Allele Dmel\zip¹

General Information
Symbol	Dmel\zip¹	Species	D. melanogaster
Name		FlyBase ID	FBal0018862
Feature type	allele	Associated gene	Dmel\zip
Also Known As	zip^1D16

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Young et al., 1993)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	axis specification defective \| embryonic stage 15 (with zip²) (Okumura et al., 2010) axis specification defective \| embryonic stage 15 (with zip³) (Okumura et al., 2010) axis specification defective \| embryonic stage 15 (with zip⁴) (Okumura et al., 2010) axis specification defective \| embryonic stage 16 (with zip²) (Okumura et al., 2010) axis specification defective \| embryonic stage 16 (with zip³) (Okumura et al., 2010) axis specification defective \| embryonic stage 16 (with zip⁴) (Okumura et al., 2010) axis specification defective \| embryonic stage 17 (with zip²) (Okumura et al., 2010) axis specification defective \| embryonic stage 17 (with zip³) (Okumura et al., 2010) axis specification defective \| embryonic stage 17 (with zip⁴) (Okumura et al., 2010) cell shape defective (Walters et al., 2006) lethal, with Scer\GAL4^en-e16E, zip^{DN.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) lethal (with zip²) (Su and Kiehart, 2001) lethal \| embryonic stage (Barros et al., 2003, Young et al., 1993) lethal \| embryonic stage (with zip²) (Franke et al., 2010) lethal \| embryonic stage \| recessive (Pederson et al., 1996, Franke et al., 2006) lethal \| larval stage (with zip²) (Okumura et al., 2010) lethal \| larval stage (with zip³) (Okumura et al., 2010) lethal \| larval stage (with zip⁴) (Okumura et al., 2010) visible, with Scer\GAL4^en-e16E, zip^{FL.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) visible, with Scer\GAL4^en-e16E, zip^{HMM.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) visible, with Scer\GAL4^en-e16E, zip^{Rod.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) visible, with Scer\GAL4^en-e16E, zip^Rod.Scer\UAS (Franke et al., 2010)
Phenotype Manifest In
	A1-7 ventral acute muscle 1 (with Df(2R)ES1) (Bloor and Kiehart, 2001) A1-7 ventral acute muscle 2 (with Df(2R)ES1) (Bloor and Kiehart, 2001) A1-7 ventral acute muscle 3 (with Df(2R)ES1) (Bloor and Kiehart, 2001) adult brain (Duboff et al., 2012) amnioserosa (with zip²) (Franke et al., 2005) anterior embryonic/larval midgut \| embryonic stage 15 (with zip²) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 15 (with zip³) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 15 (with zip⁴) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 16 (with zip²) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 16 (with zip³) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 16 (with zip⁴) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 17 (with zip²) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 17 (with zip³) (Okumura et al., 2010) anterior embryonic/larval midgut \| embryonic stage 17 (with zip⁴) (Okumura et al., 2010) central nervous system (Zhao et al., 1988) cuticle (Zhao et al., 1988) denticle (Walters et al., 2006) denticle field (Walters et al., 2006) denticle row (Walters et al., 2006) dorsal closure embryo (with zip²) (Franke et al., 2005) embryonic/larval brain \| embryonic stage (Zhao et al., 1988) embryonic/larval cuticle (Walters et al., 2006) embryonic/larval dorsal trunk (with zip²) (Chung et al., 2009) embryonic dorsal epidermis (Pederson et al., 1996) embryonic dorsal epidermis, with Scer\GAL4^en-e16E, zip^{DN.Scer\UAS.T:Avic\GFP} (Franke et al., 2005) embryonic dorsal epidermis (with zip²) (Franke et al., 2005) embryonic dorsal epidermis (with zip²), with Scer\GAL4^en-e16E, zip^{FL.Scer\UAS.T:Avic\GFP} (Franke et al., 2005) embryonic head (Jacinto et al., 2002, Blake et al., 1998) embryonic head (with zip^IIX62) (Jacinto et al., 2002) embryonic leading edge cell (Jacinto et al., 2002, Gettings et al., 2010) embryonic leading edge cell (with zip²) (Franke et al., 2005) embryonic leading edge cell (with zip^IIX62) (Jacinto et al., 2002) embryonic Malpighian tubule (Blake et al., 1998) embryonic proventriculus \| embryonic stage 15 (with zip²) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 15 (with zip³) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 15 (with zip⁴) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 16 (with zip²) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 16 (with zip³) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 16 (with zip⁴) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 17 (with zip²) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 17 (with zip³) (Okumura et al., 2010) embryonic proventriculus \| embryonic stage 17 (with zip⁴) (Okumura et al., 2010) epidermis \| dorsal (Young et al., 1993) extended germ band embryo (Bertet et al., 2004) external sensory organ \| ectopic (Pederson et al., 1996) filamentous actin & denticle field primordium (Walters et al., 2006) filopodium (Jacinto et al., 2002) filopodium (with zip^IIX62) (Jacinto et al., 2002) head (Pederson et al., 1996) hub cell (Warner and Longmore, 2009) labial disc (Pederson et al., 1996) metameric furrow \| ventral (Larsen et al., 2003) mitochondrion (Duboff et al., 2012) peripheral nervous system (Zhao et al., 1988) presumptive embryonic/larval nervous system (Zhao et al., 1988) presumptive embryonic/larval tracheal system (Brodu and Casanova, 2006) tracheal primordium (Brodu and Casanova, 2006) wing, with Scer\GAL4^en-e16E, zip^{Rod.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) wing \| posterior compartment, with Scer\GAL4^en-e16E, zip^Rod.Scer\UAS (Franke et al., 2010) wing vein, with Scer\GAL4^en-e16E, zip^{HMM.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) wing vein \| ectopic, with Scer\GAL4^en-e16E, zip^{FL.Scer\UAS.T:Avic\GFP} (Franke et al., 2010)
Detailed Description
	Statement Reference The mitochondria in the neurons of heterozygous zip[1] adult brains are markedly elongated compared to controls. (Duboff et al., 2012) Expression of a single copy of zip[FL.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[en-e16E] results in a wing vein expansion phenotype in 82% of wings. The penetrance of this phenotype is slightly decreased (to 72%) in a zip[1]/+ background. Expression of a single copy of zip[DN.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[en-e16E] in a zip[1]/+ background results in lethality. Expression of a single copy of zip[HMM.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[en-e16E] in a zip[1]/+ background results in a wing vein expansion phenotype in 41% of wings. Expression of a single copy of zip[Rod.Scer\UAS] under the control of Scer\GAL4[en-e16E] in a zip[1]/+ background results in loss of posterior compartment tissue in 100% of wings. Expression of a single copy of zip[Rod.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[en-e16E] in a zip[1]/+ background results in a more severe phenotype than expression in a wild-type background. (Franke et al., 2010) Mutant embryos show a reduced level of cell intercalation at the segment boundary during dorsal closure (in the abdominal segments of wild-type embryos at the end of dorsal closure, a mixer cell moves across the segment boundary from the anterior compartment to the posterior compartment and two cells from the ventral ectoderm intercalate into the leading edge, posterior to the mixer cell). (Gettings et al., 2010) zip[3]/zip[1] embryos show laterality defects in the proventriculus and anterior midgut. The laterality of the other parts of the embryonic gut, including the hindgut and the posterior part of the midgut is normal in these mutants. The proventriculus and the anterior midgut do not rotate (as in wild-type) in these mutants at stages 15 to 17. zip[4]/zip[1] embryos show laterality defects in the proventriculus and anterior midgut. The laterality of the other parts of the embryonic gut, including the hindgut and the posterior part of the midgut is normal in these mutants. The proventriculus and the anterior midgut do not rotate (as in wild-type) in these mutants at stages 15 to 17. zip[2]/zip[1] embryos show laterality defects in the proventriculus and anterior midgut. The laterality of the other parts of the embryonic gut, including the hindgut and the posterior part of the midgut is normal in these mutants. The proventriculus and the anterior midgut do not rotate (as in wild-type) in these mutants at stages 15 to 17. (Okumura et al., 2010) zip[1]/zip[2] stage 16 embryos have longer dorsal trunks than normal. (Chung et al., 2009) Single cell clones of zip[1] exhibit an increased apical cell area. Adherens junctions in multiple cell clones are intact. (Warner and Longmore, 2009) zip¹ mutant embryos, neither myosin nor actin accumulates tightly around the invagination edge; instead they form aggregates. In zip¹ mutants, the small group of cells that initiate apical constriction is not observed, and tracheal cells form a large cavity during invagination. (Brodu and Casanova, 2006) The eye phenotype of rok[cat.GMR] flies is suppressed in a zip[1]/+ background. zip[1]/+ partially suppresses the wing phenotype of animals expressing rok[cat.Scer\UAS] under the control of Scer\GAL4[en-e16E]. (Verdier et al., 2006) zip¹ stage 15 larvae show a range of denticle phenotypes. In the mildest phenotype, larvae show cuticle shaping defects and have slightly misaligned denticle rows. The moderate phenotype, which has the highest penetrance, consists of a reduced denticle field that is ovoid in shape, misaligned denticle rows and shortened denticles. In the most severe phenotype, denticles are missing altogether. The ventral epidermis of stage 15 zip¹ embryos show shaping defects of the actin protrusions that precede the formation of denticles. These protrusions are broad at the base, and are more elongated and wavy than those in wild-type embryos. Additionally, the protrusions are often not positioned at the posterior edge of denticle field primordium cells. (Walters et al., 2006) zip¹/zip² embryos show a dorsal closure phenotype with low penetrance. In transgenic mosaic embryos in which some cells express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^e22c in a zip¹/zip² background, leading-edge cells that do not express zip^{FL.Scer\UAS.T:Avic\GFP} cannot maintain tension and are stretched by neighbouring zip^{FL.Scer\UAS.T:Avic\GFP} expressing cells. The length of contiguous regions of Scer\GAL4^e22c>zip^{FL.Scer\UAS.T:Avic\GFP} expressing leading-edge cells along the supracellular purse string decrease in length over time, indicative of contraction. In contrast, non zip^{FL.Scer\UAS.T:Avic\GFP}-expressing contiguous regions fail to contract, increasing in length over time. In transgenic mosaic embryos in which some cells express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sqh.PW in a zip¹/zip² background, Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP} expressing leading-edge cells that contact Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP} expressing amnioserosa cells are severely contracted, and the scalloped morphology of the early leading edge is enhanced. In contrast, when non-expressing leading-edge cells contact non-expressing amnioserosa cells the leading edge cells fail to contract and become stretched. When non-expressing leading-edge cells contact Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing amnioserosa cells, leading-edge cells show some contraction. Finally, Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing cells show some contraction when they contact non-expressing amnioserosa cells, although this is to a lesser extent than when both cell types express zip^{FL.Scer\UAS.T:Avic\GFP}. Nonexpressing leading-edge cells fail to incorporate into the canthus and cause inward progression of the canthus to stall. These nonexpressors never get fully incorporated into the seam - instead, a small gap is formed when zipping fails and closure bypasses the nonexpressing cells to initiate a new seam. In contrast, Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing cells are incorporated into each canthus at a similar and nearly constant rate. In transgenic mosaic embryos in which some amnioserosa cells express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^c381 in a zip¹/zip² background, nonexpressing amnioserosa cells fail to contract apically and remain rounded. These cells do show an apical shape change at later stages but this may be due to forces generated by surrounding Scer\GAL4^c381>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing amnioserosa cells and the approaching lateral-epidermis sheet. Embryos that express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-e16E in a zip¹/zip² background display stripe-alignment defects in 65% of cases. Expression of zip^{DN.Scer\UAS.T:Avic\GFP}, under the control of Scer\GAL4^en-e16E, in a zip¹/+ background causes stripe misalignments in 52% of embryos, while only 4% of zip¹/+ embryos show this phenotype without transgene expression. (Franke et al., 2005) Mutant embryos exhibit defects in germ band elongation. (Bertet et al., 2004) Unlike in wild-type, deep metameric furrow persist ventrally in zip¹ embryos until well into stage 15. (Larsen et al., 2003) zip¹ homozygous and zip¹/zip^IIX62 embryos exhibit dramatic defects in head involution. 8% of zip¹ homozygous embryos and 58% of zip¹/zip^IIX62 embryos have a clear dorsal hole. The remaining embryos complete dorsal closure, although they frequently show puckering or segment misalignments along the closed midline seam. During dorsal closure the leading edge in zip¹/zip^IIX62 embryos is very disporganized and extends a broader extent of lamellipodial and filopodial protrusions per unit length of leading edge than wild-type. The total protrusive area of leading edge cells in zip¹/zip¹ embryos is up to 300% greater than wild-type. Filopodia extended by these cells often coalesce into lamellipodia. The cytoskeletal architecture typical of the leading edge during dorsal clonsure in wild-type embryos is lost in zip¹ homozygotes. (Jacinto et al., 2002) zip¹/Df(2R)ES1 transheterozygous mutant embryos the muscle VA3 is missing from each segment and VA1 and VA2 are often both not present in each segment. (Bloor and Kiehart, 2001) Homozygous embryos do not complete head involution. The salivary glands appear wild-type. Malpighian tubules are abnormal, remaining coiled near their juncture with the hindgut rather than extending anteriorly as in the wild-type. The diameter of the Malpighian tubules is similar to wild-type. The hindgut appears normal and the midgut constrictions appear substantially similar to wild-type. Abnormalities in the peripheral nervous system cannot be detected. (Blake et al., 1998) Embryos exhibit defects in dorsal closure and head involution. Labial lobes fail to migrate or fuse ventrally. Labial sensory organs remain external and become ectopic external sensory organs. (Pederson et al., 1996) Embryos fail to complete dorsal closure as the mutant myosin fails to contribute sufficient myosin to drive dorsal closure to completion. (Young et al., 1993) The nervous system develops abnormally in homozygotes, with brain tissue located more anteriorly and being larger than normal in the fully developed embryo. It is partially surrounded by the cuticle which never encloses the brain completely. The lateral fascicles of different abdominal segments do not respect segment boundaries in a variable manner. Sensory neurons of the gnathal sensory organs remain in the position of the progenitor cells, and their axons fasiculate in a single, thick axon bundle. Homozygous embryos also have an abnormal cuticle pattern. (Zhao et al., 1988) strong allele showing severe cuticular and neurological defects
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference zip[+]/zip¹ is an enhancer of neuroanatomy defective phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Saja et al., 2010) zip[+]/zip¹ is an enhancer of visible \| heat sensitive phenotype of fz^I.hs (Winter et al., 2001) zip[+]/zip¹ is an enhancer of visible \| recessive phenotype of dsh¹ (Winter et al., 2001) zip[+]/zip¹ is an enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053 (Djiane and Mlodzik, 2010) zip[+]/zip¹ is an enhancer of visible phenotype of Scer\GAL4^hs.PB, tow^Scer\UAS.cCa (Chung et al., 2007) zip¹ is an enhancer of cell polarity defective phenotype of S^48-5 (Gaengel and Mlodzik, 2003) zip¹ is an enhancer of cytokinesis defective phenotype of Scer\GAL4^Bx-MS1096, pbl^{ΔDH497-549.Scer\UAS} (Echard and O'Farrell, 2003)
Suppressor of
Statement Reference zip[+]/zip¹ is a suppressor \| partially of cell polarity defective \| recessive \| somatic clone phenotype of flw^FP41 (Sun et al., 2011) zip[+]/zip¹ is a suppressor of visible phenotype of flw¹, puc^A251.1F3/puc[+] (Kirchner et al., 2007) zip[+]/zip¹ is a suppressor of visible phenotype of rok^cat.GMR (Verdier et al., 2006) zip¹/flw⁷ is a suppressor of lethal \| male phenotype of flw^G0172/flw^G0172 (Vereshchagina et al., 2004) zip¹ is a suppressor of lethal \| male phenotype of flw⁶ (Vereshchagina et al., 2004) zip¹ is a suppressor of lethal phenotype of Pp1α-96A^GS11179/Df(3R)crb87-5, flw¹ (Kirchner et al., 2007) zip¹ is a suppressor of visible phenotype of MYPT-75D^{F117A.Scer\UAS}, Scer\GAL4^Bx-MS1096 (Vereshchagina et al., 2004)
Other
Statement Reference Dpse\l(2)gl^+t12.2, zip²/zip¹ has lethal \| embryonic stage phenotype (Franke et al., 2005, Franke et al., 2005) E(br)121^Ebr121, zip[+]/zip¹ has visible \| dominant phenotype (Ward et al., 2003) E(br)121^Ebr121/E(br)121[+], zip¹ has visible phenotype (Ward et al., 2003)
Phenotype Manifest In
Enhanced by
Statement Reference zip²/zip¹ has dorsal closure embryo phenotype, enhanceable by Dpse\l(2)gl^+t12.2 (Franke et al., 2005)
Enhancer of
Statement Reference zip[+]/zip¹ is an enhancer of adult brain phenotype of Hsap\MAPT^{R406W.Scer\UAS}, Scer\GAL4^elav.PU (Duboff et al., 2012) zip[+]/zip¹ is an enhancer of eye phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Saja et al., 2010) zip[+]/zip¹ is an enhancer of mitochondrion phenotype of Hsap\MAPT^{R406W.Scer\UAS}, Scer\GAL4^elav.PU (Duboff et al., 2012) zip[+]/zip¹ is an enhancer of wing hair \| supernumerary phenotype of dsh¹ (Winter et al., 2001) zip[+]/zip¹ is an enhancer of wing hair \| supernumerary phenotype of fz^I.hs (Winter et al., 2001) zip[+]/zip¹ is an enhancer of wing hair \| supernumerary phenotype of Scer\GAL4^hs.PB, tow^Scer\UAS.cCa (Chung et al., 2007) zip[+]/zip¹ is an enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053 (Djiane and Mlodzik, 2010) zip¹ is an enhancer of ommatidium phenotype of S^48-5 (Gaengel and Mlodzik, 2003) zip¹ is an enhancer of wing hair \| supernumerary phenotype of Scer\GAL4^Bx-MS1096, pbl^{ΔDH497-549.Scer\UAS} (Echard and O'Farrell, 2003) zip¹ is an enhancer of wing phenotype of MYPT-75D^{F117A.Scer\UAS}, Scer\GAL4^Bx-MS1096 (Vereshchagina et al., 2004)
Suppressor of
Statement Reference zip[+]/zip¹ is a suppressor \| partially of crossvein phenotype of Scer\GAL4^en-e16E, rok^cat.Scer\UAS (Verdier et al., 2006) zip[+]/zip¹ is a suppressor \| partially of eye phenotype of Rac1^GMR.PN (Tan et al., 2003) zip[+]/zip¹ is a suppressor \| partially of oocyte \| somatic clone phenotype of flw^FP41 (Sun et al., 2011) zip[+]/zip¹ is a suppressor of cycle 14 embryo phenotype of CycB^+t10 (Ji et al., 2002) zip[+]/zip¹ is a suppressor of eye disc \| somatic clone phenotype of Mbs^T541 (Lee and Treisman, 2004) zip[+]/zip¹ is a suppressor of eye phenotype of rok^cat.GMR (Verdier et al., 2006) zip[+]/zip¹ is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^Scer\UAS.cUa (Fiehler and Wolff, 2008) zip[+]/zip¹ is a suppressor of wing phenotype of flw¹, puc^A251.1F3/puc[+] (Kirchner et al., 2007)
NOT Suppressor of
Statement Reference zip[+]/zip¹ is a non-suppressor of aster \| embryonic cycle 5 phenotype of CycB^+t10 (Ji et al., 2002) zip[+]/zip¹ is a non-suppressor of aster \| embryonic cycle 6 phenotype of CycB^+t10 (Ji et al., 2002) zip[+]/zip¹ is a non-suppressor of aster \| embryonic cycle 7 phenotype of CycB^+t10 (Ji et al., 2002) zip[+]/zip¹ is a non-suppressor of cycle 10 embryo phenotype of CycB^+t10 (Ji et al., 2002) zip¹/zip¹ is a non-suppressor of amnioserosa phenotype of Scer\GAL4^c381, dia^{CA.Scer\UAS.T:Ivir\HA1} (Homem and Peifer, 2008, Homem and Peifer, 2008) zip¹/zip¹ is a non-suppressor of embryonic epidermis phenotype of Scer\GAL4^en-e16E, dia^{CA.Scer\UAS.T:Ivir\HA1} (Homem and Peifer, 2008, Homem and Peifer, 2008)
Other
Statement Reference E(br)121^Ebr121, zip[+]/zip¹ has leg phenotype (Ward et al., 2003) E(br)121^Ebr121, zip¹ has leg phenotype (Ward et al., 2003) ena^C14-06, zip[+]/zip¹ has gonad \| embryonic stage phenotype (Sano et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference 51.9% of gonads fail to compact properly in ena[C14-06]/+, zip[1]/+ transheterozygous embryos, compared to 33.3% in zip[1]/+ single heterozygotes. (Sano et al., 2012) Expression of psidin[Scer\UAS.cKa] under the control of Scer\GAL4[slbo.2.6] in a zip[1] heterozygous background has little or no effect on border cell migration. (Kim et al., 2011) One copy of zip[1] partially suppresses the oocyte polarity defects seen when the posterior follicle cells are mutant for flw[FP41]. (Sun et al., 2011) A zip[1]/+ background enhances the visual system degeneration seen in Scer\GAL4[GMR.PF], Ppt1[Scer\UAS.cKa] flies. (Saja et al., 2010) The multiple wing hair phenotype caused by expression of tow^Scer\UAS.cCa under the control of Scer\GAL4^hs.PB using heat shock at 24 hours after puparium formation is enhanced if the flies are also carrying one copy of zip¹. (Chung et al., 2007) The wing defects seen in flw¹/Y ; puc^A251.1F3/+ flies are suppressed to wild type by zip¹/+. (Kirchner et al., 2007) The mislocalization of photoreceptors in Mbs^T541 clones is suppressed when eye discs have a zip¹/+ background. (Lee and Treisman, 2004) The amount of blistering and crumpling of wings in flies expressing MYPT-75D^{F117A.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 is suppressed by zip¹. (Vereshchagina et al., 2004) S^48-5/zip¹ mutants show 19.34%+-7.06 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. (Gaengel and Mlodzik, 2003) The small, rough eye phenotype of Rac1^GMR.PN flies is partially suppressed by heterozygosity for zip¹. (Tan et al., 2003) The fraction of flies showing a malformed leg phenotype in at least one leg, for zip¹ in double heterozygous combination with one of the following alleles is - Sb^Ebr20: 0%, Sb^Ebr48: 0%, Sb^Ebr228: 0%, Sb^Ebr448: 1%, Sb^Ebr536: 0%, Sb^Ebr623: 0%, Rho1^Ebr233: 2%, Rho1^Ebr246: 6%, bs^Ebr292: 0%, E(br)24^Ebr24: 11%, E(br)65^Ebr65: 2%, E(br)155^Ebr155: 1%, E(br)165^Ebr165: 6%, E(br)333^Ebr333: 3%, E(br)72^Ebr72: 1%, E(br)121^Ebr121: 32%, E(br)160^Ebr160: 1%, E(br)187^Ebr187: 0%, E(br)420^Ebr420: 2% and E(br)444^Ebr444: 1%. (Ward et al., 2003)
Xenogenetic Interactions
Statement Reference One copy of zip[1] enhances the increase in mitochondria length seen when Hsap\MAPT[R406W.Scer\UAS] is expressed under the control of Scer\GAL4[elav.PU]. (Duboff et al., 2012) Expression of two copies of Dpse\l(2)gl^+t12.2 raises the penetrance of the zip¹/zip² failed dorsal closure phenotype to 100%. Ubiquitous overexpression of zip^{FL.Scer\UAS.T:Avic\GFP}, under the control of the Scer\GAL4^sqh.PW, rescues dorsal closure in more than 84% of zip¹/zip²; Dpse\l(2)gl^+t12.2/Dpse\l(2)gl^+t12.2 embryos. 61% of these rescued flies survive to hatch as larvae, 41% survive to pupal stages and 2.8% eclose as adults. Expression of zip^{FL.Scer\UAS.T:Avic\GFP} in the epidermis and a few amnioserosa cells, driven by Scer\GAL4^e22c, rescues the zip¹/zip²; Dpse\l(2)gl^+t12.2/Dpse\l(2)gl^+t12.2 dorsal closure phenotype in 88% of embryos. Rescued flies survive to larval stages in 60% of cases and to pupal stages in 21% of cases, although no flies eclose. Expression of zip^{FL.Scer\UAS.T:Avic\GFP} in the amnioserosa, driven by Scer\GAL4^c381, rescues the dorsal closure phenotype of Dpse\l(2)gl^+t12.2/Dpse\l(2)gl^+t12.2 mutants in 82% of embryos. However, none of the rescued embryos survive to larval stages. Similarly, when zip^{FL.Scer\UAS.T:Avic\GFP} expression is driven in the leading edge by Scer\GAL4^LE, dorsal closure is rescued in 87% of embryos, but only 1% of flies survive to larval stages. zip^{FL.Scer\UAS.T:Avic\GFP} expression in epidermal stripes, driven by Scer\GAL4^en-e16E, rescues dorsal closure in only half of embryos and does not rescue lethality. (Franke et al., 2005)
Complementation & Rescue Data
Rescued by	zip²/zip¹ is rescued by zip^{SA2.Ubi-p63E.T:Hsap\MYC} (Su and Kiehart, 2001) zip²/zip¹ is rescued by zip^{SD2.Ubi-p63E.T:Hsap\MYC} (Su and Kiehart, 2001)
Partially rescued by	zip¹ is partially rescued by zip^{Scer\UAS.T:Avic\GFP}/Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} (Barros et al., 2003) zip²/zip¹ is partially rescued by Scer\GAL4^sqh.PW/zip^{D1430N.Scer\UAS.T:Avic\GFP} (Franke et al., 2007) zip²/zip¹ is partially rescued by Scer\GAL4^sqh.PW/zip^{FL.Scer\UAS.T:Avic\GFP} (Franke et al., 2010, Franke et al., 2007) zip²/zip¹ is partially rescued by Scer\GAL4^sqh.PW/zip^{R1933X.Scer\UAS.T:Avic\GFP} (Franke et al., 2007) zip²/zip¹ is partially rescued by zip^{D1847K.Scer\UAS.T:Avic\GFP}/Scer\GAL4^sqh.PW (Franke et al., 2007) zip²/zip¹ is partially rescued by zip^{R1171C.Scer\UAS.T:Avic\GFP}/Scer\GAL4^sqh.PW (Franke et al., 2007)
Not rescued by	zip²/zip¹ is not rescued by Scer\GAL4^sqh.PW/zip^{HMM.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) zip²/zip¹ is not rescued by Scer\GAL4^sqh.PW/zip^{Rod.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) zip²/zip¹ is not rescued by Scer\GAL4^sqh.PW/zip^Rod.Scer\UAS (Franke et al., 2010) zip²/zip¹ is not rescued by zip^{DN.Scer\UAS.T:Avic\GFP}/Scer\GAL4^sqh.PW (Franke et al., 2010)
Comments	Expression of zip[FL.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[sqh.PW] rescues the embryonic lethality of zip[1]/zip[2] animals. 86 +/- 2% of the rescued animals survive to the pupal stage, but only 6 +/- 7% eclose as adults. Expression of zip[R1171C.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[sqh.PW] rescues the embryonic lethality of zip[1]/zip[2] animals. 62 +/- 10% of the rescued animals survive to the pupal stage, but only 18 +/- 12% eclose as adults. Expression of zip[D1430N.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[sqh.PW] rescues the embryonic lethality of zip[1]/zip[2] animals. 72 +/- 5% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage. Expression of zip[D1847K.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[sqh.PW] rescues the embryonic lethality of zip[1]/zip[2] animals. 85 +/- 12% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage. Expression of zip[R1933X.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[sqh.PW] rescues the embryonic lethality of zip[1]/zip[2] animals. 85 +/- 4% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage. (Franke et al., 2007) Expression of zip^{Scer\UAS.T:Avic\GFP}, driven by Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}, allows 34% of zip¹ mutants to hatch and undergo larval development, instead of dying as embryos. (Barros et al., 2003)
Stocks ( 2 )
Bloomington	4199 cn¹ bw¹ sp¹ zip¹/CyO
Kyoto	107626 cn¹ bw¹ sp¹ zip¹/CyO
Notes on Origin
Discoverer

Comments
	zip¹ homozygous embryos show a more severe phenotype than zip² homozygous embryos. (Zhao et al., 1988)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	ID16 (Young et al., 1993) zip-1 (Gaengel and Mlodzik, 2003) zip¹ (Franke et al., 2006, Brodu and Casanova, 2006, Christensen et al., 2008.9.3, Walters et al., 2006, Chung et al., 2007, Kirchner et al., 2007, Kirchner et al., 2007, Rodriguez-Diaz et al., 2008, Homem and Peifer, 2008, Warner and Longmore, 2009, Franke et al., 2010, Chung et al., 2009, Gettings et al., 2010, Monier et al., 2010, Djiane and Mlodzik, 2010, Verdier et al., 2006, Saja et al., 2010, Fiehler and Wolff, 2008, Okumura et al., 2010, Sun et al., 2011, Sano et al., 2012, Gault et al., 2012, Franke et al., 2007, Duboff et al., 2012) zip^1D16 (Bloor and Kiehart, 2001, Su and Kiehart, 2001, Williams et al., 2001, Pederson et al., 1996, Kim et al., 2011) zip^ID16 (Zhao et al., 1988, ) zip^ID (Tearle and Nusslein-Volhard, 1987) zpr^1D16 (Silver and Montell, 2001)
Name Synonym
Secondary FlyBase IDs

References ( 51 )

Generate a list of	All references relating to this allele ( 51 )

List References by type	Research paper ( 48 ) Personal communication to FlyBase ( 1 ) Abstract ( 1 ) Stock list ( 1 )
Recent research papers ( 5 )
	Duboff et al., 2012, Neuron 75(4): 618--632 Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo. [FBrf0219271] Gault et al., 2012, J. Cell Biol. 196(5): 605--621 Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. [FBrf0217630] Sano et al., 2012, PLoS ONE 7(12): e52649 The Drosophila Actin Regulator ENABLED Regulates Cell Shape and Orientation during Gonad Morphogenesis. [FBrf0220491] Kim et al., 2011, Genes Dev. 25(7): 730--741 Psidin, a conserved protein that regulates protrusion dynamics and cell migration. [FBrf0213388] Sun et al., 2011, Development 138(10): 1991--2001 Regulation of somatic myosin activity by Protein Phosphatase 1{beta} controls Drosophila oocyte polarization. [FBrf0213586] Show all research papers ...

Allele Dmel\zip1

Allele Dmel\zip¹