FlyBase Allele Report: Dmel\Sos[e4G]

General Information

Symbol

Dmel\Sos^e4G

Species

D. melanogaster

Name

FlyBase ID

FBal0030264

Feature type

allele

Associated gene

Dmel\Sos

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

2L:13,815,527..13,815,527 [+]

Nucleotide change:

C13815527T

Reported nucleotide change:

C?T

Amino acid change:

Q421term | Sos-PA

Reported amino acid change:

Q421term

(Simon et al., 1991)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Termination codon has the result of deleting the drk protein-binding site as well as the catalytic domain.

(Hou et al., 1995)

Amino acid replacement: ?421term.

(Hou et al., 1995)

Nucleotide substitution: C?T.

(Simon et al., 1991)

Amino acid replacement: Q421term.

(Simon et al., 1991)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage | recessive

(Simon et al., 1991)

some die during pupal stage | recessive

(Simon et al., 1991)

Phenotype Manifest In

photoreceptor cell R7

(Simon et al., 1991)

Detailed Description

Statement

Reference

Germline clones fail to rescue the female sterile phenotype of Fs(2)Ugr.

(Sapir et al., 1998)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Null embryos from homozygous female germlines differentiate poorly but have slightly more cuticle than Ras85D null embryos. Embryos from homozygous germlines that receive a paternal wild type Sos have some posterior spiracular materials and a partial A8.

(Hou et al., 1995)

Reduces the ability of a cell to develop as an R7 cell or as any other photoreceptor.

(Simon et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Sos^e4G is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

Sos^e4G is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

NOT Suppressor of

Statement

Reference

Sos^e4G/Sos[+] is a non-suppressor of lethal phenotype of Uba1^B1/Uba1^B2

(Yan et al., 2009)

Sos^e4G is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Sos^e4G is a non-suppressor of visible phenotype of C3G^{UAS.Tag:MYC,Tag:M(c-SRC)}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Ishimaru et al., 1999)

Sos^e4G is a non-suppressor of visible phenotype of C3G^{UAS.Tag:MYC,Tag:M(c-SRC)}, Scer\GAL4^dpp.blk1

(Ishimaru et al., 1999)

Other

Statement

Reference

Ras85D^V12.sev, Sos^e4G, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sos^e4G is an enhancer of phenotype of svp^hs.ro1

(Kramer et al., 1995)

NOT Enhancer of

Statement

Reference

Sos^e4G is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Sos^e4G is a non-enhancer of phenotype of sina^GMR.PN

(Neufeld et al., 1998)

Suppressor of

Statement

Reference

Sos^e4G is a suppressor | maternal effect of embryonic/first instar larval cuticle | maternal effect phenotype of tor^12D

(Li and Li, 2003)

Sos^e4G is a suppressor of phenotype of svp^2.sev

(Begemann et al., 1995, Kramer et al., 1995)

Sos^e4G is a suppressor of phenotype of svp^1.sev

(Begemann et al., 1995, Kramer et al., 1995)

Sos^e4G is a suppressor of phenotype of rho^hs.sev

(Freeman, 1994)

NOT Suppressor of

Statement

Reference

Sos^e4G is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Sos^e4G is a non-suppressor of eye phenotype of C3G^{UAS.Tag:MYC,Tag:M(c-SRC)}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Ishimaru et al., 1999)

Sos^e4G is a non-suppressor of wing vein L3 phenotype of C3G^{UAS.Tag:MYC,Tag:M(c-SRC)}, Scer\GAL4^dpp.blk1

(Ishimaru et al., 1999)

Sos^e4G is a non-suppressor of phenotype of sina^GMR.PN

(Neufeld et al., 1998)

Other

Statement

Reference

Sos^e4G, da² has follicle cell phenotype

(Smith et al., 2002)

Sos^e4G/Sos[+], da² has follicle cell phenotype

(Smith et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

A Sos^e4G/+ background does not suppress the ectopic cell divisions found in Uba1^B1/Uba1^B2 trans-heterozygous eye discs.

(Yan et al., 2009)

Has no effect on the eye phenotype caused by C3G^{Scer\UAS.T:Hsap\MYC,T:Ggal\Myr3} expressed under the control of Scer\GAL4^GMR.PF. Has no effect on the wing vein phenotype caused by C3G^{Scer\UAS.T:Hsap\MYC,T:Ggal\Myr3} expressed under the control of Scer\GAL4^dpp.blk1.

(Ishimaru et al., 1999)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by Sos^e4G.

(Maixner et al., 1998)

Suppressor of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Mutation has no effect on the rough eye phenotype caused by two insertions of P{GMR-Rho1}.

(Hariharan et al., 1995)

Suppression of the rough eye phenotype (formation of extra R7 cells) caused by P{sev-svp2} and enhancement of the P{ro-svp1} rough eye phenotype (loss of one or more outer photoreceptors from many of the ommatidia).

(Kramer et al., 1995)

Enhances the sev^B4 phenotype: disrupts sev^B4 protein signalling.

(Simon et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sos^e4G is rescued by Sos^+t10

(Simon et al., 1991)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong allele.

(Simon et al., 1991)

Probably represents the loss of function condition.

(Hou et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

E(sev)2A^e4G

(Simon et al., 1991)

Sos^e4G

Sos^e4g

(Yan et al., 2009)

sos^E4g

(Maixner et al., 1998)

sos^e4G

(Yang and Bashaw, 2006, Zhu et al., 2005, Li and Li, 2003, Smith et al., 2002, Bai et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (19)

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