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General Information
Symbol
Dmel\Sose4G
Species
D. melanogaster
Name
FlyBase ID
FBal0030264
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    C13815527T

    Reported nucleotide change:

    C?T

    Amino acid change:

    Q421term | Sos-PA

    Reported amino acid change:

    Q421term

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Termination codon has the result of deleting the drk protein-binding site as well as the catalytic domain.

    Amino acid replacement: ?421term.

    Nucleotide substitution: C?T.

    Amino acid replacement: Q421term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Germline clones fail to rescue the female sterile phenotype of Fs(2)Ugr.

    No effect on the faf eye phenotype.

    Null embryos from homozygous female germlines differentiate poorly but have slightly more cuticle than Ras85D null embryos. Embryos from homozygous germlines that receive a paternal wild type Sos have some posterior spiracular materials and a partial A8.

    Reduces the ability of a cell to develop as an R7 cell or as any other photoreceptor.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    NOT Enhancer of
    Statement
    Reference
    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference
    Other
    Statement
    Reference
    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    Sose4G is an enhancer of phenotype of svphs.ro1

    NOT Enhancer of
    Statement
    Reference

    Sose4G is a non-enhancer of phenotype of sinaGMR.PN

    Suppressor of
    Statement
    Reference

    Sose4G is a suppressor of phenotype of svp1.sev

    Sose4G is a suppressor of phenotype of svp2.sev

    Sose4G is a suppressor of phenotype of rhohs.sev

    NOT Suppressor of
    Other
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    A Sose4G/+ background does not suppress the ectopic cell divisions found in Uba1B1/Uba1B2 trans-heterozygous eye discs.

    Has no effect on the eye phenotype caused by C3GScer\UAS.T:Hsap\MYC,T:Ggal\Myr3 expressed under the control of Scer\GAL4GMR.PF. Has no effect on the wing vein phenotype caused by C3GScer\UAS.T:Hsap\MYC,T:Ggal\Myr3 expressed under the control of Scer\GAL4dpp.blk1.

    The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Sose4G.

    Suppressor of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

    Mutation has no effect on the rough eye phenotype caused by two insertions of P{GMR-Rho1}.

    Suppression of the rough eye phenotype (formation of extra R7 cells) caused by P{sev-svp2} and enhancement of the P{ro-svp1} rough eye phenotype (loss of one or more outer photoreceptors from many of the ommatidia).

    Enhances the sevB4 phenotype: disrupts sevB4 protein signalling.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Strong allele.

    Probably represents the loss of function condition.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (19)