Allele Dmel\Psc^14P4

General Information
Symbol	Dmel\Psc^14P4	Species	D. melanogaster
Name		FlyBase ID	FBal0030046
Feature type	allele	Associated gene	Dmel\Psc

Allele class	gain of function allele, hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	gain of function allele (Wu and Howe, 1995) hypomorphic allele - genetic evidence (Brunk et al., 1991, Martin and Adler, 1993)
Mutagen	P-element activity (Adler et al., 1989, Brunk et al., 1991)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P element insertion into Psc transcription unit. (Martin and Adler, 1993) P-element insertion into the Psc locus. (Adler et al., 1989)
Caused by insertion	P{}Psc^14P4 (Martin and Adler, 1993, Brunk et al., 1991, Adler et al., 1989)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective \| dominant (Wu and Howe, 1995) visible \| dominant (Wu and Howe, 1995)
Phenotype Manifest In
	alula (Wu and Howe, 1995) pigment cell (Wu and Howe, 1995) wing \| posterior compartment (Wu and Howe, 1995)
Detailed Description
	Statement Reference Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosome. (Cryderman et al., 1999) Lethal over Psc¹, shows some degree of viability over deficiencies for the region. Adult survivors of transallelic combinations of "hopeful" alleles show homeotic phenotypes. The wing is often half or less their normal size, bulbous, arched upward and curved inward in the shape of a cashew nut. The posterior compartment of the wing is more severely affected than the anterior compartment. Alula can be reduced or missing, posterior wing margin is missing and the flanking wing blade is eroded. This homeotic phenotype resembles that of the Cbx mutations, and is dominantly enhanced by Su(z)2⁴. Enhances z¹ eye color. (Wu and Howe, 1995)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	Psc^Arp.1 (Brunk et al., 1991)
Fails to complement	Psc¹ (Brunk et al., 1991)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Member of the "hopeful" class of Psc alleles, i.e. shows some degree of viability in trans to at least one of the "hapless" alleles. (Wu and Howe, 1995) Complements: Su(z)2¹. Complements: Su(z)2^Arp.1. (Brunk et al., 1991)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	l(2)49Ea⁴ Psc^14P4 vr14^P4 vr14-P4 (Brunk et al., 1991, )
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Cryderman et al., 1999, EMBO J. 18(13): 3724--3735 Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles. [FBrf0109548] Wu and Howe, 1995, Genetics 140(1): 139--181 A genetic analysis of the suppressor 2 of zeste complex of Drosophila melanogaster. [FBrf0082794] Martin and Adler, 1993, Development 117(2): 641--655 The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein. [FBrf0058093] Brunk et al., 1991, Genetics 128: 119--132 Molecular genetics of the Posterior sex combs/Suppressor 2 of zeste region of Drosophila: aberrant expression of the Suppressor 2 of zeste gene results in abnormal bristle development. [FBrf0054127] Adler et al., 1989, Dev. Genet. 10: 249--260 Genetic interactions of the Suppressor 2 of zeste region genes. [FBrf0049524]

Allele Dmel\Psc14P4

Allele Dmel\Psc^14P4