FlyBase Allele Report: Dmel\aly[1]

General Information

Symbol

Dmel\aly¹

Species

D. melanogaster

Name

FlyBase ID

FBal0019212

Feature type

allele

Associated gene

Dmel\aly

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Lin et al., 1996, Berg and Spradling, 1991)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates nervous system disease

modeled by Atpα^DTS1

(Talsma et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | recessive

abnormal meiotic cell cycle | recessive | heat sensitive

(Lin et al., 1996)

male sterile

(Berg and Spradling, 1991)

male sterile | recessive

male sterile | recessive | heat sensitive

(Lin et al., 1996)

Phenotype Manifest In

spermatocyte | heat sensitive

(Lin et al., 1996)

testis | heat sensitive

(Lin et al., 1996)

Detailed Description

Statement

Reference

Permissive temperature is 18^oC, restrictive temperature is 27^oC. Early stages of spermatogenesis up through mature primary spermatocytes are present and normal. Postmeiotic stages are completely absent. Mutant testes have an abundance of mature primary spermatocytes with large, round nuclei and prominent nucleoli. Triple mutant aly¹, can¹, sa¹ homozygotes are female fertile and male sterile, with similar effects on testis squashes as sa¹ and can¹. Spermatocytes arrest in the G₂/M transition of meiosis I with partial chromosome condensation. At 18^oC spermatocytes complete meiosis and undergo abnormal spermatid differentiation.

(Lin et al., 1996)

premeiotic defect No meiotic divisions or postmeiotic stages; spermatocytes accumulate.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

1148

P{ry11}ry2, mwh¹ aly¹ ry⁵⁰⁶ e¹/TM3, ry^RK Sb¹ Ser¹

Kyoto

106225

P{ry11}ry2, mwh¹ aly¹ ry⁵⁰⁶ e¹/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

C. Berg and A. Spradling.

(Berg and Spradling, 1991)

Comments

Not associated with a detectable P-element insertion at the aly locus.

(Lin et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Aly¹

(Talsma et al., 2014)

aly¹

(Di Cara et al., 2010, Christensen et al., 2008.4.15, Christensen et al., 2008.12.28, Boutanaev et al., 2007, Mikhaylova et al., 2006)

ms(3)2¹

ms(3)ry2

ms(3)ry2¹

Name Synonyms

Secondary FlyBase IDs

FBal0032183
FBal0035230

References (12)

Report Sections

Open Close