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General Information
Symbol
Dmel\zen7
Species
D. melanogaster
Name
FlyBase ID
FBal0018861
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
zenw36, EfW36
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Point mutation.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Nondefective in gonad assembly.

Weak ventralised phenotype. No amnioserosa and defects at the anterior segments.

Embryos are ventralised.

No salivary gland defects.

Does not interact with RpII140wimp maternal effect.

Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Disruption of germ band extension that leads to the invagination of posterior segments into the interior of the embryo.

Transformation in the cell fate of the dorsal most ectoderm toward a more ventral pathway of development during gastrulation. There is the correct number of body segments and the cuticular pattern elements associated with each element appear to be normal.

Embryos are dorsal defective.

zen7/Df(3R)Scr embryos appear normal up to gastrulation. The germ band does not elongate, and one or two deep clefts appear between the cephalic furrow and posterior midgut rudiment. The embryo may appear twisted about the antero-posterior axis. Segmentation proceeds despite the distortion and the correct number of segments is formed. The head remains external and the CNS is disrupted. Normally non-adjacent segments are joined by stretches of cuticle in the late embryo, and there are disruptions in the larval setal belts. The optic lobe is absent.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The embryonic midgut phenotype of maternal and zygotic lack15C/lack15C embryos is fully suppressed by heterozygosity for zen7.

Mutant phenotype is suppressed by increasing the dpp+ gene dosage.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Hemizygous mutant phenotype can be rescued by P element mediated transformation of a wild type zen gene. Homozygotes could not be rescued suggesting there may be an additional lethal mutation on the chromosome.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Wakimoto.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (31)