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General Information
Symbol
Dmel\zv77h
Species
D. melanogaster
Name
FlyBase ID
FBal0018848
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
Approximate location of a small deletion of 314 nucleotides that takes out the AUG initiation codon and a large portion of the 5' UTR. The exact boundaries were not reported.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Deletion of the z leader sequences.
314bp deletion that removes RNA leader sequences and the AUG initiation codon.
Deletion of approximately 300bp centered around position 0 (the site of P-element insertion in zπ1).
no P-element Carries deletion of about 320 nucleotides and addition of seven nucleotides in the first exon; P element was probably inserted, followed by excision of the P and the flanking deletion (Pirrotta, Manet, Hardon, Bickel and Benson, 1987), the deletion removing the AUG start codon.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Eye colour: yellow, when heterozygous with z1. Eye colour: essentially wild type, having a slightly diluted red, as hemizygous male or homzygous female.
Eye colour: near wild-type in males; brown in females.
Eye colour: dull brown, in male.
Eye colour: variegated brown.
Eye colour is slightly lighter in homozygous females than hemizygous males: eye colour is light in colour at the anterior margin and continuously darkens to the posterior eye margin.
Eye colour: diluted, turning brownish with age in hemizygous males and hemi- and homozygous females with a normal complement of w+ genes. Eye colour: wild-type, in za/zv77h females. Eye colour: zeste, in z1/zv77h females. Eye colour: wild-type, in zv77h hemizygous males and homozygous females with w+ duplication in each X. Eye colour: brown variegated, darkening toward posterior in zv77h w+/Y males and zv77h w+/zv77h w+ females; lighter at 28oC.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
wsp2, zv77h has eye color defective phenotype, enhanceable by e(y)11
wsp2, zv77h has eye color defective phenotype, enhanceable by e(y)21
wsp2, zv77h has eye color defective phenotype, enhanceable by e(y)34
wsp4, zv77h has eye color defective phenotype, enhanceable by e(y)11
wsp4, zv77h has eye color defective phenotype, enhanceable by e(y)21
wsp4, zv77h has eye color defective phenotype, enhanceable by e(y)34
wsp1, zv77h has eye color defective phenotype, enhanceable by e(y)11
wsp1, zv77h has eye color defective phenotype, enhanceable by e(y)21
wsp1, zv77h has eye color defective phenotype, enhanceable by e(y)34
Enhancer of
Statement
Reference
NOT Enhancer of
NOT Suppressor of
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
wE.BR, zv77h has pigment cell phenotype, enhanceable by e(y)11
wBR.E.BR, zv77h has pigment cell phenotype, enhanceable by e(y)11
wsp2, zv77h has pigment cell phenotype, enhanceable by e(y)11
wsp2, zv77h has pigment cell phenotype, enhanceable by e(y)21
wsp2, zv77h has pigment cell phenotype, enhanceable by e(y)34
wsp4, zv77h has pigment cell phenotype, enhanceable by e(y)11
wsp4, zv77h has pigment cell phenotype, enhanceable by e(y)21
wsp4, zv77h has pigment cell phenotype, enhanceable by e(y)34
wsp1, zv77h has pigment cell phenotype, enhanceable by e(y)11
wsp1, zv77h has pigment cell phenotype, enhanceable by e(y)21
wsp1, zv77h has pigment cell phenotype, enhanceable by e(y)34
zv77h has phenotype, enhanceable by e(y)34
zv77h has phenotype, enhanceable by e(y)11
zv77h has phenotype, enhanceable by e(y)21
Suppressed by
Statement
Reference
zv77h has phenotype, suppressible by Su(var)205unspecified
Enhancer of
Statement
Reference
zv77h is an enhancer of phenotype of ctpN1
zv77h is an enhancer of phenotype of ctn2s
zv77h is an enhancer of phenotype of ctpN30
zv77h is an enhancer of phenotype of ctpN2s
zv77h is an enhancer of pigment cell phenotype of wsp2
zv77h is an enhancer of pigment cell phenotype of wsp4
zv77h is an enhancer of pigment cell phenotype of wsp1
zv77h is an enhancer of phenotype of lz77a7
Suppressor of
Statement
Reference
zv77h is a suppressor | partially of ocellar bristle phenotype of scD1
zv77h is a suppressor | partially of postvertical bristle phenotype of scD1
zv77h is a suppressor | partially of scutellar bristle phenotype of scD1
zv77h is a suppressor | partially of macrochaeta & scutum phenotype of scD1
Other
Additional Comments
Genetic Interactions
Statement
Reference
zv77h significantly decreases eye pigmentation in flies carrying wScer\FRT.Ee.λWS in a w1118 background in half of the transgenic insertion lines examined. zv77h has no effect on the eye pigmentation of flies carrying wλWS in a w1118 background. zv77h significantly decreases eye pigmentation in flies carrying wScer\FRT.Ee.λΔRWS in a w1118 background, with the double mutant flies having either yellow or orange eyes. zv77h has no effect on the eye pigmentation of flies carrying wλΔRWS in a w1118 background. zv77h has no effect on the eye pigmentation of flies carrying wScer\FRT.Ee.λ4BWS in a w1118 background. zv77h has no effect on the eye pigmentation of flies carrying wλ4BWS in a w1118 background. zv77h has no effect on the eye pigmentation of flies carrying wScer\FRT.Ee.λ.loxP.4B.WS in a w1118 background. zv77h has no effect on the eye pigmentation of flies carrying wλ.loxP.4B.WS in a w1118 background.
5+/-2% of KrIf-1/+ flies born to zv77h/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.
Eye colour: flies carrying wBR.E.BR have red eyes. The eye colour is not affected if the flies are also carrying e(y)11 and zv77h. Flies that are also carrying e(y)11, zv77h and su(Hw)2/su(Hw)V have reduced eye pigmentation. Eye colour: flies carrying wE.BR have brown eyes. The eye pigmentation is reduced if these flies are also carrying e(y)11 and zv77h.
Enhancement of the cut wing phenotype of ctpN2s and ctn2s, ctpN1 and ctpN30 acts additively with e(y)34; in combination with e(y)34 and zv77h, mod(mdg4)ul enhances the mutant phenotype of ct6, though the gaps in the wing margin are still randomly distributed. No mutant phenotype in the wing, no effect on mutant wing phenotype of ct6, ct2s or ct4s.
Eye colour: lighter zeste background than comparable z1 genotypes, as zv77h wzm male. Eye colour: lighter zeste background than comparable z1 genotypes, as zv77h wzl male. Eye colour: darker than comparable z1 genotypes, as zv77h wzm homozygous female. Eye colour: almost bleached white with a few scattered red facets, as zv77h In(1)wm4 female or male. Eye colour: red, as zv77h In(1)rst3 males and homozygous females. Eye colour: zeste, as zv77h In(1)rst3/z1 In(1)rst3 females.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
Green.
Arose as: Single exceptional male offspring.
Comments
Comments
Behaves like a za mutant in combination with z1.
Effects interallelic complementation at the y locus.
No alteration in vgU or vgW dominance is seen in combination with zv77h, suggesting that the dominance is not produced by z- dependent transvection effects.
Does not alter the effect of mod(mdg4)ul mutation on y2/y+ flies.
zv77h In(1)rst3 exhibits more extreme variegation for rst than seen in z+ In(1)rst3. Recessive enhancer of PEV in a fashion clearly distinguishable from standard transvection effects.
Partially restores ocellar, post-vertical and scutellar bristles as well as the ANPs to scD1 Shows a mild "Hairy wing" type phenotype: one to three additional bristles appear on the notum. Has no effect on the Df(1)ase-1, sc5 or sc6 phenotype.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (32)