A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\al130

General Information
SymbolDmel\al130SpeciesD. melanogaster
NameFlyBase IDFBal0027956
Feature typealleleAssociated geneDmel\al
Allele class
MutagenX ray
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Description
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What does this section not display?
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
X ray
 
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Inversion breakpoint resides between the Pro- and charged domain of the al gene product at position 9332.
(Schneitz et al., 1993)
Caused by aberration
In(2L)al130
(Campbell and Tomlinson, 1998, Campbell, 2005, Schneitz et al., 1993)
Cytology
hide Phenotypic Data
hide Phenotypic Class
lethal | recessive
(Schneitz et al., 1993)
visible
(Schneitz et al., 1993)
visible (with alush)
(Wehn and Campbell, 2006)
visible | recessive
(Campbell and Tomlinson, 1998)
hide Phenotype Manifest In
arista
(Schneitz et al., 1993)
arista (with alush)
(Campbell, 2005, Wehn and Campbell, 2006)
scutellum
(Schneitz et al., 1993)
unguis
(Campbell and Tomlinson, 1998)
hide Detailed Description
Statement
Reference
al130/alush animals have an almost full length arista.
(Wehn and Campbell, 2006)
In al130/alush mutants, the arista is very slightly reduced in length.
(Campbell, 2005)
Homozygous legs have a rudimentary claw and the pulvillus is present. The tarsal segments are of normal size.
(Campbell and Tomlinson, 1998)
Arista and scutellum are reduced in size. Introduction of a 13.3kb genomic al fragment in P{al-13.3} causes partial rescue of the scutellum phenotype and complete rescue of lethality, though the aristae are still reduced in size. Homozygous flies that carry one copy of alB38 in P{al-13.3} display gaps in the most proximal part of the second longitudinal wing vein and the wing blade is bent downward at its posterior tip.
(Schneitz et al., 1993)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideEnhanced by
Statement
Reference
alush/al130 has visible phenotype, enhanceable by groEal13/gro[+]
(Wehn and Campbell, 2006)
alush/al130 has visible phenotype, enhanceable by Gug[+]/GugEal15
(Wehn and Campbell, 2006)
alush/al130 has visible phenotype, enhanceable by sbb[+]/sbbEal17
(Wehn and Campbell, 2006)
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
alush/al130 has arista phenotype, enhanceable by C152/C15[+]
(Campbell, 2005)
alush/al130 has arista phenotype, enhanceable by Df(3R)e-19
(Campbell, 2005)
alush/al130 has arista phenotype, enhanceable by Df(3R)e-BS2
(Campbell, 2005)
alush/al130 has arista phenotype, enhanceable by groEal13/gro[+]
(Wehn and Campbell, 2006)
alush/al130 has arista phenotype, enhanceable by Gug[+]/GugEal15
(Wehn and Campbell, 2006)
alush/al130 has arista phenotype, enhanceable by sbb[+]/sbbEal17
(Wehn and Campbell, 2006)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
The short arista alush/al130 phenotype is enhanced in C152/+ flies. This phenotype is also enhanced when flies carry either the Df(3R)e-19 or the Df(3R)e-BS2 deficiency; both of which remove the C15 gene.
(Campbell, 2005)
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Comments
hide Stocks ( 2 )
Bloomington
3446
In(2L)al130, al130 ds1/Df(2L)S3
Kyoto
107044
In(2L)al130, al130 ds1/Df(2L)S3
hide Notes on Origin
Discoverer
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym
al130
(Wehn and Campbell, 2006)
Name Synonym
Secondary FlyBase IDs
hide References ( 4 )
Research paper
Wehn and Campbell, 2006, Genetics 173(2): 849--861
Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression. [FBrf0193648]
Campbell, 2005, Dev. Biol. 278(2): 607--618
Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15. [FBrf0183856]
Campbell and Tomlinson, 1998, Development 125(22): 4483--4493
The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila. [FBrf0105784]
Schneitz et al., 1993, Genes Dev. 7(1): 114--129
Molecular genetics of Aristaless, a prd-type homeobox gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. [FBrf0058515]