FB2025_02 , released April 17, 2025
Allele: Dmel\Su(var)2091
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General Information
Symbol
Dmel\Su(var)2091
Species
D. melanogaster
Name
FlyBase ID
FBal0030286
Feature type
allele
Associated gene
Su(var)209
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Sinclair et al., 1983)
ethyl methanesulfonate
(Sinclair et al., 1992)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of Su(var)2091 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of Su(var)2091 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)

      Moderate to strong maternal effects as seen by elevated w+ eye pigment levels in non-suppressor bearing offspring of Su(var) females. Removal of segments of heterochromatin from the genome by loss of the Y chromosome abolishes the suppression of the position effect variegation phenotype. The effect of the Su(var)209 allele is unchanged in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin). Su(var)204 and Su(var)209 complemented all other mutants with respect to female fecundity.

      (Sinclair et al., 1992)

      Dominant suppressor of position effect variegation in eye pigment caused by In(1)wm4 or In(2R)bwVDe2. The suppressor effect on the variegation caused by In(1)wm4 is substantially reduced or eliminated entirely in male XO flies lacking a Y chromosome.

      (Sinclair et al., 1983)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      209
      (Doheny et al., 2008)
      Su(var)209
      (Sinclair et al., 1983)
      Su(var)2091
      Name Synonyms
      Secondary FlyBase IDs
        References (3)