Allele Dmel\Rdl¹

General Information
Symbol	Dmel\Rdl¹	Species	D. melanogaster
Name		FlyBase ID	FBal0030106
Feature type	allele	Associated gene	Dmel\Rdl
Also Known As	Rdl-1

Allele class
Mutagen	gamma ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	gamma ray (ffrench-Constant et al., 1991)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Breakpoint in Rdl. (Stilwell and ffrench-Constant, 1998) Cytologically not visible. (ffrench-Constant et al., 1991)
Caused by aberration	In(3L)Rdl¹ (Stilwell and ffrench-Constant, 1998)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Stilwell and ffrench-Constant, 1998) lethal \| recessive (Liu et al., 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference Rdl¹/Rdl¹¹ animals die during the late stages of embryogenesis. (Stilwell and ffrench-Constant, 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Rdl[+]/Rdl¹ is a suppressor \| partially of paralytic \| recessive phenotype of kcc^DHS1 (Hekmat-Scafe et al., 2010) Rdl[+]/Rdl¹ is a suppressor of bang sensitive \| recessive phenotype of kcc^DHS1 (Hekmat-Scafe et al., 2006)
Other
Statement Reference Rdl¹, smi26D¹/smi26D[+] has locomotor behavior defective \| dominant \| female phenotype (Anholt et al., 2003) Rdl¹, smi26D¹/smi26D[+] has smell perception defective \| dominant \| female phenotype (Anholt et al., 2003) Rdl¹, smi26D¹ has locomotor behavior defective \| dominant \| female phenotype (Anholt et al., 2003) Rdl¹, smi26D¹ has smell perception defective \| dominant \| female phenotype (Anholt et al., 2003)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference The bang-sensitive paralytic phenotype of homozygous kcc[DHS1] mutants is significantly suppressed by Rdl[1]/+. (Hekmat-Scafe et al., 2010) The penetrance of the bang sensitive phenotype seen in kcc[DHS1] homozygous adults is reduced to 1% by Rdl[1]/+. (Hekmat-Scafe et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	1687 Rdl¹/TM3, Sb¹
Kyoto	106453 Rdl¹/TM3, Sb¹
Notes on Origin
Discoverer

Comments
	Induced in a Rdl susceptible strain. (ffrench-Constant et al., 1991)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Rdl-1 (ffrench-Constant, 1993, ffrench-Constant et al., 1991) Rdl¹ (Gresens et al., 2006.7.11, Christensen et al., 2007.10.29, Hekmat-Scafe et al., 2006, Liu et al., 2007, Hekmat-Scafe et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Hekmat-Scafe et al., 2010, Genetics 184(1): 171--183 Seizure sensitivity is ameliorated by targeted expression of k+-cl- cotransporter function in the mushroom body of the Drosophila brain. [FBrf0209683] Liu et al., 2007, Neuron 56(6): 1090--1102 GABA(A) receptor RDL inhibits Drosophila olfactory associative learning. [FBrf0200439] Hekmat-Scafe et al., 2006, J. Neurosci. 26(35): 8943--8954 Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. [FBrf0192588] Anholt et al., 2003, Nat. Genet. 35(2): 180--184 The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome. [FBrf0167944] Stilwell and ffrench-Constant, 1998, J. Neurobiol. 36(4): 468--484 Transcriptional analysis of the Drosophila GABA receptor gene resistance to dieldrin. [FBrf0104519] ffrench-Constant, 1993, Pichon, 1993: 210--223 Cloning of a putative GABA_A receptor from cyclodiene-resistant Drosophila: A case study in the use of insecticide-resistant mutants to isolate neuroreceptors. [FBrf0058168] ffrench-Constant et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88: 7209--7213 Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus. [FBrf0055003]
Personal communication to FlyBase	Christensen et al., 2007.10.29, Isolation and characterization of Df(3L)BSC390. Isolation and characterization of Df(3L)BSC390. [FBrf0200309] Gresens et al., 2006.7.11, Isolation and characterization of Df(3L)BSC170. Isolation and characterization of Df(3L)BSC170. [FBrf0199000] Andrade and Cook, 2003.6.2, Isolation and characterization of Df(3L)BSC35. Isolation and characterization of Df(3L)BSC35. [FBrf0159873]

Allele Dmel\Rdl1

Allele Dmel\Rdl¹