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General Information
Symbol
Dmel\SxlF1.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0030319
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A female-specific Sxl cDNA is expressed under the control of an Hsp70 promoter.

Sxl+ cDNA under the control of an Hsp70 promoter.

Female Sxl cDNA, cF1, expression is under the control of an Hsp70 promoter.

Female specific Sxl cDNA is fused to the Hsp70 promoter.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of P{SxlcF1} in wild type males, even under nonheat shock conditions, recovers only 2% of expected males.

Phenotype varies upon site of insertion. Weak class insertions have no obvious effect on male phenotype at 25oC or 29oC, with one or two copies of the transgene. One copy of the moderate class of insertion reduces male viability at 25oC and becomes more severe at 29oC. At 25oC males are intersexes with varying degrees of feminization and are sterile, at 29oC male escapers display this same phenotype. The strong class of insertion causes male lethality at 25oC and 29oC. All phenotype are in the presence of Sxl+.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

SxlF1.hs has phenotype, suppressible by snf1

Additional Comments
Genetic Interactions
Statement
Reference

The addition of up to three copies of P{snf+,dhd+} to Sxlf1/Y;SxlF1.hs, tra1 partially feminized males does not enhance the feminisation or lethality phenotypes seen in these flies.

75% of expected males are recovered from snf1; P{SxlcF1} males, 67% of expected males are recovered from snfe8H; P{SxlcF1} males and 15% of expected males are recovered from snfJA2; P{SxlcF1} males.

The presence of SxlF1.hs, failed to rescue female lethality in vir transheterozygotes. vir2f/vir- males are fertile in the presence of SxlF1.hs.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Carried in plasmid "pB-Shsp-SxlF1cDNA", transfected into Schneider cells and used to study the role of competing splice sites in Sxl autoregulation.

Carried in plasmid "hsp-SxlF1" and assayed in Drosophila Kc cells.

Phenotype variability is due to quantitative variation of expression at different sites of insertion. Transgene does not have full female function.

Carried in plasmid "hsp-SxlF1cDNA".

Strong class of insertion exhibits constitutive expression in the absence of heat shock.

Expresses the female-specific protein in the male.

Carried in a plasmid, and cotransfected into SL-2 cells, to study the effect.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
SxlF1.hs
Name Synonyms
Secondary FlyBase IDs
    References (13)