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General Information
Symbol
Dmel\Sose2H
Species
D. melanogaster
Name
FlyBase ID
FBal0030263
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G13816065A

    Reported nucleotide change:

    G?A

    Amino acid change:

    W579term | Sos-PA

    Reported amino acid change:

    W579term

    Comment:

    TGG to TGA

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Nucleotide substitution: G?A.

    Amino acid replacement: W579term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Sose2H homozygous mutant embryos exhibit axon crossing defects.

    Heterozygous loss of Sos has no effect on size of Nf1 mutant pupae.

    Reduces the ability of a cell to develop as an R7 cell or as any other photoreceptor.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference
    Enhancer of
    Statement
    Reference
    NOT Enhancer of
    Statement
    Reference

    Sose2H is a non-enhancer of visible phenotype of Pp2B-14Dact.GMR

    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference

    Sose2H is a non-suppressor of visible phenotype of Pp2B-14Dact.GMR

    Sose2H is a non-suppressor of visible phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

    Other
    Statement
    Reference
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference
    Enhancer of
    Statement
    Reference
    NOT Enhancer of
    Statement
    Reference

    Sose2H is a non-enhancer of eye phenotype of Pp2B-14Dact.GMR

    Sose2H is a non-enhancer of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference

    Sose2H is a non-suppressor of eye phenotype of Pp2B-14Dact.GMR

    Sose2H is a non-suppressor of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Homozygous Sose2H enhances the axon tract phenotypes seen in vav2 homozygous mutant embryos, with an increased number of midline crosses per embryo. No other CNS defects are observed.

    Weakly enhances the eye phenotype produced by activated arm constructs. (either armS44Y.GMR or armS56F.GMR).

    Enhances the sevB4 phenotype: disrupts sevB4 protein signalling.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Strong allele.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (14)