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General Information
Symbol
Dmel\Pka-C1B10
Species
D. melanogaster
Name
FlyBase ID
FBal0030038
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
DC0B10, DCOB10
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A9696911T

Reported nucleotide change:

A2779T

Amino acid change:

N219I | Pka-C1-PB; N219I | Pka-C1-PC; N219I | Pka-C1-PD

Reported amino acid change:

N219I

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Missense mutation within the Pka-C1 coding region.

Amino acid replacement: N219I.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pka-C1B10 heterozygotes do not show any obvious olfactory learning or memory defects upon an olfactory aversive conditioning assay, as compared to controls.

Heterozygotes have significantly lower basal fluid secretion rates from the Malpighian tubules compared to wild type.

Pka-C1B10/Pka-C1Tw2 mutant flies show an inability to find a preferred temperature, with temperature preference across a wide gradient.

Border follicle cell migration is normal in Pka-C1B10/Pka-C1Tw2 females.

Heterozygotes exhibit rhythmic locomotor activity in constant darkness and the average circadian rhythm is slightly shorter than wild type. Heterozygotes had ostensibly normal behaviour.

Transheterozygotes for weak Pka-C1 alleles are lethal at 18oC. Hemizygotes are larval lethal with some adult escapers.

Heterozygotes exhibit an olfactory learning deficit. Pka-C1MB581/Pka-C1B10 transheterozygotes are viable and exhibit a dramatic olfactory learning and memory deficit.

hypomorphic

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

mengMI03008, Pka-C1B10 double heterozygotes show a significant decrease in 24h olfactory memory, but not in learning, upon an olfactory aversive conditioning assay, as compared to controls; however, there are no effects in residual olfactory memory upon cold-shock, as compared to controls.

Double heterozygotes for amnchpd and Pka-C1B10 show an inability to find a preferred temperature, with temperature preference spread across a wide gradient.

Double heterozygotes for rut1 and Pka-C1B10 show an inability to find a preferred temperature, with temperature preference spread across a wide gradient.

Xenogenetic Interactions
Statement
Reference

Animals expressing Zzzz\bPACScer\UAS.cSa under the control of Scer\GAL4c42 in a Pka-C1B10/+ background show significant stimulation of fluid secretion from the Malpighian tubules in response to low light activation.

Complementation and Rescue Data
Comments

One copy of Pka-C1+mTgDC0 provides full rescue of hemizygotes.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

D. Kalderon.

Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (15)