FlyBase Allele Report: Dmel\hid[rvX1]

General Information

Symbol

Dmel\hid^rvX1

Species

D. melanogaster

Name

FlyBase ID

FBal0028613

Feature type

allele

Associated gene

Dmel\hid

Associated Insertion(s)

Carried in Construct

Also Known As

hid^WR+X1

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Abbott and Lengyel, 1991)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

hid¹

(Abbott and Lengyel, 1991)

Caused by aberration

In(3L)W^rvX1

Cytology

Nature of the lesion

Statement

Reference

Deletion of the 5' end of W.

(Grether et al., 1995)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death

(Grether et al., 1995)

decreased cell death (with hid⁰⁵⁰¹⁴)

(Cordero et al., 2004)

Phenotype Manifest In

arista (with Df(3L)H99)

(Cullen and McCall, 2004)

arista lateral | ectopic (with Df(3L)H99)

(Cullen and McCall, 2004)

dorsal fold

(Grether et al., 1995)

embryonic head

(Grether et al., 1995)

eye disc (with hid⁰⁵⁰¹⁴)

(Cordero et al., 2004)

long arista lateral (with Df(3L)H99)

(Cullen and McCall, 2004)

midline glial cell

(Bergmann et al., 2002)

ommatidial precursor cluster (with hid⁰⁵⁰¹⁴)

(Cordero et al., 2004)

Detailed Description

Statement

Reference

W⁰⁵⁰¹⁴/W^rvX1 pupal eye discs lack any evidence of "early stage" cell death (this normally occurs between 18-24 hours after puparium formation). The ommatidia in these pupal retinas are disorganised compared to wild type due to the excess of cells present. The retinas often appear to be attached to what seems to be the antennal disc in the pupae.

(Cordero et al., 2004)

W^rvX1/Df(3L)H99 mutant animals exhibit ectopic branching on their aristae. The antennae of these animals are larger than wild-type, the aristae have a hairy appearance. While the number and position of anterior branches remain similar to wild-type, the posterior aristae show fewer long lateral branches along the dorsal posterior axis. These extra branches are longer than typical dorsal branches yet shorter than anterior and posterior branches. In addition, the ectopic branches are located very close to each other and often stemmed from the same, or an adjacent position on the central core, unlike the regular spacing seen in wild-type. Also mutant aristae do not terminate in the typical forked pattern but split into 4-5 small branches arranged in a spiral fashion about the central axis.

(Cullen and McCall, 2004)

W^rvX1 mutant embryos have increased numbers of midline glial cells at stage 17.

(Bergmann et al., 2002)

The ventral crustacean cardioactive peptide immunoreactive (vCCAP-IR) neurons of the ventral nervous system die on schedule in heterozygous flies.

(Draizen et al., 1999)

Homozygotes display significantly reduced viability. Pronounced defect in the morphogenetic movements of head involution which results, in part, from a failure of the dorsal fold to migrate anteriorly. Otherwise the segmented cuticle is normal and individuals reach advanced stages. There is less apoptosis when compared to wild type, most noticeably in the head region prior to completion of head involution.

(Grether et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hid^rvX1/Df(3L)H99 is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PU, p53^GUS.PB

(Fan et al., 2010)

hid^rvX1/W[+] is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, rpr^{UTR.UAS.Tag:HA}

(Sandu et al., 2010)

hid^rvX1/Df(3L)H99 is a suppressor of increased cell death | embryonic stage phenotype of bcd^unspecified

(Werz et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

hid^rvX1 has midline glial cell phenotype, enhanceable by rl^Sem/rl^Sem

(Bergmann et al., 2002)

Suppressor of

Statement

Reference

hid^rvX1/W[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, rpr^{UTR.UAS.Tag:HA}

(Sandu et al., 2010)

hid^rvX1/hid^rvX1 is a suppressor of midline glial cell phenotype of spi¹

(Bergmann et al., 2002)

hid^rvX1/hid^rvX1 is a suppressor of midline glial cell phenotype of Egfr^DN.UAS, Scer\GAL4^sli.PS

(Bergmann et al., 2002)

hid^rvX1 is a suppressor of phenotype of arm³

(Cox et al., 2000)

NOT Suppressor of

Statement

Reference

hid^rvX1/Df(3L)H99 is a non-suppressor of eye disc | posterior | third instar larval stage phenotype of Scer\GAL4^GMR.PU, p53^GUS.PB

(Fan et al., 2010)

hid^rvX1/Df(3L)H99 is a non-suppressor of larval head phenotype of bcd^unspecified

(Werz et al., 2005)

hid^rvX1/Df(3L)H99 is a non-suppressor of larval thorax phenotype of bcd^unspecified

(Werz et al., 2005)

Other

Statement

Reference

hid^rvX1/Df(3L)H99, bcd^unspecified has larval abdominal segment phenotype

(Werz et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

A W^rvX1/Df(3L)H99 background significantly suppresses the cell death seen when p53^GUS.PB is expressed in third instar eye discs under the control of Scer\GAL4^GMR.PU.

(Fan et al., 2010)

A W^rvX1 heterozygous background suppresses the degree of rpr^{UTR.Scer\UAS.T:Ivir\HA1}-induced eye ablation.

(Sandu et al., 2010)

The increased cell death that occurs in the presumptive head and thorax regions of bcd^unspecified embryos can be suppressed by mutation of W, as observed in bcd^unspecified, Df(3L)H99/W^rvX1 double mutants. bcd^unspecified, Df(3L)H99/W^rvX1 double mutant larvae have an expanded first abdominal segment that is transformed into a posterior A8 identity, but still lack the head and thorax. Therefore, the transformed abdominal segment must usually undergo cell death in bcd^unspecified single mutants, due to the mis-specificity of the cells within it.

(Werz et al., 2005)

The increase in midline glial cells seen in W^rvX1 mutant embryos is slightly enhanced by rl^Sem/rl^Sem (from 5.8 (n=182) to 6.6 (n=91)). The loss of midline glial (MG) cells in Egfr^DN.Scer\UAS; Scer\GAL4^sli.PS embryos is suppressed by W^rvX1/W^rvX1. Approximately twice as many MG cells survive as in wild-type (average of 6.1 per segment n=201, compared to average = 2.8 for wild-type). The loss of midline glial (MG) cells in spi¹ homozygous embryos is suppressed by W^rvX1/W^rvX1. Approximately twice as many MG cells survive as in wild-type (average of 5.7 per segment n=133, compared to average = 2.8 for wild-type).

(Bergmann et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

W^rvX1

Wrinkled^R+X1

(Cox et al., 1998)

hid<up>WR + X1</up>

(Fan et al., 2010)

hid^WR+X1

(Sandu et al., 2010, Werz et al., 2005, Cullen and McCall, 2004, Bergmann et al., 2002, Cox et al., 2000, Bergmann et al., 1998, Zhou et al., 1997, Grether et al., 1995)

hid^WRX+1

(Shi et al., 2003)

hid^rvX1

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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