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General Information
Symbol
Dmel\Hsp83e1D
Species
D. melanogaster
Name
FlyBase ID
FBal0029641
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
e1D
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C3194611T
Reported nucleotide change:
C113T
Amino acid change:
S38L | Hsp83-PA; S38L | Hsp83-PB
Reported amino acid change:
S38L
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: S38L. Nucleotide substitution: C113T.
Nucleotide substitution: C113T. Amino acid replacement: S38L.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Hsp83e1D has no effect on an invariant bristle trait (thoracic and scutellar bristles were analysed). Hsp83e1D has a significant effect on a variable bristle trait (the sternopleural, orbital, ocellar and vibrissa and carina bristles were analysed); there is a significant difference in trait mean compared to the background strain in which the Hsp83e1D mutation was induced.
Viable in transheterozygous combination with either Hsp8313F3 or Hsp839J1; males are sterile and females are weakly fertile. Hsp83e1D/Hsp8313F3 and Hsp83e1D/Hsp839J1 males show defects during spermatogenesis. The number and shape of spermatocytes within 16-cell cysts are mostly normal (5-10% are abnormal). Spermatids with variable number, size and shape of nuclei and nebenkern are seen. Needle-shaped crystals are present throughout developing spermatocytes and spermatids. Individualised sperm are present but they are not motile and are fragile.
Mutation fails to genetically interact with sevS11.T:Hsap\MYC, 'sev351', phl12 or phl::tor12D.hs.sev.
No effect the rough eye phenotype (formation of extra R7 cells) caused by P{sev-svp2} and no effect on the P{ro-svp1} rough eye phenotype (loss of one or more outer photoreceptors from many of the ommatidia).
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
15+/-4% of KrIf-1/+ flies born to Hsp83e1D/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.
Enhances the sevB4 phenotype: disrupts sevB4 protein signalling.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
No interaction with P{sev-svp1} or P{sev-svp2} exists.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)