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General Information
Symbol
Dmel\hidrvX1
Species
D. melanogaster
Name
FlyBase ID
FBal0028613
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hidWR+X1
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of the 5' end of W.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

W05014/WrvX1 pupal eye discs lack any evidence of "early stage" cell death (this normally occurs between 18-24 hours after puparium formation). The ommatidia in these pupal retinas are disorganised compared to wild type due to the excess of cells present. The retinas often appear to be attached to what seems to be the antennal disc in the pupae.

WrvX1/Df(3L)H99 mutant animals exhibit ectopic branching on their aristae. The antennae of these animals are larger than wild-type, the aristae have a hairy appearance. While the number and position of anterior branches remain similar to wild-type, the posterior aristae show fewer long lateral branches along the dorsal posterior axis. These extra branches are longer than typical dorsal branches yet shorter than anterior and posterior branches. In addition, the ectopic branches are located very close to each other and often stemmed from the same, or an adjacent position on the central core, unlike the regular spacing seen in wild-type. Also mutant aristae do not terminate in the typical forked pattern but split into 4-5 small branches arranged in a spiral fashion about the central axis.

WrvX1 mutant embryos have increased numbers of midline glial cells at stage 17.

The ventral crustacean cardioactive peptide immunoreactive (vCCAP-IR) neurons of the ventral nervous system die on schedule in heterozygous flies.

Homozygotes display significantly reduced viability. Pronounced defect in the morphogenetic movements of head involution which results, in part, from a failure of the dorsal fold to migrate anteriorly. Otherwise the segmented cuticle is normal and individuals reach advanced stages. There is less apoptosis when compared to wild type, most noticeably in the head region prior to completion of head involution.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressor of
Statement
Reference

hidrvX1/W[+] is a suppressor of eye phenotype of Scer\GAL4GMR.PF, rprUTR.UAS.Tag:HA

hidrvX1 is a suppressor of phenotype of arm3

NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

A WrvX1/Df(3L)H99 background significantly suppresses the cell death seen when p53GUS.PB is expressed in third instar eye discs under the control of Scer\GAL4GMR.PU.

A WrvX1 heterozygous background suppresses the degree of rprUTR.Scer\UAS.T:Ivir\HA1-induced eye ablation.

The increased cell death that occurs in the presumptive head and thorax regions of bcdunspecified embryos can be suppressed by mutation of W, as observed in bcdunspecified, Df(3L)H99/WrvX1 double mutants. bcdunspecified, Df(3L)H99/WrvX1 double mutant larvae have an expanded first abdominal segment that is transformed into a posterior A8 identity, but still lack the head and thorax. Therefore, the transformed abdominal segment must usually undergo cell death in bcdunspecified single mutants, due to the mis-specificity of the cells within it.

The increase in midline glial cells seen in WrvX1 mutant embryos is slightly enhanced by rlSem/rlSem (from 5.8 (n=182) to 6.6 (n=91)). The loss of midline glial (MG) cells in EgfrDN.Scer\UAS; Scer\GAL4sli.PS embryos is suppressed by WrvX1/WrvX1. Approximately twice as many MG cells survive as in wild-type (average of 6.1 per segment n=201, compared to average = 2.8 for wild-type). The loss of midline glial (MG) cells in spi1 homozygous embryos is suppressed by WrvX1/WrvX1. Approximately twice as many MG cells survive as in wild-type (average of 5.7 per segment n=133, compared to average = 2.8 for wild-type).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)