Overexpression of CycAhs.PK
results in an extra mitotic division in 4% of egg chambers.
Unlike wild-type, CycAC8LR1
mutants do not show an increased proportion of metaphase figures after exposure to radiation.
is over-expressed in adult females germline cysts with an aberrant number of cells are produced. Five days after heat-shock treatment cysts containing 32 instead of 16 cells are seen in 3% of egg chambers. The oocyte contains 5 ring canals (as compared to 4 in wild-type). Very rarely, cysts with an intermediate number of cells (in between 16 and 32) are seen.
Heat induced expression during third larval instar results in a rough eye phenotype, this correlates with the induction of many cells into S phase in eye discs. Wild type Rca1
cannot suppress entry into S phase.
Expression of CycAhs.PK
in embryos using a 30 minute heat shock induces premature S phase in epidermal cells and endocycling tissues. Expression of CycAhs.PK
using a 10 minute heat shock does not induce S phase in epidermal cells of wild-type embryos carrying a single copy of CycAhs.PK
Ectopic S phase entry in the morphogenetic furrow. ruxhs.PT
inhibits the ectopic S phase entry at the morphogenetic furrow but not in anterior or posterior cells.
Heat induced expression induces entry into S phase in cells of the amnioserosa.