Khc8/+, Df(3L)8ex25/+ larvae exhibit uncoordinated locomotion and a characteristic tail-flipping phenotype. Axonal swellings (axonal spheroids or neuritic beads) are observed in the segmental nerves of the double heterozygotes. Pharmacological intervention using SBL-398 (and other compounds) can partially suppress motor dysfunction and the appearance of membranous aggregates in mutant segmental nerves.
The Gl1/+ adult eye phenotype and the loss of photoreceptor nuclei from the retina in late third instar Gl1/+ larvae are almost completely suppressed by Khc8/+. The loss of photoreceptor nuclei from the retina in late third instar GlΔ.Scer\UAS; Scer\GAL4Glass38-1 larvae is almost completely suppressed by Khc8/+. Mislocalisation of the Bolwig's organ nuclei in GlΔ.Scer\UAS/Scer\GAL4elav.PLu second instar larvae is partially suppressed by Khc8/+.
The addition of Hsap\APP695.T.Scer\UAS, Hsap\APP695-Swedish.Scer\UAS, Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC, Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC or Hsap\APPV717F.LOND.Scer\UAS (driven by Scer\GAL4Appl.G1a) to Khc8/+ animals causes the organelle jamming phenotype to be seen in this animals, thus enhancing the phenotype. The addition of Hsap\APP695ΔCT.Scer\UAS.T:Hsap\MYC or Appls.Scer\UAS has no effect on this phenotype.