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General Information
Symbol
Dmel\RasGAP1B2
Species
D. melanogaster
Name
FlyBase ID
FBal0029795
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
gap1B2
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes have normal wings.

On the legs and wings of mutant adults mechanosensory bristles have two or more bracts.

Gap1B2/+ heterozygotes show wild type wing veins.

Average number of R7 cells per ommatidium is 2.9.

Mosaics in the follicular epithelium cause localized dorsalization of the embryonic cuticle, concomitant with localized disruptions in the nuclear localization of dl gene product.

Severe Gap1 allele.

Mutation has no effect on rhohs.sev rough eye phenotype.

Homozygous females lay eggs with a weak dorsalized egg shell morphology. The embryos are also partially dorsalized.

Rough eye phenotype. Ommatidia are improperly oriented and occasionally are fused. Ommatidia contain supernumerary cells that are characteristic of R7 cells. Supernumerary cells are derived from a cone cell precursor, or a mystery cell, that adopts a neural fate in the disc. Wings show additional longitudinal veinlet branches of the posterior crossvein and delta-like structures. One or two extra sex combs form in ectopic positions and in both sexes duplications of epidermal structures associated with bristles of the distal leg.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Gap1[+]/RasGAP1B2 is an enhancer of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

RasGAP1B2 is an enhancer of visible phenotype of RetMEN2B.GMR

RasGAP1B2 is an enhancer of visible phenotype of RetMEN2A.GMR

RasGAP1B2 is an enhancer of visible phenotype of RetGMR.PR

Gap1[+]/RasGAP1B2 is an enhancer of visible | dominant phenotype of EgfrE3

Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference

Gap1[+]/RasGAP1B2 is an enhancer of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

RasGAP1B2 is an enhancer of eye phenotype of RetMEN2B.GMR

RasGAP1B2 is an enhancer of eye phenotype of RetMEN2A.GMR

RasGAP1B2 is an enhancer of eye phenotype of RetGMR.PR

Gap1[+]/RasGAP1B2 is an enhancer of eye phenotype of EgfrE3

Gap1[+]/RasGAP1B2 is an enhancer of photoreceptor cell R7 | ectopic phenotype of sty226

Suppressor of
Statement
Reference

RasGAP1B2 is a suppressor of phenotype of cswlf

RasGAP1B2 is a suppressor of photoreceptor cell R7 phenotype of boss1

RasGAP1B2 is a suppressor of photoreceptor cell R7 phenotype of sev14

Other
Additional Comments
Genetic Interactions
Statement
Reference

RasGAP1B2 suppresses the wing vein loss seen when PtpmegScer\UAS.cLa is expressed under the control of Scer\GAL4en.PU.

The presence of a Gap1B2 background significantly enhances ectopic wing vein formation found in cswY279C.Scer\UAS (Scer\GAL4tub) mutants.

Gap1B2/+ flies expressing GckIIIScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Bx-MS1096 have ectopic wing veins.

The addition of heterozygous Gap1B2 moderately enhances the rough eye phenotype seen in freddsRNA.Scer\UAS, Scer\GAL4GMR.PF animals. However only 30% of animals exhibited increased roughness.

Gap1B2 pkunspecified (sple) animals show extra bracts, all with the same polarity.

Heterozygotes for Gap1B2 and ed1X5 show extra wing veins.

Enhances the extra-R7 cell eye phenotype of sty226/+ heterozygotes.

Heterozygous Gap1B2/+ in combination with sl1 show more than 80% of ommatidia with multiple R7 cells. Average number of R7 cells per ommatidium is 2.2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by

RasGAP1B2 is partially rescued by RasGAP1ΔN.sev

Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (25)