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General Information
Symbol
Dmel\Hsp83e4A
Species
D. melanogaster
Name
FlyBase ID
FBal0029643
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C3196462T
Reported nucleotide change:
C1964T
Amino acid change:
S655F | Hsp83-PA; S655F | Hsp83-PB
Reported amino acid change:
S655F
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: S655F. Nucleotide substitution: C1964T.
Nucleotide substitution: C1964T. Amino acid replacement: S655F.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Viable in transheterozygous combination with Hsp839J1; males are sterile and females are weakly fertile. Hsp839J1/Hsp83e4A males show some defects during spermatogenesis. The number and shape of spermatocytes within 16-cell cysts are mostly normal (5-10% are abnormal). The nuclei and nebenkern within spermatids are mostly normal (5-10% are abnormal). Individualised sperm are present, but are not motile. Hsp8308445/Hsp83e4A males show defects during spermatogenesis. Excessive numbers of primary spermatocytes are seen in many developing cysts. Spermatids with variable number, size and shape of nuclei and nebenkern are seen. Individualised sperm are present but they are not motile and are fragile.
Mutation fails to genetically interact with sevS11.T:Hsap\MYC, 'sev351', phl12 or phl::tor12D.hs.sev.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
6+/-2% of KrIf-1/+ flies born to Hsp83e4A/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.
Enhances the sevB4 phenotype: disrupts sevB4 protein signalling.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (8)