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General Information
Symbol
Dmel\Vha55j2E9
Species
D. melanogaster
Name
FlyBase ID
FBal0028379
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)j2E9
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion into the intron that maps between bases 160 and 161 of the characterized cDNA.

Insertion components
P{lacW}Vha55j2E9
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Predominantly mutant Vha55j2E9 eye discs (generated using Scer\FLP1ey.PN) are small in size compared to wild type and have aberrant morphology.

Vha55j2E9 eye disc cells show an increased number of multivesicular bodies (MVBs) compared to wild type. These MVBs are enlarged and contain a high number of luminal vesicles.

A portion of the cells in Vha55j2E9 mosaic clones are eliminated from the disc, especially when surrounded by wild type cells.

Vha55j2E9 mosaic eye disc clones underproliferate compared to controls.

Mutants have clear Malpighian tubules (when examined by birefringence).

Homozygotes die around the time of hatching.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Enhancer of
Statement
Reference

Vha55j2E9/Vha55[+] is an enhancer of visible | heat sensitive phenotype of Ivir\M2UAS.cAa, Scer\GAL4GMR.PU

Suppressor of
NOT Suppressor of
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

Vha55j2E9/Vha55[+] is an enhancer of eye | heat sensitive phenotype of Ivir\M2UAS.cAa, Scer\GAL4GMR.PU

Suppressor of
Statement
Reference

Vha55j2E9 is a suppressor of eye phenotype of KrIf-1

Vha55j2E9 is a suppressor of ommatidium phenotype of KrIf-1

Vha55j2E9/Vha55[+] is a suppressor of eye phenotype of KrIf-1

Vha55j2E9/Vha55[+] is a suppressor of sex comb | ectopic phenotype of Pc11

NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Eye disc clones expressing NECN.Scer\UAS.cGa under the control of Scer\GAL4Act5C.PP in a Vha55j2E9 mutant background do not proliferate as in a wild-type background and instead create only small clones, of a similar size to Vha55j2E9 mutant clones.

A Vha55j2E9 mutant clone background does not suppress the overproliferation phenotype seen when Nintra.GS.Scer\UAS is expressed in eye disc clones under the control of Scer\GAL4Act5C.PP.

Clones in the eye discs of Vha55j2E9 lsnZZ13 double mutants display the underproliferation phenotype seen in Vha55j2E9 mutant clones.

Mutation suppresses the ectopic sex comb phenotype of Pc11 mutant males.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

L. and Y. Jan.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)