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General Information
Symbol
Dmel\cswEsev1A-eOP
Species
D. melanogaster
Name
FlyBase ID
FBal0029640
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
E(sev)1Ae0P, csweOP, cswe0P, cswG547E
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G2110578A

Amino acid change:

G547E | csw-PA; G647E | csw-PB; G388E | csw-PC; G600E | csw-PD

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation is within the csw PTP domain.

Nucleotide substitution: G?A.

Amino acid replacement: G547E.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The mesoderm of homozygous embryos derived from homozygous female germline clones is able to establish contact with the ectoderm, but the overall appearance of the invaginated mesodermal tube is abnormal.

Mutation disrupts development of receptor cell R7.

Removal of one copy of csw from sev::tor13D:Y2546F.hs.sev individuals causes a very significant reduction in ommatidia with multiple R7 cells.

Overexpression results in loss of photoreceptor cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

cswEsev1A-eOP/csw[+] is a suppressor of visible phenotype of Scer\GAL4c684, ifm8.UAS

cswEsev1A-eOP/csw[+] is a suppressor of visible phenotype of Src64BΔ540.hs.sev

NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

cswEsev1A-eOP/csw[+] is a suppressor of wing phenotype of Scer\GAL4c684, ifm8.UAS

cswEsev1A-eOP is a suppressor | partially of wing phenotype of ifm8.αTub84B

cswEsev1A-eOP/csw[+] is a suppressor of eye phenotype of Src64BΔ540.hs.sev

cswEsev1A-eOP is a suppressor of phenotype of Src42AKR.hs.2sev

NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

cswEsev1A-eOP enhances the ganglionic branch outgrowth phenotype of bnlunspecified/+ embryos.

The wing blistering caused by expression of ifm8.αTub84B is suppressed by cswEsev1A-eOP/+. The wing blistering caused by expression of ifm8.Scer\UAS under the control of Scer\GAL4337Y is suppressed by cswEsev1A-eOP/+.

Presence of the mutation in Src64BΔ540.hs.sev flies alleviates the rough eye phenotype.

Suppressor of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

Suppression of the rough eye phenotype (formation of extra R7 cells) caused by P{sev-svp2} and enhancement of the P{ro-svp1} rough eye phenotype (loss of one or more outer photoreceptors from many of the ommatidia).

Half of the embryos derived from homozygous germ line clones can be rescued by Dsor1Su1, other fail to hatch despite the normal cuticle pattern.

Slightly enhances the sevB4 phenotype: disrupts sevB4 protein signalling.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Lethality and eye phenotype is rescued by cswhs.2sev.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Dominant mutation that attenuates signalling by a temperature sensitive sev allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (18)