When challenged with a large phase advance in their environmental temperature cycle in DD, Hsp83e6D
mutant flies exhibit a significant reduction in the number of 'transition days' associated with the process of phase-resetting daily locomotor activity.
67% of Hsp8308445
flies show a loss of locomotor behavioral rhythms under free-running conditions (after entrainment in light-dark cycles).
flies show a reduced fraction of flies with rhythmic locomotor activity in light-dark cycles (49% rhythmic) compared to control flies (88%-95% rhythmic).
mutants show highly variable locomotor activity patterns, including fully rhythmic, arrhythmic, and complex behavioral profiles, in contrast to wild-type flies, which show little variation among individuals.
females are reasonably healthy and produce large numbers of eggs. Very few of the embryos derived from these eggs cellularise. The 1-2% of the embryos that eventually secrete cuticle have on average 3 abdominal segments rather than the normal 8.
has no effect on an invariant bristle trait (thoracic and scutellar bristles were analysed). Hsp83e6D
has a significant effect on a variable bristle trait (the sternopleural, orbital, ocellar and vibrissa and carina bristles were analysed); there is a significant difference in trait mean compared to the background strain in which the Hsp83e6D
mutation was induced.
Viable in transheterozygous combination with either Hsp839J1
; males are sterile and females are weakly fertile. Hsp8308445
males show defects during spermatogenesis. Excessive numbers of primary spermatocytes are seen in many developing cysts. Spermatids with variable number, size and shape of nuclei and nebenkern are seen. Needle-shaped crystals are present throughout developing spermatocytes and spermatids. Individualised sperm are present but they are not motile and are fragile.