Open Close
General Information
Symbol
Dmel\S218
Species
D. melanogaster
Name
FlyBase ID
FBal0030175
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

83% of cuticles from S218 homozygous embryos show fusion of at least one pair of denticle belts, with the majority having between 1 and 3 fusions.

30% of ommatidia show a reduction in the number of photoreceptor neurons in heterozygous animals.

Homozygous clones in the follicle cells result in weak ventralisation of the eggshell; dorsal appendages are partially or completely fused.

Heterozygous adults have very slightly rough eyes.

Clonal analysis of Star alleles shows that the progression of the morphogenetic furrow is delayed and dpp expression was inhibited near the clones.

Homozygous clones in the eye are always associated with a scar, surrounded by normal ommatidia of mixed genotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

S218 has phenotype, suppressible by Egfrf2

S218 has phenotype, suppressible by spi1

Enhancer of
Statement
Reference

S218 is an enhancer of phenotype of aoshs.PSa

Suppressor of
Statement
Reference

S218 is a suppressor of phenotype of rhohs.sev

Additional Comments
Genetic Interactions
Statement
Reference

The loss of photoreceptor neurons seen in S218/+ animals is enhanced by edlJV/Df(2R)edl-L19; in the double mutant animals, 65% of ommatidia lack at least one photoreceptor neuron.

Null alleles of ru interact dominantly with S218.

The S218/+ rough eye phenotype can be enhanced by mutations in Egfr or spi. S218 EgfrE3 double heterozygous adults exhibit severely reduced and rough eyes. Most ommatidia have a reduced number of photoreceptor cells, there are also defects in orientation, spacing and pigment cell and bristle numbers. This phenotype is more severe than a simple addition of the dominant effects of Egfr and S.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
S218
Name Synonyms
Secondary FlyBase IDs
    References (12)