met in the middle repetitive part of the protein) is believed to have an important effect on the properties of the mutant product (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

eye color defective

(Rosen et al., 1998, Wu and Howe, 1995, Smolik-Utlaut and Gelbart, 1987)

eye color defective | recessive

(Chen et al., 1992)

visible

(Judd, 1995)

visible | recessive

Phenotype Manifest In

pigment cell

(Rosen et al., 1998, Wu and Howe, 1995, Chen et al., 1992, Smolik-Utlaut and Gelbart, 1987)

Detailed Description

Statement

Reference

Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosomes.

(Cryderman et al., 1999)

Eye colour: zeste with white sectors with w^11E4; T(Y;2)TE35B-51. Eye colour: zeste with white sectors with w^11E4; T(Y;2)TE35B-204. Eye colour: zeste with white sectors with w^11E4; In(2L)TE35B-63. Eye colour: zeste with white sectors with w^11E4; In(2LR)TE35B-50. Eye colour: zeste with white sectors with w^11E4; T(2;3)TE35B-202. Eye colour: zeste with white sectors with w^11E4; T(2;3)TE35B-GV209. Eye colour: zeste with white sectors with w^11E4; T(2;3)TE35B-221. Eye colour: zeste with white sectors with w^11E4; T(2;3)TE35B-229. Eye colour: zeste with white sectors with w^11E4; Tp(2;3)TE35B-203. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR17. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR20. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR2. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR5. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR9. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR19. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR57. Eye colour: orange/brown with w^11E4; Tp(1;2)TE35B-GR12. Eye colour: orange/brown with w^11E4; Tp(1;2)TE35B-GR21. Eye colour: orange/brown with w^11E4; Tp(1;2)TE35B-GR23. Eye colour: zeste with red crescent with w^11E4; T(1;2)TE35B-217. Eye colour: zeste with w^11E4; In(2LR)TE35B-4. Eye colour: dark-zeste with w^11E4; Tp(1;2)TE35B-GR20/Tp(1;2)TE35B. Eye colour: zeste with w^11E4; Tp(1;2)TE35B/Tp(1;2)TE35B. Eye colour: zeste with w^11E4; Tp(1;2)TE35B/Tp(1;2)TE35BC. Eye colour: zeste with w^11E4; Tp(1;2)TE35B-SR22/Tp(1;2)TE35B. Eye colour: zeste with w^11E4; In(2LR)TE35B-4/Tp(1;2)TE35B-SR22. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR17/Tp(1;2)TE35B. Eye colour: red with w^11E4; Tp(1;2)TE35B-GR9/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w^11E4; Tp(1;2)TE35B-SZ1/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w^11E4; Tp(1;2)TE35B-GR2/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w^11E4; Tp(1;2)TE35B-GR12/Tp(1;2)TE35B

(Gubb et al., 1997)

Eye colour: yellow, in w⁺/w⁺ female; wild-type in w⁺ male. Eye colour: dark red/brown mottled as z⁺ In(1)w^m4 at 25^oC.

(Judd, 1995)

Eye colour: yellow, in w⁺/w⁺ female; wild-type in w⁺ male.

(Wu and Howe, 1995)

Eye colour: white in z¹ w^zl; In(3)Msu¹/In(3)Msu². In(3)Msu¹ and In(3)Msu² have no effect on z¹, w^zm.

(Csink et al., 1994)

Eye colour: yellow, in w⁺/w⁺ female; wild-type in male.

(Chen and Pirrotta, 1993)

Eye colour: yellow as homozygote.

(Chen et al., 1992)

Eye colour: white in homozygous z¹ w^e59 female. Eye colour: yellow in z¹/z¹ w^e59/+ female. Eye colour: ligher than w^e59 in z¹ w^e59 male.

(Dalby and O'Hare, 1991)

Eye colour: yellow, in w⁺/w⁺ female. Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type.

(Tearle, 1991)

Eye colour: yellow, in w⁺/w⁺ female.

(Wu et al., 1989, Smolik-Utlaut and Gelbart, 1987)

Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type. Eye colour: yellow, in w⁺/w⁺ female at 25^oC, mottled yellow and brownish red at 19^oC; wild-type in w⁺/Y male.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

g^53d/g[+], z¹ has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

g^53d, z[+]/z¹ has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

g^53d, z¹ has eye color defective | male phenotype, enhanceable by E(z)¹

(Lloyd et al., 2002)

w^sp2, z¹ has eye color defective phenotype, enhanceable by e(y)1¹

(Georgiev, 1994)

w^sp2, z¹ has eye color defective phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp4, z¹ has eye color defective phenotype, enhanceable by e(y)1¹

(Georgiev, 1994)

w^sp4, z¹ has eye color defective phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp1, z¹ has eye color defective phenotype, enhanceable by e(y)1¹

(Georgiev, 1994)

w^sp1, z¹ has eye color defective phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^zm, z¹ has eye color defective phenotype, enhanceable by mw¹

(Birchler et al., 1989)

NOT Enhanced by

Statement

Reference

w^sp2, z¹ has eye color defective phenotype, non-enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp4, z¹ has eye color defective phenotype, non-enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp1, z¹ has eye color defective phenotype, non-enhanceable by e(y)2¹

(Georgiev, 1994)

Suppressed by

Statement

Reference

z¹ has eye color defective phenotype, suppressible by Su(z)2^4-31

(Emmons et al., 2009)

z¹ has eye color defective phenotype, suppressible by Su(z)2^4-34

(Emmons et al., 2009)

z¹ has eye color defective | recessive phenotype, suppressible by Dvir\z^+tCa

(Chen et al., 1992)

z¹ has eye color defective phenotype, suppressible by Su(z)2⁴

(Wu et al., 1989)

z¹ has eye color defective phenotype, suppressible by Su(z)2⁵

(Wu et al., 1989)

z¹ has eye color defective phenotype, suppressible by E(z)⁶⁰

(Wu et al., 1989)

z¹ has eye color defective phenotype, suppressible by E(z)⁶⁰/E(z)⁶¹

(Wu et al., 1989)

z¹ has eye color defective phenotype, suppressible by Su(z)2¹

(Wu et al., 1989)

z¹ has eye color defective phenotype, suppressible by E(z)⁶¹

Enhancer of

Statement

Reference

z¹ is an enhancer of eye color defective phenotype of g^53d

(Lloyd et al., 2002)

z¹ is an enhancer of eye color defective phenotype of g²

(Lloyd et al., 2002)

z¹ is an enhancer of eye color defective phenotype of g^50e

(Lloyd et al., 2002)

z¹ is an enhancer of visible | dominant phenotype of sna^Sco/sna^Sco

(Fuse et al., 1999)

z¹ is an enhancer of eye color defective phenotype of w^sp2

(Georgiev, 1994)

z¹ is an enhancer of eye color defective phenotype of w^sp4

(Georgiev, 1994)

z¹ is an enhancer of eye color defective phenotype of w^sp1

(Georgiev, 1994)

Suppressor of

Statement

Reference

z[+]/z¹ is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

z[+]/z¹ is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

z¹ is a suppressor | partially of visible phenotype of ap^56f/Df(2R)DG

(Gohl et al., 2008)

Other

Statement

Reference

E(z)^Trm, z¹ has eye color defective phenotype

(Bajusz et al., 2001)

E(z)^Trm/In(3L)Ez2, z¹ has eye color defective phenotype

(Bajusz et al., 2001)

E(z)[+]/E(z)^Trm, z¹ has eye color defective phenotype

(Bajusz et al., 2001)

Dp(1;1)w^rdp+, z¹ has eye color defective phenotype

(Rosen et al., 1998)

Dp(1;1)w⁺61e19, z¹ has eye color defective phenotype

(Bhadra et al., 1997)

Low¹, w^a, z¹ has eye color defective phenotype

(Bhadra et al., 1997)

Trl^13C, z¹ has lethal | recessive phenotype

(Laney and Biggin, 1996)

w^d1, z¹ has visible | heat sensitive phenotype

(Coen, 1990)

w^zm, z¹ has eye color defective phenotype

(Birchler et al., 1989)

Phenotype Manifest In

Enhanced by

Statement

Reference

g^53d, z¹ has pigment cell | male phenotype, enhanceable by E(z)¹

(Lloyd et al., 2002)

g^53d, z¹ has pigment cell phenotype, enhanceable | male by E(z)¹

(Lloyd et al., 2002)

g^53d/g[+], z¹ has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

g^53d, z[+]/z¹ has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

z¹ has phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp2, z¹ has pigment cell phenotype, enhanceable by e(y)1¹

(Georgiev, 1994)

w^sp2, z¹ has pigment cell phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp4, z¹ has pigment cell phenotype, enhanceable by e(y)1¹

(Georgiev, 1994)

w^sp4, z¹ has pigment cell phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp1, z¹ has pigment cell phenotype, enhanceable by e(y)1¹

(Georgiev, 1994)

w^sp1, z¹ has pigment cell phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

z¹ has phenotype, enhanceable by Df(YL)G22

(Rasmuson-Lestander et al., 1993)

z¹ has phenotype, enhanceable by Df(YL)S10

(Rasmuson-Lestander et al., 1993)

z¹ has phenotype, enhanceable by Df(2R)M41A4

(Rasmuson-Lestander et al., 1993)

z¹ has phenotype, enhanceable by Df(2R)M41A1

(Rasmuson-Lestander et al., 1993)

z¹ has phenotype, enhanceable by Df(2R)M41A8

(Rasmuson-Lestander et al., 1993)

z¹ has phenotype, enhanceable by E(z)¹

(Jones and Gelbart, 1990, Kalisch and Rasmuson, 1974)

w^zm, z¹ has pigment cell phenotype, enhanceable by mw¹

(Birchler et al., 1989)

z¹ has phenotype, enhanceable by E(z)²

(Kalisch and Rasmuson, 1974)

z¹ has phenotype, enhanceable by E(z)³

(Kalisch and Rasmuson, 1974)

z¹ has phenotype, enhanceable by E(z)⁴

(Kalisch and Rasmuson, 1974)

NOT Enhanced by

Statement

Reference

z¹ has phenotype, non-enhanceable by Alh^unspecified

(Perrin et al., 2003)

z¹ has phenotype, non-enhanceable by Low¹

(Bhadra et al., 1998)

z¹ has phenotype, non-enhanceable by Pcf11^EMS2

(Bhadra et al., 1998)

z¹ has phenotype, non-enhanceable by Mow^EMS

(Bhadra et al., 1998)

z¹ has phenotype, non-enhanceable by Ufo¹

(Bhadra et al., 1998)

z¹ has phenotype, non-enhanceable by Wow^unspecified

(Bhadra et al., 1998)

w^sp2, z¹ has pigment cell phenotype, non-enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp4, z¹ has pigment cell phenotype, non-enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp1, z¹ has pigment cell phenotype, non-enhanceable by e(y)2¹

(Georgiev, 1994)

Suppressed by

Statement

Reference

z¹ has phenotype, suppressible by Scm⁴

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm⁵

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^D1

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^D2

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^ET50

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^H1

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^K2

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^M36

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^M56

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^R5-13

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by Scm^Suz302

(Bornemann et al., 1998)

z¹ has phenotype, suppressible by w^a/Low¹

(Bhadra et al., 1997)

z¹ has phenotype, suppressible by Scm^P11

(Bornemann et al., 1996)

z¹ has phenotype, suppressible by Scm^P12

(Bornemann et al., 1996)

z¹ has phenotype, suppressible by Scm^P22

(Bornemann et al., 1996)

z¹ has phenotype, suppressible by w¹

(Judd, 1995)

z¹ has phenotype, suppressible by Sam-S¹

(Larsson et al., 1995, Kalisch and Rasmuson, 1974)

z¹ has phenotype, suppressible by Su(z)2^3-1

(Wu and Howe, 1995, Brunk et al., 1991, Kalisch and Rasmuson, 1974)

z¹ has phenotype, suppressible by mxc^G43

(Santamaria and Randsholt, 1995)

z¹ has phenotype, suppressible by mxc^G46

(Santamaria and Randsholt, 1995)

z¹ has phenotype, suppressible by mxc^G48

(Santamaria and Randsholt, 1995)

z¹ has phenotype, suppressible by Psc¹

(Wu and Howe, 1995, Martin and Adler, 1993, Brunk et al., 1991)

z¹ has phenotype, suppressible by Su(z)2⁴

(Wu and Howe, 1995, Brunk et al., 1991)

z¹ has phenotype, suppressible by Su(z)2⁵

(Wu and Howe, 1995)

z¹ has phenotype, suppressible by Su(z)2^eos

(Wu and Howe, 1995)

z¹ has phenotype, suppressible by E(z)⁶⁰

(Peterson et al., 1994, Jones and Gelbart, 1993, Jones and Gelbart, 1990)

z¹ has phenotype, suppressible by Df(YS)B4

(Rasmuson-Lestander et al., 1993)

z¹ has phenotype, suppressible by Df(YL)S6

(Rasmuson-Lestander et al., 1993)

z¹ has phenotype, suppressible by Df(YS)S12

(Rasmuson-Lestander et al., 1993)

z¹ has pigment cell phenotype, suppressible by Dvir\z^+tCa

(Chen et al., 1992)

z¹ has phenotype, suppressible by Su(z)2¹

(Brunk et al., 1991, Kalisch and Rasmuson, 1974)

z¹ has phenotype, suppressible by Psc[+]/Psc¹

(Brunk and Adler, 1990)

z¹ has phenotype, suppressible by Su(z)2¹/Su(z)2[+]

(Brunk and Adler, 1990)

z¹ has phenotype, suppressible by E(z)⁶¹

(Jones and Gelbart, 1990)

z¹ has phenotype, suppressible by E(z)⁶⁶

(Jones and Gelbart, 1990)

z¹ has phenotype, suppressible by w^sp81d

(Davison et al., 1985)

z¹ has phenotype, suppressible by Su(z)4¹

(Kalisch and Rasmuson, 1974)

z¹ has phenotype, suppressible by Su(z)6¹

(Kalisch and Rasmuson, 1974)

z¹ has phenotype, suppressible by Su(z)7¹

(Kalisch and Rasmuson, 1974)

z¹ has phenotype, suppressible by E(z)³⁷

z¹ has phenotype, suppressible by E(z)³⁸

z¹ has phenotype, suppressible by E(z)³⁹

z¹ has phenotype, suppressible by E(z)⁴⁰

z¹ has phenotype, suppressible by E(z)⁴¹

z¹ has phenotype, suppressible by E(z)⁴²

z¹ has phenotype, suppressible by E(z)⁴³

z¹ has phenotype, suppressible by E(z)⁴⁴

z¹ has phenotype, suppressible by E(z)⁴⁵

z¹ has phenotype, suppressible by E(z)⁴⁶

z¹ has phenotype, suppressible by E(z)⁴⁷

z¹ has phenotype, suppressible by E(z)⁴⁸

z¹ has phenotype, suppressible by E(z)⁴⁹

z¹ has phenotype, suppressible by E(z)⁵⁰

z¹ has phenotype, suppressible by E(z)⁵¹

z¹ has phenotype, suppressible by E(z)⁵²

z¹ has phenotype, suppressible by E(z)⁵³

z¹ has phenotype, suppressible by E(z)⁵⁴

z¹ has phenotype, suppressible by E(z)⁵⁵

z¹ has phenotype, suppressible by E(z)⁵⁶

z¹ has phenotype, suppressible by E(z)⁵⁷

z¹ has phenotype, suppressible by E(z)⁵⁸

z¹ has phenotype, suppressible by E(z)⁵⁹

z¹ has phenotype, suppressible by E(z)⁵

z¹ has phenotype, suppressible by E(z)⁶²

z¹ has phenotype, suppressible by E(z)⁶³

z¹ has phenotype, suppressible by E(z)⁶⁴

z¹ has phenotype, suppressible by E(z)⁶⁵

z¹ has phenotype, suppressible by E(z)⁶⁷

z¹ has phenotype, suppressible by E(z)⁶⁸

z¹ has phenotype, suppressible by E(z)⁶⁹

z¹ has phenotype, suppressible by E(z)⁶

z¹ has phenotype, suppressible by E(z)⁷⁰

z¹ has phenotype, suppressible by E(z)⁷¹

z¹ has phenotype, suppressible by E(z)⁷²

z¹ has phenotype, suppressible by E(z)⁷³

z¹ has phenotype, suppressible by E(z)⁷⁴

z¹ has phenotype, suppressible by E(z)⁷⁵

z¹ has phenotype, suppressible by E(z)⁸

z¹ has phenotype, suppressible by E(z)⁹

z¹ has phenotype, suppressible by E(z)¹⁰

z¹ has phenotype, suppressible by E(z)¹¹

z¹ has phenotype, suppressible by E(z)¹²

z¹ has phenotype, suppressible by E(z)¹³

z¹ has phenotype, suppressible by E(z)¹⁴

z¹ has phenotype, suppressible by E(z)¹⁵

z¹ has phenotype, suppressible by E(z)¹⁶

z¹ has phenotype, suppressible by E(z)¹⁷

z¹ has phenotype, suppressible by E(z)¹⁸

z¹ has phenotype, suppressible by E(z)¹⁹

z¹ has phenotype, suppressible by E(z)²⁰

z¹ has phenotype, suppressible by E(z)²¹

z¹ has phenotype, suppressible by E(z)²²

z¹ has phenotype, suppressible by E(z)²³

z¹ has phenotype, suppressible by E(z)²⁴

z¹ has phenotype, suppressible by E(z)²⁵

z¹ has phenotype, suppressible by E(z)²⁶

z¹ has phenotype, suppressible by E(z)²⁷

z¹ has phenotype, suppressible by E(z)²⁸

z¹ has phenotype, suppressible by E(z)²⁹

z¹ has phenotype, suppressible by E(z)³⁰

z¹ has phenotype, suppressible by E(z)³¹

z¹ has phenotype, suppressible by E(z)³²

z¹ has phenotype, suppressible by E(z)³³

z¹ has phenotype, suppressible by E(z)³⁴

z¹ has phenotype, suppressible by E(z)³⁵

z¹ has phenotype, suppressible by E(z)³⁶

NOT suppressed by

Statement

Reference

z¹ has phenotype, non-suppressible by Alh^unspecified

(Perrin et al., 2003)

z¹ has phenotype, non-suppressible by Low¹

(Bhadra et al., 1998, Bhadra et al., 1997)

z¹ has phenotype, non-suppressible by Pcf11^EMS2

(Bhadra et al., 1998)

z¹ has phenotype, non-suppressible by Mow^EMS

(Bhadra et al., 1998)

z¹ has phenotype, non-suppressible by Ufo¹

(Bhadra et al., 1998)

z¹ has phenotype, non-suppressible by Wow^unspecified

(Bhadra et al., 1998)

z¹ has phenotype, non-suppressible by w^is/Low¹

(Bhadra et al., 1997)

z¹ has phenotype, non-suppressible by Su(z)2^unspecified

(Rasmuson-Lestander et al., 1993)

Enhancer of

Statement

Reference

z¹ is an enhancer of pigment cell phenotype of g^53d

(Lloyd et al., 2002)

z¹ is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

z¹ is an enhancer of macrochaeta phenotype of sna^Sco/sna^Sco

(Fuse et al., 1999)

z¹ is an enhancer of phenotype of ct^pN1

(Melnikova et al., 1996)

z¹ is an enhancer of phenotype of ct^pN30

(Melnikova et al., 1996)

z¹ is an enhancer of pigment cell phenotype of w^sp2

(Georgiev, 1994)

z¹ is an enhancer of pigment cell phenotype of w^sp4

(Georgiev, 1994)

z¹ is an enhancer of pigment cell phenotype of w^sp1

(Georgiev, 1994)

z¹ is an enhancer of phenotype of w^AR4-24

(Hazelrigg and Petersen, 1992)

NOT Enhancer of

Statement

Reference

z¹ is a non-enhancer of sex comb phenotype of Scr^Wrv4/Scr^Tpl9

(Southworth and Kennison, 2002)

z¹ is a non-enhancer of mesothoracic leg & sex comb | ectopic phenotype of Scr^Msc

(Southworth and Kennison, 2002)

z¹ is a non-enhancer of metathoracic leg & sex comb | ectopic phenotype of Scr^Msc

(Southworth and Kennison, 2002)

z¹ is a non-enhancer of sex comb phenotype of Scr^Antp-A41/Scr^Tpl9

(Southworth and Kennison, 2002)

z¹ is a non-enhancer of sex comb phenotype of Scr^Tpl9

(Southworth and Kennison, 2002)

z¹/Low¹ is a non-enhancer of phenotype of w^is

(Bhadra et al., 1997)

Suppressor of

Statement

Reference

z[+]/z¹ is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

z[+]/z¹ is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

z¹ is a suppressor | partially of wing phenotype of ap^56f/Df(2R)DG

(Gohl et al., 2008)

Mow^gamma/z¹ is a suppressor of phenotype of w^is

(Bhadra and Birchler, 1996)

z¹ is a suppressor of phenotype of w^zvl

(Peterson et al., 1994)

NOT Suppressor of

Statement

Reference

z¹ is a non-suppressor of sex comb phenotype of Scr^Wrv4/Scr^Tpl9

(Southworth and Kennison, 2002)

z¹ is a non-suppressor of metathoracic leg & sex comb | ectopic phenotype of Scr^Msc

(Southworth and Kennison, 2002)

z¹ is a non-suppressor of mesothoracic leg & sex comb | ectopic phenotype of Scr^Msc

(Southworth and Kennison, 2002)

z¹ is a non-suppressor of sex comb phenotype of Scr^Antp-A41/Scr^Tpl9

(Southworth and Kennison, 2002)

z¹ is a non-suppressor of sex comb phenotype of Scr^Tpl9

(Southworth and Kennison, 2002)

z¹/Low¹ is a non-suppressor of phenotype of w^is

(Bhadra et al., 1997)

Other

Statement

Reference

E(z)^Trm, z¹ has pigment cell phenotype

(Bajusz et al., 2001)

E(z)^Trm/In(3L)Ez2, z¹ has pigment cell phenotype

(Bajusz et al., 2001)

E(z)[+]/E(z)^Trm, z¹ has pigment cell phenotype

(Bajusz et al., 2001)

Dp(1;1)w^rdp+, z¹ has pigment cell phenotype

(Rosen et al., 1998)

Low¹, w^a, z¹ has eye phenotype

(Bhadra et al., 1997)

Low¹, w^a, z¹ has pigment cell phenotype

(Bhadra et al., 1997)

Dp(1;1)w⁺61e19, z¹ has eye phenotype

(Bhadra et al., 1997)

Dp(1;1)w⁺61e19, z¹ has pigment cell phenotype

(Bhadra et al., 1997)

w^d1, z¹ has pigment cell phenotype

(Delattre et al., 1995, Coen, 1990)

w^zm, z¹ has pigment cell phenotype

(Birchler et al., 1989)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of z¹.

(Morimoto et al., 2016)

Su(z)2^4-31 suppresses the eye colour phenotype of z¹, and Su(z)2^4-34 is a weak suppressor of the eye colour phenotype of z¹.

(Emmons et al., 2009)

z¹ partially suppresses the wing phenotypes seen in ap^56f/Df(2R)DG mutant flies. z¹ does not enhance the mild wing phenotypes seen in ap^UGO35/Df(2R)DG mutant flies.

(Gohl et al., 2008)

g^53d, z^a double mutants have a reduced amount of red pigment in the eye compared to g^53d single mutants in both male and female flies. The same is true for g^50e and g² alleles. Male E(z)¹/+, g^53d, z¹ triple mutants have less red pigment in the eye than g^53d, z¹ double mutants. Likewise, female E(z)¹/+, g^53d/+, z¹/+ triple mutants have a reduction in red eye pigment compared to g^53d/+, z¹/+ double mutants.

(Lloyd et al., 2002)

The average number of sex comb teeth per first leg in Scr^Tpl9 heterozygous males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) is not affected if they are also carrying z¹. The average number of sex comb teeth per first leg in Scr^Tpl9/Scr^Antp-A41 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) is not affected if they are also carrying z¹. The viability and average number of sex comb teeth per first leg in Scr^Tpl9/Scr^Wrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) is not affected if they are also carrying z¹. The average number of ectopic sex comb teeth on the second and third legs in Scr^Msc heterozygous males is not affected if they are also carrying z¹.

(Southworth and Kennison, 2002)

Eye colour: small brown spots on an otherwise wild-type background in z¹/Y; E(z)^Trm/+ males or z¹/+; E(z)^Trm/+ females. Eye colour: orange-brown in z¹/Y; E(z)^Trm/In(3L)Ez2 males or z¹/+; E(z)^Trm/In(3L)Ez2 females (rescued by dissecting out of the pupal case).

(Bajusz et al., 2001)

Enhances the bristle loss phenotype of Tp(2;2)Sco/+ flies.

(Fuse et al., 1999)

Enhances the eye colour phenotype by suppressing the transactivation of the mini-w gene seen when w^Mcp.y.scs'.1 and y^we.Mcp.2 are combined and when w^Mcp.scs'.21 and y^we.Mcp.1 are combined leading to lighter eyes.

(Muller et al., 1999)

z¹ is dominantly suppressed by Scm^M56, Scm^D1, Scm^Suz302, Scm^M36, Scm⁴, Scm^D2, Scm^H1, Scm^ET50, Scm^R5-13, Scm⁵ and Scm^K2.

(Bornemann et al., 1998)

Dominantly represses w when one of the w genes contains a tandem duplication of the regulatory region, such as Dp(1;1)w^rdp+. z¹ Dp(1;1)w^rdp+/+ females exhibit a red-orange eye colour between that of wild type and the yellow of hemizygous z¹ Dp(1;1)w^rdp+ males. Supports transvection at Ubx.

(Rosen et al., 1998)

Eye colour: yellow in Dp(1;1)w⁺61e19 male.

(Bhadra et al., 1997)

z¹ has no effect on the mod(mdg4)^ul effect on ct⁶.

(Melnikova et al., 1996)

Eye colour: fewer red/brown patches on lighter background than with z⁺ as z¹ In(1)w^m4 males and females. Eye colour: as z¹ in z¹ In(1)rst³ female.

(Judd, 1995)

Eye colour: brownish, with e(y)1¹ or e(y)3⁴ in male. Eye colour: like z¹, with e(y)1².

(Georgiev, 1994)

Eye colour: orange, as w^is z¹ males. Eye colour: orange, as w^is z¹/z⁺ females. Eye colour: yellow-white variegated as In(1)w^is z¹ males. Eye colour: red-orange or orange-yellow variegated as z¹ In(1)w^is/z¹ w⁺ females. The phenotypic interactions with Df(YS)B4, Df(YL)S6, Df(YS)S12, Df(YL)G22, Df(YL)S10, Df(2R)M41A4, Df(2R)M41A1, Df(2R)M41A8 are seen in z¹ In(1)w^is; z¹ In(1)w^is; Su(z)2^unspecified have an unaltered background level of pigmentation (white) but the yellow flecks in the eye are darkened to orange or red.

(Rasmuson-Lestander et al., 1993)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is ameliorated by combination with a single copy of z¹.

(Morimoto et al., 2016)

Eye colour phenotype is rescued by Dvir\z^+tCa.

(Chen et al., 1992)

Complementation and Rescue Data

Complements

z^11G3

(Gans, 1953)

Rescued by

z¹ is rescued by z^CZ

(Chen and Pirrotta, 1993)

Comments

Rescue is dosage-dependent.

(Chen and Pirrotta, 1993)

Images (0)

Mutant

Wild-type

Stocks (75)

Bloomington

200

z¹ w^11E4

3604

sc¹ z¹ w^DZL

102

sc¹ z¹ N^fa-g62

Kyoto

101273

z¹

101167

pn¹ z¹

105784

z¹ w^11E4

101181

sc¹ z¹ w^h

101030

sc¹ z¹ ec¹

101168

pn¹ z¹ w^is

101182

sc¹ z¹ w^is

101183

sc¹ z¹ w^zmzrb

105735

sc¹ z¹ N^fa-g62

More stocks available...

Notes on Origin

Discoverer

Gans, Feb. 1946.

Comments

Supports transvection at Ubx but not at dpp.

Allelic series: z^op6 > z^op11 > z^RN4 > z¹ > z^RN1 > wild type.

(Lifschytz and Green, 1984)

This allele behaves as an antagonist of normal z function.

(Mariani et al., 1985)

z¹ product subliminally inhibits the complementation of dpp^hr4 and dpp^d-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis.

(Smolik-Utlaut and Gelbart, 1987)

Unpaired w⁺ alleles suppress z¹ eye colour.

(Wu et al., 1989)

Causes a specific underexpression of w in the eye when two copies of the w gene are physically apposed by chromosome pairing or by tandem duplication. Expression of w in other tissues is not affected. Behaves like z⁺ in promoting transvection effects at Ubx but fails to permit transvection at the dpp locus.

(Bickel and Pirrotta, 1990)

The z¹ mutation causes a new hydrophobic nucleus in the region of the protein preceding the C-terminal domain, resulting in a further stage of multimerization.

(Chen and Pirrotta, 1993)

z¹ gene product in combination with structural changes imposed by transposons and intercalary heterochromatin, modifies the determination and stability of w expression.

(Peterson et al., 1994)

The phenotype of Abd-B^iab7-MX2/Abd-B^iab8-D14 is unaffected by alleles of z.

(Hendrickson and Sakonju, 1995)

Does not alter the effect of mod(mdg4)^ul on y²/y⁺.

(Georgiev and Corces, 1995)

Every w⁺ gene must be near another w⁺ gene in order for the z¹ phenotype to be realized.

(Wu and Howe, 1995)

Does not effect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Expression of the mutant lemon yellow eye colour requires two proximate or paired copies of w⁺ Paired copies of In(1)w^m4 are not repressed by z¹. Repression of In(1)w^m4 by z¹ cannot be restored by Su(var)205. z¹ In(1)rst³ combination exhibits more extreme variegation for rst than seen in z⁺ In(1)rst³ combination. Recessive enhancer of PEV in a fashion clearly distinguishable from standard transvection effects.

(Judd, 1995)

Does not suppress transvection of Ubx^Cbx-1/+.

(Goldsborough and Kornberg, 1996)

Two synapsed copies of w⁺ are required for expression of zeste eye color.

(Gans, 1953)

z¹ mediated repression of flies carrying two to five ectopic w genes (produced using Tp(1;2)TE35B derivatives) is insensitive to copy number and does not distinguish between w genes that are in cis or in trans. Suppression does not require the juxtaposition of even numbers of w genes, but is extremely sensitive to chromosomal topology.

(Gubb et al., 1997)

All iab-7 PRE pairing-sensitive lines show strong interactions with z¹ when the transgene insert is heterozygous: dominant enhancement of iab-7 PRE repression.

(Hagstrom et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

unspecified

(Bhadra et al., 1997)

z¹

(Sultana et al., 2011, Emmons et al., 2009, Gohl et al., 2008)

Name Synonyms

Secondary FlyBase IDs

FBal0062327

References (106)

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