FB2022_02, released March 29, 2022

Allele: Dmel\z1

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General Information
Symbol
Dmel\z1
Species
D. melanogaster
Name
FlyBase ID
FBal0018822
Feature type
allele
Associated gene
Dmel\z
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps
Allele class

gain of function allele

neomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Lloyd et al., 2002)

neomorphic allele - genetic evidence

(Muller et al., 1999, Hagstrom et al., 1997, Simonelig et al., 1996, Judd, 1995, Peterson et al., 1994, Tearle, 1991, Mariani et al., 1985)
Mutagen
spontaneous
(Mariani et al., 1985)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point_mutation
X:2,449,753..2,449,753 [+]
Nucleotide change:

A2449753T

Amino acid change:

K425M | z-PA; K425M | z-PB; K425M | z-PC

Reported amino acid change:

K425M

Comment:

z1 carries several polymorphisms in addition to the K425M substitution.

(Bickel and Pirrotta, 1990, Pirrotta et al., 1987)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology

      Polytene chromosomes normal.

      (Pattatucci and Kaufman, 1991)
      Nature of the lesion
      Statement
      Reference

      Amino acid replacement: K425M.

      (Rosen et al., 1998, Chen et al., 1992, Bickel and Pirrotta, 1990)

      Single base change that causes the replacement of Lys with Met.

      (Judd, 1995)

      Point mutation.

      (Georgiev, 1994)

      Amino acid replacement: K425M. Amino acid replacement: S496A. S496A is also found in wild type flies.

      (Chen and Pirrotta, 1993)

      Comparison between the sequences of z+ and za shows many polymorphisms concentrated in the middle, repetitive part of the gene (Pirrotta, Manet, Hardon, Bickel and Benson, 1987). There are no changes in the 5' flanking region or in the untranslated leader. Most of the changes do not affect the predicted amino acid sequence since they are in the introns or in the third position of the codons; the change from A to T (Lys to Met in the middle repetitive part of the protein) is believed to have an important effect on the properties of the mutant product (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).

      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes.

      (Cryderman et al., 1999)

      Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-51. Eye colour: zeste with white sectors with w11E4; T(Y;2)TE35B-204. Eye colour: zeste with white sectors with w11E4; In(2L)TE35B-63. Eye colour: zeste with white sectors with w11E4; In(2LR)TE35B-50. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-202. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-GV209. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-221. Eye colour: zeste with white sectors with w11E4; T(2;3)TE35B-229. Eye colour: zeste with white sectors with w11E4; Tp(2;3)TE35B-203. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17. Eye colour: red with w11E4; Tp(1;2)TE35B-GR20. Eye colour: red with w11E4; Tp(1;2)TE35B-GR2. Eye colour: red with w11E4; Tp(1;2)TE35B-GR5. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9. Eye colour: red with w11E4; Tp(1;2)TE35B-GR19. Eye colour: red with w11E4; Tp(1;2)TE35B-GR57. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR12. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR21. Eye colour: orange/brown with w11E4; Tp(1;2)TE35B-GR23. Eye colour: zeste with red crescent with w11E4; T(1;2)TE35B-217. Eye colour: zeste with w11E4; In(2LR)TE35B-4. Eye colour: dark-zeste with w11E4; Tp(1;2)TE35B-GR20/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35B. Eye colour: zeste with w11E4; Tp(1;2)TE35B/Tp(1;2)TE35BC. Eye colour: zeste with w11E4; Tp(1;2)TE35B-SR22/Tp(1;2)TE35B. Eye colour: zeste with w11E4; In(2LR)TE35B-4/Tp(1;2)TE35B-SR22. Eye colour: red with w11E4; Tp(1;2)TE35B-GR17/Tp(1;2)TE35B. Eye colour: red with w11E4; Tp(1;2)TE35B-GR9/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-SZ1/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR2/Tp(1;2)TE35B. Eye colour: zeste with posterior red crescent with w11E4; Tp(1;2)TE35B-GR12/Tp(1;2)TE35B

      (Gubb et al., 1997)

      Eye colour: yellow, in w+/w+ female; wild-type in w+ male. Eye colour: dark red/brown mottled as z+ In(1)wm4 at 25oC.

      (Judd, 1995)

      Eye colour: yellow, in w+/w+ female; wild-type in w+ male.

      (Wu and Howe, 1995)

      Eye colour: white in z1 wzl; In(3)Msu1/In(3)Msu2. In(3)Msu1 and In(3)Msu2 have no effect on z1, wzm.

      (Csink et al., 1994)

      Eye colour: yellow, in w+/w+ female; wild-type in male.

      (Chen and Pirrotta, 1993)

      Eye colour: yellow as homozygote.

      (Chen et al., 1992)

      Eye colour: white in homozygous z1 we59 female. Eye colour: yellow in z1/z1 we59/+ female. Eye colour: ligher than we59 in z1 we59 male.

      (Dalby and O'Hare, 1991)

      Eye colour: yellow, in w+/w+ female. Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type.

      (Tearle, 1991)

      Eye colour: yellow, in w+/w+ female.

      (Wu et al., 1989, Smolik-Utlaut and Gelbart, 1987)

      Ocellus colour: wild-type. Testis colour: wild-type. Malpighian tubule colour: wild-type. Eye colour: yellow, in w+/w+ female at 25oC, mottled yellow and brownish red at 19oC; wild-type in w+/Y male.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      g53d/g[+], z1 has abnormal eye color | female phenotype, enhanceable by E(z)[+]/E(z)1

      (Lloyd et al., 2002)

      g53d, z[+]/z1 has abnormal eye color | female phenotype, enhanceable by E(z)[+]/E(z)1

      (Lloyd et al., 2002)

      g53d, z1 has abnormal eye color | male phenotype, enhanceable by E(z)1

      (Lloyd et al., 2002)

      wsp2, z1 has abnormal eye color phenotype, enhanceable by Taf91

      (Georgiev, 1994)

      wsp2, z1 has abnormal eye color phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp4, z1 has abnormal eye color phenotype, enhanceable by Taf91

      (Georgiev, 1994)

      wsp4, z1 has abnormal eye color phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp1, z1 has abnormal eye color phenotype, enhanceable by Taf91

      (Georgiev, 1994)

      wsp1, z1 has abnormal eye color phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wzm, z1 has abnormal eye color phenotype, enhanceable by mw1

      (Birchler et al., 1989)
      NOT Enhanced by
      Statement
      Reference

      wsp2, z1 has abnormal eye color phenotype, non-enhanceable by e(y)21

      (Georgiev, 1994)

      wsp4, z1 has abnormal eye color phenotype, non-enhanceable by e(y)21

      (Georgiev, 1994)

      wsp1, z1 has abnormal eye color phenotype, non-enhanceable by e(y)21

      (Georgiev, 1994)
      Suppressed by
      Statement
      Reference

      z1 has abnormal eye color phenotype, suppressible by Su(z)24-31

      (Emmons et al., 2009)

      z1 has abnormal eye color phenotype, suppressible by Su(z)24-34

      (Emmons et al., 2009)

      z1 has abnormal eye color | recessive phenotype, suppressible by Dvir\z+tCa

      (Chen et al., 1992)

      z1 has abnormal eye color phenotype, suppressible by Su(z)24

      (Wu et al., 1989)

      z1 has abnormal eye color phenotype, suppressible by Su(z)25

      (Wu et al., 1989)

      z1 has abnormal eye color phenotype, suppressible by E(z)60

      (Wu et al., 1989)

      z1 has abnormal eye color phenotype, suppressible by E(z)60/E(z)61

      (Wu et al., 1989)

      z1 has abnormal eye color phenotype, suppressible by Su(z)21

      (Wu et al., 1989)

      z1 has abnormal eye color phenotype, suppressible by E(z)61

      Enhancer of
      Statement
      Reference

      z1 is an enhancer of abnormal eye color phenotype of g53d

      (Lloyd et al., 2002)

      z1 is an enhancer of abnormal eye color phenotype of g2

      (Lloyd et al., 2002)

      z1 is an enhancer of abnormal eye color phenotype of g50e

      (Lloyd et al., 2002)

      z1 is an enhancer of visible | dominant phenotype of snaSco/snaSco

      (Fuse et al., 1999)

      z1 is an enhancer of abnormal eye color phenotype of wsp2

      (Georgiev, 1994)

      z1 is an enhancer of abnormal eye color phenotype of wsp4

      (Georgiev, 1994)

      z1 is an enhancer of abnormal eye color phenotype of wsp1

      (Georgiev, 1994)
      Suppressor of
      Statement
      Reference

      z[+]/z1 is a suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

      (Morimoto et al., 2016)

      z[+]/z1 is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096

      (Morimoto et al., 2016)

      z1 is a suppressor | partially of visible phenotype of ap56f/Df(2R)DG

      (Gohl et al., 2008)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      g53d, z1 has pigment cell | male phenotype, enhanceable by E(z)1

      (Lloyd et al., 2002)

      g53d, z1 has pigment cell phenotype, enhanceable | male by E(z)1

      (Lloyd et al., 2002)

      g53d/g[+], z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1

      (Lloyd et al., 2002)

      g53d, z[+]/z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1

      (Lloyd et al., 2002)

      z1 has phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp2, z1 has pigment cell phenotype, enhanceable by Taf91

      (Georgiev, 1994)

      wsp2, z1 has pigment cell phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp4, z1 has pigment cell phenotype, enhanceable by Taf91

      (Georgiev, 1994)

      wsp4, z1 has pigment cell phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp1, z1 has pigment cell phenotype, enhanceable by Taf91

      (Georgiev, 1994)

      wsp1, z1 has pigment cell phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      z1 has phenotype, enhanceable by Df(YL)G22

      (Rasmuson-Lestander et al., 1993)

      z1 has phenotype, enhanceable by Df(YL)S10

      (Rasmuson-Lestander et al., 1993)

      z1 has phenotype, enhanceable by Df(2R)M41A4

      (Rasmuson-Lestander et al., 1993)

      z1 has phenotype, enhanceable by Df(2R)M41A1

      (Rasmuson-Lestander et al., 1993)

      z1 has phenotype, enhanceable by Df(2R)M41A8

      (Rasmuson-Lestander et al., 1993)

      z1 has phenotype, enhanceable by E(z)1

      (Jones and Gelbart, 1990, Kalisch and Rasmuson, 1974)

      wzm, z1 has pigment cell phenotype, enhanceable by mw1

      (Birchler et al., 1989)

      z1 has phenotype, enhanceable by E(z)2

      (Kalisch and Rasmuson, 1974)

      z1 has phenotype, enhanceable by E(z)3

      (Kalisch and Rasmuson, 1974)

      z1 has phenotype, enhanceable by E(z)4

      (Kalisch and Rasmuson, 1974)
      NOT Enhanced by
      Statement
      Reference

      z1 has phenotype, non-enhanceable by Alhunspecified

      (Perrin et al., 2003)

      z1 has phenotype, non-enhanceable by Low1

      (Bhadra et al., 1998)

      z1 has phenotype, non-enhanceable by Pcf11EMS2

      (Bhadra et al., 1998)

      z1 has phenotype, non-enhanceable by MowEMS

      (Bhadra et al., 1998)

      z1 has phenotype, non-enhanceable by Ufo1

      (Bhadra et al., 1998)

      z1 has phenotype, non-enhanceable by Wowunspecified

      (Bhadra et al., 1998)

      wsp2, z1 has pigment cell phenotype, non-enhanceable by e(y)21

      (Georgiev, 1994)

      wsp4, z1 has pigment cell phenotype, non-enhanceable by e(y)21

      (Georgiev, 1994)

      wsp1, z1 has pigment cell phenotype, non-enhanceable by e(y)21

      (Georgiev, 1994)
      Suppressed by
      Statement
      Reference

      z1 has phenotype, suppressible by Scm4

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by Scm5

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmD1

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmD2

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmET50

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmH1

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmK2

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmM36

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmM56

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmR5-13

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by ScmSuz302

      (Bornemann et al., 1998)

      z1 has phenotype, suppressible by wa/Low1

      (Bhadra et al., 1997)

      z1 has phenotype, suppressible by ScmP11

      (Bornemann et al., 1996)

      z1 has phenotype, suppressible by ScmP12

      (Bornemann et al., 1996)

      z1 has phenotype, suppressible by ScmP22

      (Bornemann et al., 1996)

      z1 has phenotype, suppressible by Psc1

      (Wu and Howe, 1995, Martin and Adler, 1993, Brunk et al., 1991)

      z1 has phenotype, suppressible by w1

      (Judd, 1995)

      z1 has phenotype, suppressible by Sam-S1

      (Larsson et al., 1995, Kalisch and Rasmuson, 1974)

      z1 has phenotype, suppressible by Su(z)23-1

      (Wu and Howe, 1995, Brunk et al., 1991, Kalisch and Rasmuson, 1974)

      z1 has phenotype, suppressible by mxcG43

      (Santamaria and Randsholt, 1995)

      z1 has phenotype, suppressible by mxcG46

      (Santamaria and Randsholt, 1995)

      z1 has phenotype, suppressible by mxcG48

      (Santamaria and Randsholt, 1995)

      z1 has phenotype, suppressible by Su(z)24

      (Wu and Howe, 1995, Brunk et al., 1991)

      z1 has phenotype, suppressible by Su(z)25

      (Wu and Howe, 1995)

      z1 has phenotype, suppressible by Su(z)2eos

      (Wu and Howe, 1995)

      z1 has phenotype, suppressible by E(z)60

      (Peterson et al., 1994, Jones and Gelbart, 1993, Jones and Gelbart, 1990)

      z1 has phenotype, suppressible by Df(YS)B4

      (Rasmuson-Lestander et al., 1993)

      z1 has phenotype, suppressible by Df(YL)S6

      (Rasmuson-Lestander et al., 1993)

      z1 has phenotype, suppressible by Df(YS)S12

      (Rasmuson-Lestander et al., 1993)

      z1 has pigment cell phenotype, suppressible by Dvir\z+tCa

      (Chen et al., 1992)

      z1 has phenotype, suppressible by Su(z)21

      (Brunk et al., 1991, Kalisch and Rasmuson, 1974)

      z1 has phenotype, suppressible by Psc[+]/Psc1

      (Brunk and Adler, 1990)

      z1 has phenotype, suppressible by Su(z)21/Su(z)2[+]

      (Brunk and Adler, 1990)

      z1 has phenotype, suppressible by E(z)61

      (Jones and Gelbart, 1990)

      z1 has phenotype, suppressible by E(z)66

      (Jones and Gelbart, 1990)

      z1 has phenotype, suppressible by wsp81d

      (Davison et al., 1985)

      z1 has phenotype, suppressible by Su(z)41

      (Kalisch and Rasmuson, 1974)

      z1 has phenotype, suppressible by Su(z)61

      (Kalisch and Rasmuson, 1974)

      z1 has phenotype, suppressible by Su(z)71

      (Kalisch and Rasmuson, 1974)

      z1 has phenotype, suppressible by E(z)37

      z1 has phenotype, suppressible by E(z)38

      z1 has phenotype, suppressible by E(z)39

      z1 has phenotype, suppressible by E(z)40

      z1 has phenotype, suppressible by E(z)41

      z1 has phenotype, suppressible by E(z)42

      z1 has phenotype, suppressible by E(z)43

      z1 has phenotype, suppressible by E(z)44

      z1 has phenotype, suppressible by E(z)45

      z1 has phenotype, suppressible by E(z)46

      z1 has phenotype, suppressible by E(z)47

      z1 has phenotype, suppressible by E(z)48

      z1 has phenotype, suppressible by E(z)49

      z1 has phenotype, suppressible by E(z)50

      z1 has phenotype, suppressible by E(z)51

      z1 has phenotype, suppressible by E(z)52

      z1 has phenotype, suppressible by E(z)53

      z1 has phenotype, suppressible by E(z)54

      z1 has phenotype, suppressible by E(z)55

      z1 has phenotype, suppressible by E(z)56

      z1 has phenotype, suppressible by E(z)57

      z1 has phenotype, suppressible by E(z)58

      z1 has phenotype, suppressible by E(z)59

      z1 has phenotype, suppressible by E(z)5

      z1 has phenotype, suppressible by E(z)62

      z1 has phenotype, suppressible by E(z)63

      z1 has phenotype, suppressible by E(z)64

      z1 has phenotype, suppressible by E(z)65

      z1 has phenotype, suppressible by E(z)67

      z1 has phenotype, suppressible by E(z)68

      z1 has phenotype, suppressible by E(z)69

      z1 has phenotype, suppressible by E(z)6

      z1 has phenotype, suppressible by E(z)70

      z1 has phenotype, suppressible by E(z)71

      z1 has phenotype, suppressible by E(z)72

      z1 has phenotype, suppressible by E(z)73

      z1 has phenotype, suppressible by E(z)74

      z1 has phenotype, suppressible by E(z)75

      z1 has phenotype, suppressible by E(z)8

      z1 has phenotype, suppressible by E(z)9

      z1 has phenotype, suppressible by E(z)10

      z1 has phenotype, suppressible by E(z)11

      z1 has phenotype, suppressible by E(z)12

      z1 has phenotype, suppressible by E(z)13

      z1 has phenotype, suppressible by E(z)14

      z1 has phenotype, suppressible by E(z)15

      z1 has phenotype, suppressible by E(z)16

      z1 has phenotype, suppressible by E(z)17

      z1 has phenotype, suppressible by E(z)18

      z1 has phenotype, suppressible by E(z)19

      z1 has phenotype, suppressible by E(z)20

      z1 has phenotype, suppressible by E(z)21

      z1 has phenotype, suppressible by E(z)22

      z1 has phenotype, suppressible by E(z)23

      z1 has phenotype, suppressible by E(z)24

      z1 has phenotype, suppressible by E(z)25

      z1 has phenotype, suppressible by E(z)26

      z1 has phenotype, suppressible by E(z)27

      z1 has phenotype, suppressible by E(z)28

      z1 has phenotype, suppressible by E(z)29

      z1 has phenotype, suppressible by E(z)30

      z1 has phenotype, suppressible by E(z)31

      z1 has phenotype, suppressible by E(z)32

      z1 has phenotype, suppressible by E(z)33

      z1 has phenotype, suppressible by E(z)34

      z1 has phenotype, suppressible by E(z)35

      z1 has phenotype, suppressible by E(z)36

      NOT suppressed by
      Statement
      Reference

      z1 has phenotype, non-suppressible by Alhunspecified

      (Perrin et al., 2003)

      z1 has phenotype, non-suppressible by Low1

      (Bhadra et al., 1998, Bhadra et al., 1997)

      z1 has phenotype, non-suppressible by Pcf11EMS2

      (Bhadra et al., 1998)

      z1 has phenotype, non-suppressible by MowEMS

      (Bhadra et al., 1998)

      z1 has phenotype, non-suppressible by Ufo1

      (Bhadra et al., 1998)

      z1 has phenotype, non-suppressible by Wowunspecified

      (Bhadra et al., 1998)

      z1 has phenotype, non-suppressible by wis/Low1

      (Bhadra et al., 1997)

      z1 has phenotype, non-suppressible by Su(z)2unspecified

      (Rasmuson-Lestander et al., 1993)
      Enhancer of
      Statement
      Reference

      z1 is an enhancer of pigment cell phenotype of g53d

      (Lloyd et al., 2002)

      z1 is an enhancer of pigment cell phenotype of g50e

      (Lloyd et al., 2002)

      z1 is an enhancer of macrochaeta phenotype of snaSco/snaSco

      (Fuse et al., 1999)

      z1 is an enhancer of phenotype of ctpN1

      (Melnikova et al., 1996)

      z1 is an enhancer of phenotype of ctpN30

      (Melnikova et al., 1996)

      z1 is an enhancer of pigment cell phenotype of wsp2

      (Georgiev, 1994)

      z1 is an enhancer of pigment cell phenotype of wsp4

      (Georgiev, 1994)

      z1 is an enhancer of pigment cell phenotype of wsp1

      (Georgiev, 1994)

      z1 is an enhancer of phenotype of wAR4-24

      (Hazelrigg and Petersen, 1992)
      NOT Enhancer of
      Statement
      Reference

      z1 is a non-enhancer of sex comb phenotype of ScrWrv4/ScrTpl9

      (Southworth and Kennison, 2002)

      z1 is a non-enhancer of mesothoracic leg & sex comb | ectopic phenotype of ScrMsc

      (Southworth and Kennison, 2002)

      z1 is a non-enhancer of metathoracic leg & sex comb | ectopic phenotype of ScrMsc

      (Southworth and Kennison, 2002)

      z1 is a non-enhancer of sex comb phenotype of ScrAntp-A41/ScrTpl9

      (Southworth and Kennison, 2002)

      z1 is a non-enhancer of sex comb phenotype of ScrTpl9

      (Southworth and Kennison, 2002)

      z1/Low1 is a non-enhancer of phenotype of wis

      (Bhadra et al., 1997)
      Suppressor of
      Statement
      Reference

      z[+]/z1 is a suppressor of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

      (Morimoto et al., 2016)

      z[+]/z1 is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096

      (Morimoto et al., 2016)

      z1 is a suppressor | partially of wing phenotype of ap56f/Df(2R)DG

      (Gohl et al., 2008)

      Mowgamma/z1 is a suppressor of phenotype of wis

      (Bhadra and Birchler, 1996)

      z1 is a suppressor of phenotype of wzvl

      (Peterson et al., 1994)
      NOT Suppressor of
      Statement
      Reference

      z1 is a non-suppressor of sex comb phenotype of ScrWrv4/ScrTpl9

      (Southworth and Kennison, 2002)

      z1 is a non-suppressor of metathoracic leg & sex comb | ectopic phenotype of ScrMsc

      (Southworth and Kennison, 2002)

      z1 is a non-suppressor of mesothoracic leg & sex comb | ectopic phenotype of ScrMsc

      (Southworth and Kennison, 2002)

      z1 is a non-suppressor of sex comb phenotype of ScrAntp-A41/ScrTpl9

      (Southworth and Kennison, 2002)

      z1 is a non-suppressor of sex comb phenotype of ScrTpl9

      (Southworth and Kennison, 2002)

      z1/Low1 is a non-suppressor of phenotype of wis

      (Bhadra et al., 1997)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of z1.

      (Morimoto et al., 2016)

      Su(z)24-31 suppresses the eye colour phenotype of z1, and Su(z)24-34 is a weak suppressor of the eye colour phenotype of z1.

      (Emmons et al., 2009)

      z1 partially suppresses the wing phenotypes seen in ap56f/Df(2R)DG mutant flies.

      z1 does not enhance the mild wing phenotypes seen in apUGO35/Df(2R)DG mutant flies.

      (Gohl et al., 2008)

      g53d, za double mutants have a reduced amount of red pigment in the eye compared to g53d single mutants in both male and female flies. The same is true for g50e and g2 alleles. Male E(z)1/+, g53d, z1 triple mutants have less red pigment in the eye than g53d, z1 double mutants. Likewise, female E(z)1/+, g53d/+, z1/+ triple mutants have a reduction in red eye pigment compared to g53d/+, z1/+ double mutants.

      (Lloyd et al., 2002)

      The average number of sex comb teeth per first leg in ScrTpl9 heterozygous males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of sex comb teeth per first leg in ScrTpl9/ScrAntp-A41 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The viability and average number of sex comb teeth per first leg in ScrTpl9/ScrWrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying z1. The average number of ectopic sex comb teeth on the second and third legs in ScrMsc heterozygous males is not affected if they are also carrying z1.

      (Southworth and Kennison, 2002)

      Eye colour: small brown spots on an otherwise wild-type background in z1/Y; E(z)Trm/+ males or z1/+; E(z)Trm/+ females. Eye colour: orange-brown in z1/Y; E(z)Trm/In(3L)Ez2 males or z1/+; E(z)Trm/In(3L)Ez2 females (rescued by dissecting out of the pupal case).

      (Bajusz et al., 2001)

      Enhances the bristle loss phenotype of Tp(2;2)Sco/+ flies.

      (Fuse et al., 1999)

      Enhances the eye colour phenotype by suppressing the transactivation of the mini-w gene seen when wMcp.y.scs'.1 and ywe.Mcp.2 are combined and when wMcp.scs'.21 and ywe.Mcp.1 are combined leading to lighter eyes.

      (Muller et al., 1999)

      z1 is dominantly suppressed by ScmM56, ScmD1, ScmSuz302, ScmM36, Scm4, ScmD2, ScmH1, ScmET50, ScmR5-13, Scm5 and ScmK2.

      (Bornemann et al., 1998)

      Dominantly represses w when one of the w genes contains a tandem duplication of the regulatory region, such as Dp(1;1)wrdp+. z1 Dp(1;1)wrdp+/+ females exhibit a red-orange eye colour between that of wild type and the yellow of hemizygous z1 Dp(1;1)wrdp+ males. Supports transvection at Ubx.

      (Rosen et al., 1998)

      Eye colour: yellow in Dp(1;1)w+61e19 male.

      (Bhadra et al., 1997)

      z1 has no effect on the mod(mdg4)ul effect on ct6.

      (Melnikova et al., 1996)

      Eye colour: fewer red/brown patches on lighter background than with z+ as z1 In(1)wm4 males and females. Eye colour: as z1 in z1 In(1)rst3 female.

      (Judd, 1995)

      Eye colour: brownish, with e(y)11 or e(y)34 in male. Eye colour: like z1, with e(y)12.

      (Georgiev, 1994)

      Eye colour: orange, as wis z1 males. Eye colour: orange, as wis z1/z+ females. Eye colour: yellow-white variegated as In(1)wis z1 males. Eye colour: red-orange or orange-yellow variegated as z1 In(1)wis/z1 w+ females. The phenotypic interactions with Df(YS)B4, Df(YL)S6, Df(YS)S12, Df(YL)G22, Df(YL)S10, Df(2R)M41A4, Df(2R)M41A1, Df(2R)M41A8 are seen in z1 In(1)wis; z1 In(1)wis; Su(z)2unspecified have an unaltered background level of pigmentation (white) but the yellow flecks in the eye are darkened to orange or red.

      (Rasmuson-Lestander et al., 1993)
      Xenogenetic Interactions
      Statement
      Reference

      The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of z1.

      (Morimoto et al., 2016)

      Eye colour phenotype is rescued by Dvir\z+tCa.

      (Chen et al., 1992)
      Complementation and Rescue Data
      Complements

      z11G3

      (Gans, 1953)
      Rescued by

      z1 is rescued by zCZ

      (Chen and Pirrotta, 1993)
      Comments

      Rescue is dosage-dependent.

      (Chen and Pirrotta, 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (72)
      Notes on Origin
      Discoverer

      Gans, Feb. 1946.

      Comments
      Comments

      Supports transvection at Ubx but not at dpp.

      Allelic series: zop6 > zop11 > zRN4 > z1 > zRN1 > wild type.

      (Lifschytz and Green, 1984)

      This allele behaves as an antagonist of normal z function.

      (Mariani et al., 1985)

      z1 product subliminally inhibits the complementation of dpphr4 and dppd-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis.

      (Smolik-Utlaut and Gelbart, 1987)

      Unpaired w+ alleles suppress z1 eye colour.

      (Wu et al., 1989)

      Causes a specific underexpression of w in the eye when two copies of the w gene are physically apposed by chromosome pairing or by tandem duplication. Expression of w in other tissues is not affected. Behaves like z+ in promoting transvection effects at Ubx but fails to permit transvection at the dpp locus.

      (Bickel and Pirrotta, 1990)

      The z1 mutation causes a new hydrophobic nucleus in the region of the protein preceding the C-terminal domain, resulting in a further stage of multimerization.

      (Chen and Pirrotta, 1993)

      z1 gene product in combination with structural changes imposed by transposons and intercalary heterochromatin, modifies the determination and stability of w expression.

      (Peterson et al., 1994)

      The phenotype of Abd-Biab7-MX2/Abd-Biab8-D14 is unaffected by alleles of z.

      (Hendrickson and Sakonju, 1995)

      Does not alter the effect of mod(mdg4)ul on y2/y+.

      (Georgiev and Corces, 1995)

      Every w+ gene must be near another w+ gene in order for the z1 phenotype to be realized.

      (Wu and Howe, 1995)

      Does not effect the level of w expression in ph-plac+3 flies.

      (Fauvarque et al., 1995)

      Expression of the mutant lemon yellow eye colour requires two proximate or paired copies of w+ Paired copies of In(1)wm4 are not repressed by z1. Repression of In(1)wm4 by z1 cannot be restored by Su(var)205. z1 In(1)rst3 combination exhibits more extreme variegation for rst than seen in z+ In(1)rst3 combination. Recessive enhancer of PEV in a fashion clearly distinguishable from standard transvection effects.

      (Judd, 1995)

      Does not suppress transvection of UbxCbx-1/+.

      (Goldsborough and Kornberg, 1996)

      Two synapsed copies of w+ are required for expression of zeste eye color.

      (Gans, 1953)

      z1 mediated repression of flies carrying two to five ectopic w genes (produced using Tp(1;2)TE35B derivatives) is insensitive to copy number and does not distinguish between w genes that are in cis or in trans. Suppression does not require the juxtaposition of even numbers of w genes, but is extremely sensitive to chromosomal topology.

      (Gubb et al., 1997)

      All iab-7 PRE pairing-sensitive lines show strong interactions with z1 when the transgene insert is heterozygous: dominant enhancement of iab-7 PRE repression.

      (Hagstrom et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      unspecified
      (Bhadra et al., 1997)
      z1
      (Johnston and Desplan, 2014, Sultana et al., 2011, Emmons et al., 2009, Gohl et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0062327
      References (107)