Allele Dmel\Asx¹²

General Information
Symbol	Dmel\Asx¹²	Species	D. melanogaster
Name		FlyBase ID	FBal0029003
Feature type	allele	Associated gene	Dmel\Asx

Allele class	gain of function allele
Mutagen	gamma ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	gain of function allele (Sinclair et al., 1992)
Mutagen	gamma ray (Sinclair et al., 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Milne et al., 1999) visible \| homeotic (Sinclair et al., 1992)
Phenotype Manifest In
	abdominal segment 4 (Sinclair et al., 1992) thoracic segment (Sinclair et al., 1992)
Detailed Description
	Statement Reference More severe Asx phenotype than Asx^- deletion and also a more severe transformation of thoracic segments towards abdominal segments. Segmentation defects are also present: missing segments, midline denticles missing and hemisegments. Heterozygous adults have a mild transformation of A4 to A5 in males. (Sinclair et al., 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement Reference Asx¹² has phenotype, non-enhanceable by sxc⁵ (Milne et al., 1999)
Other
Statement Reference Asx¹², Df(2R)M41A4 has abdominal segment 5 phenotype (Milne et al., 1999) Asx¹², sxc³ has abdominal segment 4 phenotype (Milne et al., 1999, Milne et al., 1999) Asx¹², sxc³ has haltere phenotype (Milne et al., 1999, Milne et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference Double heterozygotes with sxc³ show reduced viability and survivors show transformations typical of Pc-G mutants including transformation of A4 to A5. Most also show haltere to wing transformations typical of trx-G mutants. No similar interaction with sxc⁵ or Df(2R)M41A4 is seen, though anterior transformations of A5 to A4 do occur with Df(2R)M41A4, similar to those seen in trx-G group mutants. (Milne et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Asx¹²
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Milne et al., 1999, Mol. Gen. Genet. 261(4-5): 753--761 The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs. [FBrf0108941] Sinclair et al., 1992, Genetics 130(4): 817--825 Genetic analysis of the additional sex combs locus of Drosophila melanogaster. [FBrf0056262]

Allele Dmel\Asx12

Allele Dmel\Asx¹²