cicD49 combined with bwkΔ4, bwk08482, bwkΔ14 and bwkΔ11 shows an extra veins phenotype. cicD49 and bwkΔ81 is a lethal combination, cicD49 and bwkΔ14 or bwkΔ11 are 'Almost lethal'. bwkΔ11, cicD49 animals are 'almost lethal' and have abnormal wings. These wings can have an extra wing vein tissue phenotype, where intervein cells acquire morphological features of vein cells at least partially. This extra tissue is usually close to the normal veins. This wings also have wing blisters. These animals also have defects in the male genitalia. The cuticle plates forming the genitalia are oriented in the opposite direction to those of wild-type. The addition of bwkΔ11 and vn1 fails to enhance the extra wing vein phenotype seen in cicD49/bwkΔ11 animals.
Scer\GAL4C5-driven expression of Hsap\ATX182Q.Scer\UAS in a cicD49/+ background results in more prominent L3 vein thickening and increased ectopic wing vein formation in the posterior part of the interveins compared to expression of Hsap\ATX182Q.Scer\UAS in a wild-type background.