1826bp deletion extending from 581bp upstream of the start site of the deletion present in the eya2 mutant and extends 344bp into the 5'UTR of the eya-RB transcript. An additional 11bp that do not correspond to the published genome sequence are also present.
1.5kb deletion upstream of the transcription start site of the type I eya transcript.
Small deletion outside the coding region.
photoreceptor cell & axon
The small eye phenotype characteristic for eya1 homozygotes carrying the eyaRB.enhE transgene, i.e. partial rescue of the eyeless phenotype of the eya1 mutants, is improved further by combination with eyaRB.enh1 (which on its own also partially rescues the no-eye phenotype of eya1 mutants) but not by combination with any of the following: eyaRB.enh2, eyaRB.enh3, eyaRB.enh4 or eyaRB.PSE (none of which on its own can rescue the eyeless phenotype of eya1 adults).
Under LD conditions eya1;cryb double mutant flies exhibit the typical bimodal activity pattern consisting of M and E activity bouts, as in wild-type. After transfer into LL conditions, eya1;cryb flies remain rhythmic and free-run with a period close to 24 hours (whereas wild-type flies become immediately arrhythmic).
The no-eye phenotype of adult eya1 homozygous mutants can be fully rescued by combination with eyaRB.enh1+E+2 and partially restored by combination with any of the following: eyaRB.enh1, eyaRB.enhE, eyaRB.enh1+E or eyaRB.enh1+s+2 but cannot be rescued by any of these transgenes: eyaRB.enh2, eyaRB.enh3, eyaRB.enh4 or eyaRB.PSE.
More than 40 alleles obtained by X-ray and EMS mutagenesis.