Allele Dmel\Abd-B^Fab7-1

General Information
Symbol	Dmel\Abd-B^Fab7-1	Species	D. melanogaster
Name	Frontabdominal-7	FlyBase ID	FBal0028656
Feature type	allele	Associated gene	Dmel\Abd-B
Also Known As	FAb7¹, Fab-7¹, Fab-7

Allele class	gain of function allele
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	gain of function allele (Gyurkovics et al., 1990, Galloni et al., 1993, Vazquez et al., 1993, Hagstrom et al., 1995)
Mutagen	P-element activity (Hogga and Karch, 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Abd-B^blt (Hogga and Karch, 1995)
Nature of the lesion	Statement Reference Deletion removes a domain boundary element and a silencer element (the iab-7 PRE). (Hagstrom et al., 1997) 4.3kb deletion. (Mihaly et al., 1997) 4kb deletion within the Fab-7 element removing a set of three strong and several weak DNaseI hypersensitive sites. (Hagstrom et al., 1996) Deletion within the Fab-7 element. (Zhou et al., 1996) Deletion in the region between iab-6 and iab-7. (Hagstrom et al., 1995) Deletion of a boundary element between the iab-6 and iab-7 regions of Abd-B. 4.3kb deletion that uncovers the insertion site of P{bluetail}. (Hogga and Karch, 1995) Deletion with a lesion in the Fab7 domain. (Karch et al., 1994) DNA from +123 to +126.5 is deleted, including three nuclease hypersensitive regions. (Galloni et al., 1993) Deletion within Fab7 region that resides between iab6 and iab7 regions. (Vazquez et al., 1993) Deletion of 4kb. (Gyurkovics et al., 1990)
Cytology
Phenotypic Data
Phenotypic Class
	homeotic \| dominant (Salvaing et al., 2008) visible \| dominant (Galloni et al., 1993, Sipos et al., 1998) visible \| homeotic (Gyurkovics et al., 1990)
Phenotype Manifest In
	abdominal segment 6 (Mihaly et al., 1997, Lupo et al., 2001, Karch et al., 1994) abdominal sternite 6 \| male limited (with Abd-B^M2) (Wang et al., 2011) abdominal tergite 6 \| male (Galloni et al., 1993, Sipos et al., 1998) abdominal tergite 6 \| male (with Abd-B^{Mcp-B116:Sz:iab8-D16}) (Sipos et al., 1998) abdominal tergite 6 \| male (with Df(3R)P9) (Sipos et al., 1998) abdominal tergite 6 \| male (with Df(3R)ul10) (Sipos et al., 1998) abdominal tergite 7 \| male (with Df(3R)P9) (Sipos et al., 1998) adult abdominal segment 5 \| male (with Df(3R)P9) (Sipos et al., 1998) adult abdominal segment 6 (Gyurkovics et al., 1990, Salvaing et al., 2008) adult abdominal segment 7 \| ectopic (Salvaing et al., 2008) adult abdominal segment 7 \| ectopic \| male limited (with Abd-B^M2) (Wang et al., 2011) adult abdominal segment 7 \| male (with Abd-B^{Mcp-B116:Sz:iab8-D16}) (Sipos et al., 1998) parasegment 11 (Hagstrom et al., 1996, Hogga and Karch, 1995, Hagstrom et al., 1997) parasegment 11 \| embryonic stage (Vazquez et al., 1993) parasegment 12 \| embryonic stage (Vazquez et al., 1993)
Detailed Description
	Statement Reference An A7-like terminal abdominal segment (similar to abdominal segment 7 found in wild-type females) forms and A6 sternite is transformed toward anterior identity in Abd-B[Fab7-1]/Abd-B[M2] trans-heterozygous males. (Wang et al., 2011) Abd-B[Fab7-1]/+ males undergo an A6 to A7 transformation, resulting in a half-reduced A6 segment. (Salvaing et al., 2008) Heterozygous males have a rudimentary A6 segment. (Lupo et al., 2001) Heterozygous males show a reduction in size of the sixth abdominal tergite to the size of the seventh abdominal tergite in Abd-B^Sz/+ males. Abd-B^Sz/Abd-B^Fab7-1 males show a reduction in size of both the sixth and seventh abdominal tergites to the size of the seventh abdominal tergite in Abd-B^Sz/+ males. Abd-B^Fab7-1/Df(3R)P9 males have A6 and A7 tergites similar to those of Abd-B^Sz/Abd-B^Fab7-1 males, and also show partial transformation of segment A5 into A4. Abd-B^iab8-D16/Abd-B^Fab7-1 males show a reduction in size of the seventh abdominal tergite to the size of the seventh abdominal tergite in Abd-B^Sz/+ males, however, the sixth abdominal tergite is larger in Abd-B^iab8-D16/Abd-B^Fab7-1 males than in Abd-B^Sz/+ males and more closely resembles wild-type. The phenotype of abdominal segment 6 is similar in Abd-B^Fab7-1/Abd-B^D18, Abd-B^Fab7-1/Df(3R)ul10 and Abd-B^Fab7-1/+ flies. (Sipos et al., 1998) Transforms PS11 to PS12. (Hagstrom et al., 1997) Homozygotes show complete transformation of abdominal segment A6 to A7. (Mihaly et al., 1997) Transforms parasegment 11 to parasegment 12 identity. (Hagstrom et al., 1996) Transformation of parasegment 11 to 12. (Hogga and Karch, 1995) Transformation of abdominal segment 6 to A7 identity. (Karch et al., 1994) A6 is completely transformed into A7 in homozygotes. (Galloni et al., 1993) Duplication of parasegment 12-like Abd-B expression in parasegment 11. (Vazquez et al., 1993) Transforms A6 into A7. Larval phenotype suggests the effect is parasegmental. Misregulates Abd-B by ectopic activation of the parasegment 12 specific function in parasegment 11. (Gyurkovics et al., 1990)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Abd-B^Fab7-1 has homeotic \| dominant phenotype, enhanceable by corto[+]/corto⁴²⁰ (Salvaing et al., 2008) Abd-B^Fab7-1 has homeotic \| dominant phenotype, enhanceable by corto^07128b/corto[+] (Salvaing et al., 2008) Abd-B^Fab7-1 has homeotic \| dominant phenotype, enhanceable by corto^07128b/corto[+]/CycG^Scer\UAS.cSa/Scer\GAL4^Act.NP3121 (Salvaing et al., 2008) Abd-B^Fab7-1 has homeotic \| dominant phenotype, enhanceable by Scer\GAL4^da.G32/CycG^{dsRNA.Scer\UAS} (Salvaing et al., 2008) Abd-B^Fab7-1 has homeotic \| dominant phenotype, enhanceable by Scer\GAL4^da.G32/CycG^Scer\UAS.cSa (Salvaing et al., 2008)
Suppressor of
Statement Reference Abd-B^Fab7-1/Abd-B^Fab7-1 is a suppressor \| partially of visible \| recessive phenotype of brk^Mcp (Kyrchanova and Georgiev, 2010, Kyrchanova and Georgiev, 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by corto[+]/corto⁴²⁰ (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by corto^07128b/corto[+] (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by corto^07128b/corto[+]/CycG^Scer\UAS.cSa/Scer\GAL4^Act.NP3121 (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by Scer\GAL4^da.G32/CycG^{dsRNA.Scer\UAS} (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by Scer\GAL4^da.G32/CycG^Scer\UAS.cSa (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 7 \| ectopic phenotype, enhanceable by corto[+]/corto⁴²⁰ (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 7 \| ectopic phenotype, enhanceable by corto^07128b/corto[+] (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 7 \| ectopic phenotype, enhanceable by corto^07128b/corto[+]/CycG^Scer\UAS.cSa/Scer\GAL4^Act.NP3121 (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 7 \| ectopic phenotype, enhanceable by Scer\GAL4^da.G32/CycG^{dsRNA.Scer\UAS} (Salvaing et al., 2008) Abd-B^Fab7-1 has adult abdominal segment 7 \| ectopic phenotype, enhanceable by Scer\GAL4^da.G32/CycG^Scer\UAS.cSa (Salvaing et al., 2008)
NOT Enhanced by
Statement Reference Abd-B^Fab7-1 has abdominal segment 6 phenotype, non-enhanceable by barr[+]/barr^L305 (Lupo et al., 2001)
NOT suppressed by
Statement Reference Abd-B^Fab7-1 has abdominal segment 6 phenotype, non-suppressible by barr[+]/barr^L305 (Lupo et al., 2001)
NOT Enhancer of
Statement Reference Abd-B^Fab7-1/Abd-B[+] is a non-enhancer of abdominal segment 6 phenotype of barr^L305 (Lupo et al., 2001)
Suppressor of
Statement Reference Abd-B^Fab7-1/Abd-B^Fab7-1 is a suppressor \| partially of wing phenotype of brk^Mcp (Kyrchanova and Georgiev, 2010, Kyrchanova and Georgiev, 2010)
NOT Suppressor of
Statement Reference Abd-B^Fab7-1/Abd-B[+] is a non-suppressor of abdominal segment 6 phenotype of barr^L305 (Lupo et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference The penetrance of the wing defect phenotype caused by brk[Mcp] is decreased to 14.5% if the animals are also homozygous for Abd-B[Fab7-1]. (Kyrchanova and Georgiev, 2010) One copy of corto[420] enhances the expressivity of the A6-A7 transformation seen in Abd-B[Fab7-1]/+ males. The A6 segment has completely disappeared in 100% of male flies. One copy of corto[07128b] enhances the expressivity of the A6-A7 transformation seen in Abd-B[Fab7-1]/+ males. The A6 segment has completely disappeared in 100% of male flies. Expression of CycG[dsRNA.Scer\UAS] under the control of Scer\GAL4[da.G32] slightly enhances the homeotic transformation from A7 to A6 seen in Abd-B[Fab7-1] male heterozygotes. The expressivity is slightly enhanced in 86% of flies but at least a thin A6 segment always persists. No cuticular defects are seen in either abdominal segment A5 or the remaining A6 tergites. Expression of CycG[Scer\UAS.cSa] under the control of Scer\GAL4[da.G32] slightly enhances the homeotic transformation from A7 to A6 seen in Abd-B[Fab7-1] male heterozygotes. The A6 segment has completely disappeared in 56% of flies. 100% of males completely lack A6 when CycG[Scer\UAS.cSa] is expressed under the control of Scer\GAL4[Act.NP3121]. Expression of CycG[dsRNA.Scer\UAS] under the control of Scer\GAL4[Act.NP3121] and one copy of corto[07128b] enhance the A7 to A6 homeotic transformation seen in the few Abd-B[Fab7-1]/+ male escapers. (Salvaing et al., 2008) The addition of barr^L305/+ has no effect on the abdominal segment phenotype of Abd-B^Fab7-1/+. (Lupo et al., 2001) The heterozygous gain of function phenotype is unchanged in a Polycomb group mutant background. (Mihaly et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Associated with: Fab-7¹.
Comments
	Deletion removes all three prominent nuclear hypersensitive sites, plus most of the minor sites. (Karch et al., 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Abd-B^Fab7-1 Abd-B^Fab7 Abd-B^Fab-7 (Wang et al., 2011) Fab (Mack et al., 1997) Fab-7 (Sipos et al., 1998, Hogga and Karch, 1995, Hendrickson and Sakonju, 1995, Hagstrom et al., 1995, Gyurkovics et al., 1990) Fab-7¹ (Brown et al., 2003, Mihaly et al., 1997, Zhou et al., 1996, Hagstrom et al., 1996, Hogga and Karch, 1995, Maeda and Karch, 2006, Bantignies et al., 2011) FAb7¹ (Hagstrom et al., 1997) Fab7¹ (McCall and Bender, 1996, Karch et al., 1994, Vazquez et al., 1993, Galloni et al., 1993, Gummalla et al., 2012, Kyrchanova and Georgiev, 2010, Kyrchanova and Georgiev, 2010, Salvaing et al., 2008)
Name Synonym	Frontabdominal-7 (Gyurkovics et al., 1990)
Secondary FlyBase IDs
	FBal0028659
References ( 23 )

Generate a list of	All references relating to this allele ( 23 )

List References by type	Research paper ( 20 ) Review ( 2 ) Abstract ( 1 )
Recent research papers ( 3 )
	Gummalla et al., 2012, PLoS Genet. 8(5): e1002720 abd-A Regulation by the iab-8 Noncoding RNA. [FBrf0218472] Bantignies et al., 2011, Cell 144(2): 214--226 Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila. [FBrf0212775] Wang et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(27): 11139--11144 Sexually dimorphic regulation of the Wingless morphogen controls sex-specific segment number in Drosophila. [FBrf0214239] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\Abd-BFab7-1

Allele Dmel\Abd-B^Fab7-1