Allele Dmel\Abd-B⁰⁵⁶⁴⁹

General Information
Symbol	Dmel\Abd-B⁰⁵⁶⁴⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0019069
Feature type	allele	Associated gene	Dmel\Abd-B
Also Known As	fs(3)05649, fs(3)5649

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Castrillon et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:12,744,787..12,744,787 (Castrillon et al., 1993, Zhou and Levine, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999, Bellen et al., 2004, Barges et al., 2000, Iampietro et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{PZ} insertion within the iab-7 domain, immediately adjacent to the minimal Fab-8 insulator. (Zhou and Levine, 1999)
Caused by insertion	P{PZ}Abd-B⁰⁵⁶⁴⁹ (Castrillon et al., 1993, Zhou and Levine, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999, Bellen et al., 2004, Barges et al., 2000, Iampietro et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Castrillon et al., 1993) female sterile \| recessive (Spradling et al., 1999) fertile, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008) homeotic, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008) male sterile (Castrillon et al., 1993) visible, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008) visible \| homeotic (with Df(3R)Abd-B^S10) (Zhou and Levine, 1999)
Phenotype Manifest In
	abdominal segment 6 \| ectopic, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008) abdominal segment 7, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008) abdominal segment 8 \| ectopic, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008) abdominal sternite 7, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008) abdominal tergite 5 (with Df(3R)Abd-B^S10) (Zhou and Levine, 1999) abdominal tergite 5 & trichome (with Df(3R)Abd-B^S10) (Zhou and Levine, 1999) abdominal tergite 7 (with Df(3R)Abd-B^S10) (Zhou and Levine, 1999) anal plate (Castrillon et al., 1993) trichome, with Abd-B^{Fab8-305-Fab7} (Iampietro et al., 2008)
Detailed Description
	Statement Reference Almost all homozygous Abd-B[Fab8-305-Fab7] mutants (in a Abd-B[05649] background) are wild type in appearance and are fertile. In rare cases flies patches of cells in A7 take on an A6 or A8 identity. Abd-B[Fab8-305-Fab7], Abd-B[05649]/Df(3R)R59 mutants display two distinct phenotypes; in some flies the A7 segments take on features characteristic of the A6 segment (a wider sternite with bristles oriented towards the lateral side) and in others they take on features normally seen in A8 (absence of trichomes). The phenotype appears identical regardless of the orientation of the insertion. (Iampietro et al., 2008) Heterozygous adult males show a normal segmentation pattern in the abdomen. Abd-B⁰⁵⁶⁴⁹/Df(3R)Abd-B^S10 males show abdominal transformations; the A7 tergite is fully developed in these animals, indicating a transformation towards an A5/A6 identity. In addition, the A5 tergite is partially transformed towards A4, as indicated by a partial loss of pigment in anterior regions and by the trichome pattern. (Zhou and Levine, 1999) Anal plate twisted in both males and females. (Castrillon et al., 1993)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	A. Spradling.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Abd-B⁰⁵⁶⁴⁹ fs(3)05649 (Bellen et al., 2004, Spradling et al., 1999, ) fs(3)5649 (Barges et al., 2000, Zhou and Levine, 1999) iab-7^p302 (Zhou and Levine, 1999) ms(3)05649 twig¹ (Castrillon et al., 1993, ) twig⁰⁵⁶⁴⁹
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Iampietro et al., 2008, Development 135(24): 3983--3987 Boundary swapping in the Drosophila Bithorax complex. [FBrf0206852] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132] Barges et al., 2000, Development 127(4): 779--790 The fab-8 boundary defines the distal limit of the Bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain. [FBrf0125451] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Zhou and Levine, 1999, Cell 99(6): 567--575 A novel cis-regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo. [FBrf0123260] Castrillon et al., 1993, Genetics 135(2): 489--505 Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. [FBrf0064394]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\Abd-B05649

Allele Dmel\Abd-B⁰⁵⁶⁴⁹