A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\Adv1

General Information
SymbolDmel\Adv1SpeciesD. melanogaster
NameFlyBase IDFBal0028921
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\Adv
Allele class
MutagenX ray
hide Nature of the Allele
Allele class
Mutagen
X ray
(Preiss and Artavanis-Tsakonas, 1991)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Caused by aberration
      In(2R)Adv
      (Preiss and Artavanis-Tsakonas, 1991, Srivastava et al., 2002)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      lethal | recessive
      (Preiss and Artavanis-Tsakonas, 1991)
      visible | dominant
      (Preiss and Artavanis-Tsakonas, 1991)
      hide Phenotype Manifest In
      wing vein
      (Heilig, 1995.1.27)
      wing vein L1
      (Preiss and Artavanis-Tsakonas, 1991, Srivastava et al., 2002)
      wing vein L3
      (Preiss and Artavanis-Tsakonas, 1991)
      wing vein L2
      (Srivastava et al., 2002)
      wing vein | ectopic
      (Srivastava et al., 2002)
      hide Detailed Description
      Statement
      Reference
      First longitudinal wing vein split, follows the route of the second vein up to the level of the anterior crossvein where it turns toward the margin, branching twice. Third longitudinal vein is no longer attached to L1. Heterozygote viable.
      (Preiss and Artavanis-Tsakonas, 1991)
      Mutants show a spur from L1 that runs further than L1 does normally, most apparent at the base of the wing.
      (Heilig, 1995.1.27)
      Adv[1]/+ flies exhibit fusion between L1 and L2 via a bridge of ectopic vein at approximately same proximal-distal position as the anterior cross-vein.
      (Srivastava et al., 2002)
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      Adv1 has wing vein L1 phenotype, enhanceable by bs03267/bs[+]
      (Srivastava et al., 2002)
      Adv1 has wing vein L2 phenotype, enhanceable by bs03267/bs[+]
      (Srivastava et al., 2002)
      Adv1 has wing vein | ectopic phenotype, enhanceable by bs03267/bs[+]
      (Srivastava et al., 2002)
      Adv1 has wing vein L1 phenotype, enhanceable by Egfr[+]/EgfrE1
      (Srivastava et al., 2002)
      Adv1 has wing vein L2 phenotype, enhanceable by Egfr[+]/EgfrE1
      (Srivastava et al., 2002)
      Adv1 has wing vein | ectopic phenotype, enhanceable by Egfr[+]/EgfrE1
      (Srivastava et al., 2002)
      Adv1 has wing vein L1 phenotype, enhanceable by pan[+]/panunspecified
      (Srivastava et al., 2002)
      Adv1 has wing vein L2 phenotype, enhanceable by pan[+]/panunspecified
      (Srivastava et al., 2002)
      Adv1 has wing vein | ectopic phenotype, enhanceable by pan[+]/panunspecified
      (Srivastava et al., 2002)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      bs[03267], Egfr[E1] and pan[unspecified] all dominantly enhance the 'additional vein' phenotype of Adv[1]/+ flies.
      (Srivastava et al., 2002)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 3 )
      Bloomington
      6
      P{hsFLP}1, w1118; Adv1/CyO
      Kyoto
      105670
      P{hsFLP}1, w1118; Adv1/CyO
      101877
      y1 w1118 P{hsFLP} ; Adv1 / CyO, Cy1 dplv1 pr1 cn2
      hide Notes on Origin
      Discoverer
      hide Comments
      While complementation data indicate that the recessive lethality of In(2R)Adv is due to disruption of en, en expression appears normal in heterozygotes, suggesting that the dominant "additional vein" phenotype of this inversion is not due to its effects on en.
      (Srivastava et al., 2002)
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      Adv1
       
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 4 )
        Research paper
        Tapanes-Castillo and Baylies, 2004, Development 131(10): 2359--2372
        Notch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor twist. [FBrf0174582]
        Srivastava et al., 2002, Genome 45(6): 1077--1082
        The relationship between the dominant Additional vein mutant in Drosophila melanogaster and engrailed. [FBrf0155819]
        Preiss and Artavanis-Tsakonas, 1991, D. I. S. 70: 275
        New mutants in Drosophila melanogaster (Meigen). [FBrf0053664]
        Personal communication to FlyBase
        Heilig, 1995.1.27, Phenotype of Adv<up>1</up>.
        Phenotype of Adv<up>1</up>. [FBrf0075505]