Allele Dmel\Asx^XF23

General Information
Symbol	Dmel\Asx^XF23	Species	D. melanogaster
Name		FlyBase ID	FBal0029011
Feature type	allele	Associated gene	Dmel\Asx

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Simon et al., 1992) loss of function allele (Muller et al., 1999)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	non-enhancer of variegation, with P{hsp26-pt-T}39C-5 (Boivin et al., 2003) non-suppressor of variegation, with P{hsp26-pt-T}39C-5 (Boivin et al., 2003) visible \| recessive \| somatic clone (Bischoff et al., 2009)
Phenotype Manifest In
	wing blade \| somatic clone (Bischoff et al., 2009)
Detailed Description
	Statement Reference Homozygous Asx[XF23] mutant clones cause various wing defects including crumpled wings. (Bischoff et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Asx^XF23/Asx[+] is an enhancer of visible \| dominant \| homeotic phenotype of ash1¹⁷, trx^B11/trx[+] (Gildea et al., 2000) Asx^XF23/Asx[+] is an enhancer of visible \| recessive \| homeotic phenotype of mxc^M1 (Saget et al., 1998)
Suppressor of
Statement Reference Asx^XF23 is a suppressor of eye color defective phenotype of w^T81 (Netter et al., 1998) Asx^XF23 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa (Secombe et al., 2007)
NOT Suppressor of
Statement Reference Asx^XF23 is a non-suppressor of eye color defective phenotype of w^Mcp.scs'.21 (Muller et al., 1999) Asx^XF23 is a non-suppressor of eye color defective phenotype of w^Mcp.scs'.21, y^we.Mcp.1 (Muller et al., 1999) Asx^XF23 is a non-suppressor of eye color defective phenotype of w^Mcp.y.scs'.1 (Muller et al., 1999) Asx^XF23 is a non-suppressor of eye color defective phenotype of w^Mcp.y.scs'.1, y^we.Mcp.1 (Muller et al., 1999) Asx^XF23 is a non-suppressor of eye color defective phenotype of w^Mcp.y.scs'.1, y^we.Mcp.2 (Muller et al., 1999)
Other
Statement Reference Asx^XF23, ash1²² has visible \| dominant \| homeotic phenotype (Gildea et al., 2000) Asx^XF23, brm² has visible \| dominant \| homeotic phenotype (Gildea et al., 2000) Asx^XF23, P{hsp26-pt-T}39C-5, ph-p⁴¹⁰ has suppressor of variegation phenotype (Boivin et al., 2003) Asx^XF23, Pc¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype (Boivin et al., 2003) Asx^XF23, Pcl¹¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype (Boivin et al., 2003) Asx^XF23, Pcl¹³, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype (Boivin et al., 2003) Asx^XF23, Psc¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype (Boivin et al., 2003) Asx^XF23, trx^B11 has visible \| dominant \| homeotic phenotype (Gildea et al., 2000) Asx^XF23/Asx[+], ash1²² has visible \| dominant \| homeotic phenotype (Gildea et al., 2000) Asx^XF23/Asx[+], brm² has visible \| dominant \| homeotic phenotype (Gildea et al., 2000) Asx^XF23/Asx[+], Hcf^HR1 has visible phenotype (Rodriguez-Jato et al., 2011) Asx^XF23/Asx[+], trx^B11 has visible \| dominant \| homeotic phenotype (Gildea et al., 2000)
Phenotype Manifest In
Enhancer of
Statement Reference Asx^XF23/Asx[+] is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+] (Gildea et al., 2000) Asx^XF23/Asx[+] is an enhancer of leg \| ectopic phenotype of hh^Mrt (Randsholt et al., 2000) Asx^XF23/Asx[+] is an enhancer of wing \| anterior phenotype of hh^Mrt (Randsholt et al., 2000)
Suppressor of
Statement Reference Asx^XF23 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa (Secombe et al., 2007)
NOT Suppressor of
Statement Reference Asx^XF23/Asx[+] is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^Scer\UAS.cMa (Moshkin et al., 2002) Asx^XF23 is a non-suppressor of pigment cell phenotype of w^Mcp.scs'.21 (Muller et al., 1999) Asx^XF23 is a non-suppressor of pigment cell phenotype of w^Mcp.scs'.21, y^we.Mcp.1 (Muller et al., 1999) Asx^XF23 is a non-suppressor of pigment cell phenotype of w^Mcp.y.scs'.1 (Muller et al., 1999) Asx^XF23 is a non-suppressor of pigment cell phenotype of w^Mcp.y.scs'.1, y^we.Mcp.1 (Muller et al., 1999) Asx^XF23 is a non-suppressor of pigment cell phenotype of w^Mcp.y.scs'.1, y^we.Mcp.2 (Muller et al., 1999)
Other
Statement Reference Asx^XF23, ash1²² has adult metathoracic segment phenotype (Gildea et al., 2000) Asx^XF23, brm² has adult metathoracic segment phenotype (Gildea et al., 2000) Asx^XF23, Df(2R)vg-D, Pcl¹⁵/Pcl[+] has mesothoracic leg phenotype (Bejarano and Busturia, 2004) Asx^XF23, Df(2R)vg-D, Pcl¹⁵/Pcl[+] has metathoracic leg phenotype (Bejarano and Busturia, 2004) Asx^XF23, Df(2R)vg-D, Pcl¹⁵/Pcl[+] has sex comb \| ectopic phenotype (Bejarano and Busturia, 2004) Asx^XF23, Df(2R)vg-D, Pcl¹⁵ has mesothoracic leg phenotype (Bejarano and Busturia, 2004) Asx^XF23, Df(2R)vg-D, Pcl¹⁵ has metathoracic leg phenotype (Bejarano and Busturia, 2004) Asx^XF23, Df(2R)vg-D, Pcl¹⁵ has sex comb \| ectopic phenotype (Bejarano and Busturia, 2004) Asx^XF23, lolal^k02512 has abdominal segment 6 phenotype (Mishra et al., 2003, Mishra et al., 2003) Asx^XF23, lolal^k02512 has abdominal segment 7 \| ectopic phenotype (Mishra et al., 2003, Mishra et al., 2003) Asx^XF23, trx^B11 has adult metathoracic segment phenotype (Gildea et al., 2000) Asx^XF23/Asx[+], ash1²² has adult metathoracic segment phenotype (Gildea et al., 2000) Asx^XF23/Asx[+], brm² has adult metathoracic segment phenotype (Gildea et al., 2000) Asx^XF23/Asx[+], Hcf^HR1 has male genitalia phenotype (Rodriguez-Jato et al., 2011) Asx^XF23/Asx[+], trx^B11 has adult metathoracic segment phenotype (Gildea et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference 2% of Asx[XF23]/+ ; Hcf[HR1] males have defects in rotation of the genitalia. (Rodriguez-Jato et al., 2011) Df(2R)vg-D, Asx^XF23, Pcl¹⁵/+ flies have almost normal wings. If the flies also carry jing^22F3, the arrangement of wing bristles at the posterior wing margin becomes disorganised and there is an increase in the appearance of cuticle patches containing a high density of small trichomes, indicative of a partial wing-to-haltere transformation. (Culi et al., 2006) Df(2R)vg-D, Asx^XF23, Pcl¹⁵/+ animals show an average of 2.5 extra sex combs hairs in either the second of third leg. (Bejarano and Busturia, 2004) The addition of lolal^k02512/+ to homozygous Asx^XF23 animals shows a partial homeotic transformation of A6 to A5 in the abdomen. (Mishra et al., 2003) Asx^XF23/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa. (Moshkin et al., 2002) No significant modification of the number of sex combs is seen in Asx^XF23/+ corto⁴²⁰/+ double heterozygotes compared to Asx^XF23/+ single heterozygotes. (Lopez et al., 2001) The addition of heterozygous Asx^XF23 has no effect on the Pairing sensitive silencing effect seen in w^Mcp.scs'.21 and w^Mcp.y.scs'.1 alleles, or the eye colour phenotype of w^Mcp.y.scs'.1/y^we.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+) and w^Mcp.scs'.21/y^we.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) double heterozygous insertions. (Muller et al., 1999) Weak suppressor of eye pigment phenotype of w^T81. (Netter et al., 1998) Hemizygous mxc^M1 males show weak homeotic phenotypes. Some enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of Asx^XF23. (Saget et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Asx^C849 (Bischoff et al., 2009) Asx^xen-72-3 (Bischoff et al., 2009)
Comments
Stocks ( 2 )
Bloomington	6041 Asx^XF23/CyO
Kyoto	108566 Asx^XF23/CyO
Notes on Origin
Discoverer

Comments
	Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost. (Muller, 1995) Weak derepression of en expression. (Moazed and O'Farrell, 1992) Ectopic abd-A is present in parasegments 2-6 in the epidermal cells. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior. By 12 hours the expression is more uniform. (Simon et al., 1992)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Asx^xf23 (Bejarano and Busturia, 2004) Asx^Xf23 (Moshkin et al., 2002, Culi et al., 2006) Asx^XF23 (Secombe et al., 2007, Gibert et al., 2011, Bischoff et al., 2009, Rodriguez-Jato et al., 2011, Halachmi et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 22 )

Generate a list of	All references relating to this allele ( 22 )

List References by type	Research paper ( 22 )
Recent research papers ( 2 )
	Gibert et al., 2011, PLoS Genet. 7(1): e1001280 Segregating Variation in the Polycomb Group Gene cramped Alters the Effect of Temperature on Multiple Traits. [FBrf0212864] Rodriguez-Jato et al., 2011, PLoS ONE 6(12): e27479 Drosophila melanogaster dHCF Interacts with both PcG and TrxG Epigenetic Regulators. [FBrf0216958] Show all research papers ...

Allele Dmel\AsxXF23

Allele Dmel\Asx^XF23