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General Information
Symbol
Dmel\heph2
Species
D. melanogaster
Name
FlyBase ID
FBal0028257
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{PZ} insertion in a large intron of heph.

Insertion components
P{PZ}heph2
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

heph2 heterozygous third instar larval mitotic neuroblasts exhibit an abnormal number of chromosomes compared to controls.

At 25[o]C, only 8% of heph2 flies reach adulthood. The survival frequency is increased to 33% and 67% when mutant flies are raised at 21[o]C and 17[o]C respectively.

The testis tips of heph2 mutants are swollen to many times their normal diameter. The testes show a lack of motile sperm, and a pronounced accumulation of cysts of elongated spermatids. A few cysts of elongated spermatids appear to be partially individualized, and spermatids in cysts often have numerous bulges along their length which is not observed in wild-type testes.

Despite severe defects in spermatid individualisation capase activity is detectable in spermatid cysts of heph2 homozygotes, as in wild-type at this stage.

The tip of the testis in homozygotes is enlarged and males are sterile. Mutant testes accumulate cysts of elongated spermatids, and the enlarged tip is also filled with these cysts. In addition mutant lack fully individualised motile sperm. All of the stages up to elongated sperm can be seen. The majority of the elongated spermatid show numerous bulges along the tails characteristic of a defect during the individualisation process.

Tip of testis is dilated to twice wild type circumference.

Tip of testis dilated to approximately twice the wild type circumference.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Enhancer of
NOT Suppressor of
Phenotype Manifest In
Enhancer of
Statement
Reference

heph[+]/heph2 is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)