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General Information
Symbol
Dmel\Arl11
Species
D. melanogaster
Name
FlyBase ID
FBal0028993
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
arf72A1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G15983378A

Amino acid change:

G2D | Arl1-PA

Reported amino acid change:

G2D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G2D.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The structure of the Golgi and cell polarity are not affected in Arl11 cell clones.

Arl11 clones in the wing disc show increased apoptosis. This phenotype is not seen in follicle cell or salivary gland clones.

Arl12/Arl11 larval salivary glands have more secretory granules of significantly smaller size, compared to controls.

Arf72A1 cells within a mutant retinal clone show proliferated internal membranes. Most strikingly, rough endoplasmic reticulum-type membranes are greatly expanded, swollen and have more pronounced heterogeneity compared to wild type.

Arf72A1 eye cells have extensive Golgi structures both in size and number throughout the cytoplasm compared to wild type.

Centrosome maturation proceeds normally in most mutant embryos through the early syncytial blastoderm but a low percentage of centrosomes are either small or fused. During the late syncytial blastoderm stage, the number of centrosome and nuclear fusions increases. Approximately 63% of embryos complete cellularization and initiate gastrulation prior to failure, but furrow- and segment-formation is weak or incomplete, giving the cortex a smooth, flat appearance. Mitotic domains have fewer cells than in wild type and many spindles have a single centrosome. The nuclear density is low in these embryos and many nuclei appear to be aneuploid.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Arfip12/Arl11 third instar larvae have significantly fewer boutons at the neuromuscular junction compared to Arfip12/+ or Arl11/+ heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Arl1+t2.5 rescues the secretory granule defects in Arl12/Arl11 salivary glands.

Homozygotes are completely rescued by Arf72A+t2.5, carried by P{arl2.5}.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)