Allele Dmel\RpS6^air8

General Information
Symbol	Dmel\RpS6^air8	Species	D. melanogaster
Name		FlyBase ID	FBal0030173
Feature type	allele	Associated gene	Dmel\RpS6
Also Known As	air8

Allele class	loss of function allele
Mutagen	P-element activity, PM hybrid dysgenesis
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Watson et al., 1992)
Mutagen	P-element activity (Watson et al., 1991) PM hybrid dysgenesis (Watson and Bryant, 1991)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P element in 5' untranslated region, 43 bases from the translation start site. (Watson et al., 1992)
Caused by insertion	P{}RpS6^air8 (Watson et al., 1992, Watson et al., 1991)
Cytology
Phenotypic Data
Phenotypic Class
	hyperplasia \| recessive (Watson et al., 1992) lethal (Watson and Bryant, 1991) lethal \| larval stage \| recessive (Watson et al., 1991, Watson et al., 1992)
Phenotype Manifest In
	embryonic/larval lymph gland (Watson and Bryant, 1991)
Detailed Description
	Statement Reference Embryonic and larval development retarded, ring gland, salivary glands, gastric cecae and most imaginal discs fail to reach normal size before late larval lethal phase. Ventral ganglion fails to condense and the brain hemispheres are undersized, and at death, large melanotic tumours resulting from abnormalities in hematopoiesis are present in the body cavity. Source of the hemocytes is a hyperplastic lymph gland, which contain lamellocytes (normally not found in lymph gland) in process of abnormal self encapsulation. (Watson et al., 1992) Melanotic tumour formation and lethality are due to the same mutation. Mutations exhibit incomplete penetrance and expressivity of the melanotic tumour phenotype. Small and/or abnormally shaped brain. Garland cells found at the junction of the oesophagus and proventriculus are melanized. Hemizygous males exhibit hypertrophied lymph glands. (Watson et al., 1991) Neoplastic growth and melanotic encapsulation of the lymph glands. Transplanted lymph glands cause melanotic tumour formation and premature host death. (Watson and Bryant, 1991)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference RpS6^air8/RpS6[+] is a suppressor of visible phenotype of CycE^JP (Brumby et al., 2004)
Phenotype Manifest In
Suppressor of
Statement Reference RpS6^air8/RpS6[+] is a suppressor of eye phenotype of CycE^JP (Brumby et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	RpS6^WG1288 (Stewart and Denell, 1993)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Dysgenesis-induced revertants of the mutant phenotype have lost the P element from the RpS6 locus. (Watson et al., 1992)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	air8 (Brumby et al., 2004, Watson and Bryant, 1991, Stewart and Denell, 1993, Watson et al., 1991) air⁸ (Hoffmann and Reichhart, 1997) RpS6^air8
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Brumby et al., 2004, Genetics 168(1): 227--251 A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. [FBrf0180291] Watson et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93(24): 13694--13698 A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene. [FBrf0090854] Stewart and Denell, 1993, Mol. Cell. Biol. 13(4): 2524--2535 Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth. [FBrf0059044] Watson et al., 1992, Proc. Natl. Acad. Sci. U.S.A. 89: 11302--11306 Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. [FBrf0057504] Watson et al., 1991, Dev. Genet. 12: 173--187 Lethal(1) aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster. [FBrf0053739]
Review	Kimbrell and Beutler, 2001, Nat. Rev. Genet. 2(4): 256--267 The evolution and genetics of innate immunity. [FBrf0141068] Hoffmann and Reichhart, 1997, Trends Cell Biol. 7(8): 309--316 Drosophila immunity. [FBrf0098260]
Abstract	Watson et al., 1994, Mol. Biol. Cell 5(Suppl.): 387a Effects of ribosomal protein S6 mutations on blood cell proliferation in Drosophila. [FBrf0079603] Watson and Bryant, 1991, A. Dros. Res. Conf. 32: 68 air8, a new tumor-suppressor gene affecting blood-forming organs. [FBrf0066331]

Allele Dmel\RpS6air8

Allele Dmel\RpS6^air8