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General Information
Symbol
Dmel\RpS12s2783
Species
D. melanogaster
Name
FlyBase ID
FBal0028400
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{lacW}RpS12s2783
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
RpS12s2783 homozygotes and RpS12s2783/RpS12c06284 and RpS12s2783/RpS12EP3025 transheterozygotes are lethal. RpS12G97D/RpS12s2783 transheterozygotes are viable, do not shown any developmental delay (assessed by the time until eclosion), and lack any obvious morphological defects, including any minute bristle-like phenotype, as compared to controls. RpS12s2783-homozygous clones in larval wing discs are not recovered, suggesting that RpS12s2783 is homozygous cell lethal. RpS12s2783-heterozygous clones in larval wing discs are not outcompeted by neighboring wild-type clones.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
RpS12s2783/RpS12[+] is a suppressor | partially of visible phenotype of CycEJP
NOT Suppressor of
Other
Phenotype Manifest In
NOT suppressed by
Statement
Reference
RpS12s2783 has wing disc | somatic clone | larval stage phenotype, non-suppressible by M(2)56FH/M(2)56FH/M(2)56F[+]
Suppressor of
Statement
Reference
RpS12s2783/RpS12[+] is a suppressor | partially of eye phenotype of CycEJP
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Df(1)su(s)R194-heterozygous clones in the larval eye disc are outcompeted by neighboring clones that also harbor RpL36+t4); this phenotype is not suppressed by homozygosity for RpS12s2783 alone or in combination with RpS12+t2. RpS12G97D/RpS12s2783 transheterozygosity do not suppress the minute phenotype observed in M(2)56FH heterozygotes (i.e. developmental delay and minute bristles). The following genotypes also result in a minute-like developmental delay phenotype as compared to controls: Df(1)su(s)R194/+, RpS12s2783/+; Df(1)su(s)R194/+, RpS12s2783/RpS12s2783; Df(1)su(s)R194/+, RpS12s2783/RpS12s2783, RpS12+t2; or Df(1)su(s)R194/+, RpS12s2783/RpS12s2783, RpS12G97D.2kb. The cell lethality of RpS12s2783 is not suppressed by Df(2R)BSC865, as RpS12s2783-homozygous clones in larval wing discs are still not recovered in a Df(2R)BSC865 heterozygous background. Df(2R)BSC865, RpS12s2783 and M(2)56FH, RpS12s2783 double heterozygous larval wing disc cells outcompete Df(2R)BSC865 and M(2)56FH single heterozygous cells, respectively, as single heterozygous clones are rarely recovered within the respective double heterozygous background. MycαTub84B.PBb homozygous clones in larval wing discs are outcompeted by neighboring wild-type clones; this phenotype is not suppressed by a RpS12G97D/RpS12s2783 transheterozygous background.
The eye phenotype seen in homozygous CycEJP adults is moderately suppressed if they are also heterozygous for RpS12s2783.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
The lethal phenotype of RpS12s2783/RpS12EP3025 transheterozygotes is rescued by two copies of RpS12Δ2-3.6kb. The cell lethality of RpS12s2783-homozygous clones in larval wing discs is suppressed by two copies of RpS12+t2 or RpS12G97D.2kb.
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
M. Scott.
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)