Allele Dmel\Fas2^EB112

General Information
Symbol	Dmel\Fas2^EB112	Species	D. melanogaster
Name		FlyBase ID	FBal0029776
Feature type	allele	Associated gene	Dmel\Fas2
Also Known As	fasII^EB112

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Grenningloh et al., 1991, Whitlock, 1993, Lin et al., 1994, Garcia-Alonso et al., 1995) loss of function allele (Schuster et al., 1996, Davis et al., 1997)
Mutagen	P-element activity (Grenningloh et al., 1991, Lin et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{A92}A31 (Grenningloh et al., 1991, Lin et al., 1994)
Nature of the lesion	Statement Reference Imprecise excision of a P-element located in the 5' end of Fas2. (Lin et al., 1994) Imprecise excision of the P-element from Ecol\lacZ^Fas2-A31. 1.7kb deletion of Fas2 genomic sequences, including 5' untranslated sequences. The deletion is entirely within the Fas2 gene and is likely to include the start of transcription. Genomic sequences more than 1kb from the 5' end of the Fas2 gene are unaffected. (Grenningloh et al., 1991)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Kohsaka et al., 2007) lethal \| larval stage (Hebbar and Fernandes, 2005) lethal \| larval stage \| recessive (Grenningloh et al., 1991, Lin et al., 1994, Schuster et al., 1996) lethal \| recessive (Garcia-Alonso et al., 1995, Whitlock, 1993) neuroanatomy defective (Sanchez-Soriano and Prokop, 2005) neuroanatomy defective (with Fas2^e76) (Hebbar and Fernandes, 2005, Kristiansen et al., 2005) neuroanatomy defective \| embryonic stage (Lin et al., 1994) neuroanatomy defective \| larval stage (Schuster et al., 1996) neuroanatomy defective \| third instar larval stage (with Fas2^e76) (Beck et al., 2012) neurophysiology defective (Baines et al., 2002) uncoordinated (Schuster et al., 1996) viable (with Fas2^e76) (Hebbar and Fernandes, 2005)
Phenotype Manifest In
	anterior orbital bristle (Garcia-Alonso et al., 1995) anterior vertical bristle (Garcia-Alonso et al., 1995) anterior vertical bristle \| somatic clone (Garcia-Alonso et al., 1995) border follicle cell (Szafranski and Goode, 2004) cone cell (with Fas2^e76) (Mao and Freeman, 2009) cone cell \| somatic clone (Mao and Freeman, 2009) dMP2 neuron \| embryonic stage (Grenningloh et al., 1991) dorsal trunk primordium (Hemphala et al., 2003) dorsal trunk primordium \| embryonic stage 14 (Tonning et al., 2005) dorsocentral bristle \| somatic clone \| supernumerary (Mao and Freeman, 2009) external sensory organ precursor cell \| somatic clone \| supernumerary (Mao and Freeman, 2009) eye (with Fas2^e76) (Mao and Freeman, 2009) eye \| somatic clone (Garcia-Alonso et al., 1995) eye photoreceptor cell (with Fas2^e76) (Mao and Freeman, 2009) eye photoreceptor cell \| somatic clone (Mao and Freeman, 2009) eye photoreceptor cell \| somatic clone \| third instar larval stage (Mao and Freeman, 2009) fascicle & mushroom body \| somatic clone (Kurusu et al., 2002) ganglionic branch primordium (Hemphala et al., 2003) indirect flight muscle motor neuron MN5 (with Fas2^e76) (Hebbar and Fernandes, 2005) mechanosensory neuron (with Fas2^e76) (Kristiansen et al., 2005) middle orbital bristle (Garcia-Alonso et al., 1995) MP1 neuron (Lin et al., 1994) MP1 neuron \| embryonic stage (Grenningloh et al., 1991) neuromuscular junction (with Fas2^e76) (Hebbar and Fernandes, 2005) NMJ bouton \| third instar larval stage (with Fas2^e76) (Beck et al., 2012) ocellar bristle (Garcia-Alonso et al., 1995) ocellar bristle \| somatic clone (Garcia-Alonso et al., 1995) ocellus (Garcia-Alonso et al., 1995) ocellus \| somatic clone (Garcia-Alonso et al., 1995) ommatidium (with Fas2^e76) (Mao and Freeman, 2009) ommatidium \| somatic clone (Mao and Freeman, 2009) photoreceptor cell R7 \| cell non-autonomous \| somatic clone \| third instar larval stage (Mao and Freeman, 2009) photoreceptor cell R7 \| somatic clone \| third instar larval stage (Mao and Freeman, 2009) photoreceptor cell R8 \| somatic clone \| third instar larval stage (Mao and Freeman, 2009) posterior orbital bristle (Garcia-Alonso et al., 1995) posterior vertical bristle (Garcia-Alonso et al., 1995) posterior vertical bristle \| somatic clone (Garcia-Alonso et al., 1995) postvertical bristle (Garcia-Alonso et al., 1995) postvertical bristle \| somatic clone (Garcia-Alonso et al., 1995) presumptive embryonic/larval tracheal system (Hemphala et al., 2003, Moussian et al., 2006) synapse (Schuster et al., 1996) synapse & aCC neuron (Baines et al., 2002) synapse & RP2 neuron (Baines et al., 2002) thorax & macrochaeta \| somatic clone (Garcia-Alonso et al., 1995) thorax & microchaeta \| somatic clone (Garcia-Alonso et al., 1995) U neuron & growth cone (Sanchez-Soriano and Prokop, 2005) vMP2 neuron (Lin et al., 1994) vMP2 neuron \| embryonic stage (Grenningloh et al., 1991)
Detailed Description
	Statement Reference Fas2[e76]/Fas2[EB112] larval NMJs have fewer synaptic boutons than controls. Fas2[EB112]/+ NMJs have no change in bouton number compared to controls. (Beck et al., 2012) Anterior follicle cells in homozygous follicle cell clones undergo normal cell shape changes during oogenesis. (Gomez et al., 2012) Fas2[EB112]/Fas2[e76] adults display a rough-eye phenotype. Ommatidial photoreceptor and cone cell numbers are disrupted, and in some cases mini-clusters of ommatidia are observed. Fas2[EB112] mutant eye clones show cone cell defects, defects in photoreceptor cell number, and mini-ommatidia are observed. Fas2[EB112] mutant clones in eye disc display abnormal elav-positive cell clusters between ommatidia which resemble R7-like photoreceptor cells. Some of the cells associated with the ectopic clusters are genotypically wild-type. No R8 photoreceptor cells are associated with the ectopic cell clusters. Loss of function clones of Fas2[EB112] in the adult notum display one or more ectopic dorsocentral bristles. other macro- and microchaetae are largely unaffected. Extra sensory organ precursor cells are observed in Fas2[EB112] mutant clones. (Mao and Freeman, 2009) There are no obvious abnormalities in the timing and dynamics of the myopodia-filopodia interactions to form the synaptic contact site in Fas2[EB112]/Y embryos. In these mutants, T-shaped presynaptic terminals of normal size form in the prospective synaptic site along the proximal edge of target muscle 12. (Kohsaka et al., 2007) Fas2^EB112 mutants exhibit amorphous and expanded tracheal tubes, where the luminal chitin does not organise correctly, in comparison to wild-type (Moussian et al., 2006) The motor neuron that innervates DLMa has a higher number of contact points with the muscle in Fas2^e76/Fas2^EB112 mutants (6) than in wild type (5). The DLMa is 11% longer in Fas2^e76/Fas2^EB112 mutants than wild type. Investigation of adult innervation pattern in Fas2^e76/Fas2^EB112 mutants shows that outgrowth of secondary branches is not affected, but that branch elaboration, which occurs at 18-24 hours APF, is affected. During this stage, the average length of Fas2^e76/Fas2^EB112 secondary branches is increased, as is the area occupied by the higher order arbors of the secondary branches. Additionally, a higher level of secondary branches are stabilized, as shown by staining for futsch, in Fas2^e76/Fas2^EB112 mutants at 24 hours APF than wild type. (Hebbar and Fernandes, 2005) Fas2[e76]/Fas2[EB112] mutants exhibit normal axon patterns. There are sporadic single BM axon defects, but no OP axon alterations are found. (Kristiansen et al., 2005) In a Fas2^EB112 mutant background, U motorneuron growth cones exhibit a wide shape that is reminiscent of aCC/RP2 pioneer growth cones. (Sanchez-Soriano and Prokop, 2005) In stage 14 Fas2^EB112 mutants, the lumenal chitin in the developing dorsal trunk of the tracheal system fails to form a filamentous cable running along the tube length, as in wild-type, but instead is amorphous and fills the lumen. (Tonning et al., 2005) In Fas2^EB112 homozygotes, the border follicle cells lose their polarity. Delamination of these cells is delayed, but their migration is accelerated. (Szafranski and Goode, 2004) Mutant embryos develop long and convoluted tracheal dorsal trunks and the apical cell surface of the dorsal trunk cells appears elongated and expanded. Tubular dilations are seen in the transverse connectives and the lumen of several tracheal branches is discontinuous. (Hemphala et al., 2003) During the first 28hr of wild-type larval life, the frequency of suprathreshold synaptic drive to aCC/RP2 increases considerably. In the absence of Fas2, such as in Fas2^EB112, the frequency of synaptic drive to aCC/RP2 still increases during this period, although this increase is significantly less than when Fas2 is present. In Fas2^EB112 mutants the number of presynaptic terminals that contact aCC remains unchanged. The ultrastructure of the presynaptic terminals at this stage is qualitatively indistinguishable from those that develop in wild-type. (Baines et al., 2002) The initial growth of the pioneer mushroom body (MB) axons is not disturbed in mutants. After converging at the protocerebral neuropil, the MB axons exhibit a normal medial turn and from the primordial medial lobe. When homozygous mutant clones are made in the MB, the axon projections exhibit no gross abnormalities. However dispersed axonal fascicles are seen in 23% of cases, in which axon bundles are randomly scattered throughout the axonal layers of the peduncle and lobes. (Kurusu et al., 2002) Fas2^EB112/+ embryos have normal axon guidance. (Abrell and Jackle, 2001) Larvae successfully hatch and begin crawling around but within hours begin to behave sluggish and uncoordinated, they ultimately stop moving and die. Synapses form and mature but in the absence of Fas2 they do not grow and then retract, the number of boutons drops to a few or zero. (Schuster et al., 1996) Transheterozygotes with Fas2^e76 exhibit missing postvertical, ocellar, vertical and orbital bristles. At 17^oC the phenotype is more penetrant with missing ocelli. Gynandromorph mosaics demonstrate hemizygous male regions fail to differentiate the postvertical, ocellar and vertical bristles and still have some orbital bristles. Ocelli are missing and the compound eye has a rough phenotype. Some macro- and microchaetes in the thorax are missing. (Garcia-Alonso et al., 1995) EM analysis of the extent of fasciculation and membrane apposition between various pairs of axons reveals normal neurite outgrowth, extension and guidance in embryos. Some aspects of selective fasciculation and axon-glia interactions appear highly abnormal, the vMP2, MP1 and FN3 pathways defasciculate. Scer\GAL4 driven expression of Fas2 can refasciculate the FN3 axons. (Lin et al., 1994) Transheterozygotes for Fas2^EB112 and Fas2^e76 are sterile. Increased branching of wing sensory axons in discs during metamorphosis. Ectopic sensory neurons are displayed in the wing. (Whitlock, 1993) The MP1 pathway does not form in Fas2^EB112 mutant embryos: at embryonic stage 12/1 the dMP2 and MP1 growth cones do not turn posteriorly (which happens in the wild-type) but rather project laterally for a short distance. Also, the vMP2 growth cone often turns anteriorly (as in the wild-type) but already shows variability in the precise orientation of its tip. The MP1, dMP2 and vMP2 growth cones stay stalled in the same position through to stage 14 in mutant embryos, in contrast to the wild-type. (Grenningloh et al., 1991)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference Fas2^EB112 is a non-enhancer of visible phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Buff et al., 2007)
Suppressor of
Statement Reference Fas2^EB112, Scer\GAL4^eve.RN2 is a suppressor of neuroanatomy defective phenotype of Rdl^Scer\UAS.cSa, Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) Fas2^EB112 is a suppressor \| partially of neuroanatomy defective \| embryonic stage phenotype of rap^ie28 (Silies and Klämbt, 2010) Fas2^EB112 is a suppressor of neurophysiology defective phenotype of Ctet\TeTxLC^TNT.Scer\UAS, Scer\GAL4^eve.RRK (Baines et al., 2002)
NOT Suppressor of
Statement Reference Fas2^EB112 is a non-suppressor of visible phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Buff et al., 2007)
Other
Statement Reference Fas2^EB112, Tao^eta has cell lethal \| somatic clone phenotype (Gomez et al., 2012)
Phenotype Manifest In
Enhanced by
Statement Reference Fas2^EB112/Fas2^e76 has eye phenotype, enhanceable by aos^Δ7 (Mao and Freeman, 2009)
Suppressed by
Statement Reference Fas2^EB112, Sema-1a^k13702 has abdominal segmental nerve phenotype, suppressible by Con^Fvex238 (Yu et al., 2000)
Enhancer of
Statement Reference Fas2^EB112/Fas2[+] is an enhancer of eye phenotype of Egfr^Scer\UAS.cBa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mao and Freeman, 2009) Fas2^EB112/Fas2[+] is an enhancer of eye phenotype of rho^hs.sev (Mao and Freeman, 2009)
NOT Enhancer of
Statement Reference Fas2^EB112 is a non-enhancer of eye phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Buff et al., 2007)
Suppressor of
Statement Reference Fas2^EB112, Scer\GAL4^eve.RN2 is a suppressor of abdominal intersegmental nerve phenotype of Rdl^Scer\UAS.cSa, Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) Fas2^EB112, Scer\GAL4^eve.RN2 is a suppressor of intersegmental nerve phenotype of Rdl^Scer\UAS.cSa, Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) Fas2^EB112, Scer\GAL4^eve.RN2 is a suppressor of mesothoracic intersegmental nerve phenotype of Rdl^Scer\UAS.cSa, Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) Fas2^EB112, Scer\GAL4^eve.RN2 is a suppressor of metathoracic intersegmental nerve phenotype of Rdl^Scer\UAS.cSa, Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) Fas2^EB112, Scer\GAL4^eve.RN2 is a suppressor of prothoracic intersegmental nerve phenotype of Rdl^Scer\UAS.cSa, Scer\GAL4^eve.RN2 (Sanchez-Soriano and Prokop, 2005) Fas2^EB112/Fas2[+] is a suppressor of eye phenotype of Scer\GAL4^sev.EP, sty^Scer\UAS.cHa (Mao and Freeman, 2009) Fas2^EB112/Fas2[+] is a suppressor of intersegmental nerve phenotype of Sema-1a^k13702 (Yu et al., 2000) Fas2^EB112/Fas2[+] is a suppressor of RP3 neuron & synapse phenotype of Sema-1a^k13702 (Yu et al., 2000) Fas2^EB112 is a suppressor \| partially of glial cell phenotype of rap^ie28 (Silies and Klämbt, 2010) Fas2^EB112 is a suppressor \| somatic clone of follicle cell \| somatic clone phenotype of Tao^eta (Gomez et al., 2012) Fas2^EB112 is a suppressor of presumptive embryonic/larval central nervous system phenotype of Sema-1a^k13702 (Yu et al., 2000) Fas2^EB112 is a suppressor of synapse & aCC neuron phenotype of Ctet\TeTxLC^TNT.Scer\UAS, Scer\GAL4^eve.RRK (Baines et al., 2002) Fas2^EB112 is a suppressor of synapse & RP2 neuron phenotype of Ctet\TeTxLC^TNT.Scer\UAS, Scer\GAL4^eve.RRK (Baines et al., 2002)
NOT Suppressor of
Statement Reference Fas2^EB112 is a non-suppressor of abdominal segmental nerve phenotype of Sema-1a^k13702 (Yu et al., 2000) Fas2^EB112 is a non-suppressor of eye phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Buff et al., 2007)
Other
Statement Reference Fas2^EB112, Kr¹, Kr^mCD has abdominal segmental nerve phenotype (Abrell and Jackle, 2001, Abrell and Jackle, 2001) Fas2^EB112, Kr¹, Kr^mCD has RP neuron phenotype (Abrell and Jackle, 2001, Abrell and Jackle, 2001) Fas2^EB112, Kr¹/Kr^mCD has abdominal segmental nerve phenotype (Abrell and Jackle, 2001) Fas2^EB112, Kr¹/Kr^mCD has RP neuron phenotype (Abrell and Jackle, 2001)
Additional Comments
Genetic Interactions
Statement Reference Large follicle cell clones doubly homozygous for Tao[eta] and Fas2[EB112] show cell lethality, while small follicle cell clones doubly homozygous for Tao[eta] and Fas2[EB112] can be recovered in stage 8/9 egg chambers. Anterior follicle cells in these small clones stretch normally. (Gomez et al., 2012) The glial cell migration defects of rap[ie28] embryos are significantly suppressed by Fas2[EB112] (54.7% of hemisegments show normal migration, 27.9% of hemisegments show partial migration). However, the increase in glial cell number and the axonal defects seen in rap[ie28] embryos is not suppressed by Fas2[EB112]. (Silies and Klämbt, 2010) rho[hs.sev] rough eye phenotype is enhanced in the presence of Fas2[EB112]/+ at 18[o]C. Expression of Egfr[Scer\UAS.cBa] under the control of Scer\GAL4[GMR.PF] results in a rough-eye phenotype, which is enhanced by the presence of Fas2[EB112]/+. The rough-eye phenotype observed in Fas2[EB112]/Fas2[e76] flies is enhanced by the presence of argos[Δ7]/+. The rough-eye phenotype observed in flies expressing sty[Scer\UAS.cHa] under the control of Scer\GAL4[sev.EP] is suppressed in the presence of Fas2[EB112]/+. (Mao and Freeman, 2009) Intersegmental nerves are co-arrested upon expression of Rdl^Scer\UAS.cSa in the aCC/RP2 neurons (under the control of Scer\GAL4^eve.RN2) in a Fas2^EB112 mutant background in 36% of cases, compared with 70% in a wild-type background. (Sanchez-Soriano and Prokop, 2005) In the absence of Fas2, in Fas2^EB112 mutants, the effect of Ctet\TeTxLC^TNT.Scer\UAS expression in aCC/RP2 neurons (under the control of Scer\GAL4^eve.RRK) on the frequency of synaptic inputs is significantly diminished compared to Ctet\TeTxLC^TNT.Scer\UAS expression in wild-type. (Baines et al., 2002) Fas2^EB112/+, Kr¹/+ double heterozygotes (that also carry Kr^mCD) exhibit an axon guidance phenotype. The SNb enters the ventral muscle field normally in most cases but the nerve stops at the second choice point by forming a growth cone-like structure. No individual RP axons are observed. (Abrell and Jackle, 2001) The intersegmental nerve b (ISNb) phenotypes seen in homozygous Sema-1a^k13702 embryos are suppressed by one copy of Fas2^EB112. Synaptic arborisations on ventral lateral muscles (VLMs) 12 and 6-7 appear normal. The Sema-1a^k13702 segmental nerve a (SNa) defasciculation defects are not suppressed by Fas2^EB112 alone. However, rescue of the Sema-1a^k13702 SNa stall phenotype is seen in Fas2^EB112/+ ; Sema-1a^k13702 ; Con^Fvex238 triple mutant embryos; the SNa dorsal branches bifurcate at lateral muscles (LMs) 22-23 and extend dorsally. Sema-1a^k13702 CNS defects are suppressed by one copy of Fas2^EB112 (they are seen in only 10% of hemisegments, compared to 31% in Sema-1a^k13702 single mutants). (Yu et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Fas2^EB112 is rescued by Fas2^+mTM31.2 (Garcia-Alonso et al., 1995) Fas2^EB112 is rescued by Fas2^Scer\UAS.cLa/Scer\GAL4^elav.PLu (Schuster et al., 1996) Fas2^EB112 is rescued by Fas2^Scer\UAS.cLa/Scer\GAL4^Mhc.PW (Schuster et al., 1996) Fas2^EB112 is rescued by Fas2^Scer\UAS.cLa/Scer\GAL4^unspecified (Garcia-Alonso et al., 1995) Fas2^EB112 is rescued by Scer\GAL4^unspecified/Fas2^{Scer\UAS.T:Avic\GFP-YFP} (Kohsaka et al., 2007)
Comments	Scer\GAL4^elav.PLu or Scer\GAL4^Mhc.PW mediated expression of Fas2^Scer\UAS.cLa rescues larval lethality. Scer\GAL4^A51 mediated expression of Fas2^Scer\UAS.cLa causes mosaic rescued larvae, rescue of boutons in the segments Scer\GAL4 is expressed (muscles 6 and 7) and elimination of boutons in segments where it is not expressed. (Schuster et al., 1996)
Stocks ( 1 )
Bloomington	36284 y¹ w^* Fas2^EB112 P{FRT(w^hs)}101/FM7a; Dr¹/TM3, Sb¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	Fas2^eB112 (Baines et al., 2002, Sone et al., 2000) Fas2^EB112 (Tonning et al., 2005) fas2^eB112 (Kristiansen et al., 2005, Kohsaka et al., 2007) fas2^eb112 (Mao and Freeman, 2009) fas2^EB112 (Silies and Klämbt, 2010) Fas2^eb112 (Gomez et al., 2012) fas II^A31eB112 (Skaer, 1993) fasII^EB112 (Hemphala et al., 2003) fas II^eb112 (Kurusu et al., 2002) FasII^eb112 (Abrell and Jackle, 2001) FasII^eB112 (Yu et al., 2000, Goodman et al., 1997, Speicher et al., 1998, Davis et al., 1997, Schuster et al., 1996) fasII^eb112 (Thomas et al., 1997, Buff et al., 2007) fasII^eB112 (Garcia-Alonso et al., 1995, Kania and Bellen, 1995, Lin et al., 1994, Grenningloh et al., 1991, Lee and Wu, 2010, Beck et al., 2012)
Name Synonym	fasciclin^eb112 (Sanchez-Soriano and Prokop, 2005)
Secondary FlyBase IDs

References ( 31 )

Generate a list of	All references relating to this allele ( 31 )

List References by type	Research paper ( 29 ) Review ( 2 )
Recent research papers ( 2 )
	Beck et al., 2012, J. Neurosci. 32(20): 7058--7073 Regulation of Fasciclin II and Synaptic Terminal Development by the Splicing Factor Beag. [FBrf0218385] Gomez et al., 2012, J. Cell Biol. 199(7): 1131--1143 Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. [FBrf0220436] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\Fas2EB112

Allele Dmel\Fas2^EB112