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General Information
Symbol
Dmel\Act88FE364K
Species
D. melanogaster
Name
FlyBase ID
FBal0028743
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Construct: Amino acid replacement: E364K.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Act88F6 null flies homozygous for Act88FE364K insert have almost normal flight ability, flies carrying one mutant copy are flightless. Indirect flight muscles in Act88F6 homozygous for Act88FE364K insert have a very disrupted structure.

IFM myofibrils are studied in transformant Act88F6 mutants. Mutants produce no fibrillar material at all.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Myosin:actin ratios determined by gel electrophoresis are greater than one, but the incorporation ratio is normal suggesting actin is unstable. Strong induction of heat shock proteins.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Act88FE364K
Name Synonyms
Secondary FlyBase IDs
    References (3)