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General Information
Symbol
Dmel\fafBX4
Species
D. melanogaster
Name
FlyBase ID
FBal0028189
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Inversion breakpoint in exon 3.
Inversion breakpoint falls in coding region of faf.
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
fafBX4 homozygous somatic clones in the eye lead to the formation of ommatidia containing one additional photoreceptor cell. For an ommatidium to show this phenotype, it is sufficient for 2 of the photoreceptors R2 to R5 to be mutant, but no particular cell of this group need be.
The external surface of the eye is irregular in fafFO8/fafBX4 flies and most facets contain more than the wild-type number of photoreceptor cells.
fafBX4/fafFO8 flies have a rough eye phenotype, due to the ommatidia containing more than the normal number of photoreceptor cells.
BrdU incorporation resembles wild type in fafFO8/fafBX4 third larval instar eye discs.
Most facets of homozygotes contain more than the normal complement of 8 photoreceptor cells, many facets have extra R7 cells and a small proportion have missing R7 cells.
Mutation causes no significant alteration to the variegated eye phenotype of In(1)wm4h.
Average fraction of wild type facets is ~4.5%.
Eyes roughened due to abnormalities in the hexagonal facet array: most facets include 1-3 extra outer photoreceptor cells which are probably mystery cells. Ovaries of homozygous females are normal in appearance but the embryos produced never form syncytial blastoderm and all fail to hatch.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
fafBX4 has visible phenotype, enhanceable by aopyan-1/aop[+]
Suppressed by
Statement
Reference
fafFO8/fafBX4 has visible phenotype, suppressible by Mmus\Usp9x+.ro
fafFO8/fafBX4 has visible phenotype, suppressible by Mmus\Usp9x-.ro
fafBX4 has visible phenotype, suppressible by pnt[+]/pntΔ88
fafBX4 has visible phenotype, suppressible by JraIA109/Jra[+]
fafBX4 has visible phenotype, suppressible by 14-3-3ζE16/14-3-3zeta[+]
fafBX4 has visible phenotype, suppressible by pnt1277
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
fafBX4/faf[+] is a suppressor of bang sensitive | dominant phenotype of pksple-1
NOT Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
fafBX4 has photoreceptor cell R1 | ectopic phenotype, enhanceable by aopyan-1/aop[+]
fafBX4 has photoreceptor cell R2 | ectopic phenotype, enhanceable by aopyan-1/aop[+]
fafBX4 has photoreceptor cell R3 | ectopic phenotype, enhanceable by aopyan-1/aop[+]
fafBX4 has photoreceptor cell R4 | ectopic phenotype, enhanceable by aopyan-1/aop[+]
fafBX4 has photoreceptor cell R5 | ectopic phenotype, enhanceable by aopyan-1/aop[+]
fafBX4 has photoreceptor cell R6 | ectopic phenotype, enhanceable by aopyan-1/aop[+]
Suppressed by
Statement
Reference
fafFO8/fafBX4 has eye phenotype, suppressible by lqf+t19G
fafFO8/fafBX4 has eye phenotype, suppressible by lqfro.Tag:FLAG
fafFO8/fafBX4 has ommatidium phenotype, suppressible by Mmus\Usp9x+.ro
fafFO8/fafBX4 has ommatidium phenotype, suppressible by Mmus\Usp9x-.ro
fafBX4 has photoreceptor cell R1 | ectopic phenotype, suppressible by pnt[+]/pntΔ88
fafBX4 has photoreceptor cell R2 | ectopic phenotype, suppressible by pnt[+]/pntΔ88
fafBX4 has photoreceptor cell R3 | ectopic phenotype, suppressible by pnt[+]/pntΔ88
fafBX4 has photoreceptor cell R4 | ectopic phenotype, suppressible by pnt[+]/pntΔ88
fafBX4 has photoreceptor cell R5 | ectopic phenotype, suppressible by pnt[+]/pntΔ88
fafBX4 has photoreceptor cell R1 | ectopic phenotype, suppressible by JraIA109/Jra[+]
fafBX4 has photoreceptor cell R2 | ectopic phenotype, suppressible by JraIA109/Jra[+]
fafBX4 has photoreceptor cell R3 | ectopic phenotype, suppressible by JraIA109/Jra[+]
fafBX4 has photoreceptor cell R4 | ectopic phenotype, suppressible by JraIA109/Jra[+]
fafBX4 has photoreceptor cell R5 | ectopic phenotype, suppressible by JraIA109/Jra[+]
fafBX4 has photoreceptor cell R6 | ectopic phenotype, suppressible by JraIA109/Jra[+]
fafBX4 has photoreceptor cell R1 | ectopic phenotype, suppressible by 14-3-3ζE16/14-3-3zeta[+]
fafBX4 has photoreceptor cell R2 | ectopic phenotype, suppressible by 14-3-3ζE16/14-3-3zeta[+]
fafBX4 has photoreceptor cell R3 | ectopic phenotype, suppressible by 14-3-3ζE16/14-3-3zeta[+]
fafBX4 has photoreceptor cell R4 | ectopic phenotype, suppressible by 14-3-3ζE16/14-3-3zeta[+]
fafBX4 has photoreceptor cell R5 | ectopic phenotype, suppressible by 14-3-3ζE16/14-3-3zeta[+]
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
fafFO8/fafBX4 is a non-suppressor of synapse phenotype of hiwunspecified
fafBX4 is a non-suppressor of synapse phenotype of hiwunspecified
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
The presence of fafBX4/+ rescues the bang-sensitive phenotype of pksple-1/+ mutants.
The addition of either homozygous fafBX4, or fafBX4/fafFO8 suppresses the physiological phenotype of hiwunspecified, leading to a more tha doubling of both quantal content and mEJP frequency. However the synaptic overgrowth phenotype is not affected.
The fafFO8/fafBX4 eye phenotype is completely suppressed by one copy of lqf+t19G or lqfro.T:Zzzz\FLAG.
The extra outer photoreceptor cell phenotype is suppressed by pnt1277 : fafBX4 ; pnt1277 double homozygotes have an average of 6.2 outer photoreceptor cells per ommatidium. The extra outer photoreceptor cell phenotype is dominantly suppressed by pntΔ88, by 14-3-3ζE16 and also by JraIA109. The extra outer photoreceptor cell phenotype is dominantly enhanced by aopyan-1 : aopyan-1/+ ; fafBX4/fafBX4 flies have an average of 8.7 outer photoreceptor cells per ommatidium. Does not alter the outer photoreceptor cell phenotype of phl12/Y males. 60% of sev14; fafBX4 double homozygous ommatidia have an R7 cell.
Suppression appears to be due to the presence of Scer\GAL4 protein ahead of the furrow.
Xenogenetic Interactions
Statement
Reference
Mmus\Usp9x+.ro or Mmus\Usp9x-.ro rescue nearly completely the eye phenotype of fafBX4/fafFO8 flies.
Complementation and Rescue Data
Comments
fafhs.T:Hsap\MYC and fafro.T:Hsap\MYC can nearly completely rescue the eye phenotype, fafglrs partially rescues and, fafglrl and fafsev.PH fail to rescue.
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments
No interaction with P{sev-svp1} or P{sev-svp2} exists.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (18)